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Nature Communications - 22 August 2018

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Diverse Cretaceous larvae reveal the evolutionary and behavioural history of antlions and lacewings OPEN
Davide Badano, Michael S. Engel, Andrea Basso, Bo Wang & Pierfilippo Cerretti

Larvae of the Myrmeleontiformia, which include antlions, are not well preserved in much of the fossil record. Here, Badano et al. describe a collection of predatory myrmeleontiform larvae from Cretaceous amber, resolving their evolutionary relationships and inferring their ecology.

22 August 2018 | doi: 10.1038/s41467-018-05484-y
Entomology  Palaeontology  Phylogenetics  Taxonomy 

Half-metallic carbon nitride nanosheets with micro grid mode resonance structure for efficient photocatalytic hydrogen evolution OPEN
Gang Zhou, Yun Shan, Youyou Hu, Xiaoyong Xu, Liyuan Long, Jinlei Zhang, Jun Dai, Junhong Guo, Jiancang Shen, Shuang Li, Lizhe Liu & Xinglong Wu

The “storage” of sunlight as a chemical fuel can provide renewable on-demand energy, although current earth-abundant materials usually show low activities. Here, authors construct a carbon nitride material whose half-metallicity and micro grid resonance structure boost light-driven H2 evolution.

22 August 2018 | doi: 10.1038/s41467-018-05590-x
Microresonators  Photocatalysis  Solar fuels  Two-dimensional materials 

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques OPEN
Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller, Debra Bratt, Cassie R. Moats, Paul T. Edlefsen, Jeremy Smedley, Nichole R. Klatt, Michael Gale Jr & Deborah Heydenburg Fuller

The immune response to Zika virus is required to curtail the infection and avoid immunopathology, but may be involved in the associated pathophysiology. Here the authors show that viral persistence and tissue tropism is shaped by an early innate immune response in a pigtail macaque model of infection.

22 August 2018 | doi: 10.1038/s41467-018-05826-w
Viral host response  Viral infection  Viral pathogenesis  Virus–host interactions 

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies OPEN
Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley & Drew Weissman

The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and protects from heterosubtypic virus infection.

22 August 2018 | doi: 10.1038/s41467-018-05482-0
Influenza virus  RNA vaccines  Viral infection 

Architecture of the native major royal jelly protein 1 oligomer OPEN
Wenli Tian, Min Li, Huiyuan Guo, Wenjun Peng, Xiaofeng Xue, Yifan Hu, Yang Liu, Yazhou Zhao, Xiaoming Fang, Kai Wang, Xiuting Li, Yufeng Tong, Michael A. Conlon, Wei Wu, Fazheng Ren & Zhongzhou Chen

Major royal jelly protein 1 (MRJP1) is the most abundant glycoprotein in royal jelly (RJ). Here the authors isolated MRJP1 from RJ and determined the 2.65 Å resolution crystal structure of the 16-molecule oligomer, which also contained 24-methylenecholesterol and apisimin bound to MRJP1.

22 August 2018 | doi: 10.1038/s41467-018-05619-1
Entomology  X-ray crystallography 

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration OPEN
Pabitra K. Sahoo, Seung Joon Lee, Poonam B. Jaiswal, Stefanie Alber, Amar N. Kar, Sharmina Miller-Randolph, Elizabeth E. Taylor, Terika Smith, Bhagat Singh, Tammy Szu-Yu Ho, Anatoly Urisman, Shreya Chand, Edsel A. Pena, Alma L. Burlingame, Clifford J. Woolf, Mike Fainzilber, Arthur W. English & Jeffery L. Twiss

G3BP1 is RasGAP SH3 domain binding protein 1 that interacts with 48S pre-initiation complex when translation is stalled. Here, Twiss and colleagues show that neuronal G3BP1 can negatively regulate axonal mRNA translation, and inhibit axonal regeneration after injury.

22 August 2018 | doi: 10.1038/s41467-018-05647-x
Cell biology  Neuroscience  Regeneration and repair in the nervous system 

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML OPEN
Shan-He Yu, Kang-Yong Zhu, Juan Chen, Xiang-Zhen Liu, Peng-Fei Xu, Wu Zhang, Li Yan, He-Zhou Guo & Jiang Zhu

Histone demethylase JMJD3 is known to be oncogenic in preleukemic states and T-cell acute lymphocytic leukemia. Here, the authors show that in some acute myeloid leukemia subsets, JMJD3 can actually act as a potential oncorepressor via mediation of C/EBPβ-centered transcriptional programming.

22 August 2018 | doi: 10.1038/s41467-018-05548-z
Acute myeloid leukaemia  Epigenetics 

Genomic patterns of progression in smoldering multiple myeloma OPEN
Niccolò Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Kevin J. Dawson, Mehmet Kemal Samur, Jorge Zamora, Patrick Tarpey, Helen Davies, Mariateresa Fulciniti, Masood A. Shammas, Yu Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Ludmil Alexandrov et al.

Smoldering MM (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM progressing to MM, and show that the genomic landscape at the SMM stage is very similar to MM, but trajectories of evolution can vary from patient to patient.

22 August 2018 | doi: 10.1038/s41467-018-05058-y
Cancer genomics  Myeloma 

Photo-generated dinuclear {Eu(II)}2 active sites for selective CO2 reduction in a photosensitizing metal-organic framework OPEN
Zhi-Hao Yan, Ming-Hao Du, Junxue Liu, Shengye Jin, Cheng Wang, Gui-Lin Zhuang, Xiang-Jian Kong, La-Sheng Long & Lan-Sun Zheng

Solar-to-chemical CO2 reduction provides a means to use light’s energy for CO2 removal and upgrading to useful products, although this photochemical conversion is challenging. Here, authors construct a Europium-containing metal-organic framework that selectively converts CO2 to formate with light.

22 August 2018 | doi: 10.1038/s41467-018-05659-7
Artificial photosynthesis  Metal–organic frameworks  Photocatalysis 

Ultra-low damping insulating magnetic thin films get perpendicular OPEN
Lucile Soumah, Nathan Beaulieu, Lilia Qassym, Cécile Carrétéro, Eric Jacquet, Richard Lebourgeois, Jamal Ben Youssef, Paolo Bortolotti, Vincent Cros & Abdelmadjid Anane

A magnetic material combining both low losses and strong perpendicular magnetic anisotropy (PMA) was so far missing in the field of magnon-spintronics. The authors here report on Bismuth doped YIG nanometer thick films showing both PMA and low magnetic losses for ultra-thin PMA materials.

22 August 2018 | doi: 10.1038/s41467-018-05732-1
Magnetic properties and materials  Spintronics 

One-pot aminobenzylation of aldehydes with toluenes OPEN
Zhiting Wang, Zhipeng Zheng, Xinyu Xu, Jianyou Mao & Patrick J. Walsh

Amines are common targets in synthetic chemistry as they often display biological activity. Here, the authors report a one-pot aminobenzylation of aldehydes with readily available toluenes in presence of a sodium amide derivative and a cesium salt additive generating an array of valuable 1,2-diarylethylamine compounds.

22 August 2018 | doi: 10.1038/s41467-018-05638-y
Synthetic chemistry methodology  Organic chemistry 

Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis OPEN
Chengyu Sheng, Uzma Javed, Mary Gibbs, Caixia Long, Jun Yin, Bo Qin & Quan Yuan

During development, dendrites display structural plasticity, as reflected in the appearance of long, thin and highly motile dendritic filopodia. Here, the authors examine dendritic dynamics of ventral lateral neurons in the developing Drosophila larva, and identify Amphiphysin as an important regulator of this process.

22 August 2018 | doi: 10.1038/s41467-018-05871-5
Molecular neuroscience  Morphogenesis  Synaptic development 

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes OPEN

Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties from the germinal centre, for rapid expansion and the induction of B memory responses.

22 August 2018 | doi: 10.1038/s41467-018-05772-7
B-2 cells  Imaging the immune system  Immunological memory  Lymph node 

MAIT cells protect against pulmonary Legionella longbeachae infection OPEN
Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J. Pediongco, Sidonia B. G. Eckle, Bronwyn S. Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey Y. W. Mak, David P. Fairlie, Yoichiro Iwakura, Jennifer M. Gunnersen, Andrew W. Stent, Dale I. Godfrey, Jamie Rossjohn, Glen P. Westall, Lars Kjer-Nielsen et al.

Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands.

22 August 2018 | doi: 10.1038/s41467-018-05202-8
Mucosal immunology  T cells 

Co-crystallization of atomically precise metal nanoparticles driven by magic atomic and electronic shells OPEN
Juanzhu Yan, Sami Malola, Chengyi Hu, Jian Peng, Birger Dittrich, Boon K. Teo, Hannu Häkkinen, Lansun Zheng & Nanfeng Zheng

Atomic shell closure and electronic shell closure are generally considered to be competing effects in stabilizing magic-sized metal nanoclusters. Here, the authors show, by co-crystallizing two differently-sized clusters, that both mechanisms can work concurrently during magic cluster synthesis.

22 August 2018 | doi: 10.1038/s41467-018-05584-9
Materials chemistry  Nanoparticles  Physical chemistry 

V2a interneuron diversity tailors spinal circuit organization to control the vigor of locomotor movements OPEN
Jianren Song, Elin Dahlberg & Abdeljabbar El Manira

Locomotor circuits in the spinal cord produce precise movements with variations in timing and vigor. Here, the authors report that such motor flexibility is generated through the specificity of connections between subtypes of V2a interneurons and motoneuron populations and their distinct plasticity mechanisms.

22 August 2018 | doi: 10.1038/s41467-018-05827-9
Motor control  Neural circuits 

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease OPEN
Daniel Tarade, Claire M. Robinson, Jeffrey E. Lee & Michael Ohh

Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mutations that helps to predict disease phenotype outcome.

22 August 2018 | doi: 10.1038/s41467-018-05554-1
Haematological diseases  Kinetics  Neuroendocrine cancer  Oncogene proteins  X-ray crystallography 

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response OPEN
Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li & Hong-Bing Shu

cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection.

22 August 2018 | doi: 10.1038/s41467-018-05559-w
Antimicrobial responses  Infection  Innate immunity  Viral host response 

Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis OPEN
Marissa A. Scavuzzo, Matthew C. Hill, Jolanta Chmielowiec, Diane Yang, Jessica Teaw, Kuanwei Sheng, Yuelin Kong, Maria Bettini, Chenghang Zong, James F. Martin & Malgorzata Borowiak

Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cells

22 August 2018 | doi: 10.1038/s41467-018-05740-1
Developmental biology  Differentiation  Gene expression analysis  RNA sequencing 

Hapten-mediated recruitment of polyclonal antibodies to tumors engenders antitumor immunity OPEN
Brett Schrand, Emily Clark, Agata Levay, Ailem Rabasa Capote, Olivier Martinez, Randall Brenneman, Iris Castro & Eli Gilboa

Efficient tumor antigen uptake by dendritic cells is facilitated by antibody coating of tumor cells. Here, the authors develop an approach based on hapten vaccination and hapten/tumor targeting ligand conjugates that potentiate anti-tumor immunity by generating and redirecting serum antibodies to tumors.

22 August 2018 | doi: 10.1038/s41467-018-05566-x
Cancer  Cancer immunotherapy  Cancer therapy  Immunology  Tumour immunology 

Chiral symmetry breaking yields the I-Au60 perfect golden shell of singular rigidity OPEN
S.-M. Mullins, H.-Ch. Weissker, R. Sinha-Roy, J. J. Pelayo, I. L. Garzón, R. L. Whetten & X. López-Lozano

Chiral-icosahedral symmetry is exceptionally rare in molecular systems. Here, the authors predict the spontaneous formation of a stable chiral-icosahedral gold shell, in which all 60 atoms are symmetrically equivalent.

22 August 2018 | doi: 10.1038/s41467-018-05215-3
Nanoparticles  Theory and computation 

Interfacing with silica boosts the catalysis of copper OPEN
Chaofa Xu, Guangxu Chen, Yun Zhao, Pengxin Liu, Xinping Duan, Lin Gu, Gang Fu, Youzhu Yuan & Nanfeng Zheng

Metal-support interaction plays an important role in heterogeneous catalysis, but silica has been rarely reported as an effective support to create active metal-support interfaces for promoting catalytic reactions. Here, the authors discover that Cu/SiO2 interface creates an exceptional effect to promote catalytic hydrogenation of esters.

22 August 2018 | doi: 10.1038/s41467-018-05757-6
Heterogeneous catalysis  Materials for energy and catalysis  Nanoscale materials  Theoretical chemistry 

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival OPEN
Jenna Geddes Sweeney, Jennifer Liang, Aristotelis Antonopoulos, Nicholas Giovannone, Shuli Kang, Tony S. Mondala, Steven R. Head, Sandra L. King, Yoshihiko Tani, Danielle Brackett, Anne Dell, George F. Murphy, Stuart M. Haslam, Hans R. Widlund & Charles J. Dimitroff

Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling.

22 August 2018 | doi: 10.1038/s41467-018-05795-0
Glycobiology  Melanoma 

Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile OPEN
Ying Liu, Tomasz Osinski, Fengbin Wang, Mart Krupovic, Stefan Schouten, Peter Kasson, David Prangishvili & Edward H. Egelman

Only a few archaeal filamentous viruses have been structurally characterized. Here the authors describe the membrane-enveloped Sulfolobus filamentous virus 1 that infects Sulfolobus shibatae and present its 3.7 Å resolution cryo-EM structure, which reveals that major coat proteins are structurally conserved among archaeal filamentous viruses.

22 August 2018 | doi: 10.1038/s41467-018-05684-6
Biochemistry  Biophysics  Cryoelectron microscopy  Evolution 

Precession-band variance missing from East Asian monsoon runoff OPEN
S. C. Clemens, A. Holbourn, Y. Kubota, K. E. Lee, Z. Liu, G. Chen, A. Nelson & B. Fox-Kemper

The underlying mechanisms driving the variability of the East Asia Monsoon during the late Pleistocene remain unclear. Here, the authors present a record of local precipitation and runoff from the East Chain Sea, which indicates strong sensitivity to greenhouse gases and high latitude ice sheet forcing.

22 August 2018 | doi: 10.1038/s41467-018-05814-0
Climate and Earth system modelling  Palaeoceanography  Palaeoclimate 

Region-specific and state-dependent action of striatal GABAergic interneurons OPEN
Elodie Fino, Marie Vandecasteele, Sylvie Perez, Frédéric Saudou & Laurent Venance

Striatal GABAergic interneurons regulate the influence of cortical inputs on striatal projection neurons through feedforward inhibition. Here, the authors report that this inhibition is mediated mainly by PV interneurons in the dorsolateral striatum and SOM interneurons in the dorsomedial striatum.

21 August 2018 | doi: 10.1038/s41467-018-05847-5
Inhibition  Neural circuits 

Direct quality control of glycoengineered erythropoietin variants OPEN
Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen & Albert J. R. Heck

Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.

21 August 2018 | doi: 10.1038/s41467-018-05536-3
Glycobiology  Recombinant protein therapy 

Isolated detection of elastic waves driven by the momentum of light OPEN
Tomaž Požar, Jernej Laloš, Aleš Babnik, Rok Petkovšek, Max Bethune-Waddell, Kenneth J. Chau, Gustavo V. B. Lukasievicz & Nelson G. C. Astrath

The exact mechanism of momentum conversion from light to an object has varied descriptions in the literature and experimental verifications are difficult. Here the authors do an in-depth experimental and numerical study of the momentum dynamics of elastic waves in a dielectric mirror hit by a pulsed laser beam.

21 August 2018 | doi: 10.1038/s41467-018-05706-3
Optical physics  Photoacoustics 

Three-dimensional atomic-scale observation of structural evolution of cathode material in a working all-solid-state battery OPEN
Yue Gong, Yuyang Chen, Qinghua Zhang, Fanqi Meng, Jin-An Shi, Xinyu Liu, Xiaozhi Liu, Jienan Zhang, Hao Wang, Jiangyong Wang, Qian Yu, Ze Zhang, Qiang Xu, Ruijuan Xiao, Yong-Sheng Hu, Lin Gu, Hong Li, Xuejie Huang & Liquan Chen

Here, with the state-of-the-state electron microscope, the authors report three-dimensional atomic-scale observation of LiNi0.5Mn1.5O4 from various directions, revealing unprecedented insight into the evolution of both atomic and electronic structures during delithiation.

21 August 2018 | doi: 10.1038/s41467-018-05833-x
Batteries  Condensed-matter physics  Materials for energy and catalysis 

Symmetry regimes for circular photocurrents in monolayer MoSe2 OPEN
Jorge Quereda, Talieh S. Ghiasi, Jhih-Shih You, Jeroen van den Brink, Bart J. van Wees & Caspar H. van der Wal

Circular photocurrents emerge in atomically thin transition metal dichalcogenides as a result of circular photogalvanic and photon drag effects. Here, the authors identify two different circular photocurrent contributions in monolater MoSe2, dominant at different voltages and with different dependence on illumination wavelength and incidence angles.

21 August 2018 | doi: 10.1038/s41467-018-05734-z
Electronic and spintronic devices  Nanophotonics and plasmonics  Nonlinear optics  Optical properties and devices 

A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers OPEN
Melissa K. Takahashi, Xiao Tan, Aaron J. Dy, Dana Braff, Reid T. Akana, Yoshikazu Furuta, Nina Donghia, Ashwin Ananthakrishnan & James J. Collins

Currently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers.

21 August 2018 | doi: 10.1038/s41467-018-05864-4
Clostridium difficile  Microbiome  Sensors and probes  Synthetic biology 

Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds OPEN
Xinxin Wu, Hong Zhang, Nana Tang, Zhen Wu, Dongping Wang, Meishan Ji, Yan Xu, Min Wang & Chen Zhu

Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.

21 August 2018 | doi: 10.1038/s41467-018-05522-9
Synthetic chemistry methodology  Reaction mechanisms 

Optical control of polarization in ferroelectric heterostructures OPEN
Tao Li, Alexey Lipatov, Haidong Lu, Hyungwoo Lee, Jung-Woo Lee, Engin Torun, Ludger Wirtz, Chang-Beom Eom, Jorge Íñiguez, Alexander Sinitskii & Alexei Gruverman

Controlling the polarization state in ferroeletric materials is a prerequisite for their application. Here an approach is presented to optically manipulate the polarization of ferroelectric BaTiO3 by exploiting photogenerated carriers at the interface with a two-dimensional semiconducting MoS2 film.

21 August 2018 | doi: 10.1038/s41467-018-05640-4
Electronic properties and materials  Two-dimensional materials 

Ultra-extensible ribbon-like magnetic microswarm OPEN
Jiangfan Yu, Ben Wang, Xingzhou Du, Qianqian Wang & Li Zhang

Manipulation of paramagnetic microparticles can be exploited for drug delivery. Here the authors manipulate a swarm of such particles and control its shape with a magnetic field so that it can elongate reversibly, split into smaller swarms and thus be guided through a maze with multiple parallel channels.

21 August 2018 | doi: 10.1038/s41467-018-05749-6
Colloids  Magnetic properties and materials  Self-assembly 

Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis OPEN
Mathieu Daynac, Malek Chouchane, Hannah Y. Collins, Nicole E. Murphy, Noemi Andor, Jianqin Niu, Stephen P. J. Fancy, William B. Stallcup & Claudia K. Petritsch

Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.

21 August 2018 | doi: 10.1038/s41467-018-05099-3
Oligodendrocyte  Tumour-suppressor proteins 

Fossil lemurs from Egypt and Kenya suggest an African origin for Madagascar’s aye-aye OPEN
Gregg F. Gunnell, Doug M. Boyer, Anthony R. Friscia, Steven Heritage, Fredrick Kyalo Manthi, Ellen R. Miller, Hesham M. Sallam, Nancy B. Simmons, Nancy J. Stevens & Erik R. Seiffert

The fossil taxon Propotto was originally identified as a primate, but is currently widely interpreted as a bat. Here, the authors identify Propotto as a stem chiromyiform lemur and, based on phylogenetic analysis, suggest two independent lemur colonizations of Madagascar.

21 August 2018 | doi: 10.1038/s41467-018-05648-w
Biogeography  Biological anthropology  Palaeontology  Phylogenetics 

Structural basis for membrane tethering by a bacterial dynamin-like pair OPEN
Jiwei Liu, Jeffrey K. Noel & Harry H. Low

Dynamin-like proteins (DLPs) such as the mitofusins form homotypic and heterotypic oligomers that bridge and fuse opposing membranes. Here, Liu, Noel and Low present the crystal structure of a bacterial DLP heterotypic pair, providing insights into the mechanism behind long-range binding of opposing membranes.

21 August 2018 | doi: 10.1038/s41467-018-05523-8
Microbiology  Structural biology 

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism OPEN
Nigel Turner, Xin Ying Lim, Hamish D. Toop, Brenna Osborne, Amanda E. Brandon, Elysha N. Taylor, Corrine E. Fiveash, Hemna Govindaraju, Jonathan D. Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M. Butler, Abhirup Das, Greg M. Kowalski, Clinton R. Bruce, Kyle L. Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory J. Cooney, Magdalene K. Montgomery et al.

Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.

21 August 2018 | doi: 10.1038/s41467-018-05613-7
Lipidomics  Metabolic diseases  Pharmacology  Sphingolipids 

Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation OPEN
Éadaoin Harney, Hila May, Dina Shalem, Nadin Rohland, Swapan Mallick, Iosif Lazaridis, Rachel Sarig, Kristin Stewardson, Susanne Nordenfelt, Nick Patterson, Israel Hershkovitz & David Reich

The Late Chalcolithic material culture in the southern Levant has unique attributes that suggest spread of people or culture. Here, the authors use genome-wide ancient DNA data from 22 individuals from a Chalcolithic site and show evidence of complex population movements and turnovers.

20 August 2018 | doi: 10.1038/s41467-018-05649-9
Anthropology  Population genetics 

Room-temperature mechanocaloric effects in lithium-based superionic materials OPEN
Arun K. Sagotra, Dewei Chu & Claudio Cazorla

Large mechanocaloric effects are disclosed in lithium-ion superionic conductors at room temperature. These occur in the absence of any structural phase transition, which is beneficial from a practical point of view, and are related to stress-induced variations in the ionic conductivity.

20 August 2018 | doi: 10.1038/s41467-018-05835-9
Materials science  Nanoscience and technology 

Evidence for auto-catalytic mineral dissolution from surface-specific vibrational spectroscopy OPEN
Jan Schaefer, Ellen H. G. Backus & Mischa Bonn

Although it is well known that silica can dissolve in water, the precise mechanism is unclear. Here, the authors employ sum frequency generation spectroscopy to probe the interfacial water structure reporting directly on the underlying dissolution mechanism, which appears to be auto-catalytic.

20 August 2018 | doi: 10.1038/s41467-018-05762-9
Environmental chemistry  Surface chemistry  Surface spectroscopy 

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors OPEN
Zhenzhen Wang, Yan Zhang, Enguo Ju, Zhen Liu, Fangfang Cao, Zhaowei Chen, Jinsong Ren & Xiaogang Qu

Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.

20 August 2018 | doi: 10.1038/s41467-018-05798-x
Cancer  Cancer therapy  Drug regulation  Nanoparticles 

A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction OPEN
Franziska Zosel, Davide Mercadante, Daniel Nettels & Benjamin Schuler

How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.

20 August 2018 | doi: 10.1038/s41467-018-05725-0
Biophysical chemistry  Biophysics  Kinetics  Reaction kinetics and dynamics  Molecular biophysics 

Unraveling exciton–phonon coupling in individual FAPbI3 nanocrystals emitting near-infrared single photons OPEN
Ming Fu, Philippe Tamarat, Jean-Baptiste Trebbia, Maryna I. Bodnarchuk, Maksym V. Kovalenko, Jacky Even & Brahim Lounis

Here, the authors perform spectroscopic investigations of individual Formamidinium lead iodide nanocrystals, demonstrate single-photon emission and unravel the mechanisms of carrier–phonon interactions. These results will guide the development of next-generation devices for photovoltaics and quantum technologies.

20 August 2018 | doi: 10.1038/s41467-018-05876-0
Electronic properties and materials  Optical materials and structures  Single photons and quantum effects 

Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection OPEN
Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu & Zhiwei Wu

SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.

20 August 2018 | doi: 10.1038/s41467-018-05746-9
Viral host response  Viral infection 

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells OPEN
Florian Wimmers, Nikita Subedi, Nicole van Buuringen, Daan Heister, Judith Vivié, Inge Beeren-Reinieren, Rob Woestenenk, Harry Dolstra, Aigars Piruska, Joannes F. M. Jacobs, Alexander van Oudenaarden, Carl G. Figdor, Wilhelm T. S. Huck, I. Jolanda M. de Vries & Jurjen Tel

Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.

20 August 2018 | doi: 10.1038/s41467-018-05784-3
Cytokines  Lab-on-a-chip  Microfluidics  Plasmacytoid dendritic cells  RNA sequencing 

Efficient non-Markovian quantum dynamics using time-evolving matrix product operators OPEN
A. Strathearn, P. Kirton, D. Kilda, J. Keeling & B. W. Lovett

In general the computational requirements for simulating quantum systems scale exponentially but in some cases it is possible to formulate more efficient schemes. Here the authors present an efficient approach to calculate non-Markovian quantum dynamics using matrix product operator methods.

20 August 2018 | doi: 10.1038/s41467-018-05617-3
Phase transitions and critical phenomena  Theoretical physics 

Sequences of purchases in credit card data reveal lifestyles in urban populations OPEN
Riccardo Di Clemente, Miguel Luengo-Oroz, Matias Travizano, Sharon Xu, Bapu Vaitla & Marta C. González

Digital traces of our lives have the potential to allow insights into collective behaviors. Here, the authors cluster consumers by their credit card purchase sequences and discover five distinct groups, within which individuals also share similar mobility and demographic attributes.

20 August 2018 | doi: 10.1038/s41467-018-05690-8
Complex networks  Interdisciplinary studies  Society 

LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation OPEN
Julie Brind’Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M. Karimi, Louis Lefebvre, Tomohiro Kono & Matthew C. Lorincz

De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.

20 August 2018 | doi: 10.1038/s41467-018-05841-x
Embryogenesis  Epigenetics  Evolutionary biology  Germline development 

Direct observation of room-temperature out-of-plane ferroelectricity and tunneling electroresistance at the two-dimensional limit OPEN
H. Wang, Z. R. Liu, H. Y. Yoong, T. R. Paudel, J. X. Xiao, R. Guo, W. N. Lin, P. Yang, J. Wang, G. M. Chow, T. Venkatesan, E. Y. Tsymbal, H. Tian & J. S. Chen

High temperature perpendicular ferroelectricity in nano thin films is crucial for miniaturization of electronic devices. Here the authors show the presence of stable and switchable out-of-plane ferroelectricity in tetragonal BiFeO3 thin films at the two-dimensional limit and 370% tunneling electroresistance in ferroelectric tunnel junctions.

20 August 2018 | doi: 10.1038/s41467-018-05662-y
Electronic devices  Ferroelectrics and multiferroics 

Evolution of the Kondo lattice and non-Fermi liquid excitations in a heavy-fermion metal OPEN
S. Seiro, L. Jiao, S. Kirchner, S. Hartmann, S. Friedemann, C. Krellner, C. Geibel, Q. Si, F. Steglich & S. Wirth

The competition between Kondo correlations and magnetic ordering in heavy fermion materials leads to emergent physics that is not fully understood. Seiro et al. show inter-site Kondo correlations only dominate over local ones at temperatures well below the single-ion Kondo temperature but this is a prerequisite for quantum critical behavior.

20 August 2018 | doi: 10.1038/s41467-018-05801-5
Electronic properties and materials  Magnetic properties and materials  Phase transitions and critical phenomena 

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species OPEN
Angeliki M. Andrianaki, Irene Kyrmizi, Kalliopi Thanopoulou, Clara Baldin, Elias Drakos, Sameh S. M. Soliman, Amol C. Shetty, Carrie McCracken, Tonia Akoumianaki, Kostas Stylianou, Petros Ioannou, Charalampos Pontikoglou, Helen A. Papadaki, Maria Tzardi, Valerie Belle, Emilien Ettiene, Anne Beauvais, George Samonis, Dimitrios P. Kontoyiannis, Evangelos Andreakos et al.

Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis.

20 August 2018 | doi: 10.1038/s41467-018-05820-2
Fungal host response  Fungal infection  Fungal pathogenesis  Infection 

Layer specific observation of slow thermal equilibration in ultrathin metallic nanostructures by femtosecond X-ray diffraction OPEN
J. Pudell, A. A. Maznev, M. Herzog, M. Kronseder, C. H. Back, G. Malinowski, A. von Reppert & M. Bargheer

Heat transport in ultrathin metal layers is important for potential applications in optical‐magnetic switching, but difficult to access experimentally. Here, the authors use ultrafast X‐ray diffraction to directly probe and explain unexpected time‐dependent transport behavior in Au–Ni nanolayers.

20 August 2018 | doi: 10.1038/s41467-018-05693-5
Statistical physics, thermodynamics and nonlinear dynamics  Surfaces, interfaces and thin films  X-ray diffraction 

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory OPEN
Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos & Marcelo A. Wood

Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms.

20 August 2018 | doi: 10.1038/s41467-018-05868-0
Circadian mechanisms  Cognitive ageing  Epigenetics and behaviour  Hippocampus 

Monolayer surface chemistry enables 2-colour single molecule localisation microscopy of adhesive ligands and adhesion proteins OPEN
Xun Lu, Philip R. Nicovich, Manchen Zhao, Daniel J. Nieves, Mahdie Mollazade, S. R. C. Vivekchand, Katharina Gaus & J. Justin Gooding

To date, the precise localisation of ligands and adhesion proteins are determined in two parallel characterization setups. Here, the authors report a self-assembled monolayer chemistry for indium tin oxide surfaces allowing single molecule localisation microscopy (SMLM) imaging of ligands and adhesion proteins in a single experiment.

20 August 2018 | doi: 10.1038/s41467-018-05837-7
Biosurfaces  Cell adhesion  Single-molecule biophysics 

Major upwelling and overturning in the mid-latitude F region ionosphere OPEN
David Hysell, Miguel Larsen, David Fritts, Brian Laughman & Michael Sulzer

The ionosphere can give rise to irregularities that can interfere with radio communication, navigation and satellite systems. Here the authors present unique observations from the Arecibo Radio Observatory in Puerto Rico to reveal the existence of plasma irregularities occur in the mid-latitude F-region.

20 August 2018 | doi: 10.1038/s41467-018-05809-x
Space physics 

The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation OPEN
Annette Aichem, Samira Anders, Nicola Catone, Philip Rößler, Sophie Stotz, Andrej Berg, Ricarda Schwab, Sophia Scheuermann, Johanna Bialas, Mira C. Schütz-Stoffregen, Gunter Schmidtke, Christine Peter, Marcus Groettrup & Silke Wiesner

The ubiquitin-like modifier FAT10 is composed of two ubiquitin-like domains (UBDs). Here the authors present the FAT10 UBD structures and show that the unstructured FAT10 N-terminal heptapeptide together with the poor stability of FAT10 facilitate the rapid proteasomal targeting of FAT10 along with its substrates.

20 August 2018 | doi: 10.1038/s41467-018-05776-3
Proteasome  Solution-state NMR  Ubiquitylation  X-ray crystallography 

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma OPEN

Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most challenging to treat. Here the authors report BCL11A as an important factor which together with SOX2 can drive lung squamous cell carcinoma development and highlight a potential novel therapeutic candidate for this devastating disease.

20 August 2018 | doi: 10.1038/s41467-018-05790-5
Non-small-cell lung cancer  Targeted therapies 

Predicting soil thickness on soil mantled hillslopes OPEN
Nicholas R. Patton, Kathleen A. Lohse, Sarah E. Godsey, Benjamin T. Crosby & Mark S. Seyfried

Soil thickness is a key parameter in earth system models, yet how it varies spatially at catchment scales is largely unknown due to measurement challenges. Here, the authors show that a continuous field of thicknesses can be predicted using high-resolution topography and a few soil thickness measurements.

20 August 2018 | doi: 10.1038/s41467-018-05743-y
Environmental sciences  Geomorphology 

Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis OPEN
Simon Braun, Mihaela Enculescu, Samarth T. Setty, Mariela Cortés-López, Bernardo P. de Almeida, F. X.  Reymond Sutandy, Laura Schulz, Anke Busch, Markus Seiler, Stefanie Ebersberger, Nuno L. Barbosa-Morais, Stefan Legewie, Julian König & Kathi Zarnack

Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splicing for the RON proto-oncogene.

17 August 2018 | doi: 10.1038/s41467-018-05748-7
Alternative splicing  Cancer genomics  Computational models  High-throughput screening 

Understanding how excess lead iodide precursor improves halide perovskite solar cell performance OPEN
Byung-wook Park, Nir Kedem, Michael Kulbak, Do Yoon Lee, Woon Seok Yang, Nam Joong Jeon, Jangwon Seo, Geonhwa Kim, Ki Jeong Kim, Tae Joo Shin, Gary Hodes, David Cahen & Sang Il Seok

Excess lead iodide in the mixed halide perovskites solar cells leads to high device performance but its origin remains elusive. Here Park et al. unveil the underlying microscopic mechanism to be promoting the oriented growth of the perovskites crystals and reducing the defect concentration.

17 August 2018 | doi: 10.1038/s41467-018-05583-w
Devices for energy harvesting  Solar cells  Solar energy 

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation OPEN
Junpei Suzuki, Takeshi Yamada, Kazuki Inoue, Shogo Nabe, Makoto Kuwahara, Nobuaki Takemori, Ayako Takemori, Seiji Matsuda, Makoto Kanoh, Yuuki Imai, Masaki Yasukawa & Masakatsu Yamashita

T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism.

17 August 2018 | doi: 10.1038/s41467-018-05854-6
Cellular immunity  Metabolomics  Senescence 

The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling OPEN
Sandipan Brahma, Mzwanele Ngubo, Somnath Paul, Maheshi Udugama & Blaine Bartholomew

INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps)  in INO80, showing that Arp8 and Arp4 module sense the DNA length separating nucleosomes and regulate nucleosome remodeling.

17 August 2018 | doi: 10.1038/s41467-018-05710-7
Chromatin remodelling  Enzyme mechanisms 

Divergent global-scale temperature effects from identical aerosols emitted in different regions OPEN
Geeta G. Persad & Ken Caldeira

The climate effects of anthropogenic aerosols depend on their spatial distribution, but emission location is often ignored in evaluating their climate impact. Here the authors show drastic divergence in the simulated global temperature response to identical aerosols emitted from eight key geopolitical regions.

17 August 2018 | doi: 10.1038/s41467-018-05838-6
Atmospheric dynamics  Climate and Earth system modelling  Climate-change mitigation  Projection and prediction 

Early selection of bZIP73 facilitated adaptation of japonica rice to cold climates OPEN
Citao Liu, Shujun Ou, Bigang Mao, Jiuyou Tang, Wei Wang, Hongru Wang, Shouyun Cao, Michael R. Schläppi, Bingran Zhao, Guoying Xiao, Xiping Wang & Chengcai Chu

Japonica rice can grow further north than wild or indica rice and is more tolerant of cold climates. Here, the authors show that bZIP73 likely underwent selection in the early phase of rice domestication to facilitate cold tolerance in japonica by modulating ABA and ROS homeostasis.

17 August 2018 | doi: 10.1038/s41467-018-05753-w
Abiotic  Agricultural genetics  Evolutionary genetics  Genetic variation 

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis OPEN
Huanjiao Jenny Zhou, Zhe Xu, Zongren Wang, Haifeng Zhang, Michael Simons & Wang Min

VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.

17 August 2018 | doi: 10.1038/s41467-018-05812-2
Angiogenesis  Protein translocation  Sumoylation 

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine OPEN
Leila S. Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick M. Fairhurst, Frederic Ariey, Didier Menard & David A. Fidock

Increasing resistance of Plasmodium falciparum strains to piperaquine (PPQ) in Southeast Asia is of concern and resistance mechanisms are incompletely understood. Here, Ross et al. show that mutations in the P. falciparum chloroquine resistance transporter are rapidly increasing in prevalence in Cambodia and confer resistance to PPQ.

17 August 2018 | doi: 10.1038/s41467-018-05652-0
Antimicrobial resistance  Antiparasitic agents  Parasite biology  Parasite genetics  Parasite genomics 

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules OPEN
Kai He, Xiaoyu Ma, Tao Xu, Yan Li, Allen Hodge, Qing Zhang, Julia Torline, Yan Huang, Jian Zhao, Kun Ling & Jinghua Hu

The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be required for cilia signaling.

17 August 2018 | doi: 10.1038/s41467-018-05867-1
Ciliogenesis  Mechanisms of disease 

Linear mapping approximation of gene regulatory networks with stochastic dynamics OPEN
Zhixing Cao & Ramon Grima

The intractability of most stochastic models of gene regulatory networks (GRNs) limits their utility. Here, the authors present a linear-mapping approximation mapping models onto simpler ones, giving approximate but accurate analytic or semi- analytic solutions for a wide range of model GRNs.

17 August 2018 | doi: 10.1038/s41467-018-05822-0
Cellular noise  Computer modelling  Regulatory networks  Stochastic modelling 

Conditional control of fluorescent protein degradation by an auxin-dependent nanobody OPEN
Katrin Daniel, Jaroslav Icha, Cindy Horenburg, Doris Müller, Caren Norden & Jörg Mansfeld

Current approaches to conditionally deplete target proteins require site-specific genetic engineering or have poor temporal control. Here the authors overcome these limitations by combining the AID system with nanobodies to reversibly degrade GFP-tagged proteins in living cells and zebrafish.

17 August 2018 | doi: 10.1038/s41467-018-05855-5
Cellular imaging  Genetic engineering  Protein design  Ubiquitylation 

Ultrafast and highly sensitive infrared photodetectors based on two-dimensional oxyselenide crystals OPEN
Jianbo Yin, Zhenjun Tan, Hao Hong, Jinxiong Wu, Hongtao Yuan, Yujing Liu, Cheng Chen, Congwei Tan, Fengrui Yao, Tianran Li, Yulin Chen, Zhongfan Liu, Kaihui Liu & Hailin Peng

Two-dimensional (2D) bismuth oxyselenide crystals with suitable electronic band-gap and ultrahigh carrier mobility enable near-infrared photodetection. Here, the authors report an infrared photodetector based on 2D-bismuth oxyselenide with high responsivity, ultrafast photoresponse of ~ 1 ps at room temperature and a detectable frequency limit of up to 500 GHz.

17 August 2018 | doi: 10.1038/s41467-018-05874-2
Two-dimensional materials 

Emerging many-body effects in semiconductor artificial graphene with low disorder OPEN
Lingjie Du, Sheng Wang, Diego Scarabelli, Loren N. Pfeiffer, Ken W. West, Saeed Fallahi, Geoff C. Gardner, Michael J. Manfra, Vittorio Pellegrini, Shalom J. Wind & Aron Pinczuk

Artificial nanostructures designed to simulate models of materials such as graphene provide insights into the material physics but can also have practical advantages. Du et al. create low-disorder artificial graphene devices, and present evidence of terahertz spin-exciton modes and large Coulomb interactions.

17 August 2018 | doi: 10.1038/s41467-018-05775-4
Electronic properties and materials  Optics and photonics  Two-dimensional materials 

An intrinsic tumour eviction mechanism in Drosophila mediated by steroid hormone signalling OPEN
Yanrui Jiang, Makiko Seimiya, Tommy Beat Schlumpf & Renato Paro

Drosophila is an excellent model to study both development and tumorigenesis. Here the authors uncover an innate mechanism for a steroid hormone-induced block to tumorigenesis during metamorphosis of Drosophila.

17 August 2018 | doi: 10.1038/s41467-018-05794-1
Cancer epigenetics  Reprogramming 

Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence OPEN
Manuel C. Martos-Maldonado, Christian T. Hjuler, Kasper K. Sørensen, Mikkel B. Thygesen, Jakob E. Rasmussen, Klaus Villadsen, Søren R. Midtgaard, Stefan Kol, Sanne Schoffelen & Knud J. Jensen

His-tagged proteins can undergo N-terminal acylation as an undesired side-reaction. Here, the authors utilize this to develop a method for highly selective acylation and further modification of peptides and proteins using an optimized His sequence and 4-methoxyphenyl esters as acyl donors.

17 August 2018 | doi: 10.1038/s41467-018-05695-3
Chemical modification  Protein design 

mTOR-dependent phosphorylation controls TFEB nuclear export OPEN
Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz & Andrea Ballabio

On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.

17 August 2018 | doi: 10.1038/s41467-018-05862-6
Autophagy  Cell signalling  Nuclear transport 

Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy OPEN
David Martino, Melanie Neeland, Thanh Dang, Joanna Cobb, Justine Ellis, Alice Barnett, Mimi Tang, Peter Vuillermin, Katrina Allen & Richard Saffery

Immunoglobulin E (IgE)-mediated food allergy is a major issue that affects 2–10% of infants. Here the authors study the epigenetic regulation of the naive CD4+ T cell activation response among children with IgE-mediated food allergy finding epigenetic dysregulation in the early stages of signal transduction through the T cell receptor complex.

17 August 2018 | doi: 10.1038/s41467-018-05608-4
DNA methylation  Epigenetics in immune cells  Epigenomics 

Smooth tracking of visual targets distinguishes lucid REM sleep dreaming and waking perception from imagination OPEN
Stephen LaBerge, Benjamin Baird & Philip G. Zimbardo

When tracking a moving object, our eyes make smooth pursuit movements; however, tracking an imaginary object produces jerky saccadic eye movements. Here, the authors show that during lucid dreams, the eyes smoothly follow dreamed objects. In this respect, dream imagery is more similar to perception than imagination.

17 August 2018 | doi: 10.1038/s41467-018-05547-0
Consciousness  Motor control  Perception  REM sleep 

Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans OPEN
N. Giovannone, J. Liang, A. Antonopoulos, J. Geddes Sweeney, S. L. King, S. M. Pochebit, N. Bhattacharyya, G. S. Lee, A. Dell, H. R. Widlund, S. M. Haslam & C. J. Dimitroff

Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.

17 August 2018 | doi: 10.1038/s41467-018-05770-9
Adaptive immunity  B-cell receptor  Glycobiology 

Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo OPEN
Hyo Min Park, Hui Liu, Joann Wu, Anthony Chong, Vanessa Mackley, Christof Fellmann, Anirudh Rao, Fuguo Jiang, Hunghao Chu, Niren Murthy & Kunwoo Lee

Optimization of the recently discovered Class 2 CRISPR protein Cpf1 has the potential to promote its applications in gene editing and therapeutics. Here, the authors find that extending the 5′ end of the crRNA can increase both the editing efficiency and delivery of Cpf1 in vitro and in vivo.

17 August 2018 | doi: 10.1038/s41467-018-05641-3
Drug delivery  Genetic engineering  Protein delivery 

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter OPEN
Do Hoon Kwon, Ok Hyun Park, Leehyeon Kim, Yang Ouk Jung, Yeonkyoung Park, Hyeongseop Jeong, Jaekyung Hyun, Yoon Ki Kim & Hyun Kyu Song

The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain in complex with various type 1 and type 2 degrons and also show the pH dependent oligomerization of p62.

17 August 2018 | doi: 10.1038/s41467-018-05825-x
Autophagy  Proteolysis  X-ray crystallography 

Mathematical modelling of the impact of expanding levels of malaria control interventions on Plasmodium vivax OPEN
Michael T. White, Patrick Walker, Stephan Karl, Manuel W. Hetzel, Tim Freeman, Andreea Waltmann, Moses Laman, Leanne J. Robinson, Azra Ghani & Ivo Mueller

Plasmodium vivax poses a unique challenge for malaria elimination worldwide. Here, White et al. develop an individual-based mathematical model of P. vivax transmission and evaluate intervention strategies in Papua New Guinea.

17 August 2018 | doi: 10.1038/s41467-018-05860-8
Infectious-disease epidemiology  Malaria  Policy and public health in microbiology 

Galectin-9 binds IgM-BCR to regulate B cell signaling OPEN
Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko & Bebhinn Treanor

The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22.

17 August 2018 | doi: 10.1038/s41467-018-05771-8
Adaptive immunity  B-cell receptor  Fluorescence imaging  Glycobiology 

Element- and momentum-resolved electronic structure of the dilute magnetic semiconductor manganese doped gallium arsenide OPEN
Slavomír Nemšák, Mathias Gehlmann, Cheng-Tai Kuo, Shih-Chieh Lin, Christoph Schlueter, Ewa Mlynczak, Tien-Lin Lee, Lukasz Plucinski, Hubert Ebert, Igor Di Marco, Ján Minár, Claus M. Schneider & Charles S. Fadley

The knowledge of the electronic structure of composite material is essential for tailoring their properties. The authors introduce a method based on standing wave angle-resolved hard X-ray photoemission to determine the element- and momentum-resolved electronic band structure simultaneously.

17 August 2018 | doi: 10.1038/s41467-018-05823-z
Characterization and analytical techniques  Electronic properties and materials 

Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles OPEN
Chaohao Chen, Fan Wang, Shihui Wen, Qian Peter Su, Mike C. L. Wu, Yongtao Liu, Baoming Wang, Du Li, Xuchen Shan, Mehran Kianinia, Igor Aharonovich, Milos Toth, Shaun P. Jackson, Peng Xi & Dayong Jin

Upconversion nanoparticles offer the potential for deep tissue biological imaging. Here, Chen et al. develop super resolution optical imaging in the near-infrared for imaging with sub-50 nm resolution through almost 100 microns of tissue.

17 August 2018 | doi: 10.1038/s41467-018-05842-w
Multiphoton microscopy  Nanoparticles  Super-resolution microscopy 

Understanding voltage decay in lithium-excess layered cathode materials through oxygen-centred structural arrangement OPEN
Seungjun Myeong, Woongrae Cho, Wooyoung Jin, Jaeseong Hwang, Moonsu Yoon, Youngshin Yoo, Gyutae Nam, Haeseong Jang, Jung-Gu Han, Nam-Soon Choi, Min Gyu Kim & Jaephil Cho

There is growing interest in the fundamental understanding of the voltage decay mechanism in Li-excess layered cathode materials. Here, the authors report a multilateral and macroscopic analysis that considers interaction between oxygen and atomic arrangement of Li1+xNiyCozMn1−x−y−zO2.

16 August 2018 | doi: 10.1038/s41467-018-05802-4
Energy science and technology  Materials science 

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner OPEN
Mette Ø. Agerbæk, Sara R. Bang-Christensen, Ming-Hsin Yang, Thomas M. Clausen, Marina A. Pereira, Shreya Sharma, Sisse B. Ditlev, Morten A. Nielsen, Swati Choudhary, Tobias Gustavsson, Poul H. Sorensen, Tim Meyer, David Propper, Jonathan Shamash, Thor G. Theander, Alexandra Aicher, Mads Daugaard, Christopher Heeschen & Ali Salanti

Isolation of circulating tumor cells (CTCs) allows for non-invasive disease monitoring and characterization. Here the authors describe an alternative CTC isolation method based on the ability of the malaria rVAR2 protein to specifically bind oncofetal chondroitin sulfate, which is expressed by all cancer cells

16 August 2018 | doi: 10.1038/s41467-018-05793-2
Assay systems  Cancer screening  Tumour biomarkers 

Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining OPEN
Yong-Xin Li, Zheng Zhong, Wei-Peng Zhang & Pei-Yuan Qian

Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.

16 August 2018 | doi: 10.1038/s41467-018-05781-6
Antibiotics  Biosynthesis  Chemical biology 

Mechanical glass transition revealed by the fracture toughness of metallic glasses OPEN
Jittisa Ketkaew, Wen Chen, Hui Wang, Amit Datye, Meng Fan, Gabriela Pereira, Udo D. Schwarz, Ze Liu, Rui Yamada, Wojciech Dmowski, Mark D. Shattuck, Corey S. O’Hern, Takeshi Egami, Eran Bouchbinder & Jan Schroers

Understanding the fracture toughness of metallic glasses remains challenging. Here, the authors show that a fictive temperature controls an abrupt mechanical toughening transition in metallic glasses, and can explain the scatter in previously reported fracture toughness data.

16 August 2018 | doi: 10.1038/s41467-018-05682-8
Glasses  Mechanical properties  Metals and alloys  Phase transitions and critical phenomena 

Local structure in deeply supercooled liquids exhibits growing lengthscales and dynamical correlations OPEN
James E. Hallett, Francesco Turci & C. Patrick Royall

The glass transition remains an unsolved problem due to the scarcity of particle-resolved data over a large dynamic range. Hallett et al. probe an unprecedented time window and show a strong correlation between local structure and slow dynamics in a deeply supercooled liquid of colloids.

16 August 2018 | doi: 10.1038/s41467-018-05371-6
Glasses  Phase transitions and critical phenomena  Statistical physics 

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration OPEN
Clotilde Cadart, Sylvain Monnier, Jacopo Grilli, Pablo J. Sáez, Nishit Srivastava, Rafaele Attia, Emmanuel Terriac, Buzz Baum, Marco Cosentino-Lagomarsino & Matthieu Piel

The size of cells fluctuates but there are limited experimental methods to measure live mammalian cell sizes. Here, the authors track single cell volume (FXm) over the cell cycle and generate a mathematical framework to compare size homeostasis in datasets ranging from bacteria to mammalian cells.

16 August 2018 | doi: 10.1038/s41467-018-05393-0
Biophysics  Cell growth 

Probing warm dense matter using femtosecond X-ray absorption spectroscopy with a laser-produced betatron source OPEN
B. Mahieu, N. Jourdain, K. Ta Phuoc, F. Dorchies, J.-P. Goddet, A. Lifschitz, P. Renaudin & L. Lecherbourg

Understanding the ultrafast dynamics of materials under extreme conditions is challenging. Here the authors use a femtosecond betatron X-ray source to investigate the solid to dense plasma phase transition in copper using XAS with unprecedented time resolution.

16 August 2018 | doi: 10.1038/s41467-018-05791-4
Laser-produced plasmas  Plasma-based accelerators  Ultrafast lasers  X-rays 

Surveying silicon nitride nanopores for glycomics and heparin quality assurance OPEN
Buddini Iroshika Karawdeniya, Y. M. Nuwan D. Y. Bandara, Jonathan W. Nichols, Robert B. Chevalier & Jason R. Dwyer

The complexity of polysaccharides significantly complicates their analysis in comparison to other biopolymers. Here, the authors demonstrate that solid-state silicon nitride nanopore sensors can be used to reliably detect native polysaccharides and to perform a simple quality assurance assay on a polysaccharide therapeutic, heparin.

16 August 2018 | doi: 10.1038/s41467-018-05751-y
Bioanalytical chemistry  Characterization and analytical techniques  Nanopores 

Large anomalous Hall effect in the chiral-lattice antiferromagnet CoNb3S6 OPEN
Nirmal J. Ghimire, A. S. Botana, J. S. Jiang, Junjie Zhang, Y.-S. Chen & J. F. Mitchell

Anomalous Hall effect (AHE) in antiferromagnets is intriguing and requires further understanding. Here the authors report large AHE in a chiral-lattice antiferromagnet CoNb3S6 of which the origin can be due to complex magnetic texture or broken time-reversal symmetry on the electronic band structure.

16 August 2018 | doi: 10.1038/s41467-018-05756-7
Magnetic properties and materials  Spintronics 

Observation of bosonic condensation in a hybrid monolayer MoSe2-GaAs microcavity OPEN
Max Waldherr, Nils Lundt, Martin Klaas, Simon Betzold, Matthias Wurdack, Vasilij Baumann, Eliezer Estrecho, Anton Nalitov, Evgenia Cherotchenko, Hui Cai, Elena A. Ostrovskaya, Alexey V. Kavokin, Sefaattin Tongay, Sebastian Klembt, Sven Höfling & Christian Schneider

Atomically thin transition metal dichalcogenides are an ideal platform to investigate the underlying physics of strongly bound excitons in low dimensions. Here, the authors demonstrate the formation of a bosonic condensate driven by excitons in two-dimensional MoSe2 strongly coupled to light in a solid-state resonator.

16 August 2018 | doi: 10.1038/s41467-018-05532-7
Polaritons  Two-dimensional materials 

Enhanced photon collection enables four dimensional fluorescence nanoscopy of living systems OPEN
Luciano A. Masullo, Andreas Bodén, Francesca Pennacchietti, Giovanna Coceano, Michael Ratz & Ilaria Testa

Super-resolution microscopy often suffers from low contrast and slow recording times. Here the authors present an optical implementation which makes the fluorescent proteins’ ON–OFF switching cycles more efficient, enhancing contrast and spatio-temporal resolution in 3D cell and tissue imaging.

16 August 2018 | doi: 10.1038/s41467-018-05799-w
Super-resolution microscopy 

Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus OPEN
Doo Hyun Kim, Eun-Sook Park, Ah Ram Lee, Soree Park, Yong Kwang Park, Sung Hyun Ahn, Hong Seok Kang, Ju Hee Won, Yea Na Ha, ByeongJune Jae, Dong-Sik Kim, Woo-Chang Chung, Moon Jung Song, Kee-Hwan Kim, Seung Hwa Park, Soo-Hyun Kim & Kyun-Hwan Kim

Cytokines such as TNF and IFN-γ are important for immunity against hepatitis B virus (HBV). Here the authors show that interleukin-32 gamma (IL-32γ) acts downstream of TNF and IFN-γ as an intracellular effector, and that IL-32γ negatively regulates host factors contributing to HBV transcription to promote HBV clearance.

16 August 2018 | doi: 10.1038/s41467-018-05782-5
Hepatitis B virus  Interleukins  Viral host response  Viral infection 

Symmetry breakdown of 4,4″-diamino-p-terphenyl on a Cu(111) surface by lattice mismatch OPEN
Qigang Zhong, Daniel Ebeling, Jalmar Tschakert, Yixuan Gao, Deliang Bao, Shixuan Du, Chen Li, Lifeng Chi & André Schirmeisen

In a symmetric molecule with identical functional groups, selective activation of only one site is challenging. Here, the authors show that 4,4″-diamino-p-terphenyl adsorbs asymmetrically to a metal surface, leading to a change in binding affinity of one of its amine groups.

16 August 2018 | doi: 10.1038/s41467-018-05719-y
Asymmetric synthesis  Molecular self-assembly  Surface chemistry 

Enantioselective radical conjugate additions driven by a photoactive intramolecular iminium-ion-based EDA complex OPEN
Zhong-Yan Cao, Tamal Ghosh & Paolo Melchiorre

In enantioselective catalysis, electron donor–acceptor (EDA) complexes are usually photochemically activated in an intermolecular fashion. Here, the authors report the stereoselective conjugate addition to β-substituted cyclic enones proceeding without external photoredox catalysts via an intramolecular EDA complex.

16 August 2018 | doi: 10.1038/s41467-018-05375-2
Catalysis  Organic chemistry  Photochemistry 

Biased genome editing using the local accumulation of DSB repair molecules system OPEN
Shota Nakade, Keiji Mochida, Atsushi Kunii, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, Tetsushi Sakuma & Takashi Yamamoto

Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.

16 August 2018 | doi: 10.1038/s41467-018-05773-6
CRISPR-Cas9 genome editing  Genetic engineering 

Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators OPEN
Eric Sage, Marc Sansa, Shawn Fostner, Martial Defoort, Marc Gély, Akshay K. Naik, Robert Morel, Laurent Duraffourg, Michael L. Roukes, Thomas Alava, Guillaume Jourdan, Eric Colinet, Christophe Masselon, Ariel Brenac & Sébastien Hentz

Nano-electro-mechanical system-based mass spectrometry holds promise for detecting supramolecular assemblies at large molecular weights, but its efficiency is too poor to be practical. Sage et al. overcome this problem using a nanomechanical resonator array, which significantly decreases detection time.

16 August 2018 | doi: 10.1038/s41467-018-05783-4
Electrical and electronic engineering  Mass spectrometry  NEMS 

Simulations tackle abrupt massive migrations of energetic beam ions in a tokamak plasma OPEN
Andreas Bierwage, Kouji Shinohara, Yasushi Todo, Nobuyuki Aiba, Masao Ishikawa, Go Matsunaga, Manabu Takechi & Masatoshi Yagi

Understanding the occurrence of sudden changes in plasma parameters is important for the operation of magnetically confined fusion devices. Here the authors use simulation to shed light on the formation of abrupt large-amplitude events and the associated redistribution of energetic ions in a tokamak.

16 August 2018 | doi: 10.1038/s41467-018-05779-0
Computational science  Magnetically confined plasmas  Nuclear fusion and fission  Phase transitions and critical phenomena 
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  Latest Author Corrections    
Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS OPEN
David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta & Arthur Ko
22 August 2018 | doi: 10.1038/s41467-018-05849-3
Gene expression profiling  Obesity 

Author Correction: Understanding the plume dynamics of explosive super-eruptions OPEN
Antonio Costa, Yujiro J. Suzuki & Takehiro Koyaguchi
22 August 2018 | doi: 10.1038/s41467-018-05545-2
Fluid dynamics  Palaeoclimate  Volcanology 

Author Correction: Reflection from a free carrier front via an intraband indirect photonic transition OPEN
Mahmoud A. Gaafar, Dirk Jalas, Liam O’Faolain, Juntao Li, Thomas F. Krauss, Alexander Yu. Petrov & Manfred Eich
20 August 2018 | doi: 10.1038/s41467-018-05836-8
Optical materials and structures  Optics and photonics  Slow light 

Author Correction: Single-pot glycoprotein biosynthesis using a cell-free transcription-translation system enriched with glycosylation machinery OPEN
Thapakorn Jaroentomeechai, Jessica C. Stark, Aravind Natarajan, Cameron J. Glasscock, Laura E. Yates, Karen J. Hsu, Milan Mrksich, Michael C. Jewett & Matthew P. DeLisa
20 August 2018 | doi: 10.1038/s41467-018-05620-8
Biosynthesis  Expression systems  Glycobiology  Post-translational modifications  Synthetic biology 

Author Correction: The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel OPEN
Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini & Peter Illes
17 August 2018 | doi: 10.1038/s41467-018-05621-7
Cellular neuroscience  Ion channels in the nervous system  Molecular neuroscience 

Author Correction: A mechanism for CO regulation of ion channels OPEN
Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey & Emma Raven
17 August 2018 | doi: 10.1038/s41467-018-05622-6
Metalloproteins  Potassium channels 

Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses OPEN
Mati Mann, Arnav Mehta, Jimmy L. Zhao, Kevin Lee, Georgi K. Marinov, Yvette Garcia-Flores, Li-Fan Lu, Alexander Y. Rudensky & David Baltimore
16 August 2018 | doi: 10.1038/s41467-018-05720-5
Acute inflammation  miRNA in immune cells  Monocytes and macrophages  NF-kappaB 
  Latest Publisher Correction    
Publisher Correction: Coupling of ocean redox and animal evolution during the Ediacaran-Cambrian transition OPEN
Dan Wang, Hong-Fei Ling, Ulrich Struck, Xiang-Kun Zhu, Maoyan Zhu, Tianchen He, Ben Yang, Antonia Gamper & Graham A. Shields
20 August 2018 | doi: 10.1038/s41467-018-05540-7
Element cycles  Geochemistry  Geology 

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