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Advertisement | | | | | | | | | Latest Articles | View all Articles | | | | | Mosaic evolution in an asymmetrically feathered troodontid dinosaur with transitional features OPEN | | | Xing Xu, Philip Currie, Michael Pittman, Lida Xing, Qingjin Meng, Junchang Lü, Dongyu Hu and Congyu Yu | | | Troodontids were theropod dinosaurs closely related to birds. Here, Xu and colleagues describe a new, feathered troodontid species, Jianianhualong tengi, dating from the Lower Cretaceous period in China that provides insight into troodontid mosaic evolution and paravian feathering. | | | 02 May 2017 | doi: 10.1038/ncomms14972 | | |
| De novo evolved interference competition promotes the spread of biofilm defectors OPEN | | | Marivic Martin, Anna Dragoš, Theresa Hölscher, Gergely Maróti, Balázs Bálint, Martin Westermann and Ákos T. Kovács | | | The production of secreted polymers in bacterial biofilms is costly, and therefore mechanisms preventing invasion of non-producing mutants are hypothesized. Here, the authors show that non-producers can evolve the ability to better incorporate into biofilms via phage-mediated interference. | | | 02 May 2017 | doi: 10.1038/ncomms15127 | | |
| Directly converting CO2 into a gasoline fuel OPEN | | | Jian Wei, Qingjie Ge, Ruwei Yao, Zhiyong Wen, Chuanyan Fang, Lisheng Guo, Hengyong Xu and Jian Sun | | | Direct hydrogenation of CO2 into liquid fuels can mitigate CO2 emissions and reduce the rapid depletion of fossil fuels. Here, the authors show an iron-based multifunctional catalyst that converts CO2 to gasoline with high selectivity due to synergistic cooperation of multiple catalytic active sites. | | | 02 May 2017 | doi: 10.1038/ncomms15174 | | |
| Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins OPEN | | | Muneyoshi Ichikawa, Dinan Liu, Panagiotis L. Kastritis, Kaustuv Basu, Tzu Chin Hsu, Shunkai Yang and Khanh Huy Bui | | | Cilia are hair-like appendages involved in cell motility and sensory reception. Here, the authors report a high resolution cryo-EM structure of the microtubule doublet from motile cilia and identify microtubule inner proteins (MIPs) bound to the inner surface of the doublet that appear to stabilize its structure. | | | 02 May 2017 | doi: 10.1038/ncomms15035 | | |
| Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling OPEN | | | Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic and Kazue Hashimoto-Torii | | | Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result in defects in cortical development. | | | 02 May 2017 | doi: 10.1038/ncomms15157 | | |
| Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism OPEN | | | Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C. Todd, Samuel Heron, Nóra M. Márkus, Jamie McQueen, David W. Hampton, Megan Torvell, Sachin S. Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J. A. Wyllie, T. Ian Simpson and Giles E. Hardingham et al. | | | How neurons and neuronal activity regulate astrocyte functions is poorly understood. Hasel et al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are dysregulated in neurodegeneration. | | | 02 May 2017 | doi: 10.1038/ncomms15132 | | |
| Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions OPEN | | | Felix E. Held, Anton A. Guryev, Tony Fröhlich, Frank Hampel, Axel Kahnt, Corina Hutterer, Mirjam Steingruber, Hanife Bahsi, Clemens von Bojničić-Kninski, Daniela S. Mattes, Tobias C. Foertsch, Alexander Nesterov-Mueller, Manfred Marschall and Svetlana B. Tsogoeva | | | Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space. Here the authors report a route to 4,5,7,8-substituted antiviral fluorescent quinazolines, to allow cellular uptake visualization without external marker. | | | 02 May 2017 | doi: 10.1038/ncomms15071 | | |
| Similarity in viral and host promoters couples viral reactivation with host cell migration OPEN | | | Kathrin Bohn-Wippert, Erin N. Tevonian, Melina R. Megaridis and Roy D. Dar | | | The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters. | | | 02 May 2017 | doi: 10.1038/ncomms15006 | | |
| Ion-specific ice recrystallization provides a facile approach for the fabrication of porous materials OPEN | | | Shuwang Wu, Chongqin Zhu, Zhiyuan He, Han Xue, Qingrui Fan, Yanlin Song, Joseph S. Francisco, Xiao Cheng Zeng and Jianjun Wang | | | Ice recrystallization is important for a range of research fields, both applied and fundamental, however the effect of ions on this process is not well known. Here the authors discover an ion-specific Hofmeister type effect on ice recrystallization, using this phenomenon to prepare porous materials with tuneable pore sizes. | | | 02 May 2017 | doi: 10.1038/ncomms15154 | | |
| Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice OPEN | | | Tina Lucas, Florian Schäfer, Patricia Müller, Sabine A. Eming, Alexander Heckel and Stefanie Dimmeler | | | Inhibition of microRNAs using antimiRs is a potential therapeutic option for a number of diseases, but systemic inhibition may cause adverse effects. Here the authors develop light-activated antimiRs directed against miR-92a, and show localized inhibition in the skin and improved wound healing in diabetic mice. | | | 02 May 2017 | doi: 10.1038/ncomms15162 | | |
| Membraneless water filtration using CO2 OPEN | | | Sangwoo Shin, Orest Shardt, Patrick B. Warren and Howard A. Stone | | | Water treatment processes mostly rely on the use of membranes and filters, which have high pumping costs and require periodic replacement. Here, the authors describe an efficient membraneless method that induces directed motion of suspended colloidal particles by exposing the suspension to CO2. | | | 02 May 2017 | doi: 10.1038/ncomms15181 | | |
| Developmental activities of the complement pathway in migrating neurons OPEN | | | Anna Gorelik, Tamar Sapir, Rebecca Haffner-Krausz, Tsviya Olender, Trent M. Woodruff and Orly Reiner | | | Emerging evidence suggests that immune molecules play an important role in regulating brain development. Gorelik et al. show that molecules in the lectin arm of the complement pathway are expressed in the developing mouse cortex, and regulate radial migration of excitatory neurons. | | | 02 May 2017 | doi: 10.1038/ncomms15096 | | |
| Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme OPEN | | | Jiangyu Yan, Thomas R. Beattie, Adriana L. Rojas, Kelly Schermerhorn, Tamzin Gristwood, Jonathan C. Trinidad, Sonja V. Albers, Pietro Roversi, Andrew F. Gardner, Nicola G. A. Abrescia and Stephen D. Bell | | | The current model for B-family DNA polymerases in archaea is one of single-subunit enzymes in contrast to the multi-subunit complexes in eukaryotes. Here the authors show that PolB1 from Sulfolobus solfataricus exists as a heterotrimeric complex in cell extracts. | | | 02 May 2017 | doi: 10.1038/ncomms15075 | | |
| Payoff information hampers the evolution of cooperation OPEN | | | Steffen Huck, Johannes Leutgeb and Ryan Oprea | | | Knowledge of payoffs has been assumed to be weakly beneficial for the emergence of cooperation between humans. Here the authors provide evidence to the contrary, showing that during interactions in a competitive environment access to information about payoffs leads to less cooperative behaviour. | | | 02 May 2017 | doi: 10.1038/ncomms15147 | | |
| The inheritance of a Mesozoic landscape in western Scandinavia OPEN | | | Ola Fredin, Giulio Viola, Horst Zwingmann, Ronald Sørlie, Marco Brönner, Jan-Erik Lie, Else Margrethe Grandal, Axel Müller, Annina Margreth, Christoph Vogt and Jochen Knies | | | The age of weathering inferred from bedrock saprolite local to Scandinavia remains loosely constrained. Here, via K-Ar dating of authigenic, syn-weathering illite from saprolitic remnants, the authors constrain weathering to the Late Triassic. | | | 28 April 2017 | doi: 10.1038/ncomms14879 | | |
| Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate OPEN | | | Young Kwang Lee, Shalini T. Low-Nam, Jean K. Chung, Scott D. Hansen, Hiu Yue Monatrice Lam, Steven Alvarez and Jay T. Groves | | | The guanine nucleotide exchange factor SOS is a critical intermediary that transduces receptor tyrosine kinase stimulation into Ras activation. Here the authors develop a single molecule assay in which SOS is captured from raw lysates using Ras-functionalized membrane microarrays and uncover an autoinhibitory mechanism of SOS regulation. | | | 28 April 2017 | doi: 10.1038/ncomms15061 | | |
| Solid-state synthesis of ordered mesoporous carbon catalysts via a mechanochemical assembly through coordination cross-linking OPEN | | | Pengfei Zhang, Li Wang, Shize Yang, Jennifer A. Schott, Xiaofei Liu, Shannon M. Mahurin, Caili Huang, Yu Zhang, Pasquale F. Fulvio, Matthew F. Chisholm and Sheng Dai | | | Ordered mesoporous carbons have shown promise in a range of applications, but sustainable methods to achieve their large scale production are lacking. Here, Dai and coworkers produce OMCs via the mechanochemical assembly of non-toxic polyphenol-metal complexes and triblock copolymers, followed by pyrolysis. | | | 28 April 2017 | doi: 10.1038/ncomms15020 | | |
| Activin A more prominently regulates muscle mass in primates than does GDF8 OPEN | | | Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos and Jesper Gromada | | | Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates. | | | 28 April 2017 | doi: 10.1038/ncomms15153 | | |
| An intermolecular FRET sensor detects the dynamics of T cell receptor clustering OPEN | | | Yuanqing Ma, Elvis Pandzic, Philip R. Nicovich, Yui Yamamoto, Joanna Kwiatek, Sophie V. Pageon, Aleš Benda, Jérémie Rossy and Katharina Gaus | | | Cellular signalling is often facilitated by membrane protein clustering, but detection of protein clustering at high spatiotemporal resolution is challenging. Here the authors develop a single-chain FRET sensor they name CliF to look at intermolecular associations and dynamics of TCR-CD3 clusters on the T cell surface. | | | 28 April 2017 | doi: 10.1038/ncomms15100 | | |
| Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis OPEN | | | Sonja Reißig, Yilang Tang, Alexei Nikolaev, Katharina Gerlach, Christine Wolf, Kathrin Davari, Christian Gallus, Joumana Masri, Ilgiz A. Mufazalov, Markus F. Neurath, F. Thomas Wunderlich, Jörn M. Schattenberg, Peter R. Galle, Benno Weigmann, Ari Waisman, Elke Glasmacher and Nadine Hövelmeyer | | | Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice. | | | 28 April 2017 | doi: 10.1038/ncomms15069 | | |
| Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism OPEN | | | Laura V. Flórez, Kirstin Scherlach, Paul Gaube, Claudia Ross, Elisabeth Sitte, Cornelia Hermes, Andre Rodrigues, Christian Hertweck and Martin Kaltenpoth | | | Observations of recent or dynamic transitions between parasitism and mutualism are scarce. Here, Flórez et al. provide evidence that Burkholderia gladioli bacteria can protect the eggs of herbivorous beetles by producing antimicrobial compounds, while retaining their ancestral ability to infect plants. | | | 28 April 2017 | doi: 10.1038/ncomms15172 | | |
| Wheat Ms2 encodes for an orphan protein that confers male sterility in grass species OPEN | | | Fei Ni, Juan Qi, Qunqun Hao, Bo Lyu, Ming-Cheng Luo, Yan Wang, Fengjuan Chen, Shuyun Wang, Chaozhong Zhang, Lynn Epstein, Xiangyu Zhao, Honggang Wang, Xiansheng Zhang, Cuixia Chen, Lanzhen Sun and Daolin Fu | | | The dominant male-sterile gene Ms2 has facilitated the release of hundreds of wheat-breeding lines and cultivars in China. Here Ni et al. describe the cloning of the Ms2 gene, which appears as an orphan gene in the Triticinae, and show that Ms2 can be used to confer male sterility in wheat, barley and Brachypodium. | | | 28 April 2017 | doi: 10.1038/ncomms15121 | | |
| HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche OPEN | | | Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald and Linda M. S. Resar | | | The function of high mobility group A1 (Hmga1) chromatin remodelling proteins in intestinal stem cells (ISC) is unknown. Here, the authors show that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and induces Sox9 to expand the Paneth cell compartment and enrich the ISC niche. | | | 28 April 2017 | doi: 10.1038/ncomms15008 | | |
| Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity OPEN | | | Takahide Kouno, Tania V. Silvas, Brendan J. Hilbert, Shivender M. D. Shandilya, Markus F. Bohn, Brian A. Kelch, William E. Royer, Mohan Somasundaran, Nese Kurt Yilmaz, Hiroshi Matsuo and Celia A. Schiffer | | | Cytidine deaminases are evolutionarily conserved enzymes that edit genomes by deaminating cytidine to uridine. Here the authors present the crystal structure of APOBEC3A with a single-stranded DNA substrate bound in the active site to shed light on the mechanism and specificity of substrate recognition. | | | 28 April 2017 | doi: 10.1038/ncomms15024 | | |
| Segregation of liquid crystal mixtures in topological defects OPEN | | | Mohammad Rahimi, Hadi Ramezani-Dakhel, Rui Zhang, Abelardo Ramirez-Hernandez, Nicholas L. Abbott and Juan J. de Pablo | | | Liquid crystal mixtures are used in commercial applications and their composition affects their properties. Here Rahimi et al. use atomistic simulations to show that defects influence the molecular arrangement of the mixture components leading to a deviation of the local order from that of the bulk. | | | 28 April 2017 | doi: 10.1038/ncomms15064 | | |
| Homogeneously catalysed conversion of aqueous formaldehyde to H2 and carbonate OPEN | | | M. Trincado, Vivek Sinha, Rafael E. Rodriguez-Lugo, Bruno Pribanic, Bas de Bruin and Hansjörg Grützmacher | | | Aqueous formaldehyde is an attractive hydrogen storage system due to the high weight percentage of hydrogen present. Here the authors report a highly active homogeneous ruthenium catalyst system, allowing hydrogen production from formaldehyde-water under mild conditions. | | | 28 April 2017 | doi: 10.1038/ncomms14990 | | |
| Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer OPEN | | | Julienne L. Carstens, Pedro Correa de Sampaio, Dalu Yang, Souptik Barua, Huamin Wang, Arvind Rao, James P. Allison, Valerie S. LeBleu and Raghu Kalluri | | | The functional significance of T-cell infiltration in pancreatic ductal adenocarcinoma in relation to desmoplastic stroma is unclear. Here the authors develop a method to spatially resolve tumour stroma composition and find that spatial T-cell infiltration correlates with patient prognosis regardless of desmoplasia. | | | 27 April 2017 | doi: 10.1038/ncomms15095 | | |
| Cell-size dependent progression of the cell cycle creates homeostasis and flexibility of plant cell size OPEN | | | Angharad R. Jones, Manuel Forero-Vargas, Simon P. Withers, Richard S. Smith, Jan Traas, Walter Dewitte and James A. H. Murray | | | The mechanistic coupling of cell growth and cell cycle control with cell size regulation in tissues is not well understood. Here, the authors show that within the shoot apical meristem of Arabidopsis cell size depends on developmental stage, genotype and environmental signals; however cell growth and cell division are cell-autonomously coordinated. | | | 27 April 2017 | doi: 10.1038/ncomms15060 | | |
| Spatial working memory alters the efficacy of input to visual cortex OPEN | | | Yaser Merrikhi, Kelsey Clark, Eddy Albarran, Mohammadbagher Parsa, Marc Zirnsak, Tirin Moore and Behrad Noudoost | | | Frontal eye field (FEF) is a visual prefrontal area involved in top-down attention. Here the authors report that FEF neurons projecting to V4/MT are persistently active during spatial working memory, and V4/MT neurons show changes in receptive field and gain at the location held in working memory. | | | 27 April 2017 | doi: 10.1038/ncomms15041 | | |
| DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6 OPEN | | | Xiaowei Xu, Shijiao Huang, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li, Qing Jiang and Chuanmao Zhang | | | Centrosome duplication is synchronized with cell cycle events but how this is regulated at a molecular level is unclear. Here, the authors show that the DNA replication licensing factor Cdc6 restrains centrosome duplication via binding and inhibiting Sas-6, and the inhibition of Cdc6 on Sas-6 is negatively regulated by Plk4 phosphorylation. | | | 27 April 2017 | doi: 10.1038/ncomms15164 | | |
| Efficient self-emulsification via cooling-heating cycles OPEN | | | Slavka Tcholakova, Zhulieta Valkova, Diana Cholakova, Zahari Vinarov, Ivan Lesov, Nikolai Denkov and Stoyan K. Smoukov | | | Emulsions are mixtures of liquids which have applications to pharmaceutical, cosmetic and food components. Here Tcholakova et al. have developed a low-energy emulsification method which requires a low amount of surfactant, works for temperature-sensitive compounds and has potential for scale-up. | | | 27 April 2017 | doi: 10.1038/ncomms15012 | | |
| Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea OPEN | | | Zhiqiang Li, Jianhua Chen, Ying Zhao, Yujiong Wang, Jinrui Xu, Jue Ji, Jingyi Shen, Weiping Zhang, Zuosong Chen, Qilin Sun, Lijuan Mao, Shulin Cheng, Bo Yang, Dongtao Zhang, Yufeng Xu, Yingying Zhao, Danping Liu, Yinhuan Shen, Weijie Zhang, Changgui Li et al. | | | Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants in ZMIZ1 and near NGF conferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population. | | | 27 April 2017 | doi: 10.1038/ncomms14900 | | |
| Distinct molecular cues ensure a robust microtubule-dependent nuclear positioning in the Drosophila oocyte OPEN | | | Nicolas Tissot, Jean-Antoine Lepesant, Fred Bernard, Kevin Legent, Floris Bosveld, Charlotte Martin, Orestis Faklaris, Yohanns Bellaïche, Maïté Coppey and Antoine Guichet | | | Asymmetric nuclear positioning in the fruit fly oocyte is essential for the correct localization of axis determinants. Here, the authors show that different microtubule-dependent mechanisms contribute to nuclear transport and ensure the robustness of nuclear positioning. | | | 27 April 2017 | doi: 10.1038/ncomms15168 | | |
| Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics OPEN | | | Joohee Kim, Minji Kim, Mi-Sun Lee, Kukjoo Kim, Sangyoon Ji, Yun-Tae Kim, Jihun Park, Kyungmin Na, Kwi-Hyun Bae, Hong Kyun Kim, Franklin Bien, Chang Young Lee and Jang-Ung Park | | | Wearable electronics have been utilized for a number of applications including for ocular use, although their use has been limited to a single function. Here, the authors developed a multifunctional contact lens with wireless electronics for measurement of glucose and intraocular pressure. | | | 27 April 2017 | doi: 10.1038/ncomms14997 | | |
| Creation of energetic biothermite inks using ferritin liquid protein OPEN | | | Joseph M. Slocik, Ruel McKenzie, Patrick B. Dennis and Rajesh R. Naik | | | Energetic liquids often suffer from low energy density. Here, the authors create a highly energetic liquid by stabilizing aluminium nanoparticles in ferritin liquid protein, and use this ink to print energetic 3D structures. | | | 27 April 2017 | doi: 10.1038/ncomms15156 | | |
| PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA OPEN | | | Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C. Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price and David M. Weinstock | | | Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA. | | | 27 April 2017 | doi: 10.1038/ncomms15110 | | |
| Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 OPEN | | | Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O’Neill, Sudipto Das, Qi Lan, Roelof Koster, null null et al. | | | Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148. | | | 27 April 2017 | doi: 10.1038/ncomms15034 | | |
| Electronegativity determination of individual surface atoms by atomic force microscopy OPEN | | | Jo Onoda, Martin Ondráček, Pavel Jelínek and Yoshiaki Sugimoto | | | Electronegativity is a fundamental concept in chemistry; however it is an elusive quantity to evaluate experimentally. Here, the authors estimate the Pauling electronegativity of individual atoms on a surface via atomic force microscopy using a variety of chemically reactive tips. | | | 26 April 2017 | doi: 10.1038/ncomms15155 | | |
| A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination OPEN | | | Yaqi Deng, Lai Man Natalie Wu, Shujun Bai, Chuntao Zhao, Haibo Wang, Jincheng Wang, Lingli Xu, Masahide Sakabe, Wenhao Zhou, Mei Xin and Q. Richard Lu | | | The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances SC proliferation and differentiation. | | | 26 April 2017 | doi: 10.1038/ncomms15161 | | |
| Rich complex behaviour of self-assembled nanoparticles far from equilibrium OPEN | | | Serim Ilday, Ghaith Makey, Gursoy B. Akguc, Özgün Yavuz, Onur Tokel, Ihor Pavlov, Oguz Gülseren and F. Ömer Ilday | | | Unravelling the fundamental mechanisms of emergence of complex behaviour is key to understanding living systems. Here, the authors provide a simple experimental platform to investigate and control a rich set of complex phenomena, akin to those seen in living organisms, from a nonliving system of colloidal nanoparticles. | | | 26 April 2017 | doi: 10.1038/ncomms14942 | | |
| Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits OPEN | | | Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher, Kristin Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley, Julius S. Ngwa, Tarunveer S. Ahluwalia, Audrey Y. Chu, Nancy L. Heard-Costa, Elise Lim, Jeremiah Perez, John D. Eicher, Zoltán Kutalik, Luting Xue, Anubha Mahajan et al. | | | Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities. | | | 26 April 2017 | doi: 10.1038/ncomms14977 | | |
| A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory OPEN | | | Virginie Freytag, Tania Carrillo-Roa, Annette Milnik, Philipp G. Sämann, Vanja Vukojevic, David Coynel, Philippe Demougin, Tobias Egli, Leo Gschwind, Frank Jessen, Eva Loos, Wolfgang Maier, Steffi G. Riedel-Heller, Martin Scherer, Christian Vogler, Michael Wagner, Elisabeth B. Binder, Dominique J. -F. de Quervain and Andreas Papassotiropoulos | | | Cortical thickness has high heritability estimates and is known to be influenced by genetic factors. Here, Freytag and colleagues show that DNA methylation patterns of peripheral blood monocytes are also correlated with cortical thickness and memory performance in human. | | | 26 April 2017 | doi: 10.1038/ncomms15193 | | |
| Fundamental limits of repeaterless quantum communications OPEN | | | Stefano Pirandola, Riccardo Laurenza, Carlo Ottaviani and Leonardo Banchi | | | Quantum communications will be used to transmit entanglement and secure keys, but it is important to estimate their optimal transfer rates. Here the authors compute the fundamental limit of repeaterless quantum communications for the most relevant practical scenario. | | | 26 April 2017 | doi: 10.1038/ncomms15043 | | |
| Holey two-dimensional transition metal oxide nanosheets for efficient energy storage OPEN | | | Lele Peng, Pan Xiong, Lu Ma, Yifei Yuan, Yue Zhu, Dahong Chen, Xiangyi Luo, Jun Lu, Khalil Amine and Guihua Yu | | | As alkali-ion battery anodes, metal oxide nanomaterials suffer from severe structural degradation after charging/discharging cycling. Here the authors develop two-dimensional holey nanosheet anodes which display minimal structural changes during electrochemical operation. | | | 26 April 2017 | doi: 10.1038/ncomms15139 | | |
| FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis OPEN | | | Feng Xie, Ke Jin, Li Shao, Yao Fan, Yifei Tu, Yihao Li, Bin Yang, Hans van Dam, Peter ten Dijke, Honglei Weng, Steven Dooley, Shuai Wang, Junling Jia, Jin Jin , Fangfang Zhou and Long Zhang | | | Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xie et al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis. | | | 26 April 2017 | doi: 10.1038/ncomms15021 | | |
| Programming mRNA decay to modulate synthetic circuit resource allocation OPEN | | | Ophelia S. Venturelli, Mika Tei, Stefan Bauer, Leanne Jade G. Chan, Christopher J. Petzold and Adam P Arkin | | | Synthetic circuits in host cells compete with endogenous processes for limited resources. Here the authors use MazF to funnel cellular resources to a synthetic circuit to increase product production and demonstrate how resource allocation can be manipulated. | | | 26 April 2017 | doi: 10.1038/ncomms15128 | | |
| Multifunctionality of silver closo-boranes OPEN | | | Mark Paskevicius, Bjarne R. S. Hansen, Mathias Jørgensen, Bo Richter and Torben R. Jensen | | | Silver compounds have long been known to possess exceptional solid-state conductivity. Here the authors present silver closo-boranes in which facile Ag+ migration occurs, leading to exceptionally high ion conductivities and potential utility in silver nanowire production and photocatalysis due to their semiconductivity. | | | 26 April 2017 | doi: 10.1038/ncomms15136 | | |
| Nanodiamond-enhanced MRI via in situ hyperpolarization OPEN | | | David E. J. Waddington, Mathieu Sarracanie, Huiliang Zhang, Najat Salameh, David R. Glenn, Ewa Rej, Torsten Gaebel, Thomas Boele, Ronald L. Walsworth, David J. Reilly and Matthew S. Rosen | | | Hyperpolarized magnetic resonance imaging can enhance imaging contrast by orders of magnitude, but applications are limited by the thermal relaxation of hyperpolarized states. Here, Waddington et al. demonstrate the on-demand hyperpolarization of hydrogen spins through the Overhauser effect with nanodiamonds. | | | 26 April 2017 | doi: 10.1038/ncomms15118 | | | | | | | | | | | | | Latest Corrigendum | | | | | | | | | |
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