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Table of Contents Alert: The EMBO Journal, Vol. 39, No. 4, 17 February 2020

Tumor Metabolism
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Volume 39, Issue 4

17 February 2020

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Legionella pneumophila balances ubiquitin transglutamination
Fujie Yan, Yongqun Zhu, Yan Zhou

EMBO J (2020) 39: e104258 | First Published: 28 January 2020

A new study reveals that L. pneumophila employs a non‐canonical ubiquitination/de‐ubiqutination cascade to allow precise temporal regulation of host immune response during infection.


Legionella pneumophila regulates the activity of UBE2N by deamidase‐mediated deubiquitination
Ninghai Gan, Hongxin Guan, Yini Huang, Ting Yu, Jiaqi Fu, Ernesto S Nakayasu, Kedar Puvar, Chittaranjan Das, Dongmei Wang, Songying Ouyang, Zhao‐Qing Luo

EMBO J (2020) 39: e102806 | First Published: 11 December 2019

Dynamic regulation of activity and atypical ubiquitination of the host E2 enzyme UBE2N via bacterial effectors MavC and MvcA over the course of infection is important for pathogen replication.

Tyrosine phosphorylation of the lectin receptor‐like kinase LORE regulates plant immunity
Xuming Luo, Wei Wu, Yingbo Liang, Ning Xu, Zongyi Wang, Huasong Zou, Jun Liu

EMBO J (2020) 39: e102856 | First Published: 10 January 2020

A bacterial fatty acid metabolite induces immune response in Arabidopsis via receptor‐like cytoplasmic kinases PBL34/PBL35/PBL36 downstream of the receptor kinase LORE.

Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells
Eleazar Rodriguez, Jonathan Chevalier, Jakob Olsen, Jeppe Ansbøl, Vaitsa Kapousidou, Zhangli Zuo, Steingrim Svenning, Christian Loefke, Stefanie Koemeda, Pedro Serrano Drozdowskyj, Jakub Jez, Gerhard Durnberger, Fabian Kuenzl, Michael Schutzbier, Karl Mechtler, Elise Nagel Ebstrup, Signe Lolle, Yasin Dagdas, Morten Petersen

EMBO J (2020) 39: e103315 | First Published: 13 January 2020

Autophagy facilitates cellular proteome adjustment to new stimuli and allows coordinated transition to a new cell state by erasing previous cellular programs.

Open Access
Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders
Manon Boivin, Véronique Pfister, Angeline Gaucherot, Frank Ruffenach, Luc Negroni, Chantal Sellier, Nicolas Charlet‐Berguerand

EMBO J (2020) 39: e100574 | First Published: 13 January 2020

ALS‐linked sense and antisense repeats are translated into toxic peptides that require clearance by C9ORF72‐dependent autophagy.

Open Access
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling
Christian Schiffer, Steffen Rieger, Christoph Brenker, Samuel Young, Hussein Hamzeh, Dagmar Wachten, Frank Tüttelmann, Albrecht Röpke, U Benjamin Kaupp, Tao Wang, Alice Wagner, Claudia Krallmann, Sabine Kliesch, Carsten Fallnich, Timo Strünker

EMBO J (2020) 39: e102363 | First Published: 19 January 2020

Live‐cell imaging unexpectedly reveals that Ca2+ influx via the CatSper channel is dispensable for rheotactic steering of sperm.

Open Access
Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation
Christian Trötschel, Hussein Hamzeh, Luis Alvarez, René Pascal, Fedir Lavryk, Wolfgang Bönigk, Heinz G Körschen, Astrid Müller, Ansgar Poetsch, Andreas Rennhack, Long Gui, Daniela Nicastro, Timo Strünker, Reinhard Seifert, U Benjamin Kaupp

EMBO J (2020) 39: e102723 | First Published: 27 December 2019

Reversed enzyme‐messenger ratios in sperm cilia ensure high‐sensitivity, low noise messenger detection.


Generation of a self‐cleaved inducible Cre recombinase for efficient temporal genetic manipulation
Xueying Tian, Lingjuan He, Kuo Liu, Wenjuan Pu, Huan Zhao, Yan Li, Xiuxiu Liu, Muxue Tang, Ruilin Sun, Jian Fei, Yong Ji, Zengyong Qiao, Kathy O Lui, Bin Zhou

EMBO J (2020) 39: e102675 | First Published: 14 January 2020

Methodological development of the inducible Cre recombinase system for in vivo genetic manipulation, based on self‐conversion of an inducible to a constitutively active Cre form, results in higher recombination efficiency than conventional Cre‐based systems.

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