| | | | | Table of ContentsOpinion News & Views Articles | Volume 37, Number 4 | Opinion | An account of how a surprising finding became a controversial topic, and how a group of researchers persevered over 20 years to attain broad acceptance. Alain Prochiantz Published online 17.01.2018 | News & Views | A C‐terminal domain of ATG16L1 determines whether it can function in LC3 lipidation of single membranes, a modification occurring during LC3‐dependent but autophagy‐unrelated processes. Dorotea Fracchiolla and Sascha Martens Published online 05.02.2018 | | Proteolytic processing allows for STARD7 localization not only in the cytosol but also in the mitochondrial intermembrane space, where STARD7 enables mitochondrial function by shuttling phosphatidylcholine from the outer to the inner mitochondrial membrane. Toshiya Endo and Yasushi Tamura Published online 30.01.2018 | Articles | Ligase complex component ATG16L1 is required for LC3 lipidation of double‐membrane autophagsomes and of single membranes during phagocytosis and influenza infection, but only single membrane lipidation depends on ATG16L1's C‐terminal WD40 domain. Katherine Fletcher, Rachel Ulferts, Elise Jacquin, Talitha Veith, Noor Gammoh, Julia M Arasteh, Ulrike Mayer, Simon R Carding, Thomas Wileman, Rupert Beale and Oliver Florey | | The rhomboid protease PARL cleaves the lipid transfer protein STARD7 at the inner membrane of mitochondria, allowing its partitioning between the mitochondrial intermembrane space and the cytosol. Shotaro Saita, Takashi Tatsuta, Philipp A Lampe, Tim König, Yohsuke Ohba and Thomas Langer Published online 04.01.2018 | | Migrating olfactory neurons extend a filopodium‐like lateral protrusion to terminate neuronal migration at the correct position in the olfactory bulb via Sema3E‐PlexinD1‐Rac1 signaling. Masato Sawada, Nobuhiko Ohno, Mitsuyasu Kawaguchi, Shih‐hui Huang, Takao Hikita, Youmei Sakurai, Huy Bang Nguyen, Truc Quynh Thai, Yuri Ishido, Yutaka Yoshida, Hidehiko Nakagawa, Akiyoshi Uemura and Kazunobu Sawamoto Published online 18.01.2018 | | Dicer inhibition by LGP2 may help to preserve viral dsRNA as substrate for innate immune receptor signalling, reinforcing the dominance of type I interferon signalling over RNAi in vertebrate antiviral defences. Annemarthe G van der Veen, Pierre V Maillard, Jan Marten Schmidt, Sonia A Lee, Safia Deddouche‐Grass, Annabel Borg, Svend Kjær, Ambrosius P Snijders and Caetano Reis e Sousa | | By acting as roadblocks for elongating RNA polymerase II, a range of DNA‐binding proteins provide a fail‐safe mechanism for canonical transcription termination, thereby preventing pervasive transcription. Tito Candelli, Drice Challal, Jean‐Baptiste Briand, Jocelyne Boulay, Odil Porrua, Jessie Colin and Domenico Libri Published online 19.01.2018 | | Palmitoylated Wnt proteins regulate the stability of their cargo receptor Evi/Wls by protecting it from ERAD‐mediated degradation, thus in turn promoting Wnt secretion. Kathrin Glaeser, Manuela Urban, Emma Fenech, Oksana Voloshanenko, Dominique Kranz, Federica Lari, John C Christianson and Michael Boutros | | Structural analyses of the Vibrio cholerae Type VI secretion system reveal a bacteriophage‐related minimalist baseplate as well as the unusual star‐like conformation of the distal end of its sheath. Sergey Nazarov, Johannes P Schneider, Maximilian Brackmann, Kenneth N Goldie, Henning Stahlberg and Marek Basler | | | | Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation. | | | |
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