The EMBO Journal Table of Contents for 02 July 2018; Vol. 37, No. 13

02 July 2018 | Volume 37, Number 13 Submit Table of Contents News & Views Articles Volume 37, Number 13 News & Views Nuclear lncRNA stabilization in the host response to bacterial infection Salmonella infection impairs the nuclear RNA decay machinery in human cells, increasing the abundance of long non‐coding RNAs with a role in innate immunity. Mathias Munschauer and Jörg Vogel Published online 22.06.2018 Articles Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs Salmonella infection in human cells triggers selective loss of the nuclear RNA degradation machinery, leading to accumulation of unstable lncRNAs and activation of immune‐related genes. Katsutoshi Imamura, Akiko Takaya, Yo‐ichi Ishida, Yayoi Fukuoka, Toshiki Taya, Ryo Nakaki, Miho Kakeda, Naoto Imamachi, Aiko Sato, Toshimichi Yamada, Rena Onoguchi‐Mizutani, Gen Akizuki, Tanzina Tanu, Kazuyuki Tao, Sotaro Miyao, Yutaka Suzuki, Masami Nagahama, Tomoko Yamamoto, Torben Heick Jensen and Nobuyoshi Akimitsu Published online 07.06.2018 The trimeric coiled‐coil HSBP1 protein promotes WASH complex assembly at centrosomes The first identified assembly factor for Arp2/3‐activating WASH operates at centrosomes and facilitates invasiveness of tumour cells. Sai P Visweshwaran, Peter A Thomason, Raphael Guerois, Sophie Vacher, Evgeny V Denisov, Lubov A Tashireva, Maria E Lomakina, Christine Lazennec‐Schurdevin, Goran Lakisic, Sergio Lilla, Nicolas Molinie, Veronique Henriot, Yves Mechulam, Antonina Y Alexandrova, Nadezhda V Cherdyntseva, Ivan Bièche, Emmanuelle Schmitt, Robert H Insall and Alexis Gautreau Published online 29.05.2018 Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics A novel, conserved role for the multifunctional adaptor protein ALIX in facilitating centrosome recruitment of γ‐tubulin and MAP1S ensures correct spindle orientation during both asymmetric and symmetric cell division. Lene Malerød, Roland Le Borgne, Anette Lie‐Jensen, Åsmund Husabø Eikenes, Andreas Brech, Knut Liestøl, Harald Stenmark and Kaisa Haglund Published online 01.06.2018 Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression Imaging studies in zebrafish, mouse and human cells reveal how macrophages play essential roles in wound angiogenesis, coordinating both the initial blood vessel sprouting and subsequent vessel regression. David B Gurevich, Charlotte E Severn, Catherine Twomey, Alexander Greenhough, Jenna Cash, Ashley M Toye, Harry Mellor and Paul Martin Published online 04.06.2018 In vivo expansion of functionally integrated GABAergic interneurons by targeted increase in neural progenitors Reduced expression of cell fate regulator Prospero triggers an expansion of differentiation‐competent neural stem cells, giving rise to supernumerary neurons that functionally integrate into neural circuits in Drosophila. Rachel E Shaw, Benjamin Kottler, Zoe N Ludlow, Edgar Buhl, Dongwook Kim, Sara Morais da Silva, Alina Miedzik, Antoine Coum, James JL Hodge, Frank Hirth and Rita Sousa‐Nunes Published online 04.05.2018 miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking While miRNAs of the miR‐200 family are known to promote EMT and cancer progression via target mRNA repression, they exert a separate effect on epithelial cell plasticity by modulating alternative splicing signatures. Katherine A Pillman, Caroline A Phillips, Suraya Roslan, John Toubia, B Kate Dredge, Andrew G Bert, Rachael Lumb, Daniel P Neumann, Xiaochun Li, Simon J Conn, Dawei Liu, Cameron P Bracken, David M Lawrence, Nataly Stylianou, Andreas W Schreiber, Wayne D Tilley, Brett G Hollier, Yeesim Khew‐Goodall, Luke A Selth, Gregory J Goodall and Philip A Gregory Published online 05.06.2018 Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus The antineoplastic photosensitizer redaporfin kills cancer cells via irreversible inactivation of endoplasmic reticulum and Golgi, paralyzing protein secretion and triggering mitochondrial cell death. Lígia C Gomes‐da‐Silva, Liwei Zhao, Lucillia Bezu, Heng Zhou, Allan Sauvat, Peng Liu, Sylvère Durand, Marion Leduc, Sylvie Souquere, Friedemann Loos, Laura Mondragón, Baldur Sveinbjørnsson, Øystein Rekdal, Gaelle Boncompain, Franck Perez, Luis G Arnaut, Oliver Kepp and Guido Kroemer Published online 28.05.2018 The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA The crystal structure of a Helicobacter pylori adhesin in complex with its receptors on human gastric epithelial cells provides insight into the interactions underlying translocation of a bacterial oncoprotein. Daniel A Bonsor, Qing Zhao, Barbara Schmidinger, Evelyn Weiss, Jingheng Wang, Daniel Deredge, Robert Beadenkopf, Blaine Dow, Wolfgang Fischer, Dorothy Beckett, Patrick L Wintrode, Rainer Haas and Eric J Sundberg Published online 03.05.2018 Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs Crystal structures of HopQ and functional analyses reveal the mechanism by which H. pylori HopQ interacts with human CEACAM to inject the oncoprotein CagA into host cells. Kristof Moonens, Youssef Hamway, Matthias Neddermann, Marc Reschke, Nicole Tegtmeyer, Tobias Kruse, Robert Kammerer, Raquel Mejías‐Luque, Bernhard B Singer, Steffen Backert, Markus Gerhard and Han Remaut Published online 01.06.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.