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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Correspondence | | | | | | | | | | | | Latest Articles | View all Articles | | | | | Thermoelectric quantum oscillations in ZrSiS OPEN | | | Marcin Matusiak, J. R. Cooper and Dariusz Kaczorowski | | | Studies of quantum oscillations provide a valuable probe into the electronic structure of topological semimetals. Matusiak et al. demonstrate that quantum features in ZrSiS can be probed with greater sensitivity using diffusive thermopower than magnetization and electrical resistivity approaches. | | | 23 May 2017 | doi: 10.1038/ncomms15219 | | |
| A light-driven artificial flytrap OPEN | | | Owies M. Wani, Hao Zeng and Arri Priimagi | | | Stimuli-responsive materials are commonly used in autonomous systems, whilst it is challenging to power them in a programmable manner. Here, Wani et al. use an optical fibre to control the shape of light-responsive liquid-crystal elastomers, which allow the device to detect and trap targeted objects. | | | 23 May 2017 | doi: 10.1038/ncomms15546 | | |
| Time-compressed preplay of anticipated events in human primary visual cortex OPEN | | | Matthias Ekman, Peter Kok and Floris P. de Lange | | | Perception is guided by anticipating future events, but it is not clear how this is computed neurally. Here, the authors use ultra-fast fMRI to show that humans preplay anticipated visual sequences in the primary visual cortex and that this preplay correlates with faster detection of the stimuli. | | | 23 May 2017 | doi: 10.1038/ncomms15276 | | |
| Structural basis for perception of diverse chemical substances by T1r taste receptors OPEN | | | Nipawan Nuemket, Norihisa Yasui, Yuko Kusakabe, Yukiyo Nomura, Nanako Atsumi, Shuji Akiyama, Eriko Nango, Yukinari Kato, Mika K. Kaneko, Junichi Takagi, Maiko Hosotani and Atsuko Yamashita | | | Nutrients taste perception is mediated by T1r receptors that discriminate specific tastes among their wide diversity. Here the authors present crystal structures of the ligand-binding domains of the fish T1r2-T1r3 receptor, providing a structural framework for its ligand recognition. | | | 23 May 2017 | doi: 10.1038/ncomms15530 | | |
| Efficient protein production inspired by how spiders make silk OPEN | | | Nina Kronqvist, Médoune Sarr, Anton Lindqvist, Kerstin Nordling, Martins Otikovs, Luca Venturi, Barbara Pioselli, Pasi Purhonen, Michael Landreh, Henrik Biverstål, Zigmantas Toleikis, Lisa Sjöberg, Carol V. Robinson, Nicola Pelizzi, Hans Jörnvall, Hans Hebert, Kristaps Jaudzems, Tore Curstedt, Anna Rising and Jan Johansson et al. | | | The properties of many transmembrane or aggregation-prone proteins make them difficult to recombinantly express. Here the authors use a modified N-terminal domain of a spider silk protein to express and purify several difficult to express proteins at levels considerably higher than with conventional tags. | | | 23 May 2017 | doi: 10.1038/ncomms15504 | | |
| Airborne observations reveal elevational gradient in tropical forest isoprene emissions OPEN | | | Dasa Gu, Alex B. Guenther, John E. Shilling, Haofei Yu, Maoyi Huang, Chun Zhao, Qing Yang, Scot T. Martin, Paulo Artaxo, Saewung Kim, Roger Seco, Trissevgeni Stavrakou, Karla M. Longo, Julio Tóta, Rodrigo Augusto Ferreira de Souza, Oscar Vega, Ying Liu, Manish Shrivastava, Eliane G. Alves, Fernando C. Santos et al. | | | Isoprene emissions are commonly estimated using satellite measurements and model simulations. Here, using eddy covariance, the authors report higher emission rates over the Amazon forest than those estimated with these techniques and a relationship between terrain elevation and isoprene emissions. | | | 23 May 2017 | doi: 10.1038/ncomms15541 | | |
| Quantifying similarity of pore-geometry in nanoporous materials OPEN | | | Yongjin Lee, Senja D. Barthel, Paweł Dłotko, S. Mohamad Moosavi, Kathryn Hess and Berend Smit | | | Pore structure plays an important role in dictating gas storage performance for nanoporous materials. Here, Smit and colleagues develop a topological approach to quantify pore structure similarity, and exploit the resulting descriptor to screen for materials that possess structural similarities with top-performers. | | | 23 May 2017 | doi: 10.1038/ncomms15396 | | |
| Long-term mutual phase locking of picosecond pulse pairs generated by a semiconductor nanowire laser OPEN | | | B. Mayer, A. Regler, S. Sterzl, T. Stettner, G. Koblmüller, M. Kaniber, B. Lingnau, K. Lüdge and J. J. Finley | | | Although nanolasers have been an active field of research for over a decade, mode-locking on the nanoscale has not been achieved yet. Here, Mayer et al. show that semiconductor nanowire lasers can emit pairs of phase-locked picosecond pulses when the nanowires are incoherently pumped. | | | 23 May 2017 | doi: 10.1038/ncomms15521 | | |
| Observed variations in U.S. frost timing linked to atmospheric circulation patterns OPEN | | | Courtenay Strong and Gregory J. McCabe | | | Over the past century, the frost-free season in the US has lengthened. Here, Strong and McCabe show that most of the variability of spring and fall-frost timing is determined by atmospheric circulation patterns and needs to be considered in future projections of growing season length. | | | 23 May 2017 | doi: 10.1038/ncomms15307 | | |
| Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus OPEN | | | Abhay Kotecha, Quan Wang, Xianchi Dong, Serban L. Ilca, Marina Ondiviela, Rao Zihe, Julian Seago, Bryan Charleston, Elizabeth E. Fry, Nicola G. A. Abrescia, Timothy A. Springer, Juha T. Huiskonen and David I. Stuart | | | Foot-and-mouth disease virus binds αvβ6 integrin, via a conserved RGD motif in the flexible, exposed GH loop of capsid protein VP1, for cell entry. Here Kotecha et al. visualize this interaction with the VP1 GH loop extending away from the viral surface, engaging αvβ6 in an open, active state. | | | 23 May 2017 | doi: 10.1038/ncomms15408 | | |
| Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus OPEN | | | Debajit Saha, Wensheng Sun, Chao Li, Srinath Nizampatnam, William Padovano, Zhengdao Chen, Alex Chen, Ege Altan, Ray Lo, Dennis L. Barbour and Baranidharan Raman | | | Sensory stimuli evoke temporally dynamic responses. Here the authors report that responses to odour onset and offset are orthogonally represented in the locust antennal lobe, differentially entrain oscillations, and propose a model in which they are necessary for initiation and termination of behaviour. | | | 23 May 2017 | doi: 10.1038/ncomms15413 | | |
| Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression OPEN | | | Joseph Rosenbluh, Han Xu, William Harrington, Stanley Gill, Xiaoxing Wang, Francisca Vazquez, David E. Root, Aviad Tsherniak and William C. Hahn | | | CRISPR-Cas9 has been utilized to screen the genome in loss-of-function studies to identify genetic interactions. Here the authors compare catalytically active and dead Cas9 and observe different off-target effects in a screen for essential genes. | | | 23 May 2017 | doi: 10.1038/ncomms15403 | | |
| Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1 OPEN | | | Xiuyuan Ou, Hongxin Guan, Bo Qin, Zhixia Mu, Justyna A. Wojdyla, Meitian Wang, Samuel R. Dominguez, Zhaohui Qian and Sheng Cui | | | Human coronavirus HKU1 can cause severe respiratory diseases in young children and immunocompromised patients. Here, the authors present the structure of the C-terminal domain of the viral spike glycoprotein S1 subunit, which is important for host cell receptor binding. | | | 23 May 2017 | doi: 10.1038/ncomms15216 | | |
| Decoding and reprogramming fungal iterative nonribosomal peptide synthetases OPEN | | | Dayu Yu, Fuchao Xu, Shuwei Zhang and Jixun Zhan | | | Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify these enzymes to produce specific nonribosomal peptides. | | | 23 May 2017 | doi: 10.1038/ncomms15349 | | |
| Top predators constrain mesopredator distributions OPEN | | | Thomas M. Newsome, Aaron C. Greenville, Duško Ćirović, Christopher R. Dickman, Chris N. Johnson, Miha Krofel, Mike Letnic, William J. Ripple, Euan G. Ritchie, Stoyan Stoyanov and Aaron J. Wirsing | | | Top predators can reduce local mesopredator abundance either through direct predation or behavioural changes. Here, Newsome and colleagues demonstrate at a landscape scale across three continents that mesopredator populations are suppressed at the core, but less so on the periphery, of top predators’ ranges. | | | 23 May 2017 | doi: 10.1038/ncomms15469 | | |
| Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1 OPEN | | | Francesca Pasutto, Matthias Zenkel, Ursula Hoja, Daniel Berner, Steffen Uebe, Fulvia Ferrazzi, Johannes Schödel, Panah Liravi, Mineo Ozaki, Daniela Paoli, Paolo Frezzotti, Takanori Mizoguchi, Satoko Nakano, Toshiaki Kubota, Shinichi Manabe, Erika Salvi, Paolo Manunta, Daniele Cusi, Christian Gieger, Heinz-Erich Wichmann et al. | | | LOXL1 is a genetic risk factor for pseudoexfoliation syndrome of the eye but a causal variant has not been identified. Here, Pasutto et al., find intronic LOXL1 risk variants influence transcription factor binding and alternative splicing of LOXL1 in affected tissues reducing levels of LOXL1 mRNA. | | | 23 May 2017 | doi: 10.1038/ncomms15466 | | |
| Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis OPEN | | | Nicolas Rosewick, Keith Durkin, Maria Artesi, Ambroise Marçais, Vincent Hahaut, Philip Griebel, Natasa Arsic, Véronique Avettand-Fenoel, Arsène Burny, Carole Charlier, Olivier Hermine, Michel Georges and Anne Van den Broeke | | | Human T-cell leukaemia virus type-1 and bovine leukaemia virus infect T and B lymphocytes and lead to aggressive leukaemia. Here, the authors show these proviruses integrate near cancer drivers perturbing transcription termination or antisense RNA-dependent interaction, suggesting post-transcriptional mechanisms in some cases. | | | 23 May 2017 | doi: 10.1038/ncomms15264 | | |
| Two forms of death in ageing Caenorhabditis elegans OPEN | | | Yuan Zhao, Ann F. Gilliat, Matthias Ziehm, Mark Turmaine, Hongyuan Wang, Marina Ezcurra, Chenhao Yang, George Phillips, David McBay, William B. Zhang, Linda Partridge, Zachary Pincus and David Gems | | | Despite its wide use in ageing research, the contribution of specific age-associated pathologies to C. elegans mortality is not well understood. Here the authors identify two types of death in worms, with either a swollen or a shrunken pharynx, that are differentially affected by age and mutations that extend worm lifespan. | | | 23 May 2017 | doi: 10.1038/ncomms15458 | | |
| An engineered high affinity Fbs1 carbohydrate binding protein for selective capture of N-glycans and N-glycopeptides OPEN | | | Minyong Chen, Xiaofeng Shi, Rebecca M. Duke, Cristian I. Ruse, Nan Dai, Christopher H. Taron and James C. Samuelson | | | Protein glycosylation is an essential post-translational modification which analysis is complicated by the diversity of glycan composition and heterogeneity at individual attachment sites. Here the authors describe a method to selectively enrich N-linked glycopeptides to facilitate the detection of micro-heterogeneity in N-glycosylation. | | | 23 May 2017 | doi: 10.1038/ncomms15487 | | |
| USP13 negatively regulates antiviral responses by deubiquitinating STING OPEN | | | He Sun, Qiang Zhang, Ying-Ying Jing, Man Zhang, Hai-Ying Wang, Zeng Cai, Tianzi Liuyu, Zhi-Dong Zhang, Tian-Chen Xiong, Yan Wu, Qi-Yun Zhu, Jing Yao, Hong-Bing Shu, Dandan Lin and Bo Zhong | | | The cGAS-STING pathway is a DNA sensing mechanism that enables response to viral infection by inducing type 1 interferon expression. Here the authors show a mechanism by which the deubiquitinating enzyme USP13 prevents STING from enabling response to virus. | | | 23 May 2017 | doi: 10.1038/ncomms15534 | | |
| Electronic evidence of temperature-induced Lifshitz transition and topological nature in ZrTe5 OPEN | | | Yan Zhang, Chenlu Wang, Li Yu, Guodong Liu, Aiji Liang, Jianwei Huang, Simin Nie, Xuan Sun, Yuxiao Zhang, Bing Shen, Jing Liu, Hongming Weng, Lingxiao Zhao, Genfu Chen, Xiaowen Jia, Cheng Hu, Ying Ding, Wenjuan Zhao, Qiang Gao, Cong Li et al. | | | To understand the anomalous electronic transport properties of ZrTe5 remains an elusive puzzle. Here, Zhang et al. report direct electronic evidence to the origin of the resistivity anomaly and temperature induced Lifshitz transition in ZrTe5, indicating it being a weak topological insulator. | | | 23 May 2017 | doi: 10.1038/ncomms15512 | | |
| Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception OPEN | | | Raffaele Mazziotti, Laura Baroncelli, Nicholas Ceglia, Gabriele Chelini, Grazia Della Sala, Christophe Magnan, Debora Napoli, Elena Putignano, Davide Silingardi, Jonida Tola, Paola Tognini, J. Simon C. Arthur, Pierre Baldi and Tommaso Pizzorusso | | | miR-132/212 has been implicated in ocular dominance plasticity during the critical period. Here the authors show that miR-132/212 regulates the expression of genes involved in visual cortex maturation, and that mice lack miR-132/212 show deficits in binocular matching of orientation preferences, which leads to impaired depth perception. | | | 23 May 2017 | doi: 10.1038/ncomms15488 | | |
| Impact of fat mass and distribution on lipid turnover in human adipose tissue OPEN | | | Kirsty L. Spalding, Samuel Bernard, Erik Näslund, Mehran Salehpour, Göran Possnert, Lena Appelsved, Keng-Yeh Fu, Kanar Alkass, Henrik Druid, Anders Thorell, Mikael Rydén and Peter Arner | | | Lipid turnover in tissues can be calculated from ratios of different carbon isotopes. Here the authors use this approach to study lipid turnover in two distinct adipose tissue depots and find that, in obese individuals, visceral fat is more lipolytic than subcutaneous fat. | | | 23 May 2017 | doi: 10.1038/ncomms15253 | | |
| Molecular basis for PrimPol recruitment to replication forks by RPA OPEN | | | Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin and Aidan J. Doherty | | | PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stimulates its primase activity. | | | 23 May 2017 | doi: 10.1038/ncomms15222 | | |
| Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 OPEN | | | Cecilie Morland, Krister A. Andersson, Øyvind P. Haugen, Alena Hadzic, Liv Kleppa, Andreas Gille, Johanne E. Rinholm, Vuk Palibrk, Elisabeth H. Diget, Lauritz H. Kennedy, Tomas Stølen, Eivind Hennestad, Olve Moldestad, Yiqing Cai, Maja Puchades, Stefan Offermanns, Koen Vervaeke, Magnar Bjørås, Ulrik Wisløff, Jon Storm-Mathisen et al. | | | Physical exercise promotes brain angiogenesis through an unknown signalling cascade. Morland et al. identify the elusive muscle-brain communication and show that lactate produced by muscle activity binds to its receptor HCAR1 in brain vessel-surrounding cells, stimulating VEGF production and brain angiogenesis. | | | 23 May 2017 | doi: 10.1038/ncomms15557 | | |
| Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope OPEN | | | Alexander Rouvinski, Wanwisa Dejnirattisai, Pablo Guardado-Calvo, Marie-Christine Vaney, Arvind Sharma, Stéphane Duquerroy, Piyada Supasa, Wiyada Wongwiwat, Ahmed Haouz, Giovanna Barba-Spaeth, Juthathip Mongkolsapaya, Félix A. Rey and Gavin R. Screaton | | | The immunodominant epitope of dengue virus envelope protein (E) induces poorly neutralizing antibodies, which poses a problem for vaccine development. Here, the authors engineer covalently locked E dimers exposing an epitope that has been shown to induce potent and broadly neutralizing antibodies. | | | 23 May 2017 | doi: 10.1038/ncomms15411 | | |
| MICU1 drives glycolysis and chemoresistance in ovarian cancer OPEN | | | Prabir K. Chakraborty, Soumyajit Banerjee Mustafi, Xunhao Xiong, Shailendra Kumar Dhar Dwivedi, Vasyl Nesin, Sounik Saha, Min Zhang, Danny Dhanasekaran, Muralidharan Jayaraman, Robert Mannel, Kathleen Moore, Scott McMeekin, Da Yang, Rosemary Zuna, Kai Ding, Leonidas Tsiokas, Resham Bhattacharya and Priyabrata Mukherjee | | | The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis. | | | 22 May 2017 | doi: 10.1038/ncomms14634 | | |
| pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase OPEN | | | Jian An, Charles M. Ponthier, Ragna Sack, Jan Seebacher, Michael B. Stadler, Katherine A. Donovan and Eric S. Fischer | | | Targeting therapeutically-relevant proteins for degradation is an emerging paradigm in drug discovery. Here the authors describe a sensitive pulse SILAC mass spectrometry-based proteomics approach that reports global changes in protein stability following drug treatment in a single time point experiment. | | | 22 May 2017 | doi: 10.1038/ncomms15398 | | |
| MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes OPEN | | | Juan Pablo Lopez, Laura M. Fiori, Cristiana Cruceanu, Rixing Lin, Benoit Labonte, Hannah M. Cates, Elizabeth A. Heller, Vincent Vialou, Stacy M. Ku, Christophe Gerald, Ming-Hu Han, Jane Foster, Benicio N. Frey, Claudio N. Soares, Daniel J. Müller, Faranak Farzan, Francesco Leri, Glenda M. MacQueen, Harriet Feilotter, Kathrin Tyryshkin et al. | | | Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways. | | | 22 May 2017 | doi: 10.1038/ncomms15497 | | |
| Deterministic strain-induced arrays of quantum emitters in a two-dimensional semiconductor OPEN | | | Artur Branny, Santosh Kumar, Raphaël Proux and Brian D Gerardot | | | The emergence of quantum emitters in 2D materials has led to the quest for methods and designs enabling their controllable spatial positioning. Here, the authors use strain engineering to fabricate a deterministic array of quantum emitters in WSe2 with nanometre positioning accuracy. | | | 22 May 2017 | doi: 10.1038/ncomms15053 | | |
| Large-scale quantum-emitter arrays in atomically thin semiconductors OPEN | | | Carmen Palacios-Berraquero, Dhiren M. Kara, Alejandro R.-P. Montblanch, Matteo Barbone, Pawel Latawiec, Duhee Yoon, Anna K. Ott, Marko Loncar, Andrea C. Ferrari and Mete Atatüre | | | Quantum emitters have been recently isolated in 2D materials, yet their spatial controllability remains an open challenge. Here, the authors devise a method to create arrays of quantum emitters in WSe2 and WS2, by taking advantage of the strain distribution induced by a nanopatterned silica substrate. | | | 22 May 2017 | doi: 10.1038/ncomms15093 | | |
| Interface-driven formation of a two-dimensional dodecagonal fullerene quasicrystal OPEN | | | M. Paßens, V. Caciuc, N. Atodiresei, M. Feuerbacher, M. Moors, R. E. Dunin-Borkowski, S. Blügel, R. Waser and S. Karthäuser | | | Quasicrystals promise exciting technological advances in optical devices, but their formation mechanism is yet not fully understood. Here, the authors describe a two-dimensional dodecagonal fullerene quasicrystal, forming on a Pt3Ti(111)-surface due to the complex adsorption-energy landscape. | | | 22 May 2017 | doi: 10.1038/ncomms15367 | | |
| Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity OPEN | | | Thi-Huong Nguyen, Nikolay Medvedev, Mihaela Delcea and Andreas Greinacher | | | Antibodies against the platelet factor 4 (PF4) support bacterial host defence but in some cases may lead to heparin-induced thrombocytopenia (HIT). Nguyen et al. show that in autoimmune HIT a subset of antibodies binds strongly to PF4 causing its conformational change that leads to association of non-pathogenic PF4 antibodies and thrombotic platelet activation. | | | 22 May 2017 | doi: 10.1038/ncomms14945 | | |
| Long-range ferrimagnetic order in a two-dimensional supramolecular Kondo lattice OPEN | | | Jan Girovsky, Jan Nowakowski, Md. Ehesan Ali, Milos Baljozovic, Harald R. Rossmann, Thomas Nijs, Elise A. Aeby, Sylwia Nowakowska, Dorota Siewert, Gitika Srivastava, Christian Wäckerlin, Jan Dreiser, Silvio Decurtins, Shi-Xia Liu, Peter M. Oppeneer, Thomas A. Jung and Nirmalya Ballav | | | Long-range magnetic order hardly ever emerges in a two-dimensional system due to the competition of fundamental magnetic interactions. Here, Girovsky et al. directly observe a long-range ferrimagnetic order emerging in a two-dimensional supramolecular Kondo lattice. | | | 22 May 2017 | doi: 10.1038/ncomms15388 | | |
| Hit and go CAS9 delivered through a lentiviral based self-limiting circuit OPEN | | | Gianluca Petris, Antonio Casini, Claudia Montagna, Francesca Lorenzin, Davide Prandi, Alessandro Romanel, Jacopo Zasso, Luciano Conti, Francesca Demichelis and Anna Cereseto | | | While CRISPR-Cas9 is a powerful technology, it’s in vivo application can be limited by unwanted off-target editing events. Here the authors present SLiCES, a self-limiting Cas9 circuit to enhance editing by preventing residual nuclease activity. | | | 22 May 2017 | doi: 10.1038/ncomms15334 | | |
| A canonical neural mechanism for behavioral variability OPEN | | | Ran Darshan, William E. Wood, Susan Peters, Arthur Leblois and David Hansel | | | Irregular neuronal activity is thought to underlie motor variability. Here the authors use a combination of modelling, neuronal recordings in singing birds and analysis of babbling vocalizations, including of human infants, to show that topographically organized inputs to a widely recurrent motor network self-organize to generate variable motor output. | | | 22 May 2017 | doi: 10.1038/ncomms15415 | | |
| Single-molecule detection of dihydroazulene photo-thermal reaction using break junction technique OPEN | | | Cancan Huang, Martyn Jevric, Anders Borges, Stine T. Olsen, Joseph M. Hamill, Jue-Ting Zheng, Yang Yang, Alexander Rudnev, Masoud Baghernejad, Peter Broekmann, Anne Ugleholdt Petersen, Thomas Wandlowski, Kurt V. Mikkelsen, Gemma C. Solomon, Mogens Brøndsted Nielsen and Wenjing Hong | | | The conductance across single-molecule junctions is highly dependent on the electronic properties of the molecule in question. Here the authors use this fact to monitor a photo-thermal reaction by analysing break junction data, and observe significant differences compared to solution state behaviour. | | | 22 May 2017 | doi: 10.1038/ncomms15436 | | |
| Thermogenetic neurostimulation with single-cell resolution OPEN | | | Yulia G. Ermakova, Aleksandr A. Lanin, Ilya V. Fedotov, Matvey Roshchin, Ilya V. Kelmanson, Dmitry Kulik, Yulia A. Bogdanova, Arina G. Shokhina, Dmitry S. Bilan, Dmitry B. Staroverov, Pavel M. Balaban, Andrei B. Fedotov, Dmitry A. Sidorov-Biryukov, Evgeny S. Nikitin, Aleksei M. Zheltikov and Vsevolod V. Belousov | | | Current approaches to thermogenetic manipulation of neuronal activity lack sufficient spatiotemporal resolution. Here the authors show that neurons expressing snake TRPA1 channels are activated at high temporal resolution with IR light and this technique can be used to elicit behaviour in zebrafish larvae. | | | 22 May 2017 | doi: 10.1038/ncomms15362 | | |
| Ultrasensitive and high-efficiency screen of de novo low-frequency mutations by o2n-seq OPEN | | | Kaile Wang, Shujuan Lai, Xiaoxu Yang, Tianqi Zhu, Xuemei Lu, Chung-I Wu and Jue Ruan | | | Detection of de novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage for detection of rare mutations. | | | 22 May 2017 | doi: 10.1038/ncomms15335 | | |
| TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis OPEN | | | Daniel Sidler, Ping Wu, Rana Herro, Meike Claus, Dennis Wolf, Yuko Kawakami, Toshiaki Kawakami, Linda Burkly and Michael Croft | | | TWEAK is a TNF family member that binds the NFκB signalling receptor Fn14. Here the authors show that TWEAK is central to skin inflammation in mouse models of atopic dermatitis and psoriasis and causes similar pathology when injected subcutaneously into mice. | | | 22 May 2017 | doi: 10.1038/ncomms15395 | | |
| Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy OPEN | | | Taisuke Kondo, Rimpei Morita, Yuumi Okuzono, Hiroko Nakatsukasa, Takashi Sekiya, Shunsuke Chikuma, Takashi Shichita, Mitsuhiro Kanamori, Masato Kubo, Keiko Koga, Takahiro Miyazaki, Yoshiaki Kassai and Akihiko Yoshimura | | | Tumour-specific T cells can be expanded in vitro and adoptively transferred for therapy, but this strategy is limited by induction of short-lived T cell populations. Here the authors activate Notch signalling in cultured mouse or human T cells, resulting in the production of a long-lived stem cell memory T cell population that can fight tumours in mice. | | | 22 May 2017 | doi: 10.1038/ncomms15338 | | |
| Generic decoding of seen and imagined objects using hierarchical visual features OPEN | | | Tomoyasu Horikawa and Yukiyasu Kamitani | | | Machine learning algorithms can decode objects that people see or imagine from their brain activity. Here the authors present a predictive decoder combined with deep neural network representations that generalizes beyond the training set and correctly identifies novel objects that it has never been trained on. | | | 22 May 2017 | doi: 10.1038/ncomms15037 | | |
| Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9 OPEN | | | Jelka Pohar, Duško Lainšček, Karolina Ivičak-Kocjan, Miša-Mojca Cajnko, Roman Jerala and Mojca Benčina | | | DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA oligonucleotides to activate Toll-like receptors. | | | 22 May 2017 | doi: 10.1038/ncomms15363 | | |
| Understanding trends in electrochemical carbon dioxide reduction rates OPEN | | | Xinyan Liu, Jianping Xiao, Hongjie Peng, Xin Hong, Karen Chan and Jens K. Nørskov | | | Identifying trends in electrocatalytic activity for carbon dioxide reduction can help with catalyst design, but are difficult to define. Here, the authors develop an electrochemical kinetic model of the process, identifying scaling relations relating transition state energies to CO adsorption energy on metal surfaces. | | | 22 May 2017 | doi: 10.1038/ncomms15438 | | |
| Deep sleep maintains learning efficiency of the human brain OPEN | | | Sara Fattinger, Toon T. de Beukelaar, Kathy L. Ruddy, Carina Volk, Natalie C. Heyse, Joshua A. Herbst, Richard H. R. Hahnloser, Nicole Wenderoth and Reto Huber | | | Deep sleep is hypothesized to restore the brain's capacity to learn. Here the authors provide causal evidence by specifically perturbing slow wave activity over the motor cortex during NREM sleep in humans and demonstrate a reduction in neurophysiological markers of plasticity and capacity for motor learning. | | | 22 May 2017 | doi: 10.1038/ncomms15405 | | |
| Shifting the optimal stiffness for cell migration OPEN | | | Benjamin L. Bangasser, Ghaidan A. Shamsan, Clarence E. Chan, Kwaku N. Opoku, Erkan Tüzel, Benjamin W. Schlichtmann, Jesse A. Kasim, Benjamin J. Fuller, Brannon R. McCullough, Steven S. Rosenfeld and David J. Odde | | | Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types. | | | 22 May 2017 | doi: 10.1038/ncomms15313 | | |
| Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors OPEN | | | Ignacio Benedicto, Guillermo L. Lehmann, Michael Ginsberg, Daniel J. Nolan, Rohan Bareja, Olivier Elemento, Zelda Salfati, Nazia M. Alam, Glen T. Prusky, Pierre Llanos, Sina Y. Rabbany, Arvydas Maminishkis, Sheldon S. Miller, Shahin Rafii and Enrique Rodriguez-Boulan | | | Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epithelial cells. | | | 19 May 2017 | doi: 10.1038/ncomms15374 | | |
| Surface chemistry governs cellular tropism of nanoparticles in the brain OPEN | | | Eric Song, Alice Gaudin, Amanda R. King, Young-Eun Seo, Hee-Won Suh, Yang Deng, Jiajia Cui, Gregory T. Tietjen, Anita Huttner and W. Mark Saltzman | | | There have been numerous attempts to develop nanomaterials to reach cells of the central nervous system for drug delivery. Here, the authors investigate the cellular fate of polymer-based nanoparticles with varying surface chemistries after administration directly into the brain. | | | 19 May 2017 | doi: 10.1038/ncomms15322 | | |
| Impact of simultaneous exposure to arboviruses on infection and transmission by Aedes aegypti mosquitoes OPEN | | | Claudia Rückert, James Weger-Lucarelli, Selene M. Garcia-Luna, Michael C. Young, Alex D. Byas, Reyes A. Murrieta, Joseph R. Fauver and Gregory D. Ebel | | | Several mosquito-transmitted viruses cocirculate in the Americas, but the potential for co-transmission is unknown. Here, Rückert et al. show that Aedes aegypti mosquitos have the potential to co-transmit chikungunya, dengue and Zika viruses and that coinfection does not overall affect dissemination or transmission rates. | | | 19 May 2017 | doi: 10.1038/ncomms15412 | | |
| Emptying Dirac valleys in bismuth using high magnetic fields OPEN | | | Zengwei Zhu, Jinhua Wang, Huakun Zuo, Benoît Fauqué, Ross D. McDonald, Yuki Fuseya and Kamran Behnia | | | Materials in large magnetic fields can be driven into the quantum limit, where electrons occupy only the lowest Landau level and the response is determined by interactions. Here the authors go beyond this limit by emptying one or two of bismuth’s electronic valleys, depending on the field direction. | | | 19 May 2017 | doi: 10.1038/ncomms15297 | | |
| Mistranslation can enhance fitness through purging of deleterious mutations OPEN | | | Sinisa Bratulic, Macarena Toll-Riera and Andreas Wagner | | | Mistranslation results in amino acid changes in proteins known as phenotypic mutations and these occur at a much higher rate than DNA mutations. Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutations. | | | 19 May 2017 | doi: 10.1038/ncomms15410 | | |
| Extended fisheries recovery timelines in a changing environment OPEN | | | Gregory L. Britten, Michael Dowd, Lisa Kanary and Boris Worm | | | Many estimates of fisheries recovery time currently assume that the environment and associated fish population dynamics are fixed. Britten et al. use Bayesian models incorporating variation in productivity and carrying capacity to provide revised estimates of recovery timelines for depleted fish stocks worldwide. | | | 19 May 2017 | doi: 10.1038/ncomms15325 | | |
| Plasmonic computing of spatial differentiation OPEN | | | Tengfeng Zhu, Yihan Zhou, Yijie Lou, Hui Ye, Min Qiu, Zhichao Ruan and Shanhui Fan | | | For specific problems, analog optical computing can be faster and more computationally efficient than digital methods. Here, Zhu et al. simplify the often metamaterial-based approach to a single thin metal film, with which they demonstrate spatial differentiation. | | | 19 May 2017 | doi: 10.1038/ncomms15391 | | |
| Energy landscape-driven non-equilibrium evolution of inherent structure in disordered material OPEN | | | Yue Fan, Takuya Iwashita and Takeshi Egami | | | Fundamental understanding of glass dynamics is challenging owing to their complex non-equilibrium nature and thus the multi-dimensional potential energy landscape. Here, Fan et al. present a model to explore the glass energy landscape driven by thermal activation and relaxation, which are temporally decoupled. | | | 19 May 2017 | doi: 10.1038/ncomms15417 | | |
| Self-assembly of a supramolecular hexagram and a supramolecular pentagram OPEN | | | Zhilong Jiang, Yiming Li, Ming Wang, Bo Song, Kun Wang, Mingyu Sun, Die Liu, Xiaohong Li, Jie Yuan, Mingzhao Chen, Yuan Guo, Xiaoyu Yang, Tong Zhang, Charles N. Moorefield, George R. Newkome, Bingqian Xu, Xiaopeng Li and Pingshan Wang | | | Star motifs are ubiquitous throughout nature and in man-made architectures, but their molecular level design remains challenging. Here the authors present a stepwise approach to self-assemble pentagonal and hexagonal star-shaped metallo-architectures through the careful design of metallo-organic ligands. | | | 19 May 2017 | doi: 10.1038/ncomms15476 | | |
| Out-of-plane chiral domain wall spin-structures in ultrathin in-plane magnets OPEN | | | Gong Chen, Sang Pyo Kang, Colin Ophus, Alpha T. N’Diaye, Hee Young Kwon, Ryan T. Qiu, Changyeon Won, Kai Liu, Yizheng Wu and Andreas K. Schmid | | | Chiral domain walls in magnetic films can be electrically controlled, which makes them attractive for applications, but domain walls in ultrathin films are normally non-chiral. Here, the authors observe chiral domain walls in ultrathin Fe/Ni bilayers that are stabilized by the magnetic anisotropy. | | | 19 May 2017 | doi: 10.1038/ncomms15302 | | |
| Iron limitation of microbial phosphorus acquisition in the tropical North Atlantic OPEN | | | T. J. Browning, E. P. Achterberg, J. C. Yong, I. Rapp, C. Utermann, A. Engel and C. M. Moore | | | The influence iron exerts over the acquisition of dissolved organic phosphorus in regions of the oceans co-limited by nitrogen and phosphorus is poorly constrained. Here, the authors demonstrate enhanced alkaline phosphatase activity of natural marine microbial communities following iron fertilization. | | | 19 May 2017 | doi: 10.1038/ncomms15465 | | |
| Sub-nanometre control of the coherent interaction between a single molecule and a plasmonic nanocavity OPEN | | | Yao Zhang, Qiu-Shi Meng, Li Zhang, Yang Luo, Yun-Jie Yu, Ben Yang, Yang Zhang, Ruben Esteban, Javier Aizpurua, Yi Luo, Jin-Long Yang, Zhen-Chao Dong and J G Hou | | | Assessing the coupling between a plasmonic nanocavity and a single quantum emitter is challenging due to the lack of spatial control at the atomic scale. Here Zhang et al. achieve control with sub-nanometre precision and demonstrate the Fano resonance and Lamb shift at the single-molecule level. | | | 19 May 2017 | doi: 10.1038/ncomms15225 | | |
| Structural basis for conductance through TRIC cation channels OPEN | | | Min Su, Feng Gao, Qi Yuan, Yang Mao, De-lin Li, Youzhong Guo, Cheng Yang, Xiao-hui Wang, Renato Bruni, Brian Kloss, Hong Zhao, Yang Zeng, Fa-ben Zhang, Andrew R Marks, Wayne A Hendrickson and Yu-hang Chen | | | Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+ release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaining molecular insight into TRICs’ function. | | | 19 May 2017 | doi: 10.1038/ncomms15103 | | |
| Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones OPEN | | | Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu and Bin Tan | | | Axially chiral arylquinazolinones are structural motifs in several natural products and can also act as chiral ligands. Here, the authors show a chiral phosphoric acid-catalysed strategy to access enantiomerically pure arylquinazolinones by efficient transfer of central chirality into axial chirality. | | | 19 May 2017 | doi: 10.1038/ncomms15489 | | |
| Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome OPEN | | | Ahmad Jomaa, Yu-Hsien Hwang Fu, Daniel Boehringer, Marc Leibundgut, Shu-ou Shan and Nenad Ban | | | Membrane proteins are inserted co-transnationally through the association between ribosome, the signal recognition particle and its receptor, and the membrane-bound translocon. Here the authors present a cryo-EM reconstruction of this quaternary complex in the activated state and propose a model for signal sequence transfer to the translocon. | | | 19 May 2017 | doi: 10.1038/ncomms15470 | | |
| A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging OPEN | | | Alexander L. Antaris, Hao Chen, Shuo Diao, Zhuoran Ma, Zhe Zhang, Shoujun Zhu, Joy Wang, Alexander X. Lozano, Quli Fan, Leila Chew, Mark Zhu, Kai Cheng, Xuechuan Hong, Hongjie Dai and Zhen Cheng | | | Near-infrared (NIR) fluorescence imaging >1,000 nm allows deep tissue imaging, but available organic dyes display poor brightness and temporal resolution. Here, the authors synthesize a NIR dye that, upon binding serum proteins, exhibits a 110-fold increase in intensity, giving an 11% quantum yield. | | | 19 May 2017 | doi: 10.1038/ncomms15269 | | |
| Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish OPEN | | | Claudia Gerri, Rubén Marín-Juez, Michele Marass, Alora Marks, Hans-Martin Maischein and Didier Y R. Stainier | | | The molecular mechanism regulating macrophage interaction with endothelial cells during development is unclear. Here, the authors show that in zebrafish mutation of hypoxia-inducible factor-1α impairs macrophage mobilization from the aorta-gonad-mesonephros, causing defects in angiogenesis and vessel repair. | | | 19 May 2017 | doi: 10.1038/ncomms15492 | | |
| Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification OPEN | | | Fan Liu, Philip Lössl, Richard Scheltema, Rosa Viner and Albert J. R. Heck | | | Chemical cross-linking combined with mass spectrometry (XL-MS) can provide information on protein conformations and interactions in highly complex samples. Here the authors describe an improved XL-MS workflow to increase the depth and fidelity of cross-link identification using whole proteome databases. | | | 19 May 2017 | doi: 10.1038/ncomms15473 | | |
| An apicobasal gradient of Rac activity determines protrusion form and position OPEN | | | Africa Couto, Natalie Ann Mack, Lucrezia Favia and Marios Georgiou | | | Polarized epithelial cells must correctly position a wide range of subcellular structures. Here the authors demonstrate an apicobasal gradient of Rac GTPase activity, which is maintained by polarity proteins in Drosophila epithelial sheets, and is required to maintain actin-dependent protrusion form and position. | | | 19 May 2017 | doi: 10.1038/ncomms15385 | | |
| Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides OPEN | | | Shaun Stairs, Arif Nikmal, Dejan-Krešimir Bučar, Shao-Liang Zheng, Jack W. Szostak and Matthew W. Powner | | | While mechanisms have been proposed for the prebiotic nucleotide synthesis, these require separate (and potentially incompatible) routes for pyrimidines and purines. Here the authors show that both of these classes of molecules can be formed by a divergent synthesis from a common prebiotic precursor. | | | 19 May 2017 | doi: 10.1038/ncomms15270 | | |
| Mesoporous metallic rhodium nanoparticles OPEN | | | Bo Jiang, Cuiling Li, Ömer Dag, Hideki Abe, Toshiaki Takei, Tsubasa Imai, Md. Shahriar A. Hossain, Md. Tofazzal Islam, Kathleen Wood, Joel Henzie and Yusuke Yamauchi | | | Mesoporous noble metal nanostructures offer great promise in catalytic applications. Here, Yamauchi and co-workers synthesize mesoporous rhodium nanoparticles using polymeric micelle templates, and report appreciable activities for methanol oxidation and NO remediation. | | | 19 May 2017 | doi: 10.1038/ncomms15581 | | |
| An invariability-area relationship sheds new light on the spatial scaling of ecological stability OPEN | | | Shaopeng Wang, Michel Loreau, Jean-Francois Arnoldi, Jingyun Fang, K. Abd. Rahman, Shengli Tao and Claire de Mazancourt | | | Just as species distribution patterns scale with area, so might the degree of variability in ecological properties. Here, Wang et al. develop a model invariability–area relationship and demonstrate the application of this theory to empirical data on plant primary production and bird biomass. | | | 19 May 2017 | doi: 10.1038/ncomms15211 | | |
| An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin OPEN | | | Sylvain Ursuegui, Marion Recher, Wojciech Krężel and Alain Wagner | | | The interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivated in vivo using click chemistry, paving the way to the design of drugs with tunable in vivo properties. | | | 19 May 2017 | doi: 10.1038/ncomms15242 | | |
| Antiferromagnetic CuMnAs multi-level memory cell with microelectronic compatibility OPEN | | | K. Olejník, V. Schuler, X. Marti, V. Novák, Z. Kašpar, P. Wadley, R. P. Campion, K. W. Edmonds, B. L. Gallagher, J. Garces, M. Baumgartner, P. Gambardella and T. Jungwirth | | | Devices based on antiferromagnetic materials have advantages of robustness to external magnetic fields and the potential for ultrafast operation. Here the authors present a multilevel antiferromagnetic memory cell that can be operated using standard electronic interfaces. | | | 19 May 2017 | doi: 10.1038/ncomms15434 | | |
| Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif OPEN | | | Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco and Mikel Garcia-Marcos | | | Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and Activating motif interact and modulate G proteins. | | | 18 May 2017 | doi: 10.1038/ncomms15163 | | |
| Unified model for singlet fission within a non-conjugated covalent pentacene dimer OPEN | | | Bettina S. Basel, Johannes Zirzlmeier, Constantin Hetzer, Brian T. Phelan, Matthew D. Krzyaniak, S. Rajagopala Reddy, Pedro B. Coto, Noah E. Horwitz, Ryan M. Young, Fraser J. White, Frank Hampel, Timothy Clark, Michael Thoss, Rik R. Tykwinski, Michael R. Wasielewski and Dirk M. Guldi | | | Singlet fission is an important process occurring in solar cells, however the mechanism is not well understood. Here the authors reveal intermediates during singlet fission of a non-conjugated pentacene dimer, developing a single kinetic model to describe the data over seven temporal orders of magnitude at room and cryogenic temperatures. | | | 18 May 2017 | doi: 10.1038/ncomms15171 | | |
| Nanometric holograms based on a topological insulator material OPEN | | | Zengji Yue, Gaolei Xue, Juan Liu, Yongtian Wang and Min Gu | | | Holograms generally need to be as thick as a wavelength of light to introduce the necessary optical phase shifts that create true three-dimensional images. Here, Yue et al. use a high-index topological insulator material to create a resonant optical cavity and thin holograms to the nanometre scale. | | | 18 May 2017 | doi: 10.1038/ncomms15354 | | |
| Selective BET bromodomain inhibition as an antifungal therapeutic strategy OPEN | | | Flore Mietton, Elena Ferri, Morgane Champleboux, Ninon Zala, Danièle Maubon, Yingsheng Zhou, Mike Harbut, Didier Spittler, Cécile Garnaud, Marie Courçon, Murielle Chauvel, Christophe d’Enfert, Boris A. Kashemirov, Mitchell Hull, Muriel Cornet, Charles E. McKenna, Jérôme Govin and Carlo Petosa | | | BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogen Candida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs. | | | 18 May 2017 | doi: 10.1038/ncomms15482 | | |
| Self-folding origami at any energy scale OPEN | | | Matthew B. Pinson, Menachem Stern, Alexandra Carruthers Ferrero, Thomas A. Witten, Elizabeth Chen and Arvind Murugan | | | Origami is widely practiced in the design of foldable structures for smart applications and usually consists of stiff sheets that only deform along prescribed creases. Pinson et al. take a statistical physics approach to design and characterize arbitrary patterns as a function of folding energy. | | | 18 May 2017 | doi: 10.1038/ncomms15477 | | |
| Signal recognition particle prevents N-terminal processing of bacterial membrane proteins OPEN | | | Amitabh Ranjan, Evan Mercier, Arshiya Bhatt and Wolfgang Wintermeyer | | | Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal recognition particle (SRP) during translation. | | | 18 May 2017 | doi: 10.1038/ncomms15562 | | |
| Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation OPEN | | | Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, Hongwei Yao, Xi Zhu, Zeming Zhang, Jiafu Ji and Xiaofeng Zheng | | | Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is a potential therapeutic strategy for colorectal cancer (CRC). Here, the authors show that adenylate kinase hCINAP is overexpressed in CRC, binds to the C-terminal domain of LDHA and its depletion inhibits invasion, self-renewal, tumorigenesis and chemoresistance of CRCSCs. | | | 18 May 2017 | doi: 10.1038/ncomms15308 | | |
| An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states OPEN | | | Caterina Alfano, Domenico Sanfelice, Stephen R. Martin, Annalisa Pastore and Piero Andrea Temussi | | | Crowding effects—important when considering cellular environments—greatly influence protein stability. Here the authors study the impact of macromolecular crowders on high and low temperature protein unfolding, and show that volume exclusion effects are larger when the protein and crowder volumes are similar. | | | 18 May 2017 | doi: 10.1038/ncomms15428 | | |
| A complete tool set for molecular QTL discovery and analysis OPEN | | | Olivier Delaneau, Halit Ongen, Andrew A. Brown, Alexandre Fort, Nikolaos I. Panousis and Emmanouil T. Dermitzakis | | | Analysis of molecular quantitative trait loci (molQTL) can help interpret genome-wide association studies and requires efficient approaches to correct for multiple testing. This study describes a bioinformatics toolkit called QTLtool that can handle large data sets and quickly perform multiple types of molQTL analyses. | | | 18 May 2017 | doi: 10.1038/ncomms15452 | | |
| Histone deacetylase 10 structure and molecular function as a polyamine deacetylase OPEN | | | Yang Hai, Stephen A. Shinsky, Nicholas J. Porter and David W. Christianson | | | Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue inhibitor. | | | 18 May 2017 | doi: 10.1038/ncomms15368 | | |
| Equilibrium oxygen storage capacity of ultrathin CeO2-δ depends non-monotonically on large biaxial strain OPEN | | | Chirranjeevi Balaji Gopal, Max García-Melchor, Sang Chul Lee, Yezhou Shi, Andrey Shavorskiy, Matteo Monti, Zixuan Guan, Robert Sinclair, Hendrik Bluhm, Aleksandra Vojvodic and William C. Chueh | | | The surface oxygen storage capacity is an important metric of catalytic activity, but its dependence on strain is not well characterized. Here, the authors show the surface oxygen nonstoichiometry in coherently strained CeO2-δ films increases non-monotonically with biaxial strain. | | | 18 May 2017 | doi: 10.1038/ncomms15360 | | |
| The effects of forest canopy shading and turbulence on boundary layer ozone OPEN | | | P. A. Makar, R. M. Staebler, A. Akingunola, J. Zhang, C. McLinden, S. K. Kharol, B. Pabla, P. Cheung and Q. Zheng | | | Fully quantifying the influence of vegetation on atmospheric chemistry remains challenging. Here, the authors show that forest canopy shading and turbulence significantly modify air pollution throughout the atmospheric boundary layer, and must be taken into account in models of the atmosphere. | | | 18 May 2017 | doi: 10.1038/ncomms15243 | | |
| ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia OPEN | | | Jean-Baptiste Micol, Alessandro Pastore, Daichi Inoue, Nicolas Duployez, Eunhee Kim, Stanley Chun-Wei Lee, Benjamin H. Durham, Young Rock Chung, Hana Cho, Xiao Jing Zhang, Akihide Yoshimi, Andrei Krivtsov, Richard Koche, Eric Solary, Amit Sinha, Claude Preudhomme and Omar Abdel-Wahab | | | While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations in AML patients | | | 18 May 2017 | doi: 10.1038/ncomms15429 | | |
| Artificial local magnetic field inhomogeneity enhances T2 relaxivity OPEN | | | Zijian Zhou, Rui Tian, Zhenyu Wang, Zhen Yang, Yijing Liu, Gang Liu, Ruifang Wang, Jinhao Gao, Jibin Song, Liming Nie and Xiaoyuan Chen | | | The signal detected in magnetic resonance imaging comes from the relaxation of proton nuclear magnetization. Here, Zhou et al. introduce magnetic field inhomogeneity as a parameter to design iron oxide nanoparticle clusters to enhance the relaxation rate of nearby protons, thereby increasing image contrast. | | | 18 May 2017 | doi: 10.1038/ncomms15468 | | |
| Vagal determinants of exercise capacity OPEN | | | Asif Machhada, Stefan Trapp, Nephtali Marina, Robert C.M. Stephens, John Whittle, Mark F. Lythgoe, Sergey Kasparov, Gareth L. Ackland and Alexander V. Gourine | | | Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents, Machhada et al. provide direct evidence that vagal drive determines the ability to exercise. | | | 18 May 2017 | doi: 10.1038/ncomms15097 | | |
| The origin and degassing history of the Earth's atmosphere revealed by Archean xenon OPEN | | | Guillaume Avice, Bernard Marty and Ray Burgess | | | The composition of the early Earth’s atmosphere remains unclear. Here, the authors using fluid inclusions trapped within quartz crystals show that at 3.3 Ga the atmosphere had a lower 129Xe excess than today, and suggest that comets may have brought xenon to the Earth’s atmosphere during terrestrial accretion. | | | 18 May 2017 | doi: 10.1038/ncomms15455 | | |
| High conductance values in π-folded molecular junctions OPEN | | | Marco Carini, Marta P. Ruiz, Imanol Usabiaga, José A. Fernández, Emilio J. Cocinero, Manuel Melle-Franco, Ismael Diez-Perez and Aurelio Mateo-Alonso | | | Foldamers are synthetic oligomers that adopt folded conformations through non-covalent intramolecular interactions. Here, Carini et al. describe a family of foldamers with a large number of anthracene units that are able to transport charge efficiently at the single-molecule level. | | | 18 May 2017 | doi: 10.1038/ncomms15195 | | |
| Electrostatic melting in a single-molecule field-effect transistor with applications in genomic identification OPEN | | | Sefi Vernick, Scott M. Trocchia, Steven B. Warren, Erik F. Young, Delphine Bouilly, Ruben L. Gonzalez, Colin Nuckolls and Kenneth L. Shepard | | | DNA hybridization of two single-strands to form a double-stranded helix is widely used for genomic identification applications. Here, Vernick et al. record duplex formation of 20-mer oligonucleotide using a single-molecule field-effect transistor, where DNA kinetics is affected by electrostatic bias. | | | 18 May 2017 | doi: 10.1038/ncomms15450 | | |
| Heat guiding and focusing using ballistic phonon transport in phononic nanostructures OPEN | | | Roman Anufriev, Aymeric Ramiere, Jeremie Maire and Masahiro Nomura | | | Heat conduction at the nanoscale is unlike macroscopic diffusion and phonons can travel in straight lines without dissipation. Here Anufriev et al. show that heat conduction can be spatially directed in nanostructured silicon and exploit this effect to concentrate heat into a focal point. | | | 18 May 2017 | doi: 10.1038/ncomms15505 | | |
| Genetic architecture of epigenetic and neuronal ageing rates in human brain regions OPEN | | | Ake T. Lu, Eilis Hannon, Morgan E. Levine, Eileen M. Crimmins, Katie Lunnon, Jonathan Mill, Daniel H. Geschwind and Steve Horvath | | | Studies on the ‘epigenetic clock’, a recently identified ageing biomarker, suggest that pathology might be linked to tissue-specific accelerated ageing. Here, the authors investigate ageing in the human brain and identify genetic loci associated with accelerated ageing in different brain regions. | | | 18 May 2017 | doi: 10.1038/ncomms15353 | | |
| Spectral correlations in a random distributed feedback fibre laser OPEN | | | Srikanth Sugavanam, Mariia Sorokina and Dmitry V. Churkin | | | The feedback mechanism in random fibre lasers has been insofar deemed incoherent. To reveal the dynamic evolution of the random fibre laser spectra, Sugavanam et al. use a real-time spectral measurement technique and observe long-lived narrowband components in the random fibre laser’s spectrum. | | | 18 May 2017 | doi: 10.1038/ncomms15514 | | |
| Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin OPEN | | | Nga Chu Lui, Wing Yip Tam, Caiji Gao, Jian-Dong Huang, Chi Chiu Wang, Liwen Jiang, Wing Ho Yung and Kin Ming Kwan | | | Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and dysregulation of this process leads to ataxia and other diseases. Here the authors show that the LIM-homeodomain transcription factors Lhx1 and Lhx5 govern dendritogenesis and dendritic spine morphogenesis in postnatal PCs through regulating Espin expression. | | | 18 May 2017 | doi: 10.1038/ncomms15079 | | |
| Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production OPEN | | | Bing-Juan Li, Hao Wang, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang and Ping Zhu | | | Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of an in vitro biochemical systems for taxol production. | | | 18 May 2017 | doi: 10.1038/ncomms15544 | | |
| YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate OPEN | | | Antonio Totaro, Martina Castellan, Giusy Battilana, Francesca Zanconato, Luca Azzolin, Stefano Giulitti, Michelangelo Cordenonsi and Stefano Piccolo | | | Notch signalling is a fundamental negative regulator of epidermal stemness. Here, the authors show that cell mechanics through YAP/TAZ activity prevent primary human keratinocytes from differentiating by inhibiting cell-autonomous Notch signals. | | | 17 May 2017 | doi: 10.1038/ncomms15206 | | |
| Inertial displacement of a domain wall excited by ultra-short circularly polarized laser pulses OPEN | | | T. Janda, P. E. Roy, R. M. Otxoa, Z. Šobáň, A. Ramsay, A. C. Irvine, F. Trojanek, M. Surýnek, R. P. Campion, B. L. Gallagher, P. Němec, T. Jungwirth and J. Wunderlich | | | Domain wall motion driven by ultra-short laser pulses has potential for storage of information in magnetoelectronic devices. Here the authors demonstrate the conversion of a circularly polarized femtosecond laser light into inertial displacement of a domain wall in a ferromagnetic semiconductor. | | | 17 May 2017 | doi: 10.1038/ncomms15226 | | |
| Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand OPEN | | | Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao et al. | | | Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation. | | | 17 May 2017 | doi: 10.1038/ncomms15383 | | |
| Global perturbation of organic carbon cycling by river damming OPEN | | | Taylor Maavara, Ronny Lauerwald, Pierre Regnier and Philippe Van Cappellen | | | The damming of rivers has large impacts on the balance of riverine carbon (C) processes and fluxes to the oceans. Here, the authors use decadal riverine organic C loads and model C transformations to quantify in-reservoir organic C burial, mineralization and assess decreases in riverine exports to the oceans. | | | 17 May 2017 | doi: 10.1038/ncomms15347 | | |
| Picocyanobacteria and deep-ocean fluorescent dissolved organic matter share similar optical properties OPEN | | | Zhao Zhao, Michael Gonsior, Jenna Luek, Stephen Timko, Hope Ianiri, Norbert Hertkorn, Philippe Schmitt-Kopplin, Xiaoting Fang, Qinglu Zeng, Nianzhi Jiao and Feng Chen | | | The sources of marine chromophoric dissolved organic matter and associated fluorescent DOM (FDOM) remain unclear. Here, the authors demonstrate that picocyanobacteria release FDOM similar to typical fluorescent signals found in the ocean, and are likely to be an important source of marine FDOM. | | | 17 May 2017 | doi: 10.1038/ncomms15284 | | |
| An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data OPEN | | | Mark Carty, Lee Zamparo, Merve Sahin, Alvaro González, Raphael Pelossof, Olivier Elemento and Christina S. Leslie | | | Genome-wide chromosome conformation capture has helped us identify features of genome topology influencing biology but requires careful statistical analysis. Here the authors present HiC-DC, a bioinformatics method that can detect statistically significant regulatory interactions. | | | 17 May 2017 | doi: 10.1038/ncomms15454 | | |
| Electricity from methane by reversing methanogenesis OPEN | | | Michael J. McAnulty, Venkata G. Poosarla, Kyoung-Yeol Kim, Ricardo Jasso-Chávez, Bruce E. Logan and Thomas K. Wood | | | Microbial fuel cells generate electricity from a variety of sources, however from methane only negligible electrical power has been reported so far. Here the authors convert methane into electricity using a synthetic consortium consisting of an engineered archaeal strain, microorganisms from methane-acclimated sludge, and Geobacter sulfurreducens. | | | 17 May 2017 | doi: 10.1038/ncomms15419 | | |
| Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen OPEN | | | Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura de las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden and Esperanza Herreros | | | There is a need for Plasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro. | | | 17 May 2017 | doi: 10.1038/ncomms15160 | | |
| Enhanced heterogeneous ice nucleation by special surface geometry OPEN | | | Yuanfei Bi, Boxiao Cao and Tianshu Li | | | Understanding ice nucleation is important for the development of accurate cloud models. Here Bi et al. show that sharp wedges can enhance ice nucleation both when the wedge geometry matches the ice lattice and when such matching is absent, in which case nucleation is promoted by topological defects. | | | 17 May 2017 | doi: 10.1038/ncomms15372 | | |
| Vacuum ultraviolet spectroscopy of the lowest-lying electronic state in subcritical and supercritical water OPEN | | | Timothy W. Marin, Ireneusz Janik, David M. Bartels and Daniel M. Chipman | | | The link between hydrogen bonding and the optical properties of water has been debated for many years, but not fully understood. Here, the authors report vacuum ultraviolet absorption spectra for subcritical and supercritical water, providing insight into the electronic structure of water and its relation to hydrogen bonding. | | | 17 May 2017 | doi: 10.1038/ncomms15435 | | |
| Thermophoretic migration of vesicles depends on mean temperature and head group chemistry OPEN | | | Emma L. Talbot, Jurij Kotar, Lucia Parolini, Lorenzo Di Michele and Pietro Cicuta | | | Thermal gradients are shown to provide a robust and chemically specific driving force to liposomes. Here the authors show controlled direction of migration of unilamellar lipid vesicles by varying the temperature in the suspension and the exposed polar lipid head groups. | | | 17 May 2017 | doi: 10.1038/ncomms15351 | | |
| Behavioural individuality in clonal fish arises despite near-identical rearing conditions OPEN | | | David Bierbach, Kate L. Laskowski and Max Wolf | | | Genetically-identical animals experiencing the same environmental conditions should develop, in theory, identical behavioral traits. However, Bierbach et al. show here that behavioral differences still emerge among cloned fish under tightly controlled experimental conditions. | | | 17 May 2017 | doi: 10.1038/ncomms15361 | | |
| Temporal dynamics of gene expression and histone marks at the Arabidopsis shoot meristem during flowering OPEN | | | Yuan You, Aneta Sawikowska, Manuela Neumann, David Posé, Giovanna Capovilla, Tobias Langenecker, Richard A. Neher, Paweł Krajewski and Markus Schmid | | | When plants flower, the shoot apical meristem switches fate to produce floral organs instead of leaves. Here You et al. perform tissue-specific epigenome profiling and show that during this transition changes in histone methylation are correlated with transcriptional responses in the meristem. | | | 17 May 2017 | doi: 10.1038/ncomms15120 | | |
| Optical determination of crystal phase in semiconductor nanocrystals OPEN | | | Sung Jun Lim, André Schleife and Andrew M. Smith | | | Identifying crystallographic phases in solution is not possible with standard diffraction methods. Here, Lim et al. demonstrate the in situ identification of cubic and hexagonal phases of cadmium selenide nanocrystals using optical methods based on first-principles electronic theory. | | | 17 May 2017 | doi: 10.1038/ncomms14849 | | |
| Tailoring spin defects in diamond by lattice charging OPEN | | | Felipe Fávaro de Oliveira, Denis Antonov, Ya Wang, Philipp Neumann, Seyed Ali Momenzadeh, Timo Häußermann, Alberto Pasquarelli, Andrej Denisenko and Jörg Wrachtrup | | | Ion implantation is used to introduce spin defects in solids, but it inflicts residual lattice damage, degrading performances. Here the authors demonstrate that the charge state of induced defects influences such damage, and that charging vacancies leads to improved coherence times and yield of centres. | | | 17 May 2017 | doi: 10.1038/ncomms15409 | | |
| Zinc is a potent and specific inhibitor of IFN-λ3 signalling OPEN | | | Scott A. Read, Kate S. O’Connor, Vijay Suppiah, Chantelle L. E. Ahlenstiel, Stephanie Obeid, Kristina M. Cook, Anthony Cunningham, Mark W. Douglas, Philip J. Hogg, David Booth, Jacob George and Golo Ahlenstiel | | | Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response. | | | 17 May 2017 | doi: 10.1038/ncomms15245 | | |
| Neuromorphic device architectures with global connectivity through electrolyte gating OPEN | | | Paschalis Gkoupidenis, Dimitrios A. Koutsouras and George G. Malliaras | | | Global regulation of synaptic strengths in neural systems is known as homeoplasticity. Here, Gkoupidenis et al. use an electrolyte to connect and control an array of organic electrochemical devices, in order to demonstrate behaviour that resembles homeoplasticity phenomena in the brain. | | | 17 May 2017 | doi: 10.1038/ncomms15448 | | |
| Experimental quantum compressed sensing for a seven-qubit system OPEN | | | C. A. Riofrío, D. Gross, S. T. Flammia, T. Monz, D. Nigg, R. Blatt and J. Eisert | | | Quantum compressed sensing can provide a scalable way to characterize quantum states and devices, but has been so far limited to states with quickly decaying eigenvalues. Here the authors show that it can be appropriate even in the general case, demonstrating reconstruction the state of a seven-qubit system. | | | 17 May 2017 | doi: 10.1038/ncomms15305 | | |
| Efficient hydrogen production on MoNi4 electrocatalysts with fast water dissociation kinetics OPEN | | | Jian Zhang, Tao Wang, Pan Liu, Zhongquan Liao, Shaohua Liu, Xiaodong Zhuang, Mingwei Chen, Ehrenfried Zschech and Xinliang Feng | | | In water-alkali electrolyzers, sluggish water dissociation kinetics on platinum-free electrocatalysts result in poor hydrogen-production activities. Here the authors report a MoNi4 electrocatalyst which reduces the kinetic energy barrier of water dissociation, leading to improved hydrogen-production performance. | | | 17 May 2017 | doi: 10.1038/ncomms15437 | | |
| Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast OPEN | | | Sergio A. Rincon, Adam Lamson, Robert Blackwell, Viktoriya Syrovatkina, Vincent Fraisier, Anne Paoletti, Meredith D. Betterton and Phong T. Tran | | | Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule-associated protein Ase1 for spindle bipolarity. | | | 17 May 2017 | doi: 10.1038/ncomms15286 | | |
| Decoding material-specific memory reprocessing during sleep in humans OPEN | | | M. Schönauer, S. Alizadeh, H. Jamalabadi, A. Abraham, A. Pawlizki and S. Gais | | | Neuronal learning activity is reactivated during sleep but the dynamics of this reactivation in humans are still poorly understood. Here the authors show that memory processing occurs during all stages of sleep in humans but that reprocessing of memory content in REM and non-REM sleep has different effects on later memory performance. | | | 17 May 2017 | doi: 10.1038/ncomms15404 | | | | | | | | | | | | | Latest Corrigenda | | | | | | Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb OPEN | | | Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland, Jiancheng Han, Alexander J. Schupper, James T. Connelly, Kevin C. Dysart, Jack Rychik, Holly L. Hedrick, William H. Peranteau and Alan W. Flake | | | 23 May 2017 | doi: 10.1038/ncomms15794 | | |
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