Wednesday, May 31, 2017

Nature Reviews Drug Discovery contents June 2017 Volume 16 Number 6 pp 369-440

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Nature Reviews Drug Discovery


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TABLE OF CONTENTS
 
June 2017 Volume 16 Number 6Advertisement

Nature Reviews Drug Discovery cover
2015 2-year Impact Factor 47.120 Journal Metrics 2-year Median 31
In this issue
Comment
News and Analysis
Research Highlights
Reviews

Also this month
 Featured article:
Delivery technologies for genome editing
Hao Yin, Kevin J. Kauffman & Daniel G. Anderson


 

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Rare disease research grants - eligibility for awards up to $1,000,000
Harrington Discovery Institute announces the call for proposals for the 2018 Harrington Rare Disease Scholar Award, sponsored by Takeda-offering scientists resources to advance research into therapeutics for rare diseases. Letters of Intent accepted through July 19, 2017. HarringtonDiscovery.org/Takeda.
 
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Comment: Lessons from immuno-oncology: a new era for cancer nanomedicine?
Wen Jiang, Hengfeng Yuan, Charles K. Chan, Christina A. von Roemeling, Zuoqin Yan, Irving L. Weissman & Betty Y. S. Kim
p369 | doi:10.1038/nrd.2017.34
Despite a decade of intensive preclinical research, the translation of cancer nanomedicine to the clinic has been slow. Here, we discuss how recent lessons learned from the successes with immuno-oncology therapies could be applied to cancer nanomedicine and how this may help to overcome some of the key technical challenges in this field.
Abstract | Full Text | PDF


 
NEWS AND ANALYSIS

Top
Zeroing in on neurodegenerative α-synuclein
Katie Kingwell
p371 | doi:10.1038/nrd.2017.95
In the search for the first disease-modifying therapy for Parkinson disease, drug developers are advancing α-synuclein-targeted agents into proof-of-concept clinical trials.
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Search for liquid biopsy grail points the way to drug discovery and development gems
Chris Morrison
p373 | doi:10.1038/nrd.2017.96
An emerging technology for early cancer diagnosis could lead to innovative clinical trial strategies, novel drug combinations and new drug targets.
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NEWS IN BRIEF
Immuno-oncology upset in bladder cancer
Asher Mullard
p375 | doi:10.1038/nrd.2017.108
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FDA approves first new ALS drug in over 20 years
Asher Mullard
p375 | doi:10.1038/nrd.2017.109
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FDA approves first targeted drug for acute myelogenous leukaemia
Asher Mullard
p375 | doi:10.1038/nrd.2017.110
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BIOBUSINESS BRIEFS
Market watch: Trends in pharmaceutical company R&D spending: 2005-2015
Richa Dixit & Frank S. David
p376 | doi:10.1038/nrd.2017.81
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Deal watch: Neurokinin 3 receptor antagonist revival heats up with Astellas acquisition
Megan Cully
p377 | doi:10.1038/nrd.2017.102
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AN AUDIENCE WITH
Birgitte Volck
p378 | doi:10.1038/nrd.2017.105
Birgitte Volck, head of rare disease R&D at GlaxoSmithKline, discusses the new era of rare disease drug discovery and development.
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FROM THE ANALYST'S COUCH
How much do clinical trials cost?
Linda Martin, Melissa Hutchens, Conrad Hawkins & Alaina Radnov
p381 | doi:10.1038/nrd.2017.70
This article presents the findings of a recent analysis of the costs of clinical trials, providing benchmark data for companies to assess their performance, as well as indicating cost drivers.
PDF

RESEARCH HIGHLIGHTS

Top

Cancer immunotherapy: T cells get a ride
p383 | doi:10.1038/nrd.2017.103
PDF


Neurodegenerative disorders: Ataxin 2 reduction rescues motor defects
p384 | doi:10.1038/nrd.2017.104
PDF


Ageing: A youthful reminder
p384 | doi:10.1038/nrd.2017.112
PDF


Neurological disorders: DAMPening damage after stroke
p385 | doi:10.1038/nrd.2017.101
PDF


Infectious disease: Peroxin inhibitor treats Trypanosoma infection
p386 | doi:10.1038/nrd.2017.93
PDF



IN BRIEF

Inflammation: Oncostatin M blockade attenuates colitis | Metabolic disease: PGC1α inhibition ameliorates diabetes | Ageing: FOXO4 inhibition eliminates senescent cells | Cystic fibrosis: Thymosin α1 rescues CFTR activity
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Drug Discovery
JOBS of the week
Institute Associate Scientist IV - Neuroinflammation Drug Discovery
The University of Texas MD Anderson Cancer Center
Research Technician – Karp Lab, Brigham and Women's Hospital, Harvard Medical School
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Drug Discovery Opportunities at D. E. Shaw Research
D. E. Shaw Research
In vitro Research Associate - GPCR Biology & Pharmacology
Evotec
Institute Associate Scientist II - In Vivo Pharmacology
The University of Texas MD Anderson Cancer Center
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REVIEWS

Top
Delivery technologies for genome editing
Hao Yin, Kevin J. Kauffman & Daniel G. Anderson
p387 | doi:10.1038/nrd.2016.280
Genome editing has emerged as an attractive approach to therapeutically manipulate gene expression. Here, Anderson and colleagues provide an overview of genome-editing platforms, focusing on the methods and challenges of intracellular biomacromolecule delivery. Preclinical and clinical trials involving genome-editing technologies are also discussed.
Abstract | Full Text | PDF


Targeting iron metabolism in drug discovery and delivery
Bart J. Crielaard, Twan Lammers & Stefano Rivella
p400 | doi:10.1038/nrd.2016.248
Dysregulation of iron homeostasis occurs in haematological disorders and in other diseases such as cancer and neurodegeneration. Crielaard and colleagues discuss the progress made in interfering with iron metabolism as a therapeutic strategy, as well as in using iron metabolism to direct drugs to target tissues.
Abstract | Full Text | PDF


Non-kinase targets of protein kinase inhibitors
Lenka Munoz
p424 | doi:10.1038/nrd.2016.266
Inhibition of proteins other than the intended target by small molecules can lead to the incorrect assignment of biological functions to particular proteins and wasted drug development efforts. Potential inhibition of off-target kinases by kinase inhibitors is often investigated, but kinase inhibitors can also inhibit non-kinases. Munoz examines the growing number of examples of this issue and suggests a systematic strategy to verify which protein is responsible for the effects of a given small molecule.
Abstract | Full Text | PDF


Corrigendum: Aptamers as targeted therapeutics: current potential and challenges
Jiehua Zhou & John Rossi
p440 | doi:10.1038/nrd.2017.86
Full Text | PDF

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5 comments:

forbes karem said...


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Pathy Ephele said...

I was diagnosed with Parkinson's disease a year ago at the age of 68. For several months I had noticed tremors in my right hand and the shaking of my right foot when I was sitting. My normally beautiful cursive writing was now small cramped printing. And I tended to lose my balance. Neurologist had me walk down the hall and said I didn't swing my right arm. I had never noticed! I was in denial for a while as there is no history in my family of parents and five older siblings, but now accept I had classic symptoms. I was taking pramipexole (Sifrol), carbidopa/levodopa and Biperiden, 2 mg. and started physical therapy to strengthen muscles. nothing was really working to help my condition.I went off the Siferol (with the doctor’s knowledge) and started on parkinson’s herbal formula i ordered from Health Herbal Clinic, my symptoms totally declined over a 3 weeks use of the Parkinsons disease natural herbal formula. i am now almost 70 and doing very well, the disease is totally reversed!! Visit there website www. healthherbalclinic. net

camila logan said...

Speaking of doctors,there was one doctor who really helped me and my family
I was diagnose of Parkinson diseaes over a year which my family doctor told me there is no cure but it can only be controled. Ever since then i have been running heather scepter looking for a solution to my problem because i was going to lose my Job if i dont get better, until i ran into this online testimony of Jennifer Snoody who have been cured of COPD by this herbal centre in Johannesburg (abumereherbalcentre@gmail.com), i immediately contacted them via their email, to God be thy glory i bought this Parkinson herbal remedy and was cured within three weeks of usage, at last this is a break through for all parkinson patients contact this herbal centre via their email or website: abumereherbalcentre@gmail.com/ www.abumereherbalcentre.simplesite.com

Benedict Anderson said...

(MUST READ: HOW I GOT CURED FROM PARKINSON’S DISEASE)
My name is Benedict Anderson.I thought i should share this here as someone out here may need this information; I was diagnosed of Parkinson’s disease in February 2015, my doctor told me it has no permanent cure, i was given monoamine oxidase (MAO)-B inhibitors and other medications to ease the situation, this continued till a friend of mine told me about Dr Odi from Africa who cured her father of parkinson’s disease and Glaucoma. I contacted this herbal doctor and bought the herbal medicine from him, i received it within 6 days and applied it as prescribed and was totally cured within 19 days of usage. my life is back again! Contact this herbal doctor via his email oyeyetemple@gmail.com or call +2348133582987



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