Nature Immunology Contents: April 2018 Volume 19 Issue 4

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Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do TABLE OF CONTENTS April 2018 Volume 19, Issue 4 Obituary Research Highlights News & Views Review Articles Articles   Advertisement Communications Biology: now publishing content Communications Biology is a new open access journal publishing high-quality primary research articles, reviews and commentary which represent significant advances and new insights in the field of biology. Visit the website to access the first papers recently published in the journal and sign up for e-alerts to access all the latest content as it becomes available.   Advertisement npj Microgravity is a new open access journal specifically dedicated to publishing research which enables space exploration and research that is enabled by spaceflight and ground-based spaceflight analogues. npj Microgravity is published in cooperation the Biodesign Institute at Arizona State University, and is part of the Nature Partner Journals series. Find out more >>>   Advertisement Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. Explore the benefits of submitting your next research article.   Obituary   Alessandro Moretta 1953–2018    p315 Lorenzo Moretta & Alberto Mantovani doi:10.1038/s41590-018-0075-5 Research Highlights   Targeting TGF-β in cancer    p316 Ioana Visan doi:10.1038/s41590-018-0076-4 Establishing T cell lineage identity    p316 Ioana Visan doi:10.1038/s41590-018-0077-3 Neuroregulation of ILC2s    p316 Laurie A. Dempsey doi:10.1038/s41590-018-0078-2 Asymmetry in PI(3)K activity    p316 Laurie A. Dempsey doi:10.1038/s41590-018-0079-1 Mast cells in autoimmune disease    p316 Zoltan Fehervari doi:10.1038/s41590-018-0080-8 Flowing into higher dimensions    p316 Zoltan Fehervari doi:10.1038/s41590-018-0081-7 News & Views   Age-associated B cells acquire a new wrinkle    pp317 - 318 Yong-Rui Zou & Anne Davidson doi:10.1038/s41590-018-0072-8 IL-33 meets allergens at the gate    pp318 - 320 Dirk E. Smith doi:10.1038/s41590-018-0069-3 Training myeloid precursors with fungi, bacteria and chips    pp320 - 322 Manfred Kopf & Peter J. Nielsen doi:10.1038/s41590-018-0073-7 CD1c caves in on lipids    pp322 - 324 Dirk M. Zajonc doi:10.1038/s41590-018-0074-6 Is it dead or alive? TLR8 can tell    pp324 - 326 Stuart G. Tangye doi:10.1038/s41590-018-0070-x Immunology JOBS of the week Malaria Pathogenesis and Immunity Postdoctoral Scientist National Institute of Allergy and Infectious Diseases Executive Director, Brown Center for Immunotherapy Indiana University School of Medicine University Professor of Immunogerontology University of Innsbruck Postdoctoral Position - Immune Oncology H. Lee Moffitt Cancer & Research Institute Scientist I / II, Immunology Bioverativ More Science jobs from Immunology EVENT Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease 24.06.18 Leesburg, USA More science events from Review Articles   Innate immune responses to trauma    pp327 - 341 Markus Huber-Lang, John D. Lambris & Peter A. Ward doi:10.1038/s41590-018-0064-8 Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Articles   Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor    pp342 - 353 Lin Jin, Xiaomin Guo, Chuanbin Shen, Xue Hao, Peng Sun et al. doi:10.1038/s41590-018-0063-9 Mosquito salivary-gland extract can modulate the host immune response. Qi and colleagues show that the salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor.   IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling    pp354 - 365 Tomasz Herjan, Lingzi Hong, Jodi Bubenik, Katarzyna Bulek, Wen Qian et al. doi:10.1038/s41590-018-0071-9 Act1 is an adaptor protein that associates with the IL-17 receptor at the cell membrane. Li and colleagues show that Act1 also exhibits unexpected RNA-binding activity and directly stabilizes select mRNAs encoding inflammatory cytokines and chemokines.   A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer    pp366 - 374 Emma L. Kuan & Steven F. Ziegler doi:10.1038/s41590-018-0066-6 Tumor cells commonly manipulate their environment to ensure their survival. Kuan and Ziegler show that breast cancer cells release IL-1α, which acts on infiltrating myeloid cells to elicit their production of TSLP. In turn, TSLP promotes the survival of TSLPR+ tumor cells by upregulating expression of the pro-survival factor Bcl-2.   Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33    pp375 - 385 Corinne Cayrol, Anais Duval, Pauline Schmitt, Stephane Roga, Mylène Camus et al. doi:10.1038/s41590-018-0067-5 The cytokine IL-33 has major roles in type 2 immunity and allergy. Girard and colleagues demonstrate that a broad range of allergens across multiple kingdoms can directly cleave IL-33 via their intrinsic protease activity and convert it into a highly active processed form.   Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses    pp386 - 396 Matteo Ugolini, Jenny Gerhard, Sanne Burkert, Kristoffer Jarlov Jensen, Philipp Georg et al. doi:10.1038/s41590-018-0068-4 Sander and colleagues show that antigen-presenting cells detect bacterial RNA from live bacteria via TLR8 and promote TFH cell differentiation and vaccine responses through the induction of a specific cytokine profile.   T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids    pp397 - 406 Kwok S. Wun, Josephine F. Reijneveld, Tan-Yun Cheng, Kristin Ladell, Adam P. Uldrich et al. doi:10.1038/s41590-018-0065-7 CD1 molecules present diverse lipid ligands to TCRs expressed by NKT cells. Rossjohn, Moody and colleagues show a unique form of autoreactivity with human CD1c molecules, whereby TCRs recognize a closed conformation of CD1c molecules, which are loaded with a diverse array of ‘headless’ glycolipids.   Regulation of age-associated B cells by IRF5 in systemic autoimmunity    pp407 - 419 Michela Manni, Sanjay Gupta, Edd Ricker, Yurii Chinenov, Sung Ho Park et al. doi:10.1038/s41590-018-0056-8 A unique subset of T-bet-expressing B cells accumulates with aging and in autoimmunity. Pernis and colleagues show that dysregulation of the transcription factor IRF5 occurs after loss of the Rho GTPase–regulatory proteins DEF6 and SWAP-70 and leads to the premature generation of age-associated B cells.   Advertisement Nature Collection: Gut-brain axis  This Nature Collection brings together Research, Reviews and News from across the Nature Research journals and presents a selection of articles covering key aspects of the gut-brain axis including the gut microbiota and immune, neuroendocrine and neural factors.  Access this collection >> Produced with support from:  Abbott    Advertisement Nature Outlook: The future of medicine Modern medicine is affording people longer and healthier lives. But researchers want to take improvements in health even further. With advances in gene editing, technology to overcome paralysis and efforts to address high drug costs, the future of medicine is bright.  Get your free access  Produced with support from Merck   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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