| | Advertisement | | Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! | | | | | | | | | | | Latest Articles | View all Articles | | | Half-metallic carbon nitride nanosheets with micro grid mode resonance structure for efficient photocatalytic hydrogen evolution OPEN | | Gang Zhou, Yun Shan, Youyou Hu, Xiaoyong Xu, Liyuan Long, Jinlei Zhang, Jun Dai, Junhong Guo, Jiancang Shen, Shuang Li, Lizhe Liu & Xinglong Wu | | | The “storage” of sunlight as a chemical fuel can provide renewable on-demand energy, although current earth-abundant materials usually show low activities. Here, authors construct a carbon nitride material whose half-metallicity and micro grid resonance structure boost light-driven H2 evolution. | | 22 August 2018 | doi: 10.1038/s41467-018-05590-x | | Microresonators Photocatalysis Solar fuels Two-dimensional materials | Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques OPEN | | Megan A. O’Connor, Jennifer Tisoncik-Go, Thomas B. Lewis, Charlene J. Miller, Debra Bratt, Cassie R. Moats, Paul T. Edlefsen, Jeremy Smedley, Nichole R. Klatt, Michael Gale Jr & Deborah Heydenburg Fuller | | | The immune response to Zika virus is required to curtail the infection and avoid immunopathology, but may be involved in the associated pathophysiology. Here the authors show that viral persistence and tissue tropism is shaped by an early innate immune response in a pigtail macaque model of infection. | | 22 August 2018 | doi: 10.1038/s41467-018-05826-w | | Viral host response Viral infection Viral pathogenesis Virus–host interactions | Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies OPEN | | Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley & Drew Weissman | | | The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and protects from heterosubtypic virus infection. | | 22 August 2018 | doi: 10.1038/s41467-018-05482-0 | | Influenza virus RNA vaccines Viral infection | Architecture of the native major royal jelly protein 1 oligomer OPEN | | Wenli Tian, Min Li, Huiyuan Guo, Wenjun Peng, Xiaofeng Xue, Yifan Hu, Yang Liu, Yazhou Zhao, Xiaoming Fang, Kai Wang, Xiuting Li, Yufeng Tong, Michael A. Conlon, Wei Wu, Fazheng Ren & Zhongzhou Chen | | | Major royal jelly protein 1 (MRJP1) is the most abundant glycoprotein in royal jelly (RJ). Here the authors isolated MRJP1 from RJ and determined the 2.65 Å resolution crystal structure of the 16-molecule oligomer, which also contained 24-methylenecholesterol and apisimin bound to MRJP1. | | 22 August 2018 | doi: 10.1038/s41467-018-05619-1 | | Entomology X-ray crystallography | Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration OPEN | | Pabitra K. Sahoo, Seung Joon Lee, Poonam B. Jaiswal, Stefanie Alber, Amar N. Kar, Sharmina Miller-Randolph, Elizabeth E. Taylor, Terika Smith, Bhagat Singh, Tammy Szu-Yu Ho, Anatoly Urisman, Shreya Chand, Edsel A. Pena, Alma L. Burlingame, Clifford J. Woolf, Mike Fainzilber, Arthur W. English & Jeffery L. Twiss | | | G3BP1 is RasGAP SH3 domain binding protein 1 that interacts with 48S pre-initiation complex when translation is stalled. Here, Twiss and colleagues show that neuronal G3BP1 can negatively regulate axonal mRNA translation, and inhibit axonal regeneration after injury. | | 22 August 2018 | doi: 10.1038/s41467-018-05647-x | | Cell biology Neuroscience Regeneration and repair in the nervous system | Genomic patterns of progression in smoldering multiple myeloma OPEN | | Niccolò Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Kevin J. Dawson, Mehmet Kemal Samur, Jorge Zamora, Patrick Tarpey, Helen Davies, Mariateresa Fulciniti, Masood A. Shammas, Yu Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Ludmil Alexandrov et al. | | | Smoldering MM (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM progressing to MM, and show that the genomic landscape at the SMM stage is very similar to MM, but trajectories of evolution can vary from patient to patient. | | 22 August 2018 | doi: 10.1038/s41467-018-05058-y | | Cancer genomics Myeloma | Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis OPEN | | Chengyu Sheng, Uzma Javed, Mary Gibbs, Caixia Long, Jun Yin, Bo Qin & Quan Yuan | | | During development, dendrites display structural plasticity, as reflected in the appearance of long, thin and highly motile dendritic filopodia. Here, the authors examine dendritic dynamics of ventral lateral neurons in the developing Drosophila larva, and identify Amphiphysin as an important regulator of this process. | | 22 August 2018 | doi: 10.1038/s41467-018-05871-5 | | Molecular neuroscience Morphogenesis Synaptic development | MAIT cells protect against pulmonary Legionella longbeachae infection OPEN | | Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J. Pediongco, Sidonia B. G. Eckle, Bronwyn S. Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey Y. W. Mak, David P. Fairlie, Yoichiro Iwakura, Jennifer M. Gunnersen, Andrew W. Stent, Dale I. Godfrey, Jamie Rossjohn, Glen P. Westall, Lars Kjer-Nielsen et al. | | | Mucosal associated invariant T (MAIT) cells have been implicated in antibacterial responses. Here the authors show MAIT cells confer IFN-γ-mediated protection from lethal infection in a mouse model of Legionella infection, which can be enhanced by synthetic MR1 ligands. | | 22 August 2018 | doi: 10.1038/s41467-018-05202-8 | | Mucosal immunology T cells | Co-crystallization of atomically precise metal nanoparticles driven by magic atomic and electronic shells OPEN | | Juanzhu Yan, Sami Malola, Chengyi Hu, Jian Peng, Birger Dittrich, Boon K. Teo, Hannu Häkkinen, Lansun Zheng & Nanfeng Zheng | | | Atomic shell closure and electronic shell closure are generally considered to be competing effects in stabilizing magic-sized metal nanoclusters. Here, the authors show, by co-crystallizing two differently-sized clusters, that both mechanisms can work concurrently during magic cluster synthesis. | | 22 August 2018 | doi: 10.1038/s41467-018-05584-9 | | Materials chemistry Nanoparticles Physical chemistry | ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response OPEN | | Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li & Hong-Bing Shu | | | cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection. | | 22 August 2018 | doi: 10.1038/s41467-018-05559-w | | Antimicrobial responses Infection Innate immunity Viral host response | Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis OPEN | | Marissa A. Scavuzzo, Matthew C. Hill, Jolanta Chmielowiec, Diane Yang, Jessica Teaw, Kuanwei Sheng, Yuelin Kong, Maria Bettini, Chenghang Zong, James F. Martin & Malgorzata Borowiak | | | Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cells | | 22 August 2018 | doi: 10.1038/s41467-018-05740-1 | | Developmental biology Differentiation Gene expression analysis RNA sequencing | Loss of GCNT2/I-branched glycans enhances melanoma growth and survival OPEN | | Jenna Geddes Sweeney, Jennifer Liang, Aristotelis Antonopoulos, Nicholas Giovannone, Shuli Kang, Tony S. Mondala, Steven R. Head, Sandra L. King, Yoshihiko Tani, Danielle Brackett, Anne Dell, George F. Murphy, Stuart M. Haslam, Hans R. Widlund & Charles J. Dimitroff | | | Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation. Here the authors provide data that show melanoma cells downregulate GCNT2 with consequent loss of I-branched glycans; this leads to the formation of extended i-linear glycans and enhances melanoma growth via increases, in part, by IGF-1- and extracellular matrix-induced signaling. | | 22 August 2018 | doi: 10.1038/s41467-018-05795-0 | | Glycobiology Melanoma | Three-dimensional atomic-scale observation of structural evolution of cathode material in a working all-solid-state battery OPEN | | Yue Gong, Yuyang Chen, Qinghua Zhang, Fanqi Meng, Jin-An Shi, Xinyu Liu, Xiaozhi Liu, Jienan Zhang, Hao Wang, Jiangyong Wang, Qian Yu, Ze Zhang, Qiang Xu, Ruijuan Xiao, Yong-Sheng Hu, Lin Gu, Hong Li, Xuejie Huang & Liquan Chen | | | Here, with the state-of-the-state electron microscope, the authors report three-dimensional atomic-scale observation of LiNi0.5Mn1.5O4 from various directions, revealing unprecedented insight into the evolution of both atomic and electronic structures during delithiation. | | 21 August 2018 | doi: 10.1038/s41467-018-05833-x | | Batteries Condensed-matter physics Materials for energy and catalysis | A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers OPEN | | Melissa K. Takahashi, Xiao Tan, Aaron J. Dy, Dana Braff, Reid T. Akana, Yoshikazu Furuta, Nina Donghia, Ashwin Ananthakrishnan & James J. Collins | | | Currently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers. | | 21 August 2018 | doi: 10.1038/s41467-018-05864-4 | | Clostridium difficile Microbiome Sensors and probes Synthetic biology | Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis OPEN | | Mathieu Daynac, Malek Chouchane, Hannah Y. Collins, Nicole E. Murphy, Noemi Andor, Jianqin Niu, Stephen P. J. Fancy, William B. Stallcup & Claudia K. Petritsch | | | Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis. | | 21 August 2018 | doi: 10.1038/s41467-018-05099-3 | | Oligodendrocyte Tumour-suppressor proteins | Fossil lemurs from Egypt and Kenya suggest an African origin for Madagascar’s aye-aye OPEN | | Gregg F. Gunnell, Doug M. Boyer, Anthony R. Friscia, Steven Heritage, Fredrick Kyalo Manthi, Ellen R. Miller, Hesham M. Sallam, Nancy B. Simmons, Nancy J. Stevens & Erik R. Seiffert | | | The fossil taxon Propotto was originally identified as a primate, but is currently widely interpreted as a bat. Here, the authors identify Propotto as a stem chiromyiform lemur and, based on phylogenetic analysis, suggest two independent lemur colonizations of Madagascar. | | 21 August 2018 | doi: 10.1038/s41467-018-05648-w | | Biogeography Biological anthropology Palaeontology Phylogenetics | A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism OPEN | | Nigel Turner, Xin Ying Lim, Hamish D. Toop, Brenna Osborne, Amanda E. Brandon, Elysha N. Taylor, Corrine E. Fiveash, Hemna Govindaraju, Jonathan D. Teo, Holly P. McEwen, Timothy A. Couttas, Stephen M. Butler, Abhirup Das, Greg M. Kowalski, Clinton R. Bruce, Kyle L. Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory J. Cooney, Magdalene K. Montgomery et al. | | | Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet. | | 21 August 2018 | doi: 10.1038/s41467-018-05613-7 | | Lipidomics Metabolic diseases Pharmacology Sphingolipids | Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation OPEN | | Éadaoin Harney, Hila May, Dina Shalem, Nadin Rohland, Swapan Mallick, Iosif Lazaridis, Rachel Sarig, Kristin Stewardson, Susanne Nordenfelt, Nick Patterson, Israel Hershkovitz & David Reich | | | The Late Chalcolithic material culture in the southern Levant has unique attributes that suggest spread of people or culture. Here, the authors use genome-wide ancient DNA data from 22 individuals from a Chalcolithic site and show evidence of complex population movements and turnovers. | | 20 August 2018 | doi: 10.1038/s41467-018-05649-9 | | Anthropology Population genetics | Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection OPEN | | Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu & Zhiwei Wu | | | SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection. | | 20 August 2018 | doi: 10.1038/s41467-018-05746-9 | | Viral host response Viral infection | Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells OPEN | | Florian Wimmers, Nikita Subedi, Nicole van Buuringen, Daan Heister, Judith Vivié, Inge Beeren-Reinieren, Rob Woestenenk, Harry Dolstra, Aigars Piruska, Joannes F. M. Jacobs, Alexander van Oudenaarden, Carl G. Figdor, Wilhelm T. S. Huck, I. Jolanda M. de Vries & Jurjen Tel | | | Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues. | | 20 August 2018 | doi: 10.1038/s41467-018-05784-3 | | Cytokines Lab-on-a-chip Microfluidics Plasmacytoid dendritic cells RNA sequencing | LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation OPEN | | Julie Brind’Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M. Karimi, Louis Lefebvre, Tomohiro Kono & Matthew C. Lorincz | | | De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs. | | 20 August 2018 | doi: 10.1038/s41467-018-05841-x | | Embryogenesis Epigenetics Evolutionary biology Germline development | Direct observation of room-temperature out-of-plane ferroelectricity and tunneling electroresistance at the two-dimensional limit OPEN | | H. Wang, Z. R. Liu, H. Y. Yoong, T. R. Paudel, J. X. Xiao, R. Guo, W. N. Lin, P. Yang, J. Wang, G. M. Chow, T. Venkatesan, E. Y. Tsymbal, H. Tian & J. S. Chen | | | High temperature perpendicular ferroelectricity in nano thin films is crucial for miniaturization of electronic devices. Here the authors show the presence of stable and switchable out-of-plane ferroelectricity in tetragonal BiFeO3 thin films at the two-dimensional limit and 370% tunneling electroresistance in ferroelectric tunnel junctions. | | 20 August 2018 | doi: 10.1038/s41467-018-05662-y | | Electronic devices Ferroelectrics and multiferroics | Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species OPEN | | Angeliki M. Andrianaki, Irene Kyrmizi, Kalliopi Thanopoulou, Clara Baldin, Elias Drakos, Sameh S. M. Soliman, Amol C. Shetty, Carrie McCracken, Tonia Akoumianaki, Kostas Stylianou, Petros Ioannou, Charalampos Pontikoglou, Helen A. Papadaki, Maria Tzardi, Valerie Belle, Emilien Ettiene, Anne Beauvais, George Samonis, Dimitrios P. Kontoyiannis, Evangelos Andreakos et al. | | | Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis. | | 20 August 2018 | doi: 10.1038/s41467-018-05820-2 | | Fungal host response Fungal infection Fungal pathogenesis Infection | Layer specific observation of slow thermal equilibration in ultrathin metallic nanostructures by femtosecond X-ray diffraction OPEN | | J. Pudell, A. A. Maznev, M. Herzog, M. Kronseder, C. H. Back, G. Malinowski, A. von Reppert & M. Bargheer | | | Heat transport in ultrathin metal layers is important for potential applications in optical‐magnetic switching, but difficult to access experimentally. Here, the authors use ultrafast X‐ray diffraction to directly probe and explain unexpected time‐dependent transport behavior in Au–Ni nanolayers. | | 20 August 2018 | doi: 10.1038/s41467-018-05693-5 | | Statistical physics, thermodynamics and nonlinear dynamics Surfaces, interfaces and thin films X-ray diffraction | Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory OPEN | | Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos & Marcelo A. Wood | | | Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates memory and contributes to age-related memory decline, independent of circadian rhythms. | | 20 August 2018 | doi: 10.1038/s41467-018-05868-0 | | Circadian mechanisms Cognitive ageing Epigenetics and behaviour Hippocampus | The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation OPEN | | Annette Aichem, Samira Anders, Nicola Catone, Philip Rößler, Sophie Stotz, Andrej Berg, Ricarda Schwab, Sophia Scheuermann, Johanna Bialas, Mira C. Schütz-Stoffregen, Gunter Schmidtke, Christine Peter, Marcus Groettrup & Silke Wiesner | | | The ubiquitin-like modifier FAT10 is composed of two ubiquitin-like domains (UBDs). Here the authors present the FAT10 UBD structures and show that the unstructured FAT10 N-terminal heptapeptide together with the poor stability of FAT10 facilitate the rapid proteasomal targeting of FAT10 along with its substrates. | | 20 August 2018 | doi: 10.1038/s41467-018-05776-3 | | Proteasome Solution-state NMR Ubiquitylation X-ray crystallography | Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis OPEN | | Simon Braun, Mihaela Enculescu, Samarth T. Setty, Mariela Cortés-López, Bernardo P. de Almeida, F. X. Reymond Sutandy, Laura Schulz, Anke Busch, Markus Seiler, Stefanie Ebersberger, Nuno L. Barbosa-Morais, Stefan Legewie, Julian König & Kathi Zarnack | | | Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splicing for the RON proto-oncogene. | | 17 August 2018 | doi: 10.1038/s41467-018-05748-7 | | Alternative splicing Cancer genomics Computational models High-throughput screening | Understanding how excess lead iodide precursor improves halide perovskite solar cell performance OPEN | | Byung-wook Park, Nir Kedem, Michael Kulbak, Do Yoon Lee, Woon Seok Yang, Nam Joong Jeon, Jangwon Seo, Geonhwa Kim, Ki Jeong Kim, Tae Joo Shin, Gary Hodes, David Cahen & Sang Il Seok | | | Excess lead iodide in the mixed halide perovskites solar cells leads to high device performance but its origin remains elusive. Here Park et al. unveil the underlying microscopic mechanism to be promoting the oriented growth of the perovskites crystals and reducing the defect concentration. | | 17 August 2018 | doi: 10.1038/s41467-018-05583-w | | Devices for energy harvesting Solar cells Solar energy | The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation OPEN | | Junpei Suzuki, Takeshi Yamada, Kazuki Inoue, Shogo Nabe, Makoto Kuwahara, Nobuaki Takemori, Ayako Takemori, Seiji Matsuda, Makoto Kanoh, Yuuki Imai, Masaki Yasukawa & Masakatsu Yamashita | | | T cells can alter their metabolism during activation and differentiation. Here the authors show that the tumor suppressor menin regulates CD8 T-cell fate via the modulation of central carbon metabolism. | | 17 August 2018 | doi: 10.1038/s41467-018-05854-6 | | Cellular immunity Metabolomics Senescence | Early selection of bZIP73 facilitated adaptation of japonica rice to cold climates OPEN | | Citao Liu, Shujun Ou, Bigang Mao, Jiuyou Tang, Wei Wang, Hongru Wang, Shouyun Cao, Michael R. Schläppi, Bingran Zhao, Guoying Xiao, Xiping Wang & Chengcai Chu | | | Japonica rice can grow further north than wild or indica rice and is more tolerant of cold climates. Here, the authors show that bZIP73 likely underwent selection in the early phase of rice domestication to facilitate cold tolerance in japonica by modulating ABA and ROS homeostasis. | | 17 August 2018 | doi: 10.1038/s41467-018-05753-w | | Abiotic Agricultural genetics Evolutionary genetics Genetic variation | Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine OPEN | | Leila S. Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick M. Fairhurst, Frederic Ariey, Didier Menard & David A. Fidock | | | Increasing resistance of Plasmodium falciparum strains to piperaquine (PPQ) in Southeast Asia is of concern and resistance mechanisms are incompletely understood. Here, Ross et al. show that mutations in the P. falciparum chloroquine resistance transporter are rapidly increasing in prevalence in Cambodia and confer resistance to PPQ. | | 17 August 2018 | doi: 10.1038/s41467-018-05652-0 | | Antimicrobial resistance Antiparasitic agents Parasite biology Parasite genetics Parasite genomics | Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules OPEN | | Kai He, Xiaoyu Ma, Tao Xu, Yan Li, Allen Hodge, Qing Zhang, Julia Torline, Yan Huang, Jian Zhao, Kun Ling & Jinghua Hu | | | The small GTPase ARL13B is mutated in the human ciliopathy Joubert syndrome. Here the authors show that ARL13B and the RAB11 effector FIP5 promote import of tubulin glutamylase into cilia and as such axoneme polyglutamylation, which is demonstrated to be required for cilia signaling. | | 17 August 2018 | doi: 10.1038/s41467-018-05867-1 | | Ciliogenesis Mechanisms of disease | Ultrafast and highly sensitive infrared photodetectors based on two-dimensional oxyselenide crystals OPEN | | Jianbo Yin, Zhenjun Tan, Hao Hong, Jinxiong Wu, Hongtao Yuan, Yujing Liu, Cheng Chen, Congwei Tan, Fengrui Yao, Tianran Li, Yulin Chen, Zhongfan Liu, Kaihui Liu & Hailin Peng | | | Two-dimensional (2D) bismuth oxyselenide crystals with suitable electronic band-gap and ultrahigh carrier mobility enable near-infrared photodetection. Here, the authors report an infrared photodetector based on 2D-bismuth oxyselenide with high responsivity, ultrafast photoresponse of ~ 1 ps at room temperature and a detectable frequency limit of up to 500 GHz. | | 17 August 2018 | doi: 10.1038/s41467-018-05874-2 | | Two-dimensional materials | Emerging many-body effects in semiconductor artificial graphene with low disorder OPEN | | Lingjie Du, Sheng Wang, Diego Scarabelli, Loren N. Pfeiffer, Ken W. West, Saeed Fallahi, Geoff C. Gardner, Michael J. Manfra, Vittorio Pellegrini, Shalom J. Wind & Aron Pinczuk | | | Artificial nanostructures designed to simulate models of materials such as graphene provide insights into the material physics but can also have practical advantages. Du et al. create low-disorder artificial graphene devices, and present evidence of terahertz spin-exciton modes and large Coulomb interactions. | | 17 August 2018 | doi: 10.1038/s41467-018-05775-4 | | Electronic properties and materials Optics and photonics Two-dimensional materials | Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans OPEN | | N. Giovannone, J. Liang, A. Antonopoulos, J. Geddes Sweeney, S. L. King, S. M. Pochebit, N. Bhattacharyya, G. S. Lee, A. Dell, H. R. Widlund, S. M. Haslam & C. J. Dimitroff | | | Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans. | | 17 August 2018 | doi: 10.1038/s41467-018-05770-9 | | Adaptive immunity B-cell receptor Glycobiology | Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo OPEN | | Hyo Min Park, Hui Liu, Joann Wu, Anthony Chong, Vanessa Mackley, Christof Fellmann, Anirudh Rao, Fuguo Jiang, Hunghao Chu, Niren Murthy & Kunwoo Lee | | | Optimization of the recently discovered Class 2 CRISPR protein Cpf1 has the potential to promote its applications in gene editing and therapeutics. Here, the authors find that extending the 5′ end of the crRNA can increase both the editing efficiency and delivery of Cpf1 in vitro and in vivo. | | 17 August 2018 | doi: 10.1038/s41467-018-05641-3 | | Drug delivery Genetic engineering Protein delivery | Galectin-9 binds IgM-BCR to regulate B cell signaling OPEN | | Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko & Bebhinn Treanor | | | The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22. | | 17 August 2018 | doi: 10.1038/s41467-018-05771-8 | | Adaptive immunity B-cell receptor Fluorescence imaging Glycobiology | Element- and momentum-resolved electronic structure of the dilute magnetic semiconductor manganese doped gallium arsenide OPEN | | Slavomír Nemšák, Mathias Gehlmann, Cheng-Tai Kuo, Shih-Chieh Lin, Christoph Schlueter, Ewa Mlynczak, Tien-Lin Lee, Lukasz Plucinski, Hubert Ebert, Igor Di Marco, Ján Minár, Claus M. Schneider & Charles S. Fadley | | | The knowledge of the electronic structure of composite material is essential for tailoring their properties. The authors introduce a method based on standing wave angle-resolved hard X-ray photoemission to determine the element- and momentum-resolved electronic band structure simultaneously. | | 17 August 2018 | doi: 10.1038/s41467-018-05823-z | | Characterization and analytical techniques Electronic properties and materials | Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles OPEN | | Chaohao Chen, Fan Wang, Shihui Wen, Qian Peter Su, Mike C. L. Wu, Yongtao Liu, Baoming Wang, Du Li, Xuchen Shan, Mehran Kianinia, Igor Aharonovich, Milos Toth, Shaun P. Jackson, Peng Xi & Dayong Jin | | | Upconversion nanoparticles offer the potential for deep tissue biological imaging. Here, Chen et al. develop super resolution optical imaging in the near-infrared for imaging with sub-50 nm resolution through almost 100 microns of tissue. | | 17 August 2018 | doi: 10.1038/s41467-018-05842-w | | Multiphoton microscopy Nanoparticles Super-resolution microscopy | Understanding voltage decay in lithium-excess layered cathode materials through oxygen-centred structural arrangement OPEN | | Seungjun Myeong, Woongrae Cho, Wooyoung Jin, Jaeseong Hwang, Moonsu Yoon, Youngshin Yoo, Gyutae Nam, Haeseong Jang, Jung-Gu Han, Nam-Soon Choi, Min Gyu Kim & Jaephil Cho | | | There is growing interest in the fundamental understanding of the voltage decay mechanism in Li-excess layered cathode materials. Here, the authors report a multilateral and macroscopic analysis that considers interaction between oxygen and atomic arrangement of Li1+xNiyCozMn1−x−y−zO2. | | 16 August 2018 | doi: 10.1038/s41467-018-05802-4 | | Energy science and technology Materials science | The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner OPEN | | Mette Ø. Agerbæk, Sara R. Bang-Christensen, Ming-Hsin Yang, Thomas M. Clausen, Marina A. Pereira, Shreya Sharma, Sisse B. Ditlev, Morten A. Nielsen, Swati Choudhary, Tobias Gustavsson, Poul H. Sorensen, Tim Meyer, David Propper, Jonathan Shamash, Thor G. Theander, Alexandra Aicher, Mads Daugaard, Christopher Heeschen & Ali Salanti | | | Isolation of circulating tumor cells (CTCs) allows for non-invasive disease monitoring and characterization. Here the authors describe an alternative CTC isolation method based on the ability of the malaria rVAR2 protein to specifically bind oncofetal chondroitin sulfate, which is expressed by all cancer cells | | 16 August 2018 | doi: 10.1038/s41467-018-05793-2 | | Assay systems Cancer screening Tumour biomarkers | Mechanical glass transition revealed by the fracture toughness of metallic glasses OPEN | | Jittisa Ketkaew, Wen Chen, Hui Wang, Amit Datye, Meng Fan, Gabriela Pereira, Udo D. Schwarz, Ze Liu, Rui Yamada, Wojciech Dmowski, Mark D. Shattuck, Corey S. O’Hern, Takeshi Egami, Eran Bouchbinder & Jan Schroers | | | Understanding the fracture toughness of metallic glasses remains challenging. Here, the authors show that a fictive temperature controls an abrupt mechanical toughening transition in metallic glasses, and can explain the scatter in previously reported fracture toughness data. | | 16 August 2018 | doi: 10.1038/s41467-018-05682-8 | | Glasses Mechanical properties Metals and alloys Phase transitions and critical phenomena | Observation of bosonic condensation in a hybrid monolayer MoSe2-GaAs microcavity OPEN | | Max Waldherr, Nils Lundt, Martin Klaas, Simon Betzold, Matthias Wurdack, Vasilij Baumann, Eliezer Estrecho, Anton Nalitov, Evgenia Cherotchenko, Hui Cai, Elena A. Ostrovskaya, Alexey V. Kavokin, Sefaattin Tongay, Sebastian Klembt, Sven Höfling & Christian Schneider | | | Atomically thin transition metal dichalcogenides are an ideal platform to investigate the underlying physics of strongly bound excitons in low dimensions. Here, the authors demonstrate the formation of a bosonic condensate driven by excitons in two-dimensional MoSe2 strongly coupled to light in a solid-state resonator. | | 16 August 2018 | doi: 10.1038/s41467-018-05532-7 | | Polaritons Two-dimensional materials | Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus OPEN | | Doo Hyun Kim, Eun-Sook Park, Ah Ram Lee, Soree Park, Yong Kwang Park, Sung Hyun Ahn, Hong Seok Kang, Ju Hee Won, Yea Na Ha, ByeongJune Jae, Dong-Sik Kim, Woo-Chang Chung, Moon Jung Song, Kee-Hwan Kim, Seung Hwa Park, Soo-Hyun Kim & Kyun-Hwan Kim | | | Cytokines such as TNF and IFN-γ are important for immunity against hepatitis B virus (HBV). Here the authors show that interleukin-32 gamma (IL-32γ) acts downstream of TNF and IFN-γ as an intracellular effector, and that IL-32γ negatively regulates host factors contributing to HBV transcription to promote HBV clearance. | | 16 August 2018 | doi: 10.1038/s41467-018-05782-5 | | Hepatitis B virus Interleukins Viral host response Viral infection | Symmetry breakdown of 4,4″-diamino-p-terphenyl on a Cu(111) surface by lattice mismatch OPEN | | Qigang Zhong, Daniel Ebeling, Jalmar Tschakert, Yixuan Gao, Deliang Bao, Shixuan Du, Chen Li, Lifeng Chi & André Schirmeisen | | | In a symmetric molecule with identical functional groups, selective activation of only one site is challenging. Here, the authors show that 4,4″-diamino-p-terphenyl adsorbs asymmetrically to a metal surface, leading to a change in binding affinity of one of its amine groups. | | 16 August 2018 | doi: 10.1038/s41467-018-05719-y | | Asymmetric synthesis Molecular self-assembly Surface chemistry | Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators OPEN | | Eric Sage, Marc Sansa, Shawn Fostner, Martial Defoort, Marc Gély, Akshay K. Naik, Robert Morel, Laurent Duraffourg, Michael L. Roukes, Thomas Alava, Guillaume Jourdan, Eric Colinet, Christophe Masselon, Ariel Brenac & Sébastien Hentz | | | Nano-electro-mechanical system-based mass spectrometry holds promise for detecting supramolecular assemblies at large molecular weights, but its efficiency is too poor to be practical. Sage et al. overcome this problem using a nanomechanical resonator array, which significantly decreases detection time. | | 16 August 2018 | doi: 10.1038/s41467-018-05783-4 | | Electrical and electronic engineering Mass spectrometry NEMS | | | | | | | | Latest Author Corrections | | | | Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS OPEN | | David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta & Arthur Ko | | 22 August 2018 | doi: 10.1038/s41467-018-05849-3 | | Gene expression profiling Obesity | Author Correction: The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel OPEN | | Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini & Peter Illes | | 17 August 2018 | doi: 10.1038/s41467-018-05621-7 | | Cellular neuroscience Ion channels in the nervous system Molecular neuroscience | Author Correction: A mechanism for CO regulation of ion channels OPEN | | Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey & Emma Raven | | 17 August 2018 | doi: 10.1038/s41467-018-05622-6 | | Metalloproteins Potassium channels | | | | | Latest Publisher Correction | | | | | | | | Advertisement | | Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up. | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. Nature is part of Springer Nature. © 2018 Springer Nature Limited. All rights reserved. | | | | |
No comments:
Post a Comment