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 | The EMBO Journal Volume 39, Issue 3 03 February 2020 |
News & Views
The heat's on: nuclear stress bodies signal intron retention
EMBO J (2020) 39: e104154 | First Published: 09 January 2020
A new study reveals that nuclear stress bodies serve as a platform for SR protein phosphorylation, thereby altering splicing of sequestered mRNAs during the recovery from heat shock.
Towards the unified principles of transcription termination
EMBO J (2020) 39: e104112 | First Published: 30 December 2019
An RNase J1 role in Bacillus subtilis transcription termination supports the existence of common allosteric principles of termination mechanisms, but also suggests higher mechanistic diversity in bacteria than expected.
Review
Open Access Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair
EMBO J (2020) 39: e102309 | First Published: 12 December 2019
Kellner and Luke review how RNase H2 or topoisomerase enzymes remove misincorporated ribonucleotides from genomic DNA, and the relevance of such mechanisms for both malignant and autoimmune diseases such as Aicardi–Goutières syndrome.
Articles
Open Access The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis
EMBO J (2020) 39: e101625 | First Published: 26 September 2019
Phosphorylation of the HORMA domain protein ASY1 by the central cell cycle kinase promotes its recruitment onto meiotic chromosomes both via protein interactions and by countering disassembly ATPase PCH2.
HighlightLncRNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
EMBO J (2020) 39: e102729 | First Published: 29 November 2019
Nuclear stress bodies assembled on highly repetitive satellite III lncRNAs function as a platform for phosphorylation of Ser/Arg‐rich splicing factors to promote rapid recovery of gene expression after thermal stress exposure.
The torpedo effect in Bacillus subtilis: RNase J1 resolves stalled transcription complexes
EMBO J (2020) 39: e102500 | First Published: 16 December 2019
Nascent RNA degradation by RNase J1 invokes disassembly of bacterial transcription complex upon collision with RNA polymerase.
Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts
EMBO J (2020) 39: e103365 | First Published: 20 December 2019
A combination of in vitro biochemistry, ribosome profiling, and cryo‐EM reveals that elongation‐slowing mRNA elements stall ribosomes in decoding‐incompatible RNA conformations in the ribosomal decoding center.
Open Access Respiratory supercomplexes act as a platform for complex III‐mediated maturation of human mitochondrial complexes I and IV
EMBO J (2020) 39: e102817 | First Published: 08 January 2020
Biogenesis of the human mitochondrial respiratory chain requires the cooperative and interdependent action of respiratory supercomplexes.
Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells
EMBO J (2020) 39: e102525 | First Published: 10 January 2020
Adipocyte‐derived extracellular vesicles laden with enzymatic machinery and lipid substrates promote fatty acid oxidation and aggressiveness of melanoma cells, a process that is amplified in obesity.
Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development
EMBO J (2020) 39: e103205 | First Published: 02 January 2020
Transplantation studies aiming to identify the origin of tissue alveolar macrophages implicate a contribution of fetal monocytes with higher mitochondrial bioenergetic and glycolytic capacity than primitive macrophages.
Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila
EMBO J (2020) 39: e103594 | First Published: 20 December 2019
Substitution of larval abdominal epithelium with adult tissue during fruit fly development is regulated by interplay of physical forces induced by adult tissue proliferation and delamination of larval cells.
Open Access Biomechanical stress regulates mammalian tooth replacement via the integrin β1‐RUNX2‐Wnt pathway
EMBO J (2020) 39: e102374 | First Published: 12 December 2019
Eruption of the deciduous tooth triggers maturation of the permanent tooth primordium via mechanical stress release in the mandible.
Open Access NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
EMBO J (2020) 39: e102771 | First Published: 23 December 2019
NEDD4 and NEDD4L E3 ligases control LGR5 receptor turnover in intestinal homeostasis and colorectal cancer.
Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability
EMBO J (2020) 39: e101863 | First Published: 26 November 2019
Bub1‐mediated mitotic phosphorylation of H2A threonine‐120 is necessary and sufficient for topoisomerase IIα (TOP2A) centromeric localization and decatenation of sister chromatids.
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