The EDGE

Rethinking JAK2 inhibition: towards novel strategies of more specific and versatile janus kinase inhibition

E Leroy and S N Constantinescu

Leukemia 2017 31: 1023-1038; advance online publication, January 25, 2017; 10.1038/leu.2017.43

Monoclonal antibody therapy in multiple myeloma

C Touzeau, P Moreau and C Dumontet

Leukemia 2017 31: 1039-1047; advance online publication, February 17, 2017; 10.1038/leu.2017.60

Original Articles

ACUTE MYELOID LEUKEMIA

Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia

P N Ojamies, M Kontro, H Edgren, P Ellonen, S Lagström, H Almusa, T Miettinen, S Eldfors, D Tamborero, K Wennerberg, C Heckman, K Porkka, M Wolf and O Kallioniemi

Leukemia 2017 31: 1048-1058; advance online publication, October 31, 2016; 10.1038/leu.2016.286

Expression of CD33 is a predictive factor for effect of gemtuzumab ozogamicin at different doses in adult acute myeloid leukaemia

N Khan, R K Hills, P Virgo, S Couzens, N Clark, A Gilkes, P Richardson, S Knapper, D Grimwade, N H Russell, A K Burnett and S D Freeman on behalf of the UK NCRI-AML Study Group

Leukemia 2017 31: 1059-1068; advance online publication, October 31, 2016; 10.1038/leu.2016.309

Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients

E K von der Heide, M Neumann, S Vosberg, A R James, M P Schroeder, J Ortiz-Tanchez, K Isaakidis, C Schlee, M Luther, K Jöhrens, I Anagnostopoulos, L H Mochmann, D Nowak, W K Hofmann, P A Greif and C D Baldus

Leukemia 2017 31: 1069-1078; advance online publication, November 11, 2016; 10.1038/leu.2016.324

ACUTE LYMPHOBLASTIC LEUKEMIA

Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin

T-H Liu, Y-J Tang, Y Huang, L Wang, X-L Guo, J-Q Mi, L-G Liu, H Zhu, Y Zhang, L Chen, X Liu, L-H Zhang, Q-J Ye, B-S Li, J-Y Tang, A Ford, T Enver, F Liu, G-Q Chen and D-L Hong

Leukemia 2017 31: 1079-1086; advance online publication, November 3, 2016; 10.1038/leu.2016.313

Vaccination to improve the persistence of CD19CAR gene-modified T cells in relapsed pediatric acute lymphoblastic leukemia

C Rossig, M Pule, B Altvater, S Saiagh, G Wright, S Ghorashian, L Clifton-Hadley, K Champion, Z Sattar, B Popova, A Hackshaw, P Smith, T Roberts, E Biagi, B Dreno, R Rousseau, S Kailayangiri, M Ahlmann, R Hough, B Kremens, M G Sauer, P Veys, N Goulden, M Cummins and P J Amrolia

Leukemia 2017 31: 1087-1095; advance online publication, January 27, 2017; 10.1038/leu.2017.39

CHRONIC MYELOGENOUS LEUKEMIA

Identification and characterization of activating ABL1 1b kinase mutations: impact on sensitivity to ATP-competitive and allosteric ABL1 inhibitors

B J Lee and N P Shah

Leukemia 2017 31: 1096-1107; advance online publication, November 28, 2016; 10.1038/leu.2016.353

Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia OPEN

M Ilander, U Olsson-Strömberg, H Schlums, J Guilhot, O Brück, H Lähteenmäki, T Kasanen, P Koskenvesa, S Söderlund, M Höglund, B Markevärn, A Själander, K Lotfi, A Dreimane, A Lübking, E Holm, M Björeman, S Lehmann, L Stenke, L Ohm, T Gedde-Dahl, W Majeed, H Ehrencrona, S Koskela, S Saussele, F-X Mahon, K Porkka, H Hjorth-Hansen, Y T Bryceson, J Richter and S Mustjoki

Leukemia 2017 31: 1108-1116; advance online publication, November 28, 2016; 10.1038/leu.2016.360

CHRONIC LYMPHOCYTIC LEUKEMIA

Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib OPEN

L Kazianka, C Drucker, C Skrabs, W Thomas, T Melchardt, S Struve, M Bergmann, P B Staber, E Porpaczy, C Einberger, M Heinz, A Hauswirth, M Raderer, I Pabinger, R Thalhammer, A Egle, C-M Wendtner, G Follows, G Hoermann, P Quehenberger, B Jilma and U Jaeger

Leukemia 2017 31: 1117-1122; advance online publication, November 2, 2016; 10.1038/leu.2016.316

MULTIPLE MYELOMA, GAMMOPATHIES

Epigenetic silencing of miR-137 induces drug resistance and chromosomal instability by targeting AURKA in multiple myeloma

Y Qin, S Zhang, S Deng, G An, X Qin, F Li, Y Xu, M Hao, Y Yang, W Zhou, H Chang and L Qiu

Leukemia 2017 31: 1123-1135; advance online publication, November 18, 2016; 10.1038/leu.2016.325

CHRONIC MYELOPROLIFERATIVE NEOPLASMS

Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib OPEN

K Shide, T Kameda, T Yamaji, M Sekine, N Inada, A Kamiunten, K Akizuki, K Nakamura, T Hidaka, Y Kubuki, H Shimoda, A Kitanaka, A Honda, A Sawaguchi, H Abe, T Miike, H Iwakiri, Y Tahara, M Sueta, S Hasuike, S Yamamoto, K Nagata and K Shimoda

Leukemia 2017 31: 1136-1144; advance online publication, November 3, 2016; 10.1038/leu.2016.308

STEM CELL TRANSPLANTATION

Tracking T-cell immune reconstitution after TCRαβ/CD19-depleted hematopoietic cells transplantation in children

I V Zvyagin, I Z Mamedov, O V Tatarinova, E A Komech, E E Kurnikova, E V Boyakova, V Brilliantova, L N Shelikhova, D N Balashov, M Shugay, A L Sycheva, S A Kasatskaya, Y B Lebedev, A A Maschan, M A Maschan and D M Chudakov

Leukemia 2017 31: 1145-1153; advance online publication, November 4, 2016; 10.1038/leu.2016.321

MOLECULAR TARGETS FOR THERAPY

Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway

J Xin, D You, P Breslin, J Li, J Zhang, W Wei, J Cannova, A Volk, R Gutierrez, Y Xiao, A Ni, G Ng, R Schmidt, Z Xia, J Pan, H Chen, M M Patel, P C Kuo, S Nand, A R Kini, J Zhang, J Chen, J Zhu and J Zhang

Leukemia 2017 31: 1154-1165; advance online publication, October 17, 2016; 10.1038/leu.2016.287

Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target

F Barabé, L Gil, M Celton, A Bergeron, V Lamontagne, É Roques, K Lagacé, A Forest, R Johnson, L Pécheux, J Simard, J Pelloux, A Bellemare-Pelletier, E Gagnon, J Hébert, S Cellot and B T Wilhelm

Leukemia 2017 31: 1166-1176; advance online publication, October 26, 2016; 10.1038/leu.2016.302

MECHANISMS OF RESISTANCE

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

G Lohmann, E Vasyutina, J Bloehdorn, N Reinart, J I Schneider, V Babu, G Knittel, G Crispatzu, P Mayer, C Prinz, J K Muenzner, B Biersack, D G Efremov, L Chessa, C D Herling, S Stilgenbauer, M Hallek, R Schobert, H C Reinhardt, B Schumacher and M Herling

Leukemia 2017 31: 1177-1186; advance online publication, October 24, 2016; 10.1038/leu.2016.294

Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML OPEN

D Malani, A Murumägi, B Yadav, M Kontro, S Eldfors, A Kumar, R Karjalainen, M M Majumder, P Ojamies, T Pemovska, K Wennerberg, C Heckman, K Porkka, M Wolf, T Aittokallio and O Kallioniemi

Leukemia 2017 31: 1187-1195; advance online publication, November 11, 2016; 10.1038/leu.2016.314

TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION, CELL CYCLE

JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia

C Zhou, E Martinez, D Di Marcantonio, N Solanki-Patel, T Aghayev, S Peri, F Ferraro, T Skorski, C Scholl, S Fröhling, S Balachandran, D L Wiest and S M Sykes

Leukemia 2017 31: 1196-1205; advance online publication, November 14, 2016; 10.1038/leu.2016.329

ANIMAL MODELS

Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte–specific reporter line in zebrafish

Q Lin, Y Zhang, R Zhou, Y Zheng, L Zhao, M Huang, X Zhang, A Y H Leung, W Zhang and Y Zhang

Leukemia 2017 31: 1206-1216; advance online publication, November 4, 2016; 10.1038/leu.2016.320

Letters to the Editor

Impact of pretreatment characteristics and salvage strategy on outcome in patients with relapsed acute myeloid leukemia OPEN

R F Schlenk, P Frech, D Weber, P Brossart, H-A Horst, D Kraemer, G Held, M Ringhoffer, A Burchardt, G Kobbe, K Götze, D Nachbaur, T Fischer, M Lübbert, H R Salih, H Salwender, G Wulf, E Koller, M Wattad, W Fiedler, S Kremers, H Kirchen, B Hertenstein, P Paschka, V I Gaidzik, V Teleanu, M Heuser, F Thol, K Döhner, J Krauter, A Ganser, H Döhner and and for the German-Austrian AMLSG

Leukemia 2017 31: 1217-1220; advance online publication, January 18, 2017; 10.1038/leu.2017.22

Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia

N Yoshida, H Sakaguchi, H Muramatsu, Y Okuno, C Song, S Dovat, A Shimada, M Ozeki, H Ohnishi, T Teramoto, T Fukao, N Kondo, Y Takahashi, K Matsumoto, K Kato and S Kojima

Leukemia 2017 31: 1221-1223; advance online publication, January 18, 2017; 10.1038/leu.2017.25

JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1 OPEN

N Gupta, B Edelmann, T M Schnoeder, F C Saalfeld, D Wolleschak, S Kliche, B Schraven, F H Heidel and T Fischer

Leukemia 2017 31: 1223-1226; advance online publication, January 18, 2017; 10.1038/leu.2017.26

Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes OPEN

L Guidugli, A K Johnson, G Alkorta-Aranburu, V Nelakuditi, K Arndt, J E Churpek, L A Godley, D Townsley, N S Young, C Fitzpatrick, D del Gaudio, S Das and Z Li

Leukemia 2017 31: 1226-1229; advance online publication, January 20, 2017; 10.1038/leu.2017.28

Deletion of Ptpn1 induces myeloproliferative neoplasm

F Jobe, B Patel, T Kuzmanovic, H Makishima, Y Yang, B Przychodzen, R E Hutchison, K K Bence, J P Maciejewski and G Mohi

Leukemia 2017 31: 1229-1234; advance online publication, January 23, 2017; 10.1038/leu.2017.31

Clinical relevance of failed and missing cytogenetic analysis in acute myeloid leukaemia

L Chilton, C J Harrison, I Ashworth, D Murdy, A K Burnett, D Grimwade, A V Moorman and R K Hills

Leukemia 2017 31: 1234-1237; advance online publication, January 23, 2017; 10.1038/leu.2017.37

Blastic plasmacytoid dendritic cell neoplasm and chronic myelomonocytic leukemia: a shared clonal origin

L Brunetti, V Di Battista, A Venanzi, G Schiavoni, M P Martelli, S Ascani, C Mecucci, E Tiacci and B Falini

Leukemia 2017 31: 1238-1240; advance online publication, January 23, 2017; 10.1038/leu.2017.38

Randomized phase 3 study of lenalidomide versus chlorambucil as first-line therapy for older patients with chronic lymphocytic leukemia (the ORIGIN trial) OPEN

A Chanan-Khan, M Egyed, T Robak, F A Martinelli de Oliveira, M A Echeveste, S Dolan, P Desjardins, J Z Blonski, J Mei, N Golany, J Zhang and J G Gribben

Leukemia 2017 31: 1240-1243; advance online publication, January 31, 2017; 10.1038/leu.2017.47

Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach OPEN

A Coppe, E I Andersson, A Binatti, V R Gasparini, S Bortoluzzi, M Clemente, M Herling, J Maciejewski, S Mustjoki and S Bortoluzzi

Leukemia 2017 31: 1243-1246; advance online publication, February 7, 2017; 10.1038/leu.2017.49

MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling

T Itkin, A Kumari, E Schneider, S Gur-Cohen, C Ludwig, R Brooks, O Kollet, K Golan, E Khatib-Massalha, C M Russo, J D Chisholm, A Rouhi, H Geiger, E Hornstein, W G Kerr, F Kuchenbauer and T Lapidot

Leukemia 2017 31: 1247-1250; advance online publication, February 8, 2017; 10.1038/leu.2017.50

Correspondence

Validation of a prognostic score for patients with POEMS syndrome: a mayo clinic cohort

T V Kourelis and A Dispenzieri

Leukemia 2017 31: 1251; advance online publication, March 10, 2017; 10.1038/leu.2017.68

Corrigendum

A randomized study of pomalidomide vs placebo in persons with myeloproliferative neoplasm-associated myelofibrosis and RBC-transfusion dependence

A Tefferi, H K Al-Ali, G Barosi, T Devos, H Gisslinger, Q Jiang, J-J Kiladjian, R Mesa, F Passamonti, M F McMullin, V Ribrag, G Schiller, A M Vannucchi, D Zhou, D Reiser, J Zhong and R P Gale for the RESUME trialists

Leukemia 2017 31: 1252; 10.1038/leu.2017.2

Erratum

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia

A M Eiring, B D G Page, I L Kraft, C C Mason, N A Vellore, D Resetca, M S Zabriskie, T Y Zhang, J S Khorashad, A J Engar, K R Reynolds, D J Anderson, A Senina, A D Pomicter, C C Arpin, S Ahmad, W L Heaton, S K Tantravahi, A Todic, R Colaguori, R Moriggl, D J Wilson, R Baron, T O'Hare, P T Gunning and M W Deininger

Leukemia 2017 31: 1253-1254; 10.1038/leu.2017.14