Wednesday, May 31, 2017

Nature Cell Biology contents: June 2017 Volume 19 Number 6, pp 579 - 740

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Nature Cell Biology

Do You Know All about Cell Identification? 
How certain are you that you still work with the original cell line and not with HELA? Refresh your knowledge of the essential steps to ensure avoiding cell misidentification.   

June 2017 Volume 19, Issue 6

News and Views
Research Highlights
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Naturejobs Career Guide Melbourne 2017

Melbourne's institutes cluster into discrete geographic hubs, with a solid culture of collaboration and an emphasis on biomedical research. Learn more about the area's leading scientific entities; their ties to each other; success from a scientific data-driven perspective and much more. 

Read the full Career Guide
Presented by: Ospedale San Raffaele | Nature

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November 16-18, 2017 | Milan, Italy

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Hosting Organizations: National Key Laboratory of Crop Genetic Improvement | Huazhong Agricultural University | Nature Genetics | Nature Plants | Nature Communications

October 25-27, 2017
Conference Hall, National Key Laboratory of Crop Genetic Improvement | Wuhan, China



Forces in cell biology   p579
Mechanobiology — the study of how physical forces control the behaviour of cells and tissues — is a rapidly growing field. In this issue, we launch a Series of specially commissioned Review articles that discuss exciting recent developments in this area.

Championing authorship attribution   p579
Nature Cell Biology is among the Springer Nature journals taking part in a recently launched trial that mandates the provision of ORCID identifiers for the corresponding authors of our papers.



Multiscale force sensing in development   pp581 - 588
Nicoletta I. Petridou, Zoltan Spiro and Carl-Philipp Heisenberg
In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development.

News and Views


Mitochondria link metabolism and epigenetics in haematopoiesis   pp589 - 591
John C. Schell and Jared Rutter
Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

See also: Article by Liu et al. | Article by Ansó et al.

Cell forces meet cell metabolism   pp591 - 593
Tadamoto Isogai, Jin Suk Park and Gaudenz Danuser
Epithelial cells form energetically costly cell–cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.

See also: Letter by Bays et al.

Endoglin moves and shapes endothelial cells   pp593 - 595
Victoria L. Bautch
Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand–receptor signalling and flow-mediated mechanical cues.

See also: Article by Sugden et al. | Article by Jin et al.

Reversing stratification during wound healing   pp595 - 597
Denis Headon
The involvement of proliferation and migration in epidermal healing has long been recognized, but three studies now reveal how a variety of individual cell behaviours achieve a collective epithelial response, and how diverse repair routes are taken by cells of different origins.

See also: Article by Donati et al. | Article by Park et al. | Article by Aragona et al.

Reducing interferon'ce in stem cells   pp597 - 599
Alycia Gardner and Brian Ruffell
Little is known regarding how the interactions of stem cells with the immune system regulate their plasticity. A study now describes a mechanism by which normal breast and cancer stem cells utilize miR-199a to downregulate the corepressor LCOR and minimize responses to type I interferon.

See also: Article by Celià-Terrassa et al.

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Research Highlights


Formin' a perinuclear actin cage in confined migration | Force sensing in cytokinesis | Mechanical control of antigen uptake | EGFR probes matrix stiffness

Collection: On Growth and Form Centenary

Join Nature in celebrating the centenary of D'Arcy Wentworth Thompson's seminal publication "On Growth and Form". We present an online collection of research and comment reflecting the diversity of explorative activity across the physical and biological sciences over the past 100 years. 

Access the On Growth and Form Centenary Collection



Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties   pp603 - 613
Giacomo Donati, Emanuel Rognoni, Toru Hiratsuka, Kifayathullah Liakath-Ali, Esther Hoste et al.
Donati et al. show that following skin wounding a differentiated Gata6+ cell population resident in the sebaceous duct migrates to the interfollicular epidermis and reattaches to the basal membrane, dedifferentiating into stem cells.

See also: News and Views by Headon

The mitochondrial respiratory chain is essential for haematopoietic stem cell function   pp614 - 625
Elena Ansó, Samuel E. Weinberg, Lauren P. Diebold, Benjamin J. Thompson, Sébastien Malinge et al.
Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

See also: Article by Liu et al. | News and Views by Schell & Rutter

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation   pp626 - 638
Xin Liu, Yuannyu Zhang, Min Ni, Hui Cao, Robert A. J. Signer et al.
Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

See also: Article by Anso et al. | News and Views by Schell & Rutter

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling   pp639 - 652
Yi Jin, Lars Muhl, Mikhail Burmakin, Yixin Wang, Anne-Claire Duchez et al.
Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.

See also: Article by Sugden et al. | News and Views by Bautch

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues   pp653 - 665
Wade W. Sugden, Robert Meissner, Tinri Aegerter-Wilmsen, Roman Tsaryk, Elvin V. Leonard et al.
Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.

See also: Article by Jin et al. | News and Views by Bautch

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss   pp666 - 676
Joerg D. Hoeck, Brian Biehs, Antonina V. Kurtova, Noelyn M. Kljavin, Felipe de Sousa e Melo et al.
Hoeck et al. show that disruption of the hair follicle stem cell compartment by loss of Lgr5+ stem cells is followed by an inflammatory response and CD34+ stem cell activation and proliferation, to eventually replenish the Lgr5+ population.

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis   pp677 - 688
Matthew Decker, Leticia Martinez-Morentin, Guannan Wang, Yeojin Lee, Qingxue Liu et al.
Decker et al. show that leptin-receptor-positive mesenchymal stromal cells are the source of the fibrogenic myofibroblasts that expand in primary myelofibrosis in a process mediated by PDGFRA pathway activation.

Actin cortex architecture regulates cell surface tension   pp689 - 697
Priyamvada Chugh, Andrew G. Clark, Matthew B. Smith, Davide A. D. Cassani, Kai Dierkes et al.
Cortical tension is thought to be generated by myosin II, and little is known about the role of actin network properties. Chugh et al. demonstrate that actin cortex thickness, determined by actin filament length, influences cortical tension.

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival   pp698 - 710
Simon J. Tavernier, Fabiola Osorio, Lana Vandersarren, Jessica Vetters, Nele Vanlangenakker et al.
Tavernier et al. show that loss of the protective IRE1–XBP1 stress sensor results in the death of conventional dendritic cells in the lung, whereas those in the intestine survive due to a stronger ATF4-dependent stress response and RIDD activation.

Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis   pp711 - 723
Toni Celià-Terrassa, Daniel D. Liu, Abrar Choudhury, Xiang Hang, Yong Wei et al.
Celià-Terrassa et al. find that by repressing LCOR, a modulator of the interferon response, miR-199a allows both normal and cancer mammary stem cells to evade senescence and differentiation, thus promoting tumorigenesis.

See also: News and Views by Gardner & Ruffell

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Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK   pp724 - 731
Jennifer L. Bays, Hannah K. Campbell, Christy Heidema, Michael Sebbagh and Kris A. DeMali
Bays et al. demonstrate that application of force to E-cadherin leads to LKB1-dependent activation of AMPK and recruitment of AMPK to E-cadherin complexes to increase glucose uptake and ATP production and re-enforce cell-cell junctions.

See also: News and Views by Isogai et al.

Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation    pp732 - 739
Kefeng Lu, Fabian den Brave and Stefan Jentsch
Lu et al. show that the choice between proteasomal degradation and selective autophagy is independent of the ubiquitin-binding properties of the receptors but largely determined by oligomerization potential.



Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis   p740
Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra et al.



Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation   p740
Justin Decarreau, Michael Wagenbach, Eric Lynch, Aaron R. Halpern, Joshua C. Vaughan et al.

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