Wednesday, August 29, 2018

Nature Immunology Contents: September 2018 Volume 19 Issue 9

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Nature Immunology

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September 2018 Volume 19, Issue 9

Research Highlights
News & Views
Review Articles
Amendments & Corrections

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Harald von Boehmer 1942–2018    p899
Iannis Aifantis & Christine Borowski

Kimishige Ishizaka 1925–2018    p900
Toshiaki Kawakami

Research Highlights


Brain lymphatic (dys)function    p901
Zoltan Fehervari

All about timing    p901
Zoltan Fehervari

Keeper of specificity    p901
Ioana Visan

Starved NK cells    p901
Ioana Visan

ICAM-1 in ILC2s    p901
Laurie A. Dempsey

cGAS liquid droplets    p901
Laurie A. Dempsey

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News & Views


Silencing of TLM B cells by chronic HIV infection    pp902 - 903
Amanda E. Agazio, Roberta Pelanda & Raul M. Torres

Singling out the out-of-tune in lymphoma    pp903 - 905
Katia Basso

Old vaccines, new diseases: when BCG meets SPPL2a    pp906 - 907
Sergio D. Rosenzweig

Glucocorticoids and NK cell PD-1    pp908 - 910
Christine A. Biron

PI3Kδ: Too much of a good thing    pp910 - 911
Domenick E. Kennedy & Marcus R. Clark

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Review Articles


RIP kinases as modulators of inflammation and immunity    pp912 - 922
Sudan He & Xiaodong Wang

He and Wang review the immunological functions of RIP kinases in inflammatory responses to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.


The immunoproteasome and thymoproteasome: functions, evolution and human disease    pp923 - 931
Shigeo Murata, Yousuke Takahama, Masanori Kasahara & Keiji Tanaka

The immunoproteasome and thymoproteasome are specialized proteasomes operating within the immune system. In this Review, Murata et al. recount the discovery of the immunoproteasome and thymoproteasome and delve into their function, context in evolution and relation to human disease.




Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation    pp932 - 941
Sergi Cuartero, Felix D. Weiss, Gopuraja Dharmalingam, Ya Guo, Elizabeth Ing-Simmons et al.

Cohesin is a chromatin-binding factor that interacts at CTCF motifs to organize chromatin looping domains. Merkenschlager and colleagues show that cohesin regulates the inducible expression of inflammatory genes in macrophages and HSPCs and in human AML.


PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing    pp942 - 953
Amanda L. Gavin, Deli Huang, Christoph Huber, Annica Mårtensson, Virginie Tardif et al.

Nemazee and colleagues show that PLD3 and PLD4 are endolysosomal exonucleases that digest ingested nucleic acids and thereby prevent activation of endosomal TLRs. Mice that lack PLD3 and PLD4 develop autoinflammatory disease.


Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells    pp954 - 962
Linda Quatrini, Elisabeth Wieduwild, Bertrand Escaliere, Jessica Filtjens, Lionel Chasson et al.

Ugolini and colleagues show that glucocorticoid signaling induces expression of the checkpoint receptor PD-1 on NK cells to control immunopathology in a tissue-specific way.


Epigenetic control of innate and adaptive immune memory    pp963 - 972
Colleen M. Lau, Nicholas M. Adams, Clair D. Geary, Orr-El Weizman, Moritz Rapp et al.

Natural killer (NK) cells can acquire ‘memory’ signatures. Sun and colleagues examine the dynamic ATAC-seq and functional RNA-seq changes observed upon generation of NK cell memory and show distinct roles for transcription factors STAT1 and STAT4.


Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency    pp973 - 985
Xiao-Fei Kong, Ruben Martinez-Barricarte, James Kennedy, Federico Mele, Tomi Lazarov et al.

Primary immunodeficiency can predispose patients to mycobacterial disease. Casanova and colleagues identify novel human mutations in the enzyme SPPL2A that result in selective accumulation of CD74 in a dendritic cell subset and lead to their death and the failure to mount effective TH1 responses.


Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity    pp986 - 1000
Silvia Preite, Jennifer L. Cannons, Andrea J. Radtke, Ivan Vujkovic-Cvijin, Julio Gomez-Rodriguez et al.

Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.


IgG3 regulates tissue-like memory B cells in HIV-infected individuals    pp1001 - 1012
Lela Kardava, Haewon Sohn, Christine Youn, James W. Austin, Wei Wang et al.

Circulating IgG3 increases in chronic HIV infection. Moir and colleagues describe a negative regulatory role of secreted IgG3 in response to chronic HIV infection through its action on nonconventional CD27 memory B cells.


Human germinal center transcriptional programs are de-synchronized in B cell lymphoma    pp1013 - 1024
Pierre Milpied, Iñaki Cervera-Marzal, Marie-Laure Mollichella, Bruno Tesson, Gabriel Brisou et al.

Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.


IL-9 receptor signaling in memory B cells regulates humoral recall responses    pp1025 - 1034
Shogo Takatsuka, Hiroyuki Yamada, Kei Haniuda, Hiroshi Saruwatari, Marina Ichihashi et al.

Signaling via the cytokine IL-9 receptor regulates humoral recall responses. Kitamura and colleagues report that IL-9 triggers memory B cells to proliferate and terminally differentiate into antibody-secreting cells rather than re-entering germinal centers.


Amendments & Corrections


Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes    p1035
Ophélie Rouxel, Jennifer DaSilva, Lucie Beaudoin, Isabelle Nel, Céline Tard et al.

Author Correction: Charles D. Surh 1960–2017    p1035
Janko Nikolich-Žugich

Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes    p1035
Bénédicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil et al.

Publisher Correction: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27    p1036
Heeju Ryu, Hoyong Lim, Garam Choi, Young-Jun Park, Minkyoung Cho et al.

Publisher Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells    p1036
Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li et al.

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes    p1036
Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao et al.

Publisher Correction: Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection    p1037
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker et al.

Publisher Correction: A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer    p1037
Emma L. Kuan & Steven F. Ziegler

Publisher Correction: Feeling stressed? It might be your T cells    p1037
Laura Strauss, Nikolaos Patsoukis & Vassiliki A Boussiotis

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