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| TABLE OF CONTENTS |
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| April 2018 Volume 18 Number 4 |
| 2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29 | In this issue
  Research Highlights
Reviews
Perspectives
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RESEARCH HIGHLIGHTS
| Top | | Immunotherapy: Tear down this wall
p221 | doi:10.1038/nri.2018.20
Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response.
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Antibodies: Septic shock absorbers
p222 | doi:10.1038/nri.2018.17
Gut commensals induce systemic IgA responses that protect mice against lethal sepsis.
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Neuroimmunology: No pain, all gain
p222 | doi:10.1038/nri.2018.21
Sensory neurons in the lungs suppress immune responses to bacterial lung infections.
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Vaccines: Stem cell hope for cancer treatment
p223 | doi:10.1038/nri.2018.16
An irradiated induced pluripotent stem cell-based vaccine induces cancer immunity in vivo.
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Stem cells: Escape from the Jedi
p224 | doi:10.1038/nri.2018.18
Quiescent adult stem cells escape immune surveillance by downregulating the antigen presentation machinery.
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JOURNAL CLUB
A novel genetic architecture of infectious diseases
p224 | doi:10.1038/nri.2018.19
Laurent Abel describes two landmark studies from 1996 that described the genetic susceptibility of children to severe mycobacterial infections.
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REVIEWS
| Top |
Microglia and macrophages in brain homeostasis and disease
Qingyun Li & Ben A. Barres
p225 | doi:10.1038/nri.2017.125
This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases.
Abstract | Full Text | PDF
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Peptidoglycan recognition by the innate immune system
Andrea J. Wolf & David M. Underhill
p243 | doi:10.1038/nri.2017.136
Peptidoglycan is an important structural component of bacterial cell walls, and mammalian cells express a number of distinct pattern-recognition receptors that detect peptidoglycan fragments. Here, the authors discuss new insights into the role of peptidoglycan recognition in inflammation, metabolism and disease.
Abstract | Full Text | PDF
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Viral subversion of B cell responses within secondary lymphoid organs
Mirela Kuka & Matteo Iannacone
p255 | doi:10.1038/nri.2017.133
The development of multiphoton intravital microscopy has enabled detailed studies of humoral responses within lymphoid tissues. Here, Kuka and Iannacone cover recent studies of the viral subversion of B cell responses and discuss how these findings relate to our understanding of B cell activation within secondary lymphoid organs.
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Tissue-specific immunopathology during malaria infection
Cevayir Coban, Michelle Sue Jann Lee & Ken J. Ishii
p266 | doi:10.1038/nri.2017.138
Although systemic infection is a hallmark of malaria disease, less is known regarding how parasitized erythrocytes interact locally with host tissues. In this Review, the authors discuss how infected erythrocytes reach different tissue environments and cause specific pathological consequences in malaria.
Abstract | Full Text | PDF
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PERSPECTIVES
| Top |
OPINION
How poverty affects diet to shape the microbiota and chronic disease
Christy A. Harrison & Douglas Taren
p279 | doi:10.1038/nri.2017.121
In this Opinion article, the authors consider how poverty and diet can shape the microbiota and immune health. They highlight how this contributes to the greater levels of chronic disease that are experienced by low-income individuals in high-income societies.
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