Wednesday, May 31, 2017

Nature Reviews Drug Discovery contents June 2017 Volume 16 Number 6 pp 369-440

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Nature Reviews Drug Discovery

Nature Milestones: Antibodies 

Nature Milestones: Antibodies chronicles the history of antibodies from their earliest description in antisera, their structure, generation and function, right through to their recent application in cancer immunotherapy. It also includes a timeline and a collection of seminal papers reproduced from Springer Nature. 

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June 2017 Volume 16 Number 6Advertisement

Nature Reviews Drug Discovery cover
2015 2-year Impact Factor 47.120 Journal Metrics 2-year Median 31
In this issue
News and Analysis
Research Highlights

Also this month
 Featured article:
Delivery technologies for genome editing
Hao Yin, Kevin J. Kauffman & Daniel G. Anderson


Genomics has met its match!


A powerful first-line phenotyping technology delivering a readout of the molecular phenotype and all its influences, both genetic and non-genetic. See how genomics and metabolomics are breaking through together.

Recommend to library
Rare disease research grants - eligibility for awards up to $1,000,000
Harrington Discovery Institute announces the call for proposals for the 2018 Harrington Rare Disease Scholar Award, sponsored by Takeda-offering scientists resources to advance research into therapeutics for rare diseases. Letters of Intent accepted through July 19, 2017.

BioPharma DealmakersCompany Profiles and Partnering Opportunities

Nature Reviews Microbiology: Collection on Antimicrobial Resistance 

This collection of articles from several Nature journals describes how antimicrobial resistance emerges and details discovery strategies for urgently needed new antimicrobials. 

Access this collection free online for six months

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Merck & Co., Inc., Kenilworth, NJ, USA
Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications

This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer.

September 17-20, 2017 | Beijing, China

Comment: Lessons from immuno-oncology: a new era for cancer nanomedicine?
Wen Jiang, Hengfeng Yuan, Charles K. Chan, Christina A. von Roemeling, Zuoqin Yan, Irving L. Weissman & Betty Y. S. Kim
p369 | doi:10.1038/nrd.2017.34
Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent lessons learned from the successes with immuno-oncology therapies could be applied to cancer nanomedicine and how this may help to overcome some of the key technical challenges in this field.
Abstract | Full Text | PDF


Zeroing in on neurodegenerative α-synuclein
Katie Kingwell
p371 | doi:10.1038/nrd.2017.95
In the search for the first disease-modifying therapy for Parkinson disease, drug developers are advancing α-synuclein-targeted agents into proof-of-concept clinical trials.

Search for liquid biopsy grail points the way to drug discovery and development gems
Chris Morrison
p373 | doi:10.1038/nrd.2017.96
An emerging technology for early cancer diagnosis could lead to innovative clinical trial strategies, novel drug combinations and new drug targets.

Immuno-oncology upset in bladder cancer
Asher Mullard
p375 | doi:10.1038/nrd.2017.108

FDA approves first new ALS drug in over 20 years
Asher Mullard
p375 | doi:10.1038/nrd.2017.109

FDA approves first targeted drug for acute myelogenous leukaemia
Asher Mullard
p375 | doi:10.1038/nrd.2017.110

Market watch: Trends in pharmaceutical company R&D spending: 2005-2015
Richa Dixit & Frank S. David
p376 | doi:10.1038/nrd.2017.81

Deal watch: Neurokinin 3 receptor antagonist revival heats up with Astellas acquisition
Megan Cully
p377 | doi:10.1038/nrd.2017.102

Birgitte Volck
p378 | doi:10.1038/nrd.2017.105
Birgitte Volck, head of rare disease R&D at GlaxoSmithKline, discusses the new era of rare disease drug discovery and development.

How much do clinical trials cost?
Linda Martin, Melissa Hutchens, Conrad Hawkins & Alaina Radnov
p381 | doi:10.1038/nrd.2017.70
This article presents the findings of a recent analysis of the costs of clinical trials, providing benchmark data for companies to assess their performance, as well as indicating cost drivers.



Cancer immunotherapy: T cells get a ride
p383 | doi:10.1038/nrd.2017.103

Neurodegenerative disorders: Ataxin 2 reduction rescues motor defects
p384 | doi:10.1038/nrd.2017.104

Ageing: A youthful reminder
p384 | doi:10.1038/nrd.2017.112

Neurological disorders: DAMPening damage after stroke
p385 | doi:10.1038/nrd.2017.101

Infectious disease: Peroxin inhibitor treats Trypanosoma infection
p386 | doi:10.1038/nrd.2017.93


Inflammation: Oncostatin M blockade attenuates colitis | Metabolic disease: PGC1α inhibition ameliorates diabetes | Ageing: FOXO4 inhibition eliminates senescent cells | Cystic fibrosis: Thymosin α1 rescues CFTR activity

Drug Discovery
JOBS of the week
Institute Associate Scientist IV - Neuroinflammation Drug Discovery
The University of Texas MD Anderson Cancer Center
Research Technician – Karp Lab, Brigham and Women's Hospital, Harvard Medical School
Brigham & Women's Hospital - Harvard Medical School
Drug Discovery Opportunities at D. E. Shaw Research
D. E. Shaw Research
In vitro Research Associate - GPCR Biology & Pharmacology
Institute Associate Scientist II - In Vivo Pharmacology
The University of Texas MD Anderson Cancer Center
More Science jobs from
Drug Discovery
4th Annual Drug Discovery USA Congress
San Diego, USA
More science events from


Delivery technologies for genome editing
Hao Yin, Kevin J. Kauffman & Daniel G. Anderson
p387 | doi:10.1038/nrd.2016.280
Genome editing has emerged as an attractive approach to therapeutically manipulate gene expression. Here, Anderson and colleagues provide an overview of genome-editing platforms, focusing on the methods and challenges of intracellular biomacromolecule delivery. Preclinical and clinical trials involving genome-editing technologies are also discussed.
Abstract | Full Text | PDF

Targeting iron metabolism in drug discovery and delivery
Bart J. Crielaard, Twan Lammers & Stefano Rivella
p400 | doi:10.1038/nrd.2016.248
Dysregulation of iron homeostasis occurs in haematological disorders and in other diseases such as cancer and neurodegeneration. Crielaard and colleagues discuss the progress made in interfering with iron metabolism as a therapeutic strategy, as well as in using iron metabolism to direct drugs to target tissues.
Abstract | Full Text | PDF

Non-kinase targets of protein kinase inhibitors
Lenka Munoz
p424 | doi:10.1038/nrd.2016.266
Inhibition of proteins other than the intended target by small molecules can lead to the incorrect assignment of biological functions to particular proteins and wasted drug development efforts. Potential inhibition of off-target kinases by kinase inhibitors is often investigated, but kinase inhibitors can also inhibit non-kinases. Munoz examines the growing number of examples of this issue and suggests a systematic strategy to verify which protein is responsible for the effects of a given small molecule.
Abstract | Full Text | PDF

Corrigendum: Aptamers as targeted therapeutics: current potential and challenges
Jiehua Zhou & John Rossi
p440 | doi:10.1038/nrd.2017.86
Full Text | PDF

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forbes karem said...

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