The EMBO Journal Volume 39, Issue 4 17 February 2020 |
News & Views
Legionella pneumophila balances ubiquitin transglutamination
EMBO J (2020) 39: e104258 | First Published: 28 January 2020
A new study reveals that L. pneumophila employs a non‐canonical ubiquitination/de‐ubiqutination cascade to allow precise temporal regulation of host immune response during infection.
Articles
Legionella pneumophila regulates the activity of UBE2N by deamidase‐mediated deubiquitination
EMBO J (2020) 39: e102806 | First Published: 11 December 2019
Dynamic regulation of activity and atypical ubiquitination of the host E2 enzyme UBE2N via bacterial effectors MavC and MvcA over the course of infection is important for pathogen replication.
Tyrosine phosphorylation of the lectin receptor‐like kinase LORE regulates plant immunity
EMBO J (2020) 39: e102856 | First Published: 10 January 2020
A bacterial fatty acid metabolite induces immune response in Arabidopsis via receptor‐like cytoplasmic kinases PBL34/PBL35/PBL36 downstream of the receptor kinase LORE.
Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells
EMBO J (2020) 39: e103315 | First Published: 13 January 2020
Autophagy facilitates cellular proteome adjustment to new stimuli and allows coordinated transition to a new cell state by erasing previous cellular programs.
Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders
EMBO J (2020) 39: e100574 | First Published: 13 January 2020
ALS‐linked sense and antisense repeats are translated into toxic peptides that require clearance by C9ORF72‐dependent autophagy.
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling
EMBO J (2020) 39: e102363 | First Published: 19 January 2020
Live‐cell imaging unexpectedly reveals that Ca2+ influx via the CatSper channel is dispensable for rheotactic steering of sperm.
Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation
EMBO J (2020) 39: e102723 | First Published: 27 December 2019
Reversed enzyme‐messenger ratios in sperm cilia ensure high‐sensitivity, low noise messenger detection.
Resource
Generation of a self‐cleaved inducible Cre recombinase for efficient temporal genetic manipulation
EMBO J (2020) 39: e102675 | First Published: 14 January 2020
Methodological development of the inducible Cre recombinase system for in vivo genetic manipulation, based on self‐conversion of an inducible to a constitutively active Cre form, results in higher recombination efficiency than conventional Cre‐based systems.
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