EMBO reports Table of Contents for June 2017; Vol. 18, No. 6

June 2017 | Volume 18, Number 6 Submit Table of Contents Opinion News & Views Correspondence Science & Society Scientific Reports Articles Volume 18, Number 6 Opinion Optical and chemical discoveries recognized for impact on biology and psychiatry The 2017 EKF Prize winner discusses his work in optogenetics and hydrogel‐tissue chemistry and how it leads to a better understanding of the structural and functional changes in the brain of depression patients. Karl Deisseroth Published online 31.05.2017 News & Views TZAP‐ing telomeres down to size The zinc finger protein ZBTB48/TZAP directly binds telomeres and limits their elongation. TZAP also transcriptionally activates a defined set of genes, including mitochondrial fission process 1, linking telomere length regulation and mitochondrial metabolism. Laura Garcia‐Exposito and Roderick J O'Sullivan Published online 12.05.2017 Parkin‐independent mitophagy—FKBP8 takes the stage A study in this issue identifies FKBP8 as a novel Parkin‐independent mitophagy receptor that interacts preferentially with LC3A. FKBP8 itself avoids degradation by escaping from the mitochondria before their destruction. Grace GY Lim and Kah‐Leong Lim Published online 17.05.2017 Correspondence Comment on “Improving research misconduct policies” by Redman & Caplan A comment on “Improving research misconduct policies” by Barbara K Redman & Arthur L Caplan. Brian C Martinson, Carol R Thrush, and CK Gunsalus Published online 04.05.2017 Response by the authors The response by the authors. Barbara K Redman and Arthur L Caplan Published online 04.05.2017 Science & Society Self‐healing capacity of deep‐sea ecosystems affected by petroleum hydrocarbons: Understanding microbial oil degradation at hydrocarbon seeps is key to sustainable bioremediation protocols A rich microbiota in the deep‐sea oceans has evolved to live off petroleum from natural oil seeps. Understanding their ecology and biology could inform measures for sustainable bioremediation of artificial oil spills. Alberto Scoma, Michail M Yakimov, Daniele Daffonchio, and Nico Boon Published online 17.05.2017 Understanding the brain in health and disease: An interview with Karl Deisseroth, Professor of Bioengineering and Psychiatry at Stanford University Karl Deisseroth, winner of the 2017 EKF prize, talks about the potential of recent and future developments in neuroscience and how these help to illuminate our understanding of the brain in health and psychiatric disease (photo credit: Steve Fisch). Esther Schnapp and Holger Breithaupt Published online 31.05.2017 Agricultural pest control with CRISPR‐based gene drive: time for public debate: Should we use gene drive for pest control? Gene drive technology to control disease vectors or pests has great potential for addressing humanitarian and public health problems. Its application for pest control in agriculture, however, raises important environmental, social and ethical issues. Virginie Courtier‐Orgogozo, Baptiste Morizot, and Christophe Boëte Published online 16.05.2017 Novel diagnostic technologies for clinical and frontline use: Advanced diagnostics based on molecular markers and analysis technologies has been improving diagnosis across a wide range of diseases Misdiagnosis is a major problem in health care that can cause preventable suffering or even death. Advanced diagnostics based on molecular cues can greatly improve speed and accuracy of diagnosis and help practitioners identify appropriate treatments. Philip Hunter Published online 17.05.2017 Scientific Reports Hyper‐reactive cloned mice generated by direct nuclear transfer of antigen‐specific CD4+ T cells TCR‐transgenic mice are important tools to analyze antigen‐response mechanisms. This study describes the generation of antigen‐specific mice cloned from T cells, which exhibit rearranged TCR‐dependent antigen reactivity and allergic predispositions. Osamu Kaminuma, Kazufumi Katayama, Kimiko Inoue, Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Yusuke Shimo, Soichi Tofukuji, Satoru Ishida, Narumi Ogonuki, Satoshi Kamimura, Mami Oikawa, Shigeki Katoh, Akio Mori, Michitaka Shichijo, Takachika Hiroi, and Atsuo Ogura Published online 02.05.2017 Molecular basis for Cdk1‐regulated timing of Mis18 complex assembly and CENP‐A deposition The cell cycle‐dependent assembly of the Mis18 complex is essential for HJURP‐mediated CENP‐A deposition at centromeres. This study presents the molecular basis for how the Mis18 complex is assembled and how Cdk1 times the assembly. Frances Spiller, Bethan Medina‐Pritchard, Maria Alba Abad, Martin A Wear, Oscar Molina, William C Earnshaw, and A Arockia Jeyaprakash Published online 04.04.2017 Structural insight into recognition of phosphorylated threonine‐4 of RNA polymerase II C‐terminal domain by Rtt103p Phosphorylation of RNA Pol II CTD recruits several transcription and RNA processing factors, including yeast transcription termination factor Rtt103p. This study provides the structural basis for how the CTD‐interacting domain of Rtt103p recognizes pThr4 and pSer2 CTD. Olga Jasnovidova, Magdalena Krejcikova, Karel Kubicek, and Richard Stefl Published online 02.05.2017 Articles The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats This study shows that ATRX recruitment to G‐rich tandem repeats depends on repeat transcription, length and orientation and is associated with R‐loops. ATRX loss increases R‐loops at these sites suggesting that ATRX resolves DNA secondary structures. Diu TT Nguyen, Hsiao Phin J Voon, Barbara Xella, Caroline Scott, David Clynes, Christian Babbs, Helena Ayyub, Jon Kerry, Jacqueline A Sharpe, Jackie A Sloane‐Stanley, Sue Butler, Chris A Fisher, Nicki E Gray, Thomas Jenuwein, Douglas R Higgs, and Richard J Gibbons Published online 09.05.2017 ZBTB48 is both a vertebrate telomere‐binding protein and a transcriptional activator The zinc finger protein ZBTB48 directly binds telomeres and limits their elongation. ZBTB48 also transcriptionally activates a defined set of genes, including mitochondrial fission process 1, linking telomere length regulation and mitochondrial metabolism. Arne Jahn, Grishma Rane, Maciej Paszkowski‐Rogacz, Sergi Sayols, Alina Bluhm, Chung‐Ting Han, Irena Draškovič, José Arturo Londoño‐Vallejo, Alan Prem Kumar, Frank Buchholz, Falk Butter, and Dennis Kappei Published online 12.05.2017 FKBP8 recruits LC3A to mediate Parkin‐independent mitophagy FKBP8 (also called FKBP38) is a novel mitophagy receptor that selectively recruits LC3A to damaged mitochondria to mediate Parkin‐independent degradation of mitochondria by autophagy. The anti‐apoptotic FKBP8 itself escapes degradation to ensure cell survival. Zambarlal Bhujabal, Åsa B Birgisdottir, Eva Sjøttem, Hanne B Brenne, Aud Øvervatn, Sabrina Habisov, Vladimir Kirkin, Trond Lamark, and Terje Johansen Published online 05.04.2017 Posttranslational modification impact on the mechanism by which amyloid‐β induces synaptic dysfunction This study shows that posttranslationally modified Aβ oligomers trigger synaptic dysfunction via different pathological signalling. Variability in modified Aβ isoforms between AD patients may result in different pathomechanisms and clinical trajectories. Katarzyna M Grochowska, PingAn Yuanxiang, Julia Bär, Rajeev Raman, Gemma Brugal, Giriraj Sahu, Michaela Schweizer, Arthur Bikbaev, Stephan Schilling, Hans‐Ulrich Demuth, and Michael R Kreutz Published online 18.04.2017 Structural basis for ligand capture and release by the endocytic receptor ApoER2 The crystal structure of the ApoER2 ectodomain in complex with reelin serves as a representative model for the pH‐dependent ligand uptake mechanism conserved within the LDLR family. Hidenori Hirai, Norihisa Yasui, Keitaro Yamashita, Sanae Tabata, Masaki Yamamoto, Junichi Takagi, and Terukazu Nogi Published online 26.04.2017 Chromatin determinants impart camptothecin sensitivity Camptothecin traps topoisomerase on DNA, which generates DNA damage and topological chromosomal stress in S phase. Synthetic viability screening reveals that Sir2 deacetylase activity drives topology‐mediated camptothecin sensitivity in yeast and human cells. Fabio Puddu, Israel Salguero, Mareike Herzog, Nicola J Geisler, Vincenzo Costanzo, and Stephen P Jackson Published online 07.04.2017 Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns Post‐translational modifications of tubulin control the function of the microtubule cytoskeleton. Modeling of the molecular interactions between two tubulin glutamylases and their tubulin substrates reveals how these enzymes could generate distinct glutamylation patterns. Kathiresan Natarajan, Sudarshan Gadadhar, Judith Souphron, Maria M Magiera, and Carsten Janke Published online 08.05.2017 Vesicular stomatitis virus N protein‐specific single‐domain antibody fragments inhibit replication Nanobodies are promising tools to target and study RNA viruses. In this study the binding sites of alpaca single‐domain antibodies on the vesicular stomatitis virus are determined and their antiviral activity is analyzed using escape mutants. Leo Hanke, Florian I Schmidt, Kevin E Knockenhauer, Benjamin Morin, Sean PJ Whelan, Thomas U Schwartz, and Hidde L Ploegh Published online 10.04.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.