Nature Reviews Cancer contents June 2017 Volume 17 Number 6 pp333-392

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TABLE OF CONTENTS
June 2017 Volume 17 Number 6		Advertisement
2015 2-year Impact Factor 34.244 Journal Metrics 2-year Median 27	In this issue Research Highlights Reviews Also this month  Featured article: Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy Silvia von Karstedt, Antonella Montinaro & Henning Walczak	Find out how Ginger got her voice back. Behind every patient stands thousands of scientists and researchers working together to develop life-saving treatments. So what happens when a patient meets the people that helped save her life? Watch as Ginger Tam, a professional singer and lung cancer patient, meets the researchers who worked on her cancer treatment.  View the video
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RESEARCH HIGHLIGHTS Top Immunotherapy: T cells get a ride p333 | doi:10.1038/nrc.2017.39 PDF Tumorigenesis: Cancer as a symptom of evolution? p373 | doi:10.1038/nrc.2017.33 A paper in Science by Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types. PDF Metastasis: The plastic state p373 | doi:10.1038/nrc.2017.34 ZEB1-mediated epithelial-mesenchymal transition (EMT) and cellular plasticity promotes metastasis in pancreatic cancer. PDF IN BRIEF Genetics: Gender-specific factors in cancer susceptibility | Immunotherapy: Programming T cells in situ PDF Cancer JOBS of the week Assistant / Associate Editor for Cancer Immunology Research American Association for Cancer Research (AACR) Postdoctoral Fellow - Comparative Analysis of Cancer Genomes Wellcome Trust Sanger Institute Postdoctoral position available in Cancer Immunology and Immunotherapy at Weill Cornell Medicine in New York City Weill Cornell Medicine Post-doctoral position – Carolina Cancer Nanotechnology T32 Training program The University of North Carolina Professorship in Cancer Genomics Ecole Polytechnique Fédérale de Lausanne (EPFL) More Science jobs from Cancer EVENT 3rd World Congress on Thyroid Cancer 27.07.17 Boston, USA More science events from
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REVIEWS		Top
The ETS family of oncogenic transcription factors in solid tumours Gina M. Sizemore, Jason R. Pitarresi, Subhasree Balakrishnan & Michael C. Ostrowski p337 | doi:10.1038/nrc.2017.20 Initially identified more than 30 years ago, the ETS family of transcription factors has been found to take part in all steps of tumorigenesis. This Review discusses the different mechanisms of ETS activation and the oncogenic implications of this activation, as well as how to target ETS factors in cancer treatment. Abstract | Full Text | PDF
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy Silvia von Karstedt, Antonella Montinaro & Henning Walczak p352 | doi:10.1038/nrc.2017.28 Clinical trials testing activators of tumour necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) signalling in cancer have not met expectations. This Review discusses new insights that might explain clinical failure, but also provide the basis for harnessing TRAIL-Rs for cancer therapy. Abstract | Full Text | PDF
The calcium-cancer signalling nexus Gregory R. Monteith, Natalia Prevarskaya & Sarah J. Roberts-Thomson p367 | doi:10.1038/nrc.2017.18 Changes in the calcium signal enable cells to achieve specific outcomes. In this Review, Monteith et al. describe how the remodelling of the expression and activity of calcium channels and pumps in cancer cells can influence tumour progression. Abstract | Full Text | PDF
RNA editing-dependent epitranscriptome diversity in cancer stem cells Qingfei Jiang, Leslie A. Crews, Frida Holm & Catriona H. M. Jamieson p381 | doi:10.1038/nrc.2017.23 This Review discusses the roles of deregulated RNA processing, including RNA methylation, RNA editing, RNA splicing and RNA binding protein activity, in cancer stem cells and highlights the potential of these events as biomarkers and therapeutic targets. Abstract | Full Text | PDF
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