The EMBO Journal Table of Contents for 01 June 2017; Vol. 36, No. 11

01 June 2017 | Volume 36, Number 11 Submit Table of Contents News & Views Review Articles Corrigenda Volume 36, Number 11 News & Views Judging a tumor cell by its cover: a matter of mitochondrial contact sites ER–mitochondria contacts control glycan surface expression and immune sensitivity of glioma stem cells. Sowmya Lakshminarayanan and Luca Scorrano Published online 16.03.2017 Dalmatian: spotting the difference in cohesin protectors A single fly protein combines the respective roles of vertebrate sororin and shugoshin in establishment and protection of sister chromatid cohesion. Adele L Marston Published online 08.05.2017 Gene body DNA methylation conspires with H3K36me3 to preclude aberrant transcription Intragenic DNA methylation by DNMT3B prevents spurious transcription initiation in murine embryonic stem cells. Aurélie Teissandier and Déborah Bourc'his Published online 25.04.2017 Review Focus: Metabolism: Brain metabolism in health, aging, and neurodegeneration As part of our metabolism focus, this review provides an overview of cellular and molecular mechanisms that regulate brain energy metabolism and how such mechanisms are altered during aging and disease. Simonetta Camandola and Mark P Mattson Published online 24.04.2017 Articles ER–mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem‐like cells The increased immune sensitivity of glioma stem‐like cells is linked to mitochondrial morphology and dynamics, which affect presentation of sialylated glycan markers. Esen Yonca Bassoy, Atsuko Kasahara, Valentina Chiusolo, Guillaume Jacquemin, Emma Boydell, Sebastian Zamorano, Cristina Riccadonna, Serena Pellegatta, Nicolas Hulo, Valérie Dutoit, Madiha Derouazi, Pierre Yves Dietrich, Paul R Walker, and Denis Martinvalet Published online 10.03.2017 Drosophila Dalmatian combines sororin and shugoshin roles in establishment and protection of cohesion The ortholog of vertebrate sororin combines classical Wapl‐counteracting functions for mitotic cohesin establishment with shugoshin‐like, heterochromatin‐dependent cohesin maintenance activities. Takashi Yamada, Eri Tahara, Mai Kanke, Keiko Kuwata, and Tomoko Nishiyama Published online 08.05.2017 PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing In addition to activating expression of brown fat‐specific genes, PRDM16 prevents the induction of type I interferon‐stimulated genes, thereby ensuring maintenance of mitochondrial function and brown and beige adipocyte character. Megan Kissig, Jeff Ishibashi, Matthew J Harms, Hee‐Woong Lim, Rachel R Stine, Kyoung‐Jae Won, and Patrick Seale Published online 13.04.2017 Mfn2 is critical for brown adipose tissue thermogenic function Mitofusin 2 (Mfn2) is critical for brown adipose tissue thermogenic function and participates in the functional relationship between mitochondria and lipid droplets. Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera‐Alberni, Roy Combe, Antonio Zorzano, and Carles Cantó Published online 27.03.2017 The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum Oceanic algae can be metabolically re‐wired for lipid production. In the unicellular photosynthetic eukaryote P. tricornutum, the widely conserved transcription factor bZIP14 is linked to TCA cycle modulation upon reduced nitrogen availability and diurnal changes. Michiel Matthijs, Michele Fabris, Toshihiro Obata, Imogen Foubert, José Manuel Franco‐Zorrilla, Roberto Solano, Alisdair R Fernie, Wim Vyverman, and Alain Goossens Published online 18.04.2017 Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis Electron cryotomography of intact Gram‐negative bacteria shows asymmetric initiation of the division furrow, accompanied by localized peptidoglycan synthesis and incomplete FtsZ ring formation. Qing Yao, Andrew I Jewett, Yi‐Wei Chang, Catherine M Oikonomou, Morgan Beeby, Cristina V Iancu, Ariane Briegel, Debnath Ghosal, and Grant J Jensen Published online 24.04.2017 Sen1 has unique structural features grafted on the architecture of the Upf1‐like helicase family The core domain of RNA helicase Sen1 displays unique structural features that contribute to RNA unwinding activity and transcription termination, and explains the impact of patient mutations from the human ortholog senataxin. Bronislava Leonaitė, Zhong Han, Jérôme Basquin, Fabien Bonneau, Domenico Libri, Odil Porrua, and Elena Conti Published online 13.04.2017 A new sub‐pathway of long‐patch base excision repair involving 5′ gap formation Formation of a ssDNA gap and involvement of PARP1, RECQ1 and ERCC1‐XPF in response to various forms of oxidative and alkylation damage challenge current models of mammalian base excision repair. Jordan Woodrick, Suhani Gupta, Sharon Camacho, Swetha Parvathaneni, Sujata Choudhury, Amrita Cheema, Yi Bai, Pooja Khatkar, Hayriye Verda Erkizan, Furqan Sami, Yan Su, Orlando D Schärer, Sudha Sharma, and Rabindra Roy Published online 03.04.2017 USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling Reversible ubiquitination controls dynamic SMAD4 activity in mESCs and zebrafish, showing that the SMURF2 ubiquitin ligase is not only involved in initiation but also in termination of TGF‐β family signaling. Fangfang Zhou, Feng Xie, Ke Jin, Zhengkui Zhang, Marcello Clerici, Rui Gao, Maarten van Dinther, Titia K Sixma, Huizhe Huang, Long Zhang, and Peter ten Dijke Published online 03.05.2017 Corrigenda BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response Karen Castillo, Diego Rojas‐Rivera, Fernanda Lisbona, Benjamín Caballero, Melissa Nassif, Felipe A Court, Sebastian Schuck, Consuelo Ibar, Peter Walter, Jimena Sierralta, Alvaro Glavic, and Claudio Hetz Published online 01.06.2017 Plant virus‐mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation Éva Várallyay, Anna Válóczi, Ákos Ágyi, József Burgyán, and Zoltán Havelda Published online 01.06.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.