Wednesday, August 22, 2018

Nature Chemical Biology Contents: September 2018, Volume 14 No 9

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Nature Chemical Biology


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September 2018 Volume 14, Issue 9

Research Highlights
News & Views
Brief Communications
Amendments & Corrections
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Communications Chemistry: Open for Submissions Communications Chemistry is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of chemistry. The journal is now open for submissions. Find out more >>

Research Highlights


Stuck on you    p831
Caitlin Deane

Catch and identify your prey    p831
Karin Kuehnel

TA gets a PG rating    p831
Mirella Bucci

A ribonucleotide trap    p831
Yiyun Song

Nature Chemical Biology
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News & Views


PAINTing translation    pp832 - 833
Yuichiro Mishima

Mimicking cross-α amyloids    pp833 - 834
Meytal Landau

An optical sensor to monitor dynamics of extracellular glycine    pp835 - 836
Dmitri A. Rusakov

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Brief Communications


Acetylation blocks DNA damage–induced chromatin ADP-ribosylation    pp837 - 840
Glen Liszczak, Katharine L. Diehl, Geoffrey P. Dann & Tom W. Muir

Histone H3 serine 10 is found to be the major chromatin acceptor residue for DNA damage–induced ADP-ribosylation and is blocked by specific acetylation sites on PARP1 and/or H3.



Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system    pp841 - 843
Ron Hermenau, Keishi Ishida, Sofia Gama, Bianca Hoffmann, Michel Pfeifer-Leeg et al.

Plant-associated rhizosphere bacteria produce gramibactin, a cyclic lipodepsipeptide siderophore that tightly binds iron via an unexpected functional group, the N-nitrosohydroxylamine (diazeniumdiolate) moieties of the amino acid graminine.



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Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells    pp844 - 852
Youngnam N. Jin, Peter J. Schlueter, Nathalie Jurisch-Yaksi, Pui-Ying Lam, Shan Jin et al.

Primordazine inhibits poly(A)-tail-independent noncanonical translation (PAINT) in early zebrafish embryos and in mammalian cells under select conditions, an effect mediated by deadenylated 3ʹ UTRs that results in ablation of primordial germ cells.



Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase    pp853 - 860
Jiasong Li, Wendell P. Griffith, Ian Davis, Inchul Shin, Jiangyun Wang et al.

Engineered variants of cysteine dioxygenase containing a halogen-substituted tyrosine analog provide insights into the process of Cys–Tyr cross-link formation and indicate that the enzyme can catalyze oxidative cleavage of a carbon–fluorine bond.



Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS    pp861 - 869
William H. Zhang, Michel K. Herde, Joshua A. Mitchell, Jason H. Whitfield, Andreas B. Wulff et al.

A genetically encoded FRET-based optical sensor generated from a computational design approach can monitor hippocampal glycine levels in brain tissue to determine differences between spines and shafts and changes induced by high- and low-frequency stimulation.



Designed peptides that assemble into cross-α amyloid-like structures    pp870 - 875
Shao-Qing Zhang, Hai Huang, Junjiao Yang, Huong T. Kratochvil, Marco Lolicato et al.

Structural analysis reveals how certain designed peptides adopt unusual spiraling cross-α amyloid-like structures and also rearrange to helical polymers upon mutation of small nonpolar residues that are critical for packing and stabilization.



Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin    pp876 - 886
Fan Yang, Peng Xiao, Chang-xiu Qu, Qi Liu, Liu-yang Wang et al.

NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation.



ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands    pp887 - 894
Alla Peselis & Alexander Serganov

Structural analysis of PRPP and ppGpp riboswitches reveals that they employ a helical element to create a tunnel for the ligand, whose specificity is determined by the conserved nucleotides forming the tunnel and long-distance contacts.



Facile target validation in an animal model with intracellularly expressed monobodies    pp895 - 900
Ankit Gupta, Jing Xu, Shirley Lee, Steven T. Tsai, Bo Zhou et al.

The development of a selective and potent monobody to WDR5, a component of the mixed linear leukemia methyltransferase complex, as genetically encoded inhibitor enables suppression of leukemogenesis and confers survival in a mouse leukemia model.



Amendments & Corrections


Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes    p901
Simon Wisnovsky, Sae Rin Jean & Shana O Kelley

Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters    p901
Kiryl D. Piatkevich, Erica E. Jung, Christoph Straub, Changyang Linghu, Demian Park et al.

Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases    p901
Yong-Xin Li, Zheng Zhong, Peng Hou, Wei-Peng Zhang & Pei-Yuan Qian

Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells    p902
Aaron H. Nile, Felipe de Sousa e Melo, Susmith Mukund, Robert Piskol, Simon Hansen et al.

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases    p902
Lukas Reisky, Hanna C. Büchsenschütz, Jennifer Engel, Tao Song, Thomas Schweder et al.

Publisher Correction: Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET    p902
Daria M. Shcherbakova, Natasha Cox Cammer, Tsipora M. Huisman, Vladislav V. Verkhusha & Louis Hodgson

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