Thursday, March 5, 2020

Table of Contents Alert: EMBO reports, Vol. 21, No. 2, 05 February 2020

Tumor Metabolism
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Volume 21, Issue 2

05 February 2020

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News & Views

PCAF, ISX, and BRD4: a maleficent alliance serving lung cancer malignancy
Marc P Stemmler

EMBO Rep (2020) 21: e49766 | First Published: 07 January 2020

Tumor progression is frequently associated with aberrant activation of epithelial‐mesenchymal transition (EMT). A study in this issue shows how epigenetic modifiers are utilized to induce EMT and to promote metastasis.

Another hijack! Some enteroviruses co‐opt the c10orf76/PI4KB complex for their own good
Laetitia Voilquin, Thomas Di Mattia, Fabien Alpy

EMBO Rep (2020) 21: e49876 | First Published: 09 January 2020

A new study characterizes a complex involved in PI4P production and shows that this machinery is hijacked by specific enteroviruses such as Coxsackievirus A10 for their replication.

Science & Society

Microfluidic tools for probing micro‐culprits : Opportunities and challenges in microfluidic diagnostics
Su Bin Lim, Nishanth Venugopal Menon, Chwee Teck Lim

EMBO Rep (2020) 21: e49749 | First Published: 29 January 2020

Microfluidics is a highly promising technology platform for cancer diagnosis. It will need a change of mindset among engineers, clinicians and regulators to fully embrace its potential.

Open Access
Conjectures, refutations and the search for truths : Science, symbolic truths and the devil
G Paolo Dotto

EMBO Rep (2020) 21: e49924 | First Published: 13 January 2020

In times of fake news, post‐truths and post‐science, the principles of science can inform all kinds of inquiries into the true nature of reality.

Open Access
Real‐time ethics engagement in biomedical research : Ethics from bench to bedside
Jeremy Sugarman, Annelien L Bredenoord

EMBO Rep (2020) 21: e49919 | First Published: 15 January 2020

Biomedical research often raises ethical questions that are usually addressed ad hoc or in retrospective. Real‐time ethical engagement as part of research may be better suited to identify ethical issues.

Open Access
The Natural Fallacy in a Post‐Truth era : A perspective on the natural sciences' permeability to values
Mariana RP Alves

EMBO Rep (2020) 21: e49859 | First Published: 10 January 2020

The natural sciences are not immune to societal values and beliefs. Understanding the interference of these factors is key to protect science from becoming a servant to opportunistic interests.

The "industrial" revolution in biomedical research : Data explosion and reproducibility crisis drive changes in lab workflows
Philip Hunter

EMBO Rep (2020) 21: e50003 | First Published: 27 January 2020

The ever increasing amount of data, new technologies and the need for reproducible results drive profound changes in the workflows of diagnostic and basic research laboratories.


Monomeric cohesin state revealed by live‐cell single‐molecule spectroscopy
Wenjie Liu, Elisheva Biton, Anjali Pathania, Avi Matityahu, Joseph Irudayaraj, Itay Onn

EMBO Rep (2020) 21: e48211 | First Published: 29 December 2019

Models describing the tethering mechanism of cohesin depend on either a monomeric cohesin ring or a dimer. Fluorescence correlation microscopy and photon counting histogram analysis now show that cohesin exists mostly as a monomer.


Anti‐HIV‐1 antibodies trigger non‐lytic complement deposition on infected cells
Jérémy Dufloo, Florence Guivel‐Benhassine, Julian Buchrieser, Valérie Lorin, Ludivine Grzelak, Emilie Dupouy, Guillaume Mestrallet, Katia Bourdic, Olivier Lambotte, Hugo Mouquet, Timothée Bruel, Olivier Schwartz

EMBO Rep (2020) 21: e49351 | First Published: 12 December 2019

Anti‐HIV‐1 antibodies trigger complement deposition at the surface of infected cells. Some viral and cellular components independently limit complement activation after infection, preventing rapid cell lysis, although coated cells disappear faster than non‐coated cells.

Open Access
PCAF‐mediated acetylation of ISX recruits BRD4 to promote epithelial‐mesenchymal transition
Li‐Ting Wang, Kwei‐Yan Liu, Wen‐Yih Jeng, Cheng‐Ming Chiang, Chee‐Yin Chai, Shyh‐Shin Chiou, Ming‐Shyang Huang, Kazunari K Yokoyama, Shen‐Nien Wang, Shau‐Ku Huang, Shih‐Hsien Hsu

EMBO Rep (2020) 21: e48795 | First Published: 07 January 2020

The PCAF–ISX–BRD4 axis is an important regulator of tumor metastasis and cell plasticity. PCAF‐mediated acetylation of the transcription factor ISX promotes translocation of ISX‐BRD4 to the nucleus to activate EMT genes and to induce metastasis.

Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication
Jacob A McPhail, Heyrhyoung Lyoo, Joshua G Pemberton, Reece M Hoffmann, Wendy van Elst, Jeroen RPM Strating, Meredith L Jenkins, Jordan TB Stariha, Cameron J Powell, Martin J Boulanger, Tamas Balla, Frank JM van Kuppeveld, John E Burke

EMBO Rep (2020) 21: e48441 | First Published: 12 December 2019

Enteroviruses hijack host PI4KB and GBF1 to build replication organelles. This study reveals that the direct interaction between c10orf76 and PI4KB is required for c10orf76 recruitment to the Golgi and the replication of c10orf76‐dependent enteroviruses.

Open Access
Peroxisomal fission is modulated by the mitochondrial Rho‐GTPases, Miro1 and Miro2
Christian Covill‐Cooke, Viktoriya S Toncheva, James Drew, Nicol Birsa, Guillermo López‐Doménech, Josef T Kittler

EMBO Rep (2020) 21: e49865 | First Published: 02 January 2020

Miro1 and Miro2 localise to peroxisomes and negatively regulate peroxisomal fission rather than long‐range transport and distribution.

Open Access
Heme oxygenase‐1 deficiency triggers exhaustion of hematopoietic stem cells
Krzysztof Szade, Monika Zukowska, Agata Szade, Witold Nowak, Izabella Skulimowska, Maciej Ciesla, Karolina Bukowska‐Strakova, Gunsagar Singh Gulati, Neli Kachamakova‐Trojanowska, Anna Kusienicka, Elisa Einwallner, Jacek Kijowski, Szymon Czauderna, Harald Esterbauer, Vladimir Benes, Irving L Weissman, Jozef Dulak, Alicja Jozkowicz

EMBO Rep (2020) 21: e47895 | First Published: 29 December 2019

The bone marrow niche harbors cell populations that constitutively express heme oxygenase 1 (HO‐1). HO‐1 regulates the niche and protects HSCs from exhaustion in a cell extrinsic manner.

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response
Angela C Court, Alice Le‐Gatt, Patricia Luz‐Crawford, Eliseo Parra, Victor Aliaga‐Tobar, Luis Federico Bátiz, Rafael A Contreras, María Ignacia Ortúzar, Mónica Kurte, Roberto Elizondo‐Vega, Vinicius Maracaja‐Coutinho, Karina Pino‐Lagos, Fernando E Figueroa, Maroun Khoury

EMBO Rep (2020) 21: e48052 | First Published: 27 January 2020

This study reveals that MitoT directly shapes the immune response by inducing Tregs, which could be potentially used as a therapy for autoimmune diseases such as GVHD.

HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53‐dependent mitochondrial apoptosis
Marilena Castelli, Danilo Piobbico, Martina Chiacchiaretta, Cinzia Brunacci, Stefania Pieroni, Daniela Bartoli, Marco Gargaro, Francesca Fallarino, Paolo Puccetti, Silvia Soddu, Maria Agnese Della‐Fazia, Giuseppe Servillo

EMBO Rep (2020) 21: e48073 | First Published: 23 December 2019

Cytoplasmic p53 has important functions in apoptosis and autophagy. HOPS retains and stabilizes p53 in the cytoplasm and thereby promotes p53‐dependent mitochondrial apoptosis.

TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety‐related behaviors
Chang‐Hoon Cho, Sangjoon Lee, Ajung Kim, Oleg Yarishkin, Kanghyun Ryoo, Young‐Sun Lee, Hyun‐Gug Jung, Esther Yang, Da Yong Lee, Byeongjun Lee, Hyun Kim, Uhtaek Oh, Heh‐In Im, Eun Mi Hwang, Jae‐Yong Park

EMBO Rep (2020) 21: e48097 | First Published: 29 November 2019

The TMEM16A chloride channel has an excitatory role in cholinergic neurons of the medial habenula (mHb). Mice deficient for TMEM16A in mHb cholinergic neurons display anxiety‐related behaviors.

Open Access
SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability
Francesco Rossi, Anne Helbling‐Leclerc, Ryotaro Kawasumi, Nanda Kumar Jegadesan, Xinlin Xu, Pierre Devulder, Takuya Abe, Minoru Takata, Dongyi Xu, Filippo Rosselli, Dana Branzei

EMBO Rep (2020) 21: e48222 | First Published: 23 December 2019

The structural maintenance complex SMC5/6 interacts with and functions jointly with key components of the Fanconi anemia pathway to facilitate DNA repair and preserve genome stability.

Open Access
CEP41‐mediated ciliary tubulin glutamylation drives angiogenesis through AURKA‐dependent deciliation
Soo Mi Ki, Ji Hyun Kim, So Yeon Won, Shin Ji Oh, In Young Lee, Young‐Ki Bae, Ki Wha Chung, Byung‐Ok Choi, Boyoun Park, Eui‐Ju Choi, Ji Eun Lee

EMBO Rep (2020) 21: e48290 | First Published: 29 December 2019

CEP41 regulates cilia disassembly and angiogenesis through AURKA activation by modulating axonemal tubulin glutamylation in mammalian and zebrafish endothelial cells.

CrRLK1L receptor‐like kinases HERK1 and ANJEA are female determinants of pollen tube reception
Sergio Galindo‐Trigo, Noel Blanco‐Touriñán, Thomas A DeFalco, Eloise S Wells, Julie E Gray, Cyril Zipfel, Lisa M Smith

EMBO Rep (2020) 21: e48466 | First Published: 23 December 2019

The CrRLK1L receptor kinases HERK1 and ANJ are genetically redundant during pollen tube reception in Arabidopsis. Both proteins interact with the CrRLK1L receptor FER and its putative co‐receptor LRE and contribute to NTA relocalisation but not to ROS production.

Arginine methylation‐dependent LSD1 stability promotes invasion and metastasis of breast cancer
Jiwei Liu, Jingxin Feng, Lili Li, Luyao Lin, Jiafei Ji, Cong Lin, Lingxia Liu, Na Zhang, Dandan Duan, Zhongwei Li, Baiqu Huang, Yu Zhang, Jun Lu

EMBO Rep (2020) 21: e48597 | First Published: 12 December 2019

The protein arginine methyltransferase CARM1 targets the histone lysine demethylase LSD1 and promotes its stabilization via USP7‐dependent deubiqutination. Stabilised LSD1 enhances migration and invasion of breast cancer cells, further facilitating metastasis.

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