.png)
 | EMBO reports Volume 21, Issue 2 05 February 2020 |
News & Views
PCAF, ISX, and BRD4: a maleficent alliance serving lung cancer malignancy
EMBO Rep (2020) 21: e49766 | First Published: 07 January 2020
Tumor progression is frequently associated with aberrant activation of epithelial‐mesenchymal transition (EMT). A study in this issue shows how epigenetic modifiers are utilized to induce EMT and to promote metastasis.
Another hijack! Some enteroviruses co‐opt the c10orf76/PI4KB complex for their own good
EMBO Rep (2020) 21: e49876 | First Published: 09 January 2020
A new study characterizes a complex involved in PI4P production and shows that this machinery is hijacked by specific enteroviruses such as Coxsackievirus A10 for their replication.
Science & Society
Microfluidic tools for probing micro‐culprits : Opportunities and challenges in microfluidic diagnostics
EMBO Rep (2020) 21: e49749 | First Published: 29 January 2020
Microfluidics is a highly promising technology platform for cancer diagnosis. It will need a change of mindset among engineers, clinicians and regulators to fully embrace its potential.
Open Access Conjectures, refutations and the search for truths : Science, symbolic truths and the devil
EMBO Rep (2020) 21: e49924 | First Published: 13 January 2020
In times of fake news, post‐truths and post‐science, the principles of science can inform all kinds of inquiries into the true nature of reality.
Open Access Real‐time ethics engagement in biomedical research : Ethics from bench to bedside
EMBO Rep (2020) 21: e49919 | First Published: 15 January 2020
Biomedical research often raises ethical questions that are usually addressed ad hoc or in retrospective. Real‐time ethical engagement as part of research may be better suited to identify ethical issues.
Open Access The Natural Fallacy in a Post‐Truth era : A perspective on the natural sciences' permeability to values
EMBO Rep (2020) 21: e49859 | First Published: 10 January 2020
The natural sciences are not immune to societal values and beliefs. Understanding the interference of these factors is key to protect science from becoming a servant to opportunistic interests.
The "industrial" revolution in biomedical research : Data explosion and reproducibility crisis drive changes in lab workflows
EMBO Rep (2020) 21: e50003 | First Published: 27 January 2020
The ever increasing amount of data, new technologies and the need for reproducible results drive profound changes in the workflows of diagnostic and basic research laboratories.
Report
Monomeric cohesin state revealed by live‐cell single‐molecule spectroscopy
EMBO Rep (2020) 21: e48211 | First Published: 29 December 2019
Models describing the tethering mechanism of cohesin depend on either a monomeric cohesin ring or a dimer. Fluorescence correlation microscopy and photon counting histogram analysis now show that cohesin exists mostly as a monomer.
Articles
Anti‐HIV‐1 antibodies trigger non‐lytic complement deposition on infected cells
EMBO Rep (2020) 21: e49351 | First Published: 12 December 2019
Anti‐HIV‐1 antibodies trigger complement deposition at the surface of infected cells. Some viral and cellular components independently limit complement activation after infection, preventing rapid cell lysis, although coated cells disappear faster than non‐coated cells.
Open Access PCAF‐mediated acetylation of ISX recruits BRD4 to promote epithelial‐mesenchymal transition
EMBO Rep (2020) 21: e48795 | First Published: 07 January 2020
The PCAF–ISX–BRD4 axis is an important regulator of tumor metastasis and cell plasticity. PCAF‐mediated acetylation of the transcription factor ISX promotes translocation of ISX‐BRD4 to the nucleus to activate EMT genes and to induce metastasis.
Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication
EMBO Rep (2020) 21: e48441 | First Published: 12 December 2019
Enteroviruses hijack host PI4KB and GBF1 to build replication organelles. This study reveals that the direct interaction between c10orf76 and PI4KB is required for c10orf76 recruitment to the Golgi and the replication of c10orf76‐dependent enteroviruses.
Open Access Peroxisomal fission is modulated by the mitochondrial Rho‐GTPases, Miro1 and Miro2
EMBO Rep (2020) 21: e49865 | First Published: 02 January 2020
Miro1 and Miro2 localise to peroxisomes and negatively regulate peroxisomal fission rather than long‐range transport and distribution.
Open Access Heme oxygenase‐1 deficiency triggers exhaustion of hematopoietic stem cells
EMBO Rep (2020) 21: e47895 | First Published: 29 December 2019
The bone marrow niche harbors cell populations that constitutively express heme oxygenase 1 (HO‐1). HO‐1 regulates the niche and protects HSCs from exhaustion in a cell extrinsic manner.
Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response
EMBO Rep (2020) 21: e48052 | First Published: 27 January 2020
This study reveals that MitoT directly shapes the immune response by inducing Tregs, which could be potentially used as a therapy for autoimmune diseases such as GVHD.
HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53‐dependent mitochondrial apoptosis
EMBO Rep (2020) 21: e48073 | First Published: 23 December 2019
Cytoplasmic p53 has important functions in apoptosis and autophagy. HOPS retains and stabilizes p53 in the cytoplasm and thereby promotes p53‐dependent mitochondrial apoptosis.
TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety‐related behaviors
EMBO Rep (2020) 21: e48097 | First Published: 29 November 2019
The TMEM16A chloride channel has an excitatory role in cholinergic neurons of the medial habenula (mHb). Mice deficient for TMEM16A in mHb cholinergic neurons display anxiety‐related behaviors.
Open Access SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability
EMBO Rep (2020) 21: e48222 | First Published: 23 December 2019
The structural maintenance complex SMC5/6 interacts with and functions jointly with key components of the Fanconi anemia pathway to facilitate DNA repair and preserve genome stability.
Open Access CEP41‐mediated ciliary tubulin glutamylation drives angiogenesis through AURKA‐dependent deciliation
EMBO Rep (2020) 21: e48290 | First Published: 29 December 2019
CEP41 regulates cilia disassembly and angiogenesis through AURKA activation by modulating axonemal tubulin glutamylation in mammalian and zebrafish endothelial cells.
CrRLK1L receptor‐like kinases HERK1 and ANJEA are female determinants of pollen tube reception
EMBO Rep (2020) 21: e48466 | First Published: 23 December 2019
The CrRLK1L receptor kinases HERK1 and ANJ are genetically redundant during pollen tube reception in Arabidopsis. Both proteins interact with the CrRLK1L receptor FER and its putative co‐receptor LRE and contribute to NTA relocalisation but not to ROS production.
Arginine methylation‐dependent LSD1 stability promotes invasion and metastasis of breast cancer
EMBO Rep (2020) 21: e48597 | First Published: 12 December 2019
The protein arginine methyltransferase CARM1 targets the histone lysine demethylase LSD1 and promotes its stabilization via USP7‐dependent deubiqutination. Stabilised LSD1 enhances migration and invasion of breast cancer cells, further facilitating metastasis.
You are receiving this content alert because you are subscribed to EMBO reports as edgeblog.alerts.2011.001@gmail.com.
If you no longer wish to receive these alerts you can unsubscribe here.
You can manage all of your EMBO Press content alerts at https://www.embopress.org.
No comments:
Post a Comment