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Table of Contents Alert: The EMBO Journal, Vol. 39, No. 3, 03 February 2020

Tumor Metabolism
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Volume 39, Issue 3

03 February 2020

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The heat's on: nuclear stress bodies signal intron retention
Sylvia Erhardt, Georg Stoecklin

EMBO J (2020) 39: e104154 | First Published: 09 January 2020

A new study reveals that nuclear stress bodies serve as a platform for SR protein phosphorylation, thereby altering splicing of sequestered mRNAs during the recovery from heat shock.

Towards the unified principles of transcription termination
Vladimir Svetlov, Evgeny Nudler

EMBO J (2020) 39: e104112 | First Published: 30 December 2019

An RNase J1 role in Bacillus subtilis transcription termination supports the existence of common allosteric principles of termination mechanisms, but also suggests higher mechanistic diversity in bacteria than expected.


Open Access
Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair
Vanessa Kellner, Brian Luke

EMBO J (2020) 39: e102309 | First Published: 12 December 2019

Kellner and Luke review how RNase H2 or topoisomerase enzymes remove misincorporated ribonucleotides from genomic DNA, and the relevance of such mechanisms for both malignant and autoimmune diseases such as Aicardi–Goutières syndrome.


Open Access
The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis
Chao Yang, Kostika Sofroni, Erik Wijnker, Yuki Hamamura, Lena Carstens, Hirofumi Harashima, Sara Christina Stolze, Daniel Vezon, Liudmila Chelysheva, Zsuzsanna Orban‐Nemeth, Gaëtan Pochon, Hirofumi Nakagami, Peter Schlögelhofer, Mathilde Grelon, Arp Schnittger

EMBO J (2020) 39: e101625 | First Published: 26 September 2019

Phosphorylation of the HORMA domain protein ASY1 by the central cell cycle kinase promotes its recruitment onto meiotic chromosomes both via protein interactions and by countering disassembly ATPase PCH2.

LncRNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
Kensuke Ninomiya, Shungo Adachi, Tohru Natsume, Junichi Iwakiri, Goro Terai, Kiyoshi Asai, Tetsuro Hirose

EMBO J (2020) 39: e102729 | First Published: 29 November 2019

Nuclear stress bodies assembled on highly repetitive satellite III lncRNAs function as a platform for phosphorylation of Ser/Arg‐rich splicing factors to promote rapid recovery of gene expression after thermal stress exposure.

The torpedo effect in Bacillus subtilis: RNase J1 resolves stalled transcription complexes
Michaela Šiková, Jana Wiedermannová, Martin Převorovský, Ivan Barvík, Petra Sudzinová, Olga Kofroňová, Oldřich Benada, Hana Šanderová, Ciarán Condon, Libor Krásný

EMBO J (2020) 39: e102500 | First Published: 16 December 2019

Nascent RNA degradation by RNase J1 invokes disassembly of bacterial transcription complex upon collision with RNA polymerase.

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts
Petr Tesina, Laura N Lessen, Robert Buschauer, Jingdong Cheng, Colin Chih‐Chien Wu, Otto Berninghausen, Allen R Buskirk, Thomas Becker, Roland Beckmann, Rachel Green

EMBO J (2020) 39: e103365 | First Published: 20 December 2019

A combination of in vitro biochemistry, ribosome profiling, and cryo‐EM reveals that elongation‐slowing mRNA elements stall ribosomes in decoding‐incompatible RNA conformations in the ribosomal decoding center.

Open Access
Respiratory supercomplexes act as a platform for complex III‐mediated maturation of human mitochondrial complexes I and IV
Margherita Protasoni, Rafael Pérez‐Pérez, Teresa Lobo‐Jarne, Michael E Harbour, Shujing Ding, Ana Peñas, Francisca Diaz, Carlos T Moraes, Ian M Fearnley, Massimo Zeviani, Cristina Ugalde, Erika Fernández‐Vizarra

EMBO J (2020) 39: e102817 | First Published: 08 January 2020

Biogenesis of the human mitochondrial respiratory chain requires the cooperative and interdependent action of respiratory supercomplexes.

Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells
Emily Clement, Ikrame Lazar, Camille Attané, Lorry Carrié, Stéphanie Dauvillier, Manuelle Ducoux‐Petit, David Esteve, Thomas Menneteau, Mohamed Moutahir, Sophie Le Gonidec, Stéphane Dalle, Philippe Valet, Odile Burlet‐Schiltz, Catherine Muller, Laurence Nieto

EMBO J (2020) 39: e102525 | First Published: 10 January 2020

Adipocyte‐derived extracellular vesicles laden with enzymatic machinery and lipid substrates promote fatty acid oxidation and aggressiveness of melanoma cells, a process that is amplified in obesity.

Fetal monocytes possess increased metabolic capacity and replace primitive macrophages in tissue macrophage development
Fengqi Li, Katarzyna Maria Okreglicka, Lea Maria Pohlmeier, Christoph Schneider, Manfred Kopf

EMBO J (2020) 39: e103205 | First Published: 02 January 2020

Transplantation studies aiming to identify the origin of tissue alveolar macrophages implicate a contribution of fetal monocytes with higher mitochondrial bioenergetic and glycolytic capacity than primitive macrophages.

Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila
Carla Prat‐Rojo, Philippe‐Alexandre Pouille, Javier Buceta, Enrique Martin‐Blanco

EMBO J (2020) 39: e103594 | First Published: 20 December 2019

Substitution of larval abdominal epithelium with adult tissue during fruit fly development is regulated by interplay of physical forces induced by adult tissue proliferation and delamination of larval cells.

Open Access
Biomechanical stress regulates mammalian tooth replacement via the integrin β1‐RUNX2‐Wnt pathway
Xiaoshan Wu, Jinrong Hu, Guoqing Li, Yan Li, Yang Li, Jing Zhang, Fu Wang, Ang Li, Lei Hu, Zhipeng Fan, Shouqin Lü, Gang Ding, Chunmei Zhang, Jinsong Wang, Mian Long, Songlin Wang

EMBO J (2020) 39: e102374 | First Published: 12 December 2019

Eruption of the deciduous tooth triggers maturation of the permanent tooth primordium via mechanical stress release in the mandible.

Open Access
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, Maria Prange‐Barczynska, Anna Baulies, Pedro Antas, Jelte van der Vaart, Helmuth Gehart, Madelon M Maurice, Vivian SW Li

EMBO J (2020) 39: e102771 | First Published: 23 December 2019

NEDD4 and NEDD4L E3 ligases control LGR5 receptor turnover in intestinal homeostasis and colorectal cancer.

Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability
Miao Zhang, Cai Liang, Qinfu Chen, Haiyan Yan, Junfen Xu, Hongxia Zhao, Xueying Yuan, Jingbo Liu, Shixian Lin, Weiguo Lu, Fangwei Wang

EMBO J (2020) 39: e101863 | First Published: 26 November 2019

Bub1‐mediated mitotic phosphorylation of H2A threonine‐120 is necessary and sufficient for topoisomerase IIα (TOP2A) centromeric localization and decatenation of sister chromatids.

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