Nature Chemical Biology Contents: September 2018, Volume 14 No 9

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Advertisement Discover the LOPAC(R) 1280 small molecule library. The power and performance of our Library of Pharmacologically Active Compounds is assured. 1,280 pharmacologically active compounds Ready-to-use DMSO stocks: less time-consuming sample preparation Highly pure compounds with full QC: re-supply as individual catalog items  Learn More TABLE OF CONTENTS September 2018 Volume 14, Issue 9 Research Highlights News & Views Brief Communications Articles Amendments & Corrections   Advertisement   Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>    Advertisement 2018 longlist - see the full line up The nominations for the 2018 Nature Research Awards for Inspiring Science and Innovating Science are in. See who's been long listed here > In partnership with The Estée Lauder Companies.   Advertisement Communications Chemistry: Open for Submissions Communications Chemistry is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of chemistry. The journal is now open for submissions. Find out more >>   Research Highlights   Stuck on you    p831 Caitlin Deane doi:10.1038/s41589-018-0124-2 Catch and identify your prey    p831 Karin Kuehnel doi:10.1038/s41589-018-0125-1 TA gets a PG rating    p831 Mirella Bucci doi:10.1038/s41589-018-0126-0 A ribonucleotide trap    p831 Yiyun Song doi:10.1038/s41589-018-0127-z Nature Chemical Biology JOBS of the week Biomedical Research Scientist Science and Technology Facilities Council (STFC) Cancer Biology ULB - IRIBHM Postdoctoral Fellowship / Research Scientist Boston University School of Medicine, BUMC Postdoctoral Fellow - Weill Cornell Medicine Weill Cornell Medicine | NewYork-Presbyterian Faculty Positions Department of Cell and Molecular Biology St. Jude Children's Research Hospital (SJCRH) More Science jobs from Nature Chemical Biology EVENT ICBEE 2018 10th International Conference on Chemical, Biological and Environmental Engineering(ICBEE 2018) 27.09.18 Berlin, Germany More science events from News & Views   PAINTing translation    pp832 - 833 Yuichiro Mishima doi:10.1038/s41589-018-0102-8 Mimicking cross-α amyloids    pp833 - 834 Meytal Landau doi:10.1038/s41589-018-0118-0 An optical sensor to monitor dynamics of extracellular glycine    pp835 - 836 Dmitri A. Rusakov doi:10.1038/s41589-018-0123-3   Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Brief Communications   Acetylation blocks DNA damage–induced chromatin ADP-ribosylation    pp837 - 840 Glen Liszczak, Katharine L. Diehl, Geoffrey P. Dann & Tom W. Muir doi:10.1038/s41589-018-0097-1 Histone H3 serine 10 is found to be the major chromatin acceptor residue for DNA damage–induced ADP-ribosylation and is blocked by specific acetylation sites on PARP1 and/or H3.     Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system    pp841 - 843 Ron Hermenau, Keishi Ishida, Sofia Gama, Bianca Hoffmann, Michel Pfeifer-Leeg et al. doi:10.1038/s41589-018-0101-9 Plant-associated rhizosphere bacteria produce gramibactin, a cyclic lipodepsipeptide siderophore that tightly binds iron via an unexpected functional group, the N-nitrosohydroxylamine (diazeniumdiolate) moieties of the amino acid graminine.     Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do.   Articles   Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells    pp844 - 852 Youngnam N. Jin, Peter J. Schlueter, Nathalie Jurisch-Yaksi, Pui-Ying Lam, Shan Jin et al. doi:10.1038/s41589-018-0098-0 Primordazine inhibits poly(A)-tail-independent noncanonical translation (PAINT) in early zebrafish embryos and in mammalian cells under select conditions, an effect mediated by deadenylated 3ʹ UTRs that results in ablation of primordial germ cells.     Cleavage of a carbon–fluorine bond by an engineered cysteine dioxygenase    pp853 - 860 Jiasong Li, Wendell P. Griffith, Ian Davis, Inchul Shin, Jiangyun Wang et al. doi:10.1038/s41589-018-0085-5 Engineered variants of cysteine dioxygenase containing a halogen-substituted tyrosine analog provide insights into the process of Cys–Tyr cross-link formation and indicate that the enzyme can catalyze oxidative cleavage of a carbon–fluorine bond.     Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS    pp861 - 869 William H. Zhang, Michel K. Herde, Joshua A. Mitchell, Jason H. Whitfield, Andreas B. Wulff et al. doi:10.1038/s41589-018-0108-2 A genetically encoded FRET-based optical sensor generated from a computational design approach can monitor hippocampal glycine levels in brain tissue to determine differences between spines and shafts and changes induced by high- and low-frequency stimulation.     Designed peptides that assemble into cross-α amyloid-like structures    pp870 - 875 Shao-Qing Zhang, Hai Huang, Junjiao Yang, Huong T. Kratochvil, Marco Lolicato et al. doi:10.1038/s41589-018-0105-5 Structural analysis reveals how certain designed peptides adopt unusual spiraling cross-α amyloid-like structures and also rearrange to helical polymers upon mutation of small nonpolar residues that are critical for packing and stabilization.     Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin    pp876 - 886 Fan Yang, Peng Xiao, Chang-xiu Qu, Qi Liu, Liu-yang Wang et al. doi:10.1038/s41589-018-0115-3 NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation.     ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands    pp887 - 894 Alla Peselis & Alexander Serganov doi:10.1038/s41589-018-0114-4 Structural analysis of PRPP and ppGpp riboswitches reveals that they employ a helical element to create a tunnel for the ligand, whose specificity is determined by the conserved nucleotides forming the tunnel and long-distance contacts.     Facile target validation in an animal model with intracellularly expressed monobodies    pp895 - 900 Ankit Gupta, Jing Xu, Shirley Lee, Steven T. Tsai, Bo Zhou et al. doi:10.1038/s41589-018-0099-z The development of a selective and potent monobody to WDR5, a component of the mixed linear leukemia methyltransferase complex, as genetically encoded inhibitor enables suppression of leukemogenesis and confers survival in a mouse leukemia model.     Amendments & Corrections   Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes    p901 Simon Wisnovsky, Sae Rin Jean & Shana O Kelley doi:10.1038/s41589-018-0040-5 Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters    p901 Kiryl D. Piatkevich, Erica E. Jung, Christoph Straub, Changyang Linghu, Demian Park et al. doi:10.1038/s41589-018-0023-6 Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases    p901 Yong-Xin Li, Zheng Zhong, Peng Hou, Wei-Peng Zhang & Pei-Yuan Qian doi:10.1038/s41589-018-0022-7 Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells    p902 Aaron H. Nile, Felipe de Sousa e Melo, Susmith Mukund, Robert Piskol, Simon Hansen et al. doi:10.1038/s41589-018-0069-5 Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases    p902 Lukas Reisky, Hanna C. Büchsenschütz, Jennifer Engel, Tao Song, Thomas Schweder et al. doi:10.1038/s41589-018-0020-9 Publisher Correction: Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET    p902 Daria M. Shcherbakova, Natasha Cox Cammer, Tsipora M. Huisman, Vladislav V. Verkhusha & Louis Hodgson doi:10.1038/s41589-018-0070-z Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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