Nature Immunology Contents: September 2018 Volume 19 Issue 9

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Advertisement Talk to MedGenome about their OncoPept™ immunotherapy solutions at the IO Summit 2018 in Boston. We will present a talk on "Overcoming challenges in therapeutic vaccine design to treat cancer". Learn More TABLE OF CONTENTS September 2018 Volume 19, Issue 9 Obituary Research Highlights News & Views Review Articles Articles Amendments & Corrections   Advertisement Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions.  Find out more >>>   Advertisement Register for the latest nature.com webcast: Discover how fluorescent imaging is providing new insights into immune processes. Dr. Garry Nolan of Stanford University will present evidence of deep internal order in immune functionality demonstrating that differentiation and immune activities have evolved with a definable "shape".  Register for FREE today  Sponsored by Akoya Bio   Advertisement Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>   Advertisement Register for the latest nature.com webcast Simultaneous gene expression and epitope analysis of immune cells from astronauts - Thursday, 6th September, 2018 Listen to Dr Christopher Mason from Weil Cornell Medical College discuss his plan for the survival of the human species on Earth, in space and on other planets.  Register for FREE today  Sponsored by BD   Obituary   Harald von Boehmer 1942–2018    p899 Iannis Aifantis & Christine Borowski doi:10.1038/s41590-018-0192-1 Kimishige Ishizaka 1925–2018    p900 Toshiaki Kawakami doi:10.1038/s41590-018-0187-y Research Highlights   Brain lymphatic (dys)function    p901 Zoltan Fehervari doi:10.1038/s41590-018-0194-z All about timing    p901 Zoltan Fehervari doi:10.1038/s41590-018-0195-y Keeper of specificity    p901 Ioana Visan doi:10.1038/s41590-018-0196-x Starved NK cells    p901 Ioana Visan doi:10.1038/s41590-018-0197-9 ICAM-1 in ILC2s    p901 Laurie A. Dempsey doi:10.1038/s41590-018-0198-8 cGAS liquid droplets    p901 Laurie A. Dempsey doi:10.1038/s41590-018-0199-7 Immunology JOBS of the week Post-Doctoral Researcher The Maynooth University Tenure-Track Faculty Positions Ohio State University Tenure-track faculty positions The Ohio State University, Comprehensive Cancer Center Postdoc in DNA Damage Response and Innate Immunity The Laboratory for Molecular Infection Medicine Sweden (MIMS) More Science jobs from Immunology EVENT Cancer Immunotherapy: Recent Progress and Future Challenges 12.10.18 Palermo, Italy More science events from Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    News & Views   Silencing of TLM B cells by chronic HIV infection    pp902 - 903 Amanda E. Agazio, Roberta Pelanda & Raul M. Torres doi:10.1038/s41590-018-0191-2 Singling out the out-of-tune in lymphoma    pp903 - 905 Katia Basso doi:10.1038/s41590-018-0189-9 Old vaccines, new diseases: when BCG meets SPPL2a    pp906 - 907 Sergio D. Rosenzweig doi:10.1038/s41590-018-0193-0 Glucocorticoids and NK cell PD-1    pp908 - 910 Christine A. Biron doi:10.1038/s41590-018-0190-3 PI3Kδ: Too much of a good thing    pp910 - 911 Domenick E. Kennedy & Marcus R. Clark doi:10.1038/s41590-018-0183-2 Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do   Review Articles   RIP kinases as modulators of inflammation and immunity    pp912 - 922 Sudan He & Xiaodong Wang doi:10.1038/s41590-018-0188-x He and Wang review the immunological functions of RIP kinases in inflammatory responses to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.   The immunoproteasome and thymoproteasome: functions, evolution and human disease    pp923 - 931 Shigeo Murata, Yousuke Takahama, Masanori Kasahara & Keiji Tanaka doi:10.1038/s41590-018-0186-z The immunoproteasome and thymoproteasome are specialized proteasomes operating within the immune system. In this Review, Murata et al. recount the discovery of the immunoproteasome and thymoproteasome and delve into their function, context in evolution and relation to human disease.   Articles   Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation    pp932 - 941 Sergi Cuartero, Felix D. Weiss, Gopuraja Dharmalingam, Ya Guo, Elizabeth Ing-Simmons et al. doi:10.1038/s41590-018-0184-1 Cohesin is a chromatin-binding factor that interacts at CTCF motifs to organize chromatin looping domains. Merkenschlager and colleagues show that cohesin regulates the inducible expression of inflammatory genes in macrophages and HSPCs and in human AML.   PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing    pp942 - 953 Amanda L. Gavin, Deli Huang, Christoph Huber, Annica Mårtensson, Virginie Tardif et al. doi:10.1038/s41590-018-0179-y Nemazee and colleagues show that PLD3 and PLD4 are endolysosomal exonucleases that digest ingested nucleic acids and thereby prevent activation of endosomal TLRs. Mice that lack PLD3 and PLD4 develop autoinflammatory disease.   Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells    pp954 - 962 Linda Quatrini, Elisabeth Wieduwild, Bertrand Escaliere, Jessica Filtjens, Lionel Chasson et al. doi:10.1038/s41590-018-0185-0 Ugolini and colleagues show that glucocorticoid signaling induces expression of the checkpoint receptor PD-1 on NK cells to control immunopathology in a tissue-specific way.   Epigenetic control of innate and adaptive immune memory    pp963 - 972 Colleen M. Lau, Nicholas M. Adams, Clair D. Geary, Orr-El Weizman, Moritz Rapp et al. doi:10.1038/s41590-018-0176-1 Natural killer (NK) cells can acquire ‘memory’ signatures. Sun and colleagues examine the dynamic ATAC-seq and functional RNA-seq changes observed upon generation of NK cell memory and show distinct roles for transcription factors STAT1 and STAT4.   Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency    pp973 - 985 Xiao-Fei Kong, Ruben Martinez-Barricarte, James Kennedy, Federico Mele, Tomi Lazarov et al. doi:10.1038/s41590-018-0178-z Primary immunodeficiency can predispose patients to mycobacterial disease. Casanova and colleagues identify novel human mutations in the enzyme SPPL2A that result in selective accumulation of CD74 in a dendritic cell subset and lead to their death and the failure to mount effective TH1 responses.   Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity    pp986 - 1000 Silvia Preite, Jennifer L. Cannons, Andrea J. Radtke, Ivan Vujkovic-Cvijin, Julio Gomez-Rodriguez et al. doi:10.1038/s41590-018-0182-3 Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.   IgG3 regulates tissue-like memory B cells in HIV-infected individuals    pp1001 - 1012 Lela Kardava, Haewon Sohn, Christine Youn, James W. Austin, Wei Wang et al. doi:10.1038/s41590-018-0180-5 Circulating IgG3 increases in chronic HIV infection. Moir and colleagues describe a negative regulatory role of secreted IgG3 in response to chronic HIV infection through its action on nonconventional CD27– memory B cells.   Human germinal center transcriptional programs are de-synchronized in B cell lymphoma    pp1013 - 1024 Pierre Milpied, Iñaki Cervera-Marzal, Marie-Laure Mollichella, Bruno Tesson, Gabriel Brisou et al. doi:10.1038/s41590-018-0181-4 Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.   IL-9 receptor signaling in memory B cells regulates humoral recall responses    pp1025 - 1034 Shogo Takatsuka, Hiroyuki Yamada, Kei Haniuda, Hiroshi Saruwatari, Marina Ichihashi et al. doi:10.1038/s41590-018-0177-0 Signaling via the cytokine IL-9 receptor regulates humoral recall responses. Kitamura and colleagues report that IL-9 triggers memory B cells to proliferate and terminally differentiate into antibody-secreting cells rather than re-entering germinal centers.   Amendments & Corrections   Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes    p1035 Ophélie Rouxel, Jennifer DaSilva, Lucie Beaudoin, Isabelle Nel, Céline Tard et al. doi:10.1038/s41590-017-0023-9 Author Correction: Charles D. Surh 1960–2017    p1035 Janko Nikolich-Žugich doi:10.1038/s41590-017-0025-7 Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes    p1035 Bénédicte Machiels, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil et al. doi:10.1038/s41590-017-0024-8 Publisher Correction: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27    p1036 Heeju Ryu, Hoyong Lim, Garam Choi, Young-Jun Park, Minkyoung Cho et al. doi:10.1038/s41590-018-0158-3 Publisher Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells    p1036 Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li et al. doi:10.1038/s41590-018-0055-9 Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes    p1036 Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao et al. doi:10.1038/s41590-018-0154-7 Publisher Correction: Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection    p1037 Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker et al. doi:10.1038/s41590-018-0054-x Publisher Correction: A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer    p1037 Emma L. Kuan & Steven F. Ziegler doi:10.1038/s41590-018-0152-9 Publisher Correction: Feeling stressed? It might be your T cells    p1037 Laura Strauss, Nikolaos Patsoukis & Vassiliki A Boussiotis doi:10.1038/s41590-018-0140-0 Advertisement Register for the latest nature.com webcast The Neuronal Composition of Somatosensation - Wednesday, 5th September, 2018  Register for FREE today  Sponsored by ACD   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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