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www.milliporesigma.com |  | | | | | | | | Latest Reviews | View all Reviews | | | | | Modeling the process of human tumorigenesis OPEN | | | Sneha Balani, Long V. Nguyen and Connie J. Eaves | | | A better understanding of the earliest stages of human cancer formation can enable future improvements in early detection, diagnosis and treatment. In this review, the authors summarize the methods enabling de novo tumorigenesis protocols to be applied to human cells and the insights derived from them to date, as well as the exciting and relevant technical developments anticipated to extend even further the utility of these strategies. | | | 25 May 2017 | doi: 10.1038/ncomms15422 | | |
| | | | | Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology OPEN | | | Helen M. Burke, Lauren McSweeney and Eoin M. Scanlan | | | The conversion of thioesters to amides via acyl transfer has become one of the most important synthetic techniques for the chemical synthesis and modification of proteins. This review discusses this S-to-N acyl transfer process, and highlights some of the key applications across chemistry and biology. | | | 24 May 2017 | doi: 10.1038/ncomms15655 | | | | | | | | | | Latest Articles | View all Articles | | | | | Modelling the role of groundwater hydro-refugia in East African hominin evolution and dispersal OPEN | | | M. O. Cuthbert, T. Gleeson, S. C. Reynolds, M. R. Bennett, A. C. Newton, C. J. McCormack and G. M. Ashley | | | Water is a fundamental resource, but its role in hominin evolution is not well explored. Here, the authors use a combination of groundwater, climate and agent-based models to show that groundwater availability may be critical to past patterns of taxonomic diversity in hominin development in East Africa. | | | 30 May 2017 | doi: 10.1038/ncomms15696 | | |
| Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods OPEN | | | Verena J. Schuenemann, Alexander Peltzer, Beatrix Welte, W. Paul van Pelt, Martyna Molak, Chuan-Chao Wang, Anja Furtwängler, Christian Urban, Ella Reiter, Kay Nieselt, Barbara Teßmann, Michael Francken, Katerina Harvati, Wolfgang Haak, Stephan Schiffels and Johannes Krause | | | Archaeological and historical records had shown ancient Egypt before and after Ptolemaic and Roman periods to be a hub of human migration and exchange. Here, Schuenemann and colleagues analyse ancient mitochondrial and nuclear DNA to investigate the genetic history of Egypt. | | | 30 May 2017 | doi: 10.1038/ncomms15694 | | |
| Interactive models of communication at the nanoscale using nanoparticles that talk to one another OPEN | | | Antoni Llopis-Lorente, Paula Díez, Alfredo Sánchez, María D. Marcos, Félix Sancenón, Paloma Martínez-Ruiz, Reynaldo Villalonga and Ramón Martínez-Máñez | | | In the interactive model of communication, information is exchanged bidirectionally between a sender and receiver. Here, the authors realise interactive communication between two artificial nanoparticles, which relay information between each other in the form of chemical messengers and enzymatic reactions. | | | 30 May 2017 | doi: 10.1038/ncomms15511 | | |
| Designing lead-free antiferroelectrics for energy storage OPEN | | | Bin Xu, Jorge Íñiguez and L. Bellaiche | | | Antiferroelectric capacitors hold great promise for high-power energy storage. Here, through a first-principles-based computational approach, authors find high theoretical energy densities in rare earth substituted bismuth ferrite, and propose a simple model to assess the storage properties of a general antiferroelectric material. | | | 30 May 2017 | doi: 10.1038/ncomms15682 | | |
| Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery OPEN | | | Dunja Sobot, Simona Mura, Semen O. Yesylevskyy, Laura Dalbin, Fanny Cayre, Guillaume Bort, Julie Mougin, Didier Desmaële, Sinda Lepetre-Mouelhi, Grégory Pieters, Bohdan Andreiuk, Andrey S. Klymchenko, Jean-Louis Paul, Christophe Ramseyer and Patrick Couvreur | | | The interaction of nanoparticles with a range of biomolecules once they have been injected within the body can affect their performance. Here, the authors demonstrate that squalene nanomaterials conjugated with anticancer drugs can interact with lipoproteins and can be used to target cancer cells. | | | 30 May 2017 | doi: 10.1038/ncomms15678 | | |
| Deposition and drying dynamics of liquid crystal droplets OPEN | | | Zoey S. Davidson, Yongyang Huang, Adam Gross, Angel Martinez, Tim Still, Chao Zhou, Peter J. Collings, Randall D. Kamien and A. G. Yodh | | | When particle-laden drops evaporate, coffee ring patterns form which can affect particle deposition. Here Davidson et al. show that unlike previously investigated drops, the flows in drying drops of liquid crystals are driven by an increase in surface tension due to liquid crystal concentration. | | | 30 May 2017 | doi: 10.1038/ncomms15642 | | |
| Electric field imaging of single atoms OPEN | | | Naoya Shibata, Takehito Seki, Gabriel Sánchez-Santolino, Scott D. Findlay, Yuji Kohno, Takao Matsumoto, Ryo Ishikawa and Yuichi Ikuhara | | | The ability of scanning transmission electron microscopy (STEM) to image single atoms is becoming increasingly sophisticated. Here, the authors use differential phase contrast STEM to map the atomic electric fields within single Au atoms and SrTiO3 crystals, a step toward visualizing such intra- and interatomic electronic structure as chemical bonds. | | | 30 May 2017 | doi: 10.1038/ncomms15631 | | |
| Rapid mass production of two-dimensional metal oxides and hydroxides via the molten salts method OPEN | | | Zhimi Hu, Xu Xiao, Huanyu Jin, Tianqi Li, Ming Chen, Zhun Liang, Zhengfeng Guo, Jia Li, Jun Wan, Liang Huang, Yanrong Zhang, Guang Feng and Jun Zhou | | | 2D materials with exotic electronic properties are increasingly important for the development of low-dimensional electronic devices. Here, Hu et al. have developed a fast and efficient method to synthesize 2D metal oxides and hydroxides, further enabling 2D electronics. | | | 30 May 2017 | doi: 10.1038/ncomms15630 | | |
| Coral calcification in a changing World and the interactive dynamics of pH and DIC upregulation OPEN | | | Malcolm T. McCulloch, Juan Pablo D’Olivo, James Falter, Michael Holcomb and Julie A. Trotter | | | Coral reefs are biologically diverse and productive ecosystems, yet our understanding of the impacts of ocean acidification on biocalcification is limited. Here, the authors show that pH upregulation and the biological control of dissolved inorganic carbon in calcifying fluids of Porites corals are linked. | | | 30 May 2017 | doi: 10.1038/ncomms15686 | | |
| JunB is essential for IL-23-dependent pathogenicity of Th17 cells OPEN | | | Zafrul Hasan, Shin-ichi Koizumi, Daiki Sasaki, Hayato Yamada, Nana Arakaki, Yoshitaka Fujihara, Shiho Okitsu, Hiroki Shirahata and Hiroki Ishikawa | | | T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes. | | | 30 May 2017 | doi: 10.1038/ncomms15628 | | |
| Attosecond interferometry with self-amplified spontaneous emission of a free-electron laser OPEN | | | Sergey Usenko, Andreas Przystawik, Markus Alexander Jakob, Leslie Lamberto Lazzarino, Günter Brenner, Sven Toleikis, Christian Haunhorst, Detlef Kip and Tim Laarmann | | | Phase-sensitive measurements are important to gain insights of light-matter interactions and require phase-controlled pulses. Here the authors demonstrate the phase control and interferometric autocorrelation on a free electron laser using SASE pulse pair created with a split and delay unit. | | | 30 May 2017 | doi: 10.1038/ncomms15626 | | |
| A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers OPEN | | | Giuseppina Pisignano, Sara Napoli, Marco Magistri, Sarah N. Mapelli, Chiara Pastori, Stefano Di Marco, Gianluca Civenni, Domenico Albino, Claudia Enriquez, Sara Allegrini, Abhishek Mitra, Gioacchino D’Ambrosio, Maurizia Mello-Grand, Giovanna Chiorino, Ramon Garcia-Escudero, Gabriele Varani, Giuseppina M. Carbone and Carlo V. Catapano | | | Promoter-proximal transcripts have been proposed to act as cis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers. | | | 30 May 2017 | doi: 10.1038/ncomms15622 | | |
| Glucose represses dendritic cell-induced T cell responses OPEN | | | Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray and David K. Finlay | | | Glucose is an important nutrient that feeds into glycolytic control of T cell function and differentiation. Here the authors show that T cells are superior to dendritic cells (DC) at glucose uptake, and by depriving DCs of this nutrient in their microenvironment T cells activate DC proinflammatory functions, which in turn enhance T cell effector functions in DC-T cell cocultures. | | | 30 May 2017 | doi: 10.1038/ncomms15620 | | |
| MiCASA is a new method for quantifying cellular organization OPEN | | | Andrew Sornborger, Jie Li, Cullen Timmons, Floria Lupu, Jonathan Eggenschwiler, Yousuke Takahama and Nancy R. Manley | | | There are few methods available that can quantify relationships between cell types in tissue images. Here the authors present a quantitative method to evaluate cellular organization, validated in the mouse thymus and spinal cord, called Multitaper Circularly Averaged Spectral Analysis (MiCASA). | | | 30 May 2017 | doi: 10.1038/ncomms15619 | | |
| Geomagnetic spikes on the core-mantle boundary OPEN | | | Christopher Davies and Catherine Constable | | | Rapid and spatially localized geomagnetic field variations around 1000 BC are hard to reconcile with expected field behaviour arising from the core dynamo. Here, the authors show that the intensity spike is consistent with an intense flux patch on the core-mantle boundary (8–22°) located under Saudi Arabia. | | | 30 May 2017 | doi: 10.1038/ncomms15593 | | |
| Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model OPEN | | | Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer and Jean-Antoine Girault | | | Several kinases regulate spine morphology and plasticity. Here, the authors show that the tyrosine kinase Pyk2 regulates hippocampal plasticity and contributes to cognitive and hippocampal plasticity deficits in a mouse model of Huntington’s disease. | | | 30 May 2017 | doi: 10.1038/ncomms15592 | | |
| Coherent control of the silicon-vacancy spin in diamond OPEN | | | Benjamin Pingault, David-Dominik Jarausch, Christian Hepp, Lina Klintberg, Jonas N. Becker, Matthew Markham, Christoph Becher and Mete Atatüre | | | Silicon vacancy centres in diamond have favourable optical properties for use in quantum information processing. Here, the authors demonstrate coherent control of silicon vacancy spins, a prerequisite for the implementation of quantum computing operations. | | | 30 May 2017 | doi: 10.1038/ncomms15579 | | |
| Clonally stable Vκ allelic choice instructs Igκ repertoire OPEN | | | Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, Louise S. Matheson, Osnat Bartok, Yuval Nevo, Sebastian Kadener, Anne E. Corcoran, Howard Cedar and Yehudit Bergman | | | B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optimal generation of a diverse repertoire. | | | 30 May 2017 | doi: 10.1038/ncomms15575 | | |
| Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila OPEN | | | Mareike Selcho, Carola Millán, Angelina Palacios-Muñoz, Franziska Ruf, Lilian Ubillo, Jiangtian Chen, Gregor Bergmann, Chihiro Ito, Valeria Silva, Christian Wegener and John Ewer | | | The emergence of the adult fruit flies from the pupae is jointly regulated by the central and peripheral clocks. Selcho et al. show that synchronization of the two clocks is mediated by the master clock brain neurons producing sNPF, and non-clock PTTH neurons that regulate the peripheral clock producing the steroid moulting hormone, ecdysone. | | | 30 May 2017 | doi: 10.1038/ncomms15563 | | |
| Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα OPEN | | | Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow and Daniel I. Simon | | | The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may provide clues for the development of new anti-thrombotic drugs. | | | 30 May 2017 | doi: 10.1038/ncomms15559 | | |
| Hydrodynamic cavitation in Stokes flow of anisotropic fluids OPEN | | | Tillmann Stieger, Hakam Agha, Martin Schoen, Marco G. Mazza and Anupam Sengupta | | | Cavitation is the formation of vapour bubbles within a liquid and is undesirable in many industrial applications. Here Stieger et al. show how the anisotropic fluids influence this process in a nematic liquid crystal and find that orientational ordering of molecules can tune the onset of cavitation. | | | 30 May 2017 | doi: 10.1038/ncomms15550 | | |
| Amazonian forest-savanna bistability and human impact OPEN | | | Bert Wuyts, Alan R. Champneys and Joanna I. House | | | Deforestation and edge effects around cleared areas impact forest stability. Here, the authors examine human impacts on Amazonian forest-savanna bistability and show that tree cover bimodality is enhanced in regions close to human activities and is nearly absent in regions unaffected by human activities. | | | 30 May 2017 | doi: 10.1038/ncomms15519 | | |
| TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension OPEN | | | Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffrey C. Robinson, Daniel E. Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Alexandre McKeon, Suzette Riddle, R. Dale Brown, Leslie E. Morgan, Christopher M. Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James P. Maloney et al. | | | Thrombospondin-1 (TSP-1) activates latent TGF-β in the extracellular matrix. Here the authors show that inappropriate activation of latent TGF-β in murine, bovine and human lung by monocyte-produced TSP-1 causes pulmonary hypertension, and that interference with the activation process prevents disease development. | | | 30 May 2017 | doi: 10.1038/ncomms15494 | | |
| A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells OPEN | | | Tetsuro Yoshimaru, Masaya Ono, Yoshimi Bando, Yi-An Chen, Kenji Mizuguchi, Hiroshi Shima, Masato Komatsu, Issei Imoto, Keisuke Izumi, Junko Honda, Yasuo Miyoshi, Mitsunori Sasa and Toyomasa Katagiri | | | BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner. | | | 30 May 2017 | doi: 10.1038/ncomms15427 | | |
| Recent enhancement of central Pacific El Niño variability relative to last eight centuries OPEN | | | Yu Liu, Kim M. Cobb, Huiming Song, Qiang Li, Ching-Yao Li, Takeshi Nakatsuka, Zhisheng An, Weijian Zhou, Qiufang Cai, Jinbao Li, Steven W. Leavitt, Changfeng Sun, Ruochen Mei, Chuan-Chou Shen, Ming-Hsun Chan, Junyan Sun, Libin Yan, Ying Lei, Yongyong Ma, Xuxiang Li et al. | | | El Niño events in the Central Pacific may be changing due to climate change, but long records to support this are lacking. Here, the authors present sea surface temperature reconstructions from tree cellulose for the last 800 years which suggest the variability of Central Pacific El Niño events has increased. | | | 30 May 2017 | doi: 10.1038/ncomms15386 | | |
| Overcoming the crystallization and designability issues in the ultrastable zirconium phosphonate framework system OPEN | | | Tao Zheng, Zaixing Yang, Daxiang Gui, Zhiyong Liu, Xiangxiang Wang, Xing Dai, Shengtang Liu, Linjuan Zhang, Yang Gao, Lanhua Chen, Daopeng Sheng, Yanlong Wang, Juan Diwu, Jianqiang Wang, Ruhong Zhou, Zhifang Chai, Thomas E. Albrecht-Schmitt and Shuao Wang | | | Zirconium phosphonate based metal-organic frameworks often exhibit superior chemical stabilities, but typically exist as poorly crystalline or amorphous materials. Here the authors exploit an ionothermal method to obtain highly porous and remarkably stable single crystalline zirconium phosphonate frameworks that can efficiently remove uranyl ions from aqueous solutions. | | | 30 May 2017 | doi: 10.1038/ncomms15369 | | |
| Redesigning metabolism based on orthogonality principles OPEN | | | Aditya Vikram Pandit, Shyam Srinivasan and Radhakrishnan Mahadevan | | | Growth-coupled designs for chemical production are limited by native metabolic networks’ optimality for growth. Here, the authors introduce pathway orthogonality as a measure of the independence of biomass and chemical production pathways, identify metabolic valves that allow substrate utilization to be switched between the two, and demonstrate advantages of orthogonal designs. | | | 30 May 2017 | doi: 10.1038/ncomms15188 | | |
| Rationally designed mineralization for selective recovery of the rare earth elements OPEN | | | Takaaki Hatanaka, Akimasa Matsugami, Takamasa Nonaka, Hideki Takagi, Fumiaki Hayashi, Takao Tani and Nobuhiro Ishida | | | Lanthanide elements are difficult to separate from aqueous solution with low energy input. Here, the authors design a peptide that recognizes and drives the precipitation of an insoluble lanthanide complex under physiological conditions, introducing a biomineralization-based approach for rare earth recovery. | | | 26 May 2017 | doi: 10.1038/ncomms15670 | | |
| Hierarchically structured lithium titanate for ultrafast charging in long-life high capacity batteries OPEN | | | Mateusz Odziomek, Frédéric Chaput, Anna Rutkowska, Konrad Świerczek, Danuta Olszewska, Maciej Sitarz, Frédéric Lerouge and Stephane Parola | | | Both electronic and ionic transport must be optimized in Li4Ti5O12 for its use in Li-ion batteries, most promisingly against high voltage cathodes. Here authors synthesize hierarchical porous micrometre-scale structures composed of primary nanoparticles to demonstrate an attractive combination of rate performance, capacity and cycling stability. | | | 26 May 2017 | doi: 10.1038/ncomms15636 | | |
| Virtual substrate method for nanomaterials characterization OPEN | | | Bo Da, Jiangwei Liu, Mahito Yamamoto, Yoshihiro Ueda, Kazuyuki Watanabe, Nguyen Thanh Cuong, Songlin Li, Kazuhito Tsukagoshi, Hideki Yoshikawa, Hideo Iwai, Shigeo Tanuma, Hongxuan Guo, Zhaoshun Gao, Xia Sun and Zejun Ding | | | Quantitative characterization of supported nanomaterials is challenging, because the nanomaterial signals cannot easily be deconvoluted from those of the substrate. Here, the authors introduce an inventive approach to overcome this problem for electron-based surface analysis techniques. | | | 26 May 2017 | doi: 10.1038/ncomms15629 | | |
| Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits OPEN | | | Lorraine Southam, Arthur Gilly, Dániel Süveges, Aliki-Eleni Farmaki, Jeremy Schwartzentruber, Ioanna Tachmazidou, Angela Matchan, Nigel W. Rayner, Emmanouil Tsafantakis, Maria Karaleftheri, Yali Xue, George Dedoussis and Eleftheria Zeggini | | | Isolated populations can provide useful information on low-frequency variants for dissecting genetic architecture of complex traits. Here, Zeggini and colleagues show enrichment of rare and low-frequency variants and 8 novel low-frequency variant signals for cardiometabolic traits in two Greek isolated populations | | | 26 May 2017 | doi: 10.1038/ncomms15606 | | |
| Targeted recombination between homologous chromosomes for precise breeding in tomato OPEN | | | Shdema Filler Hayut, Cathy Melamed Bessudo and Avraham A. Levy | | | Targeted homologous recombination between parental chromosomes could facilitate precision breeding of crop plants. Here, Filler Hayut et al. show that CRISPR-Cas9 can be used to induce DNA double strand breaks in somatic tissue and achieve targeted recombination between homologs at an endogenous locus in tomato. | | | 26 May 2017 | doi: 10.1038/ncomms15605 | | |
| Perirhinal firing patterns are sustained across large spatial segments of the task environment OPEN | | | Jeroen J. Bos, Martin Vinck, Laura A. van Mourik-Donga, Jadin C. Jackson, Menno P. Witter and Cyriel M. A. Pennartz | | | Spatial navigation and memory depend on neural coding of an organism’s location as well as large-scale knowledge of the environment, but how animals organize information in task-relevant spatial segments is not well understood. Here the authors show that, in rats, perirhinal neurons perform integrative operations, globally specifying where, in the task context, an animal is located. | | | 26 May 2017 | doi: 10.1038/ncomms15602 | | |
| Atomic-scale age resolution of planetary events OPEN | | | L. F. White, J. R. Darling, D. E. Moser, D. A. Reinhard, T. J. Prosa, D. Bullen, D. Olson, D. J. Larson, D. Lawrence and I. Martin | | | Constraining the timing of crustal processes and impact events remains challenging. Here, the authors show that atom probe tomography can produce highly accurate U-Pb isotopic age constraints in baddeleyite crystals, which is a common phase in terrestrial, Martian, Lunar and asteroidal materials. | | | 26 May 2017 | doi: 10.1038/ncomms15597 | | |
| Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals OPEN | | | Tao Yu, Yongjin J. Zhou, Leonie Wenning, Quanli Liu, Anastasia Krivoruchko, Verena Siewers, Jens Nielsen and Florian David | | | Production of chemicals by microbial fermentation is an economical alternative to chemical synthesis. Here the authors re-engineer the yeast S. cerevisiae to produce the very long chain fatty alcohol docosanol by expressing a heterologous Mycobacteria fatty acid synthase and a specific fatty acid reductase. | | | 26 May 2017 | doi: 10.1038/ncomms15587 | | |
| Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration OPEN | | | Hasini Jayatilaka, Pranay Tyle, Jonathan J. Chen, Minsuk Kwak, Julia Ju, Hyun Ji Kim, Jerry S. H. Lee, Pei-Hsun Wu, Daniele M. Gilkes, Rong Fan and Denis Wirtz | | | Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models. | | | 26 May 2017 | doi: 10.1038/ncomms15584 | | |
| Ultrafast coherence transfer in DNA-templated silver nanoclusters OPEN | | | Erling Thyrhaug, Sidsel Ammitzbøll Bogh, Miguel R Carro-Temboury, Charlotte Stahl Madsen, Tom Vosch and Donatas Zigmantas | | | DNA-templated silver nanoclusters possess desirable optical properties, but their excited state dynamics remain poorly understood. Here the authors show that intracluster relaxations in such clusters are strongly coupled to a vibrational mode, resulting in ultrafast concerted transfer of population and coherence between excited states. | | | 26 May 2017 | doi: 10.1038/ncomms15577 | | |
| Direct observation of coherent energy transfer in nonlinear micromechanical oscillators OPEN | | | Changyao Chen, Damián H. Zanette, David A. Czaplewski, Steven Shaw and Daniel López | | | Energy drain on micromechanical resonators is always compensated by energy gain from external sources during operation. Here, Chen et al. show a strategy that can sustain stable oscillations by redistributing mechanical energy between coupled vibrational modes when the external energy supply is off. | | | 26 May 2017 | doi: 10.1038/ncomms15523 | | |
| Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome OPEN | | | Jiani C. Yin, Mathew J. Platt, Xixi Tian, Xue Wu, Peter H. Backx, Jeremy A. Simpson, Toshiyuki Araki and Benjamin G. Neel | | | The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardiac hypertrophy caused by a NS-associated Raf allele. | | | 26 May 2017 | doi: 10.1038/ncomms15518 | | |
| Highly indistinguishable and strongly entangled photons from symmetric GaAs quantum dots OPEN | | | Daniel Huber, Marcus Reindl, Yongheng Huo, Huiying Huang, Johannes S. Wildmann, Oliver G. Schmidt, Armando Rastelli and Rinaldo Trotta | | | Scalable and integratable sources of entangled-photon pairs are an important building block for quantum photonic applications. Here, Huber et al. demonstrate that droplet-etched gallium arsenide quantum dots can emit highly indistinguishable photon pairs with a high degree of entanglement. | | | 26 May 2017 | doi: 10.1038/ncomms15506 | | |
| The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition OPEN | | | Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke et al. | | | Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition. | | | 26 May 2017 | doi: 10.1038/ncomms15503 | | |
| Solid-state ensemble of highly entangled photon sources at rubidium atomic transitions OPEN | | | Robert Keil, Michael Zopf, Yan Chen, Bianca Höfer, Jiaxiang Zhang, Fei Ding and Oliver G. Schmidt | | | Scalable and integratable sources of entangled-photon pairs are an important building block for quantum photonic applications. Here, Keil et al. demonstrate that an ensemble of droplet-etched gallium arsenide quantum dots can emit polarization-entangled photons with almost 100% yield. | | | 26 May 2017 | doi: 10.1038/ncomms15501 | | |
| All pure bipartite entangled states can be self-tested OPEN | | | Andrea Coladangelo, Koon Tong Goh and Valerio Scarani | | | Device-independent self-testing is an approach that allows a complete certification of an unknown quantum state, simply by inspecting outcomes of measurements. Here, the authors demonstrate that any pure bipartite entangled state can be self-tested. | | | 26 May 2017 | doi: 10.1038/ncomms15485 | | |
| Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy OPEN | | | Maria P. Cabral, Patricia García, Alejandro Beceiro, Carlos Rumbo, Astrid Pérez, Miriam Moscoso and Germán Bou | | | D-glutamate is an essential component of the bacterial cell wall. Here, the authors use mouse models of infection with Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus to show that bacterial mutants unable to synthesize D-glutamate can potentially be used as live attenuated vaccines. | | | 26 May 2017 | doi: 10.1038/ncomms15480 | | |
| Finding multiple reaction pathways via global optimization of action OPEN | | | Juyong Lee, In-Ho Lee, InSuk Joung, Jooyoung Lee and Bernard R. Brooks | | | Identifying pathways and transition states is critical to understanding chemical and biological reactions. Here, the authors introduce a capable computational approach using conformational space annealing to find multiple reaction pathways via global optimization of the Onsager-Machlup action. | | | 26 May 2017 | doi: 10.1038/ncomms15443 | | |
| Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies OPEN | | | Edurne San José-Enériz, Xabier Agirre, Obdulia Rabal, Amaia Vilas-Zornoza, Juan A. Sanchez-Arias, Estibaliz Miranda, Ana Ugarte, Sergio Roa, Bruno Paiva, Ander Estella-Hermoso de Mendoza, Rosa María Alvarez, Noelia Casares, Victor Segura, José I. Martín-Subero, François-Xavier Ogi, Pierre Soule, Clara M. Santiveri, Ramón Campos-Olivas, Giancarlo Castellano, Maite Garcia Fernandez de Barrena et al. | | | Epigenetic drugs are emerging as a powerful therapeutic option for cancer treatment. Here, the authors synthesized selective chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity and demonstrate their anti-tumour activity using in vitro and in vivo models of haematological neoplasia. | | | 26 May 2017 | doi: 10.1038/ncomms15424 | | |
| Scalable focused ion beam creation of nearly lifetime-limited single quantum emitters in diamond nanostructures OPEN | | | Tim Schröder, Matthew E. Trusheim, Michael Walsh, Luozhou Li, Jiabao Zheng, Marco Schukraft, Alp Sipahigil, Ruffin E. Evans, Denis D. Sukachev, Christian T. Nguyen, Jose L. Pacheco, Ryan M. Camacho, Edward S. Bielejec, Mikhail D. Lukin and Dirk Englund | | | Interfacing spin quantum memories with photons requires the controlled creation of defect centre—nanocavity systems. Here the authors demonstrate direct, maskless creation of single silicon vacancy centres in diamond nanostructures, and report linewidths comparable to naturally occurring centres | | | 26 May 2017 | doi: 10.1038/ncomms15376 | | |
| Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy OPEN | | | Sandra M. Kallert, Stephanie Darbre, Weldy V. Bonilla, Mario Kreutzfeldt, Nicolas Page, Philipp Müller, Matthias Kreuzaler, Min Lu, Stéphanie Favre, Florian Kreppel, Max Löhning, Sanjiv A. Luther, Alfred Zippelius, Doron Merkler and Daniel D. Pinschewer | | | Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice. | | | 26 May 2017 | doi: 10.1038/ncomms15327 | | |
| Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations OPEN | | | Jiang Chang, Wenle Tan, Zhiqiang Ling, Ruibin Xi, Mingming Shao, Mengjie Chen, Yingying Luo, Yanjie Zhao, Yun Liu, Xiancong Huang, Yuchao Xia, Jinlin Hu, Joel S. Parker, David Marron, Qionghua Cui, Linna Peng, Jiahui Chu, Hongmin Li, Zhongli Du, Yaling Han et al. | | | Oesophageal squamous-cell carcinoma (ESCC) is a leading cause of cancer death, and half of ESCC cases occur in China. Here, the authors provide an in depth genomic landscape for this disease and identify specific mutation signatures—one of which is linked to alcohol intake. | | | 26 May 2017 | doi: 10.1038/ncomms15290 | | |
| Morphometric convergence between Proterozoic and post-vegetation rivers OPEN | | | Alessandro Ielpi, Robert H. Rainbird, Dario Ventra and Massimiliano Ghinassi | | | It has been previously assumed that deep river channels could not have developed in the Proterozoic due to lack of vegetation. Here, the authors present remote sensing and outcrop data to show that large scale and deeply channelled river networks did exist in the Proterozoic despite the absence of vegetation. | | | 26 May 2017 | doi: 10.1038/ncomms15250 | | |
| Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET OPEN | | | Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao and Song Gao | | | MxA (myxovirus resistance protein A) is a viral restriction factor whose activity depends on self-assembly into polymeric rings and helical filaments. Here the authors reveal the conformational movements involved in generating torque within polymeric MxA molecules and the dynamic conformational changes that occur upon GTP loading and hydrolysis. | | | 26 May 2017 | doi: 10.1038/ncomms15744 | | |
| Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex OPEN | | | Teng Teng, Jennifer HC Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Sudeep Prajapati, Daniel Aird, Silvia Buonamici, Benjamin Caleb, Betty Chan, Laura Corson, Jacob Feala, Peter Fekkes, Baudouin Gerard, Craig Karr, Manav Korpal, Xiang Liu, Jason T. Lowe, Yoshiharu Mizui, James Palacino et al. | | | A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex. | | | 25 May 2017 | doi: 10.1038/ncomms15522 | | |
| Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs OPEN | | | David Haselbach, Jil Schrader, Felix Lambrecht, Fabian Henneberg, Ashwin Chari and Holger Stark | | | The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynamic behaviour of the proteasome. | | | 25 May 2017 | doi: 10.1038/ncomms15578 | | |
| ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics OPEN | | | Yanlei Ma, Jiping Yue, Yao Zhang, Chenzhang Shi, Matt Odenwald, Wenguang G. Liang, Qing Wei, Ajay Goel, Xuewen Gou, Jamie Zhang, Shao-Yu Chen, Wei-Jen Tang, Jerrold R. Turner, Feng Yang, Hong Liang, Huanlong Qin and Xiaoyang Wu | | | The cytoskeleton plays a key role in cell/cell junction formation, but how the coordinated behaviour of the cytoskeleton contributes is not known. Here the authors show that actin-microtubule crosslinker ACF7 plays a key role in tight junction stabilization and wound healing in intestinal epithelium. | | | 25 May 2017 | doi: 10.1038/ncomms15375 | | |
| Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve OPEN | | | Bo Yang, Wei Zhou, Jiao Jiao, Jonas B. Nielsen, Michael R. Mathis, Mahyar Heydarpour, Guillaume Lettre, Lasse Folkersen, Siddharth Prakash, Claudia Schurmann, Lars Fritsche, Gregory A. Farnum, Maoxuan Lin, Mohammad Othman, Whitney Hornsby, Anisa Driscoll, Alexandra Levasseur, Marc Thomas, Linda Farhat, Marie-Pierre Dubé et al. | | | Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development. | | | 25 May 2017 | doi: 10.1038/ncomms15481 | | |
| Tailoring nanoscopic confines to maximize catalytic activity of hydronium ions OPEN | | | Hui Shi, Sebastian Eckstein, Aleksei Vjunov, Donald M. Camaioni and Johannes A. Lercher | | | The rates of acid-catalysed reactions vary in constrained environments. Here the authors show that molecularly sized pores greatly promote aqueous phase alcohol dehydration by enhancing the association between substrate and hydronium ions, and even by lowering the free energy barrier. | | | 25 May 2017 | doi: 10.1038/ncomms15442 | | |
| Construction of hierarchically porous metal–organic frameworks through linker labilization OPEN | | | Shuai Yuan, Lanfang Zou, Jun-Sheng Qin, Jialuo Li, Lan Huang, Liang Feng, Xuan Wang, Mathieu Bosch, Ali Alsalme, Tahir Cagin and Hong-Cai Zhou | | | Expanding pore sizes and volumes in metal-organic frameworks is challenging, but crucial for the encapsulation of larger guest molecules. Here, Zhou and colleagues report a linker labilization strategy to construct MOFs containing hierarchical pore architectures with dimensions ranging from 1.5 to 18 nm. | | | 25 May 2017 | doi: 10.1038/ncomms15356 | | |
| The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion OPEN | | | Runqiu Jiang, Junwei Tang, Yun Chen, Lei Deng, Jie Ji, Yu Xie, Ke Wang, Wei Jia, Wen-Ming Chu and Beicheng Sun | | | The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression. | | | 25 May 2017 | doi: 10.1038/ncomms15129 | | |
| Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells OPEN | | | Maarten Jaspers, Sarah L. Vaessen, Pim van Schayik, Dion Voerman, Alan E. Rowan and Paul H. J. Kouwer | | | Mechanical properties of living organisms are determined by intra- and extra-cellular biopolymer networks. Here, the authors show how the mechanics of polyisocyanopeptide hydrogels, mimicking biopolymers, can be readily manipulated by introducing a second polymer network. | | | 25 May 2017 | doi: 10.1038/ncomms15478 | | |
| Digital logic circuits in yeast with CRISPR-dCas9 NOR gates OPEN | | | Miles W. Gander, Justin D. Vrana, William E. Voje, James M. Carothers and Eric Klavins | | | The leakiness of commonly used genetic components can make the construction of complex synthetic circuits difficult. Here the authors construct NOR gate architecture, using dCas9 fused to the chromatin remodeller Mxi1, that can be wired together into complex circuits. | | | 25 May 2017 | doi: 10.1038/ncomms15459 | | |
| Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations OPEN | | | Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L. Nana, Owen Adam Brady, Jean C. Cruz Hernandez, Nozomi Nishimura, William W. Seeley and Fenghua Hu | | | Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that decreased prosaposin expression in mice leads to FTLD-like behaviour. | | | 25 May 2017 | doi: 10.1038/ncomms15277 | | |
| High pressure synthesis of a hexagonal close-packed phase of the high-entropy alloy CrMnFeCoNi OPEN | | | Cameron L. Tracy, Sulgiye Park, Dylan R. Rittman, Steven J. Zinkle, Hongbin Bei, Maik Lang, Rodney C. Ewing and Wendy L. Mao | | | High-entropy alloys represent a new strategy for the design of materials with properties superior to those of conventional alloys, but are largely limited to simple phases of cubic symmetry. By applying high pressures on CrMnFeCoNi, here authors demonstrate synthesis of a hexagonal close-packed phase. | | | 25 May 2017 | doi: 10.1038/ncomms15634 | | |
| miR-29b contributes to multiple types of muscle atrophy OPEN | | | Jin Li, Mun Chun Chan, Yan Yu, Yihua Bei, Ping Chen, Qiulian Zhou, Liming Cheng, Lei Chen, Olivia Ziegler, Glenn C. Rowe, Saumya Das and Junjie Xiao | | | Skeletal muscle atrophy can occur in response to stimuli such as inactivity, fasting, and ageing. Here the authors show that expression of microRNA-29b promotes muscle atrophy by targeting IGF-1 and PI3K, and that its inhibition attenuates atrophy induced by denervation and immobilization in mice. | | | 25 May 2017 | doi: 10.1038/ncomms15201 | | |
| Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy OPEN | | | Luuk Steemers, Martin J. Wanner, Martin Lutz, Henk Hiemstra and Jan H. van Maarseveen | | | Spiro compounds contain two or more rings linked together through one common atom. Here the authors provide a method to backfold both rings, producing spiro quasi[1]catenanes, via a strategy of temporarily linking the linear intermediates with covalent bonds. | | | 25 May 2017 | doi: 10.1038/ncomms15392 | | |
| The geography of measles vaccination in the African Great Lakes region OPEN | | | Saki Takahashi, C. Jessica E. Metcalf, Matthew J. Ferrari, Andrew J. Tatem and Justin Lessler | | | The WHO targets measles elimination by 2020, a goal that relies on high vaccination coverage. Here, Takahashi et al. identify ‘coldspots’ in the African Great Lakes region where measles vaccine coverage is below 80%, suggesting that these regions should be targeted in future vaccination campaigns. | | | 25 May 2017 | doi: 10.1038/ncomms15585 | | |
| A reaction mode of carbene-catalysed aryl aldehyde activation and induced phenol OH functionalization OPEN | | | Xingkuan Chen, Hongling Wang, Kazuki Doitomi, Chong Yih Ooi, Pengcheng Zheng, Wangsheng Liu, Hao Guo, Song Yang, Bao-An Song, Hajime Hirao and Yonggui Robin Chi | | | Selective functionalization of aromatic compounds is important in synthetic chemistry. Here the authors report an N-heterocyclic carbene-catalysed approach for enantioselectively converting ortho-hydroxyaldehydes to cyclic products, via activation of both phenol and aldehyde groups. | | | 25 May 2017 | doi: 10.1038/ncomms15598 | | |
| Skilful prediction of Sahel summer rainfall on inter-annual and multi-year timescales OPEN | | | K. L. Sheen, D. M. Smith, N. J. Dunstone, R. Eade, D. P. Rowell and M. Vellinga | | | Summer rainfall in the agriculturally-reliant Sahel is extremely variable, with the region particularly vulnerable to major droughts. Here, the authors investigate the mechanisms that drive Sahel summer rainfall change on inter-annual and multi-year timescales and show that Sahel rainfall can be skilfully predicted. | | | 25 May 2017 | doi: 10.1038/ncomms14966 | | |
| Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi OPEN | | | Paola Pisacane and Mario Halic | | | While RNA interference is a highly conserved mechanism of gene regulation, how Argonaute-bound small RNAs are targeted for degradation is not well understood. Here the authors show that Cid14 and Cid16 target Argonaute-bound small RNAs for degradation and protect the genome from uncontrolled RNAi activity. | | | 25 May 2017 | doi: 10.1038/ncomms15332 | | |
| Gigantic negative magnetoresistance in the bulk of a disordered topological insulator OPEN | | | Oliver Breunig, Zhiwei Wang, A A Taskin, Jonathan Lux, Achim Rosch and Yoichi Ando | | | Large negative magnetoresistance is usually related to magnetism and the exceptions are rare. Here, Breunig et al. report a large negative magnetoresistance in a topological insulator, TlBi0.15Sb0.85Te2, which is likely due to the Zeeman effect on a barely percolating current path formed in the disordered bulk. | | | 25 May 2017 | doi: 10.1038/ncomms15545 | | |
| A scalable double-barcode sequencing platform for characterization of dynamic protein-protein interactions OPEN | | | Ulrich Schlecht, Zhimin Liu, Jamie R. Blundell, Robert P. St.Onge and Sasha F. Levy | | | Protein-protein interactions (PPIs) play a major role in defining biological functions. Here, the authors present PPiSeq, a method to quantitatively score dynamic PPIs in yeast combining fragment complementation assays, genomic double-barcoding, and an analytical framework to precisely call fitness from barcode lineage trajectories. | | | 25 May 2017 | doi: 10.1038/ncomms15586 | | |
| Negative Poisson’s ratio in 1T-type crystalline two-dimensional transition metal dichalcogenides OPEN | | | Liping Yu, Qimin Yan and Adrienn Ruzsinszky | | | Auxetic materials—those that expand laterally when stretched—can possess enhanced mechanical properties, including shear modulus, indentation resistance, and fracture toughness. Here the authors show that 1T-type crystalline 2D transition metal dichalcogenides exhibit intrinsic in-plane negative Poisson’s ratios. | | | 25 May 2017 | doi: 10.1038/ncomms15224 | | |
| Coordination of cortical and thalamic activity during non-REM sleep in humans OPEN | | | Rachel A. Mak-McCully, Matthieu Rolland, Anna Sargsyan, Chris Gonzalez, Michel Magnin, Patrick Chauvel, Marc Rey, Hélène Bastuji and Eric Halgren | | | During non-REM sleep, the thalamus produces spindles and the cortex produces downstates, but the interaction between these two areas in these sleep phenomena is not understood. Here, authors describe the dynamic loop between the thalamus and cortex that organizes the production of spindles and downstates in the human brain. | | | 25 May 2017 | doi: 10.1038/ncomms15499 | | |
| Endogenous opioids regulate social threat learning in humans OPEN | | | Jan Haaker, Jonathan Yi, Predrag Petrovic and Andreas Olsson | | | Though humans often learn about negative outcomes from observing the response of others, the neurochemistry underlying this learning is unknown. Here, authors show that blocking opioid receptors enhances social threat learning and describe the brain regions underlying this effect. | | | 25 May 2017 | doi: 10.1038/ncomms15495 | | |
| Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence OPEN | | | Nafees Rahman, Patrick M. Brauer, Lilian Ho, Tatiana Usenko, Mukul Tewary, Juan Carlos Zúñiga-Pflücker and Peter W. Zandstra | | | The derivation of blood progenitor cells from human pluripotent stem cells is of interest for cell therapy but remains an inefficient process. Here the authors micropattern hPSC-derived haemogenic endothelial (HE) cells into spatially-organized, size-controlled colonies and identify a geometry that achieves increased efficiency in deriving blood cells. | | | 25 May 2017 | doi: 10.1038/ncomms15380 | | |
| Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain OPEN | | | Amandine Perrin, Elise Larsonneur, Ainsley C. Nicholson, David J. Edwards, Kristin M. Gundlach, Anne M. Whitney, Christopher A. Gulvik, Melissa E. Bell, Olaya Rendueles, Jean Cury, Perrine Hugon, Dominique Clermont, Vincent Enouf, Vladimir Loparev, Phalasy Juieng, Timothy Monson, David Warshauer, Lina I. Elbadawi, Maroya Spalding Walters, Matthew B. Crist et al. | | | Elizabethkingia anophelis is an emerging pathogen of high antimicrobial resistance. Perrin and colleagues sequenced isolates of a 2015/2016 E. anophelis outbreak in Wisconsin and found substantial genetic diversity, accelerated evolutionary rate and a disruptive mutation in the DNA repair gene mutY. | | | 24 May 2017 | doi: 10.1038/ncomms15483 | | |
| A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance OPEN | | | Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros et al. | | | Artemisinin-resistant Plasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is efficient in Plasmodium mouse models. | | | 24 May 2017 | doi: 10.1038/ncomms15159 | | |
| Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants OPEN | | | Lam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N. Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D. Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G. Krueger, Henry W. Lim et al. | | | Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals. | | | 24 May 2017 | doi: 10.1038/ncomms15382 | | |
| Draft genome of spinach and transcriptome diversity of 120 Spinacia accessions OPEN | | | Chenxi Xu, Chen Jiao, Honghe Sun, Xiaofeng Cai, Xiaoli Wang, Chenhui Ge, Yi Zheng, Wenli Liu, Xuepeng Sun, Yimin Xu, Jie Deng, Zhonghua Zhang, Sanwen Huang, Shaojun Dai, Beiquan Mou, Quanxi Wang, Zhangjun Fei and Quanhua Wang | | | Spinach is an economically important vegetable crop but previous genomic resources were of limited use for comparative and functional analyses. Here, Xu et al. present a high quality draft spinach genome and transcriptome data for multiple Spinacia accessions providing insight into Caryophyllales genome evolution. | | | 24 May 2017 | doi: 10.1038/ncomms15275 | | |
| Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism OPEN | | | Yadav Sapkota, Valgerdur Steinthorsdottir, Andrew P. Morris, Amelie Fassbender, Nilufer Rahmioglu, Immaculata De Vivo, Julie E. Buring, Futao Zhang, Todd L. Edwards, Sarah Jones, Dorien O, Daniëlle Peterse, Kathryn M. Rexrode, Paul M. Ridker, Andrew J. Schork, Stuart MacGregor, Nicholas G. Martin, Christian M. Becker, Sosuke Adachi, Kosuke Yoshihara et al. | | | Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis. | | | 24 May 2017 | doi: 10.1038/ncomms15539 | | |
| An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans OPEN | | | Abbey D. Zuehlke, Michael Reidy, Coney Lin, Paul LaPointe, Sarah Alsomairy, D. Joshua Lee, Genesis M. Rivera-Marquez, Kristin Beebe, Thomas Prince, Sunmin Lee, Jane B. Trepel, Wanping Xu, Jill Johnson, Daniel Masison and Len Neckers | | | The eukaryotic heat shock protein 90 (Hsp90) undergoes an ATP-dependent conformational cycle that is influenced by posttranslational modifications and co-chaperones. Here, the authors show that the yeast co-chaperone Hch1 can be functionally substituted by site-specific phosphorylation in human Hsp90. | | | 24 May 2017 | doi: 10.1038/ncomms15328 | | |
| Visualization of lithium-ion transport and phase evolution within and between manganese oxide nanorods OPEN | | | Feng Xu, Lijun Wu, Qingping Meng, Merzuk Kaltak, Jianping Huang, Jessica L. Durham, Marivi Fernandez-Serra, Litao Sun, Amy C. Marschilok, Esther S. Takeuchi, Kenneth J. Takeuchi, Mark S. Hybertsen and Yimei Zhu | | | Hollandite structured materials are potentially useful for battery technologies. Here the authors report the unusual lateral transport of lithium ions between lithiated silver manages oxide nanorods where the reaction fronts and kinetics are maintained within the neighbouring nanorods. | | | 24 May 2017 | doi: 10.1038/ncomms15400 | | |
| Genomic variation associated with local adaptation of weedy rice during de-domestication OPEN | | | Jie Qiu, Yongjun Zhou, Lingfeng Mao, Chuyu Ye, Weidi Wang, Jianping Zhang, Yongyi Yu, Fei Fu, Yunfei Wang, Feijian Qian, Ting Qi, Sanling Wu, Most Humaira Sultana, Ya-Nan Cao, Yu Wang, Michael P. Timko, Song Ge, Longjiang Fan and Yongliang Lu | | | De-domestication is the process by which cultivated plants adopt characteristics similar to that of their wild predecessors. Here Qiu et al. re-sequence de-domesticated weedy rice and matched cultivated varieties and identify genetic variants indicative of convergent evolution across multiple de-domestication events. | | | 24 May 2017 | doi: 10.1038/ncomms15323 | | |
| Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin OPEN | | | Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, Tao Yang, Yin Huang, Xinyang Song, Yongqin Li, Lilin Ye, Nan Shen, Yufang Shi, Xiaoxia Li, Feng Wang and Youcun Qian | | | Perforin is part of the cytotoxic effector mechanism of CD8+ T cells. Here the authors show that antigen-induced perforin release from CD8 T cells into antigen-presenting cells can activate NLRP3 inflammasome to constitute a positive feedback loop to promote anti-tumour immunity and allo-responses. | | | 24 May 2017 | doi: 10.1038/ncomms15402 | | |
| Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition OPEN | | | Evgenia Shishkova, Hao Zeng, Fabao Liu, Nicholas W. Kwiecien, Alexander S. Hebert, Joshua J. Coon and Wei Xu | | | Arginine methylation is an abundant post-translational modification catalysed by protein arginine methyltransferases (PRMTs). Here the authors use quantitative mass spectrometry to globally profile the substrates of the PRMT CARM1 in breast cancer cells, and establish a role for CARM1’s N-terminus in substrate recognition. | | | 24 May 2017 | doi: 10.1038/ncomms15571 | | |
| Non-Poissonian photon statistics from macroscopic photon cutting materials OPEN | | | Mathijs de Jong, Andries Meijerink and Freddy T. Rabouw | | | Photon-cutting materials provide a way around efficiency limits for energy conversion by absorbing high-energy photons and ‘cutting’ them into multiple low-energy excitations. Here, the authors show that photon-cutting material can be identified and characterised by studying their bunched emission statistics. | | | 24 May 2017 | doi: 10.1038/ncomms15537 | | |
| TAL effector driven induction of a SWEET gene confers susceptibility to bacterial blight of cotton OPEN | | | Kevin L. Cox, Fanhong Meng, Katherine E. Wilkins, Fangjun Li, Ping Wang, Nicholas J. Booher, Sara C. D. Carpenter, Li-Qing Chen, Hui Zheng, Xiquan Gao, Yi Zheng, Zhangjun Fei, John Z. Yu, Thomas Isakeit, Terry Wheeler, Wolf B. Frommer, Ping He, Adam J. Bogdanove and Libo Shan | | | Transcription activator-like effectors contribute to virulence of the Xanthomonas strain responsible for bacterial blight in cotton. Here Cox et al. show that the Xanthomonas Avrb6 effector induces expression of the cotton SWEET10 sugar transporter and that this induction promotes disease. | | | 24 May 2017 | doi: 10.1038/ncomms15588 | | |
| In situ dynamic tracking of heterogeneous nanocatalytic processes by shell-isolated nanoparticle-enhanced Raman spectroscopy OPEN | | | Hua Zhang, Chen Wang, Han-Lei Sun, Gang Fu, Shu Chen, Yue-Jiao Zhang, Bing-Hui Chen, Jason R. Anema, Zhi-Lin Yang, Jian-Feng Li and Zhong-Qun Tian | | | Rational design of heterogeneous catalysts requires molecular understanding of catalytic processes. Here, the authors attach PtFe and Pd nanocatalysts to Raman signal-enhancing Au-silica nanoparticles, allowing them to spectroscopically observe the active species and bonds involved in CO oxidation in real time. | | | 24 May 2017 | doi: 10.1038/ncomms15447 | | |
| Induction of resident memory T cells enhances the efficacy of cancer vaccine OPEN | | | Mevyn Nizard, Hélène Roussel, Mariana O. Diniz, Soumaya Karaki, Thi Tran, Thibault Voron, Estelle Dransart, Federico Sandoval, Marc Riquet, Bastien Rance, Elie Marcheteau, Elizabeth Fabre, Marion Mandavit, Magali Terme, Charlotte Blanc, Jean-Baptiste Escudie, Laure Gibault, Françoise Le Pimpec Barthes, Clemence Granier, Luis C. S. Ferreira et al. | | | Resident memory T cells (Trm) are memory T cells that remain in tissue. Here, the authors show that induction of Trm cells is required for control of tumour growth following mucosal vaccination in mice bearing head and neck cancer and that Trm cells in human lung cancer correlates with a better survival. | | | 24 May 2017 | doi: 10.1038/ncomms15221 | | |
| Magnetic-field induced multiple topological phases in pyrochlore iridates with Mott criticality OPEN | | | Kentaro Ueda, Taekoo Oh, Bohm-Jung Yang, Ryoma Kaneko, Jun Fujioka, Naoto Nagaosa and Yoshinori Tokura | | | The interplay between multiple electronic interactions in solid promotes the emergence of exotic phases. Here, Ueda et al. report magnetotransport study on pyrochlore iridates R 2Ir2O7 near quantum metal-insulator transition reflecting the emergence of multiple Weyl semimetal states. | | | 24 May 2017 | doi: 10.1038/ncomms15515 | | |
| Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core OPEN | | | Hsiang-Kai Lin, Jennifer C. Boatz, Inge E. Krabbendam, Ravindra Kodali, Zhipeng Hou, Ronald Wetzel, Amalia M. Dolga, Michelle A. Poirier and Patrick C. A. van der Wel | | | Huntington's disease is caused by a polyglutamine stretch expansion in the first exon of huntingtin. Here, the authors use infrared spectroscopy and solid-state NMR and show that polymorphic huntingtin exon1 fibres differ in their flanking regions but not their core polyglutamine amyloid structures. | | | 24 May 2017 | doi: 10.1038/ncomms15462 | | |
| The interfacial structure of water droplets in a hydrophobic liquid OPEN | | | Nikolay Smolentsev, Wilbert J. Smit, Huib J. Bakker and Sylvie Roke | | | Nanoscopic water droplets in a hydrophobic liquid are abundant in the earth, our bodies and the sky. Here, it is shown that the surface of such a droplet has stronger hydrogen bonds than a planar interface of water and a hydrophobic liquid, equivalent to a 50 K reduction of the surface temperature. | | | 24 May 2017 | doi: 10.1038/ncomms15548 | | |
| Spin-orbit torque-driven skyrmion dynamics revealed by time-resolved X-ray microscopy OPEN | | | Seonghoon Woo, Kyung Mee Song, Hee-Sung Han, Min-Seung Jung, Mi-Young Im, Ki-Suk Lee, Kun Soo Song, Peter Fischer, Jung-Il Hong, Jun Woo Choi, Byoung-Chul Min, Hyun Cheol Koo and Joonyeon Chang | | | Magnetic skyrmions are potentially suitable for future spintronic devices, but their dynamical behaviour in real space remains elusive. Here, Woo et al. report nanosecond-dynamics of a 100nm-size magnetic skyrmion triggered by current-induced spin-orbit torques. | | | 24 May 2017 | doi: 10.1038/ncomms15573 | | |
| A synthetic biochemistry platform for cell free production of monoterpenes from glucose OPEN | | | Tyler P. Korman, Paul H. Opgenorth and James U. Bowie | | | Terpenes are bioactive natural products derived from plants with several commercial applications. Here, the authors engineer a cell-free system composed of 27 enzymes that convert glucose into terpenes, highlighting the potential of synthetic biochemistry approaches for biocompounds production. | | | 24 May 2017 | doi: 10.1038/ncomms15526 | | |
| Measuring the orbital angular momentum spectrum of an electron beam OPEN | | | Vincenzo Grillo, Amir H. Tavabi, Federico Venturi, Hugo Larocque, Roberto Balboni, Gian Carlo Gazzadi, Stefano Frabboni, Peng-Han Lu, Erfan Mafakheri, Frédéric Bouchard, Rafal E. Dunin-Borkowski, Robert W. Boyd, Martin P. J. Lavery, Miles J. Padgett and Ebrahim Karimi | | | Existing methods of characterizing electron beams carrying orbital angular momentum are inefficient as they allow measuring one OAM state at a time. Here the authors demonstrate an OAM spectrometer capable of analysing multiple OAM states and a potential tool for probing magnetic materials. | | | 24 May 2017 | doi: 10.1038/ncomms15536 | | |
| Coherent structural trapping through wave packet dispersion during photoinduced spin state switching OPEN | | | Henrik T. Lemke, Kasper S. Kjær, Robert Hartsock, Tim B. van Driel, Matthieu Chollet, James M. Glownia, Sanghoon Song, Diling Zhu, Elisabetta Pace, Samir F. Matar, Martin M. Nielsen, Maurizio Benfatto, Kelly J. Gaffney, Eric Collet and Marco Cammarata | | | Ultrafast nonadiabatic chemical dynamics during molecular photo-transformations remain challenging to describe since electronic/nuclear configurations are coupled. Here the authors use time-resolved X-ray absorption spectroscopy to probe the light-induced spin-state trapping dynamics of [Fe(bpy)3]2+ beyond the Born-Oppenheimer approximation. | | | 24 May 2017 | doi: 10.1038/ncomms15342 | | |
| Natural allelic variation of FRO2 modulates Arabidopsis root growth under iron deficiency OPEN | | | Santosh B. Satbhai, Claudia Setzer, Florentina Freynschlag, Radka Slovak, Envel Kerdaffrec and Wolfgang Busch | | | Iron is an essential micronutrient for plants and a lack of iron availability limits crop yield in many parts of the world. Here the authors show that natural variation in root growth of Arabidopsis plants under iron deficiency can be caused by allelic variation at the FRO2 locus. | | | 24 May 2017 | doi: 10.1038/ncomms15603 | | | | | | | | | | | | | Latest Corrigenda | | | | |
| | | | | Corrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action OPEN | | | Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri and Man-Wah Tan | | | 25 May 2017 | doi: 10.1038/ncomms15779 | | |
| | | | | | | | | | | Latest Erratum | | | | | | | | | |
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