| A molecular atlas of cell types and zonation in the brain vasculature Single-cell transcriptomic analysis of the murine blood–brain barrier provides molecular definitions of the main vascular cell types, classifies perivascular cell types and sheds light on the organization of the arteriovenous axis. | A coherent spin–photon interface in silicon A single spin in silicon is strongly coupled to a microwave-frequency photon and coherent single-spin dynamics are observed using circuit quantum electrodynamics. | MEK drives BRAF activation through allosteric control of KSR proteins KSR–MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts, thus challenging the accepted role of KSR as a scaffold for MEK recruitment to RAF. | TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal cancers in mice. | Meridional overturning circulation conveys fast acidification to the deep Atlantic Ocean There has been a reduction of about forty per cent in the transport of carbonate ions to the deep North Atlantic Ocean since preindustrial times, severely endangering cold-water corals. | TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling. | Peptidoglycan synthesis drives an FtsZ-treadmilling-independent step of cytokinesis Single-cell fluorescence microscopy reveals that cytokinesis occurs in two stages in Staphylococcus aureus, an initial slow phase followed by a faster phase after MurJ protein recruitment to the midcell triggers peptidoglycan synthesis. | Global patterns of tropical forest fragmentation Satellite data and modelling reveal that tropical forest fragments have similar size distributions across continents, and that forest fragmentation is close to a critical point, beyond which fragment numbers will strongly increase. | Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo Stiffening of the mesoderm owing to an accumulation of cells triggers collective migration of neural crest cells during morphogenesis. | Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an epithelial-cell-autonomous basal pre-inflammatory state. | A programmable two-qubit quantum processor in silicon A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm. | Erratum: Measurement of the multi-TeV neutrino interaction cross-section with IceCube using Earth absorption | Corrigendum: Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors | | A parsec-scale optical jet from a massive young star in the Large Magellanic Cloud Observations of a highly collimated, parsec-scale jet emitted from a massive young stellar object in the Large Magellanic Cloud indicate that jet launching and collimation are independent of stellar mass. Anna F. McLeod, Megan Reiter, Rolf Kuiper et al. | Pulsating aurora from electron scattering by chorus waves High-angular-resolution measurements allow the direct observation of the scattering of energetic electrons by chorus waves in the magnetosphere, which causes quasiperiodic electron precipitation that gives rise to pulsating aurorae. S. Kasahara, Y. Miyoshi, S. Yokota et al. | A spin–orbital-entangled quantum liquid on a honeycomb lattice A quantum-liquid state of spin–orbital-entangled magnetic moments is observed in the 5d-electron honeycomb iridate H3LiIr2O6, evidenced by the absence of magnetic ordering down to 0.05 kelvin. K. Kitagawa, T. Takayama, Y. Matsumoto et al. | Freezing on a sphere Freezing on a spherical surface is shown to proceed by the sequestration of defects into 12 icosahedrally coordinated ‘seas’ that enable the formation of a crystalline ‘continent’ with long-range orientational order. Rodrigo E. Guerra, Colm P. Kelleher, Andrew D. Hollingsworth et al. | Southern Hemisphere climate variability forced by Northern Hemisphere ice-sheet topography An Antarctic ice core reveals that, during the last ice age, the topography of Northern Hemisphere ice sheets shifted tropical Pacific convection eastward, increasing climate variability in the high southern latitudes. T. R. Jones, W. H. G. Roberts, E. J. Steig et al. | Global patterns of declining temperature variability from the Last Glacial Maximum to the Holocene Temperature variability decreased globally by a factor of four between the Last Glacial Maximum and the Holocene epoch, as a result of changes in the meridional temperature gradient. Kira Rehfeld, Thomas Münch, Sze Ling Ho et al. | Fluctuating interaction network and time-varying stability of a natural fish community A method for modelling time-varying dynamic stability in a natural marine fish community finds that seasonal patterns in community stability are driven by species diversity and interspecific interactions. Masayuki Ushio, Chih-hao Hsieh, Reiji Masuda et al. | Cognitive performance is linked to group size and affects fitness in Australian magpies Wild Australian magpies (Cracticus tibicen dorsalis) living in large groups show increased cognitive performance, which is associated with increased reproductive success. Benjamin J. Ashton, Amanda R. Ridley, Emily K. Edwards et al. | Posterior parietal cortex represents sensory history and mediates its effects on behaviour A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information. Athena Akrami, Charles D. Kopec, Mathew E. Diamond et al. | c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory TH17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease. Mo Xu, Maria Pokrovskii, Yi Ding et al. | Asparagine bioavailability governs metastasis in a model of breast cancer In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression. Simon R. V. Knott, Elvin Wagenblast, Showkhin Khan et al. | Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis Formation of inter-organelle contacts between mitochondria and lysosomes, regulated by lysosomal RAB7 GTP hydrolysis, allows for bidirectional regulation of mitochondrial and lysosomal dynamics. Yvette C. Wong, Daniel Ysselstein, Dimitri Krainc | Structural basis for DNMT3A-mediated de novo DNA methylation A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes its aetiological link to human disease. Zhi-Min Zhang, Rui Lu, Pengcheng Wang et al. | | | | Receive up to $35,000 to fund your science outreach project The ASCB Public Engagement Grants will provide funding, mentoring, and project assessment to ASCB members interested in public outreach in scientific areas. Funded by the Simons Foundation's Science Sandbox. 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