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TABLE OF CONTENTS
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June 2017 Volume 19, Issue 6 |
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| Editorials Review News and Views Research Highlights Articles Letters Erratum Corrigendum | |
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Naturejobs Career Guide Melbourne 2017 Melbourne's institutes cluster into discrete geographic hubs, with a solid culture of collaboration and an emphasis on biomedical research. Learn more about the area's leading scientific entities; their ties to each other; success from a scientific data-driven perspective and much more. Read the full Career Guide | | |
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REGENERATION 2017 Presented by: Ospedale San Raffaele | Nature The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration. November 16-18, 2017 | Milan, Italy REGISTER NOW! | | |
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Editorials | Top |
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Forces in cell biology p579 doi:10.1038/ncb3552 Mechanobiology — the study of how physical forces control the behaviour of cells and tissues — is a rapidly growing field. In this issue, we launch a Series of specially commissioned Review articles that discuss exciting recent developments in this area. |
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Championing authorship attribution p579 doi:10.1038/ncb3553 Nature Cell Biology is among the Springer Nature journals taking part in a recently launched trial that mandates the provision of ORCID identifiers for the corresponding authors of our papers. |
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Review | Top |
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Multiscale force sensing in development pp581 - 588 Nicoletta I. Petridou, Zoltan Spiro and Carl-Philipp Heisenberg doi:10.1038/ncb3524 In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development. |
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News and Views | Top |
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Research Highlights | Top |
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Formin' a perinuclear actin cage in confined migration | Force sensing in cytokinesis | Mechanical control of antigen uptake | EGFR probes matrix stiffness |
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Collection: On Growth and Form Centenary Join Nature in celebrating the centenary of D'Arcy Wentworth Thompson's seminal publication "On Growth and Form". We present an online collection of research and comment reflecting the diversity of explorative activity across the physical and biological sciences over the past 100 years. Access the On Growth and Form Centenary Collection | | |
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Articles | Top |
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Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties pp603 - 613 Giacomo Donati, Emanuel Rognoni, Toru Hiratsuka, Kifayathullah Liakath-Ali, Esther Hoste et al. doi:10.1038/ncb3532 Donati et al. show that following skin wounding a differentiated Gata6+ cell population resident in the sebaceous duct migrates to the interfollicular epidermis and reattaches to the basal membrane, dedifferentiating into stem cells.
See also: News and Views by Headon |
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The mitochondrial respiratory chain is essential for haematopoietic stem cell function pp614 - 625 Elena Ansó, Samuel E. Weinberg, Lauren P. Diebold, Benjamin J. Thompson, Sébastien Malinge et al. doi:10.1038/ncb3529 Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.
See also: Article by Liu et al. | News and Views by Schell & Rutter |
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Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation pp626 - 638 Xin Liu, Yuannyu Zhang, Min Ni, Hui Cao, Robert A. J. Signer et al. doi:10.1038/ncb3527 Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.
See also: Article by Anso et al. | News and Views by Schell & Rutter |
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Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling pp639 - 652 Yi Jin, Lars Muhl, Mikhail Burmakin, Yixin Wang, Anne-Claire Duchez et al. doi:10.1038/ncb3534 Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.
See also: Article by Sugden et al. | News and Views by Bautch |
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Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues pp653 - 665 Wade W. Sugden, Robert Meissner, Tinri Aegerter-Wilmsen, Roman Tsaryk, Elvin V. Leonard et al. doi:10.1038/ncb3528 Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.
See also: Article by Jin et al. | News and Views by Bautch |
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Stem cell plasticity enables hair regeneration following Lgr5+ cell loss pp666 - 676 Joerg D. Hoeck, Brian Biehs, Antonina V. Kurtova, Noelyn M. Kljavin, Felipe de Sousa e Melo et al. doi:10.1038/ncb3535 Hoeck et al. show that disruption of the hair follicle stem cell compartment by loss of Lgr5+ stem cells is followed by an inflammatory response and CD34+ stem cell activation and proliferation, to eventually replenish the Lgr5+ population. |
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Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis pp677 - 688 Matthew Decker, Leticia Martinez-Morentin, Guannan Wang, Yeojin Lee, Qingxue Liu et al. doi:10.1038/ncb3530 Decker et al. show that leptin-receptor-positive mesenchymal stromal cells are the source of the fibrogenic myofibroblasts that expand in primary myelofibrosis in a process mediated by PDGFRA pathway activation. |
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Actin cortex architecture regulates cell surface tension pp689 - 697 Priyamvada Chugh, Andrew G. Clark, Matthew B. Smith, Davide A. D. Cassani, Kai Dierkes et al. doi:10.1038/ncb3525 Cortical tension is thought to be generated by myosin II, and little is known about the role of actin network properties. Chugh et al. demonstrate that actin cortex thickness, determined by actin filament length, influences cortical tension. |
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Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival pp698 - 710 Simon J. Tavernier, Fabiola Osorio, Lana Vandersarren, Jessica Vetters, Nele Vanlangenakker et al. doi:10.1038/ncb3518 Tavernier et al. show that loss of the protective IRE1–XBP1 stress sensor results in the death of conventional dendritic cells in the lung, whereas those in the intestine survive due to a stronger ATF4-dependent stress response and RIDD activation. |
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Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis pp711 - 723 Toni Celià-Terrassa, Daniel D. Liu, Abrar Choudhury, Xiang Hang, Yong Wei et al. doi:10.1038/ncb3533 Celià-Terrassa et al. find that by repressing LCOR, a modulator of the interferon response, miR-199a allows both normal and cancer mammary stem cells to evade senescence and differentiation, thus promoting tumorigenesis.
See also: News and Views by Gardner & Ruffell |
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Letters | Top |
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Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK pp724 - 731 Jennifer L. Bays, Hannah K. Campbell, Christy Heidema, Michael Sebbagh and Kris A. DeMali doi:10.1038/ncb3537 Bays et al. demonstrate that application of force to E-cadherin leads to LKB1-dependent activation of AMPK and recruitment of AMPK to E-cadherin complexes to increase glucose uptake and ATP production and re-enforce cell-cell junctions.
See also: News and Views by Isogai et al. |
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Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation pp732 - 739 Kefeng Lu, Fabian den Brave and Stefan Jentsch doi:10.1038/ncb3531 Lu et al. show that the choice between proteasomal degradation and selective autophagy is independent of the ubiquitin-binding properties of the receptors but largely determined by oligomerization potential. |
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Erratum | Top |
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Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis p740 Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra et al. doi:10.1038/ncb3536
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Corrigendum | Top |
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Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation p740 Justin Decarreau, Michael Wagenbach, Eric Lynch, Aaron R. Halpern, Joshua C. Vaughan et al. doi:10.1038/ncb3546 |
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