Table of Contents Alert: The EMBO Journal, Vol. 39, No. 5, 02 March 2020

The EMBO Journal Volume 39, Issue 5 02 March 2020

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News & Views

Open Access

Beating the ER: novel insights into FAM134B function and regulation

Chiara De Leonibus, Laura Cinque, Carmine Settembre

EMBO J (2020) 39: e104546 | First Published: 19 February 2020

A new study reveals that oligomerization of the autophagy receptor FAM134B drives endoplasmic reticulum fragmentation and ER‐phagy, two processes deregulated in hereditary neuropathies.

Articles

Open Access

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact

Sudha Kumari, Michael Mak, Yeh‐Chuin Poh, Mira Tohme, Nicki Watson, Mariane Melo, Erin Janssen, Michael Dustin, Raif Geha, Darrell J Irvine

EMBO J (2020) 39: e102783 | First Published: 02 January 2020

The stability of contact sites between T‐cells and antigen‐presenting cells—the immunological synapse– is regulated by WASP‐mediated nucleation of F‐actin foci and the actomyosin network, generating cytoskeletal tension that prevents synapse breaking.

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER‐phagy

Xiao Jiang, Xinyi Wang, Xianming Ding, Mengjie Du, Boran Li, Xialian Weng, Jingzi Zhang, Lin Li, Rui Tian, Qi Zhu, She Chen, Liang Wang, Wei Liu, Lei Fang, Dante Neculai, Qiming Sun

EMBO J (2020) 39: e102608 | First Published: 13 January 2020

CAMK2B‐dependent phosphorylation of autophagy receptor FAM134B promotes its oligomerization and membrane‐scission activity, a process deregulated in sensory neuropathy.

UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism

Xing Feng, Dong Ma, Jiabao Zhao, Yongxi Song, Yuekun Zhu, Qingxin Zhou, Fei Ma, Xing Liu, Mengya Zhong, Yu Liu, Yubo Xiong, Xingfeng Qiu, Zhen Zhang, Heng Zhang, Yongxiang Zhao, Kaiguang Zhang, Xuehui Hong, Zhiyong Zhang

EMBO J (2020) 39: e102541 | First Published: 23 January 2020

Nuclear serine/threonine kinase UHMK1 mutations enhance gastric cancer by activating de novo purine synthesis.

Ependyma‐expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular‐subventricular zone

Jun Wu, Wen‐Jia Tian, Yang Liu, Huanhuan J Wang, Jiangli Zheng, Xin Wang, Han Pan, Ji Li, Junyu Luo, Xuerui Yang, Lester F Lau, H Troy Ghashghaei, Qin Shen

EMBO J (2020) 39: e101679 | First Published: 03 February 2020

Secretion of the matricellular protein CCN1 from ependymal cells regulates adult neural stem cell (NSCs) expansion but also the capacity of stem cell niches for holding a specific number of NSCs and their progeny.

Open Access Highlight

Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono‐phosphorylated Pbs2 MAP2K

Kazuo Tatebayashi, Katsuyoshi Yamamoto, Taichiro Tomida, Akiko Nishimura, Tomomi Takayama, Masaaki Oyama, Hiroko Kozuka‐Hata, Satomi Adachi‐Akahane, Yuji Tokunaga, Haruo Saito

EMBO J (2020) 39: e103444 | First Published: 03 February 2020

Activation of the osmostress response regulator Hog1 is potentiated by a mechanism independent from transmembrane osmosensors, thus insulating it from the mating‐pheromone‐induced MAPK cascade.

Open Access

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli

Manuel Banzhaf, Hamish CL Yau, Jolanda Verheul, Adam Lodge, George Kritikos, André Mateus, Baptiste Cordier, Ann Kristin Hov, Frank Stein, Morgane Wartel, Manuel Pazos, Alexandra S Solovyova, Eefjan Breukink, Sven van Teeffelen, Mikhail M Savitski, Tanneke den Blaauwen, Athanasios Typas, Waldemar Vollmer

EMBO J (2020) 39: e102246 | First Published: 03 February 2020

An adaptor protein for peptidoglycan hydrolases and synthases coordinates bacterial cell wall growth.

α‐Actinin‐1 promotes activity of the L‐type Ca2+ channel Cav1.2

Matthew Turner, David E Anderson, Peter Bartels, Madeline Nieves‐Cintron, Andrea M Coleman, Peter B Henderson, Kwun Nok Mimi Man, Pang‐Yen Tseng, Vladimir Yarov‐Yarovoy, Donald M Bers, Manuel F Navedo, Mary C Horne, James B Ames, Johannes W Hell

EMBO J (2020) 39: e102622 | First Published: 27 January 2020

The scaffold protein α‐actinin is a positive regulator of Ca_V1.2 channel open probability and gating.

Resource

In situ CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer

Stefano Annunziato, Catrin Lutz, Linda Henneman, Jinhyuk Bhin, Kim Wong, Bjørn Siteur, Bas van Gerwen, Renske de Korte‐Grimmerink, Maria Paz Zafra, Emma M Schatoff, Anne Paulien Drenth, Eline van der Burg, Timo Eijkman, Siddhartha Mukherjee, Katharina Boroviak, Lodewyk FA Wessels, Marieke van de Ven, Ivo J Huijbers, David J Adams, Lukas E Dow, Jos Jonkers

EMBO J (2020) 39: e102169 | First Published: 13 January 2020

A new knock‐in mouse model allows for Cre‐mediated conditional expression of the BE3 cytidine base editor and in vivo analysis of somatic missense mutations.

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