Friday, February 5, 2016

[NASA HQ News] NASA Administrator Remembers Apollo-Era Astronaut Edgar Mitchell

  February 05, 2016 
RELEASE 16-014
NASA Administrator Remembers Apollo-Era Astronaut Edgar Mitchell
Apollo astronaut Edgar Mitchell
Apollo astronaut Edgar Mitchell in front of a graphic of the mission patch.
Credits: NASA

The following is a statement from NASA Administrator Charles Bolden on the passing of NASA astronaut Edgar Mitchell:

"On behalf of the entire NASA family, I would like to express my condolences to the family and friends of NASA astronaut Edgar Mitchell. As a member of the Apollo 14 crew, Edgar is one of only 12 men to walk on the moon and he helped to change how we view our place in the universe. 

"Edgar spoke poetically about seeing our home planet from the moon saying: 'Suddenly, from behind the rim of the moon, in long, slow-motion moments of immense majesty, there emerges a sparkling blue and white jewel, a light, delicate sky-blue sphere laced with slowly swirling veils of white, rising gradually like a small pearl in a thick sea of black mystery. It takes more than a moment to fully realize this is Earth … home.'

"He believed in exploration, having been drawn to NASA by President Kennedy's call to send humans to the moon. He is one of the pioneers in space exploration on whose shoulders we now stand." 

For more information about Mitchell's NASA career, and his agency biography, visit:

http://www.nasa.gov/feature/apollo-astronaut-edgar-mitchell-dies-at-age-85

-end-

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Nature Biotechnology Contents: Volume 34 pp 115 - 212

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Nature Biotechnology


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TABLE OF CONTENTS

February 2016 Volume 34, Issue 2

Editorial
News
Correction
Bioentrepreneur
Opinion and Comment
Features
News and Views
Computational Biology
Research
Careers and Recruitment

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Editorial

Top

Research not fit to print   p115
doi:10.1038/nbt.3488
Some biotech companies now eschew traditional publication in peer-reviewed journals. Does it matter?

News

Top

FDA approves 'farmaceutical' drug from transgenic chickens   pp117 - 119
Cormac Sheridan
doi:10.1038/nbt0216-117

Obama's cancer moonshot   p119
doi:10.1038/nbt0216-119

Biotechs target stagnant baldness market   pp120 - 121
Charles Schmidt
doi:10.1038/nbt0216-120

CRISPR patents to go on trial   p121
doi:10.1038/nbt0216-121a

Bayer joins CRISPR   p121
doi:10.1038/nbt0216-121b

Proteasome play C4 debuts   p122
doi:10.1038/nbt0216-122a

Direct Genomics revives Helicos sequencing system for China's hospitals   pp122 - 123
David Cyranoski
doi:10.1038/nbt0216-122b

New partner for Galapagos JAK drug   p123
doi:10.1038/nbt0216-123

Chimera research under the spotlight   pp124 - 125
Laura DeFrancesco
doi:10.1038/nbt0216-124

Correction

Top

Corrections   p125
doi:10.1038/nbt0216-125a

News

Top

Around the world in a month   p125
doi:10.1038/nbt0216-125b

FDA approves three different multiple myeloma drugs in one month   p126
Mark Ratner
doi:10.1038/nbt0216-126

Data Page

2015—another banner year for biotech   p127
Walter Yang
doi:10.1038/nbt.3480

Drug pipeline Q4 2015   p128
Laura DeFrancesco
doi:10.1038/nbt.3484

News Feature

Fresh from the biotech pipeline—2015   pp129 - 132
Chris Morrison
doi:10.1038/nbt.3472
Novel drug approvals in the United States surpassed even 2014's unprecedented totals. The broad trends are familiar but, as Chris Morrison reports, 2015 had its share of pioneering achievements.

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Bioentrepreneur

Top
Building a business

Preparing for crises   pp133 - 136
Mark Kessel and Robert Masella
doi:10.1038/nbt.3475

Opinion and Comment

Top
Correspondence

Cas9-triggered chain ablation of cas9 as a gene drive brake   pp137 - 138
Bing Wu, Liqun Luo and Xiaojing J Gao
doi:10.1038/nbt.3444

Precision and robustness of 2D-NMR for structure assessment of filgrastim biosimilars   pp139 - 141
Houman Ghasriani, Derek J Hodgson, Robert G Brinson, Ian McEwen, Lucinda F Buhse et al.
doi:10.1038/nbt.3474

Evolving Japanese regulations on companion diagnostics   pp141 - 144
Sumimasa Nagai, Masaaki Urata, Hiroyuki Sato, Motoki Mikami, Wataru Kuga et al.
doi:10.1038/nbt.3478

Features

Top
Patents

Persistent confusion and controversy surrounding gene patents   pp145 - 147
Christi J Guerrini, Mary A Majumder and Amy L McGuire
doi:10.1038/nbt.3470
The development of patent-specific educational resources and prompt resolution of patentability rules unsettled by recent US Supreme Court decisions are urgently needed in the genomics industry.

Recent patents in computational biology   p148
doi:10.1038/nbt.3487

News and Views

Top

Can CRISPR-Cas9 gene drives curb malaria?   pp149 - 150
Luke Alphey
doi:10.1038/nbt.3473
Gene drives in mosquitoes to reduce the spread of malaria move closer, though technical and regulatory hurdles remain.

Mapping regulatory elements   pp151 - 152
Yuexin Zhou and Wensheng Wei
doi:10.1038/nbt.3477
Regulatory genomic elements can now be studied in their native context using two CRISPR-based high-throughput approaches.

See also: Research by Rajagopal et al. | Research by Korkmaz et al.

Personalized nutrition through big data   pp152 - 154
Daniel McDonald, Gustavo Glusman and Nathan D Price
doi:10.1038/nbt.3476
A systems model of glycemic response identifies individually tailored diets that keep blood sugar in check.

Research Highlights   p154
doi:10.1038/nbt.3482

Biotechnology
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Computational Biology

Top
Analysis

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity   pp155 - 163
Matthew T Chang, Saurabh Asthana, Sizhi Paul Gao, Byron H Lee, Jocelyn S Chapman et al.
doi:10.1038/nbt.3391
Detection of recurrently mutated nucleotides identifies novel cancer hotspots in an analysis of >11,000 human tumor samples.

Research

Top
Brief Communications

Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay   pp164 - 166
Tomoki T Nomakuchi, Frank Rigo, Isabel Aznarez and Adrian R Krainer
doi:10.1038/nbt.3427
Antisense oligonucleotides target genetic disease via gene-specific inhibition of nonsense-mediated mRNA decay.

Articles

High-throughput mapping of regulatory DNA   pp167 - 174
Nisha Rajagopal, Sharanya Srinivasan, Kameron Kooshesh, Yuchun Guo, Matthew D Edwards et al.
doi:10.1038/nbt.3468
Cis-regulatory genomic regions necessary for gene expression are revealed by a high-throughput CRISPR-Cas9-based assay.

See also: News and Views by Zhou & Wei

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes   pp175 - 183
Janos Fuzik, Amit Zeisel, Zoltan Mate, Daniela Calvigioni, Yuchio Yanagawa et al.
doi:10.1038/nbt.3443
Patch-seq reveals new neuronal subtypes by combining electrophysiological and RNA-seq data on single neurons in situ.

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9   pp184 - 191
John G Doench, Nicolo Fusi, Meagan Sullender, Mudra Hegde, Emma W Vaimberg et al.
doi:10.1038/nbt.3437
Genome-wide sgRNA libraries based on rules for on-target activity improve results of Cas9-based screens and facilitate a further refinement of on- and off-target prediction algorithms.

Letters

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9   pp192 - 198
Gozde Korkmaz, Rui Lopes, Alejandro P Ugalde, Ekaterina Nevedomskaya, Ruiqi Han et al.
doi:10.1038/nbt.3450
CRISPR-Cas9 is used for both enrichment and dropout screens of functional enhancers in human cells.

See also: News and Views by Zhou & Wei

Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq   pp199 - 203
Cathryn R Cadwell, Athanasia Palasantza, Xiaolong Jiang, Philipp Berens, Qiaolin Deng et al.
doi:10.1038/nbt.3445
Patch-seq reveals new neuronal subtypes by combining electrophysiological and RNA-seq data on single neurons in situ.

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain   pp204 - 209
Benjamin E Deverman, Piers L Pravdo, Bryan P Simpson, Sripriya Ravindra Kumar, Ken Y Chan et al.
doi:10.1038/nbt.3440
AAV vectors that efficiently transduce the mouse brain after intravenous injection are generated with a CRE-dependent selection system.

Errata

Erratum: Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation   p210
Dimos Gaidatzis, Lukas Burger, Maria Florescu and Michael B Stadler
doi:10.1038/nbt0216-210a

Erratum: Share and share alike   p210
Samuel K Sia and Matthew P Owens
doi:10.1038/nbt0216-210b

Corrigendum

Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining   p210
Takeshi Maruyama, Stephanie K Dougan, Matthias C Truttmann, Angelina M Bilate, Jessica R Ingram et al.
doi:10.1038/nbt0216-210c

Careers and Recruitment

Top

Fourth-quarter biotech job picture   p211
Michael Francisco
doi:10.1038/nbt.3479

People

People   p212
doi:10.1038/nbt.3486

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