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| | | Rational design of non-resistant targeted cancer therapies ▶ | | | Francisco Martínez-Jiménez, John P. Overington, Bissan Al-Lazikani et al. | | | Drug resistance is one of the major problems in targeted cancer therapy. A major cause of resistance is changes in the amino acids that form the drug-target binding site. Despite … | | | | |
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| | | Long term stability and infectivity of herpesviruses in water ▶ | | | Anisha Dayaram, Mathias Franz, Alexander Schattschneider et al. | | | For viruses to utilize environmental vectors (hard surfaces, soil, water) for transmission, physical and chemical stability is a prerequisite. There are many factors including … | | | | |
| | | A large-scale benchmark of gene prioritization methods ▶ | | | Dimitri Guala, Erik L. L. Sonnhammer | | | In order to maximize the use of results from high-throughput experimental studies, e.g. GWAS, for identification and diagnostics of new disease-associated genes, it is important … | | | | |
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| | | Plant gum identification in historic artworks ▶ | | | Clara Granzotto, Julie Arslanoglu, Christian Rolando et al. | | | We describe an integrated and straightforward new analytical protocol that identifies plant gums from various sample sources including cultural heritage. Our approach is based on … | | | | |
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| | | Oncogenic activity of SOX1 in glioblastoma ▶ | | | Idoia Garcia, Juncal Aldaregia, Jelena Marjanovic Vicentic et al. | | | Glioblastoma remains the most common and deadliest type of brain tumor and contains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), which contributes … | | | | |
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| | | Running exercise strengthens the intervertebral disc ▶ | | | Daniel L. Belavý, Matthew J. Quittner, Nicola Ridgers et al. | | | There is currently no evidence that the intervertebral discs (IVDs) can respond positively to exercise in humans. Some authors have argued that IVD metabolism in humans is too … | | | | |
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| | | Light-Patterned Current Generation in a Droplet Bilayer Array ▶ | | | Vanessa Restrepo Schild, Michael J. Booth, Stuart J. Box et al. | | | We have created a 4 × 4 droplet bilayer array comprising light-activatable aqueous droplet bio-pixels. Aqueous droplets containing bacteriorhodopsin (bR), a light-driven proton … | | | | |
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| | | Live imaging of H3K9 acetylation in plant cells ▶ | | | Kazuki Kurita, Takuya Sakamoto, Noriyoshi Yagi et al. | | | Proper regulation of histone acetylation is important in development and cellular responses to environmental stimuli. However, the dynamics of histone acetylation at the … | | | | |
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