Tuesday, April 4, 2017

Scientific Reports Biology Table of Contents e-alert: 04 April 2017

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Biological Sciences

Multi-compartment encapsulation of communicating droplets and droplet networks in hydrogel as a model for artificial cells


Mariam Bayoumi, Hagan Bayley, Giovanni Maglia et al.


Constructing a cell mimic is a major challenge posed by synthetic biologists. Efforts to this end have been primarily focused on lipid- and polymer-encapsulated containers, …


Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome


Syed Faraz Kazim, Julie Blanchard, Riccardo Bianchi et al.


Down syndrome (DS), caused by trisomy 21, is the most common genetic cause of intellectual disability and is associated with a greatly increased risk of early-onset Alzheimer’s …


A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription


Mitsuko Fukuhara, Yue Ma, Kazuo Nagasawa et al.


The H19 gene, one of the best known imprinted genes, encodes a long non-coding RNA that regulates cell proliferation and differentiation. H19 RNA is widely expressed in embryonic …


A novel treatment for metastatic lymph nodes using lymphatic delivery and photothermal therapy


Adewale O. Oladipo, Oluwatobi S. Oluwafemi, Sandile P. Songca et al.


Systemic delivery of an anti-cancer agent often leads to only a small fraction of the administered dose accumulating in target sites. Delivering anti-cancer agents through the …


Housekeeping in Tephritid insects: the best gene choice for expression analyses in the medfly and the olive fly


Efthimia Sagri, Panagiota Koskinioti, Maria-Eleni Gregoriou et al.


Real-time quantitative-PCR has been a priceless tool for gene expression analyses. The reaction, however, needs proper normalization with the use of housekeeping genes (HKGs), …


A mitochondria-targeting artemisinin derivative with sharply increased antitumor but depressed anti-yeast and anti-malaria activities


Chen Sun, Yu Cao, Pan Zhu et al.


The potent anti-malarial drug artemisinins are additionally anti-tumorigenic and inhibitory to yeast growth. The action mechanism of artemisinins, however, is not well …


Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation


Yong Ryoul Yang, Seungju Song, Hongik Hwang et al.


O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of …


CRISPR/Cas9-mediated efficient genome editing via blastospore-based transformation in entomopathogenic fungus Beauveria bassiana


Jingjing Chen, Yiling Lai, Lili Wang et al.


Beauveria bassiana is an environmentally friendly alternative to chemical insecticides against various agricultural insect pests and vectors of human diseases. However, its …


Network-based characterization and prediction of human DNA repair genes and pathways


Yan-Hui Li, Gai-Gai Zhang


Network biology is a useful strategy to understand cell’s functional organization. In this study, for the first time, we successfully introduced network approaches to study …


Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction


Jun Suzuki, Ken Hashimoto, Ru Xiao et al.


The use of viral vectors for inner ear gene therapy is receiving increased attention for treatment of genetic hearing disorders. Most animal studies to date have injected viral …


Phylogeny and historical biogeography of leafhopper subfamily Evacanthinae (Hemiptera: Cicadellidae) based on morphological and molecular data


Yang Wang, Christopher H. Dietrich, Yalin Zhang


Phylogenetic relationships among major lineages of the Evacanthinae, a highly diverse leafhopper subfamily distributed worldwide, were explored by analysing a dataset of 100 …


Genetic and Proteomic characterization of Bile Salt Export Pump (BSEP) in Snake Liver


Xinle Tan, Fei Gao, Hexiu Su et al.


Snake gallbladder, a traditional Chinese medicine, has been believed in various Asian countries to improve visual acuity and alleviate rheumatism. Bile acids, a major component …


Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133


Wonhee Hur, Jae Yong Ryu, Hyun Uk Kim et al.


Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be …


Important roles of Vilse in dendritic architecture and synaptic plasticity


Jin-Yu Lee, Li-Jen Lee, Chih-Chen Fan et al.


Vilse/Arhgap39 is a Rho GTPase activating protein (RhoGAP) and utilizes its WW domain to regulate Rac/Cdc42-dependent morphogenesis in Drosophila and murine hippocampal neurons. …


Actual measurement, hygrothermal response experiment and growth prediction analysis of microbial contamination of central air conditioning system in Dalian, China


Yang Lv, Guangyao Hu, Chunyang Wang et al.


The microbial contamination of central air conditioning system is one of the important factors that affect the indoor air quality. Actual measurement and analysis were carried …


Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways


Yue Hou, Guoxun Li, Jian Wang et al.


The EtOAc extract of Coreopsis tinctoria Nutt. significantly inhibited LPS-induced nitric oxide (NO) production, as judged by the Griess reaction, and attenuated the LPS-induced …


Chitosan promotes cancer progression and stem cell properties in association with Wnt signaling in colon and hepatocellular carcinoma cells


Po-Hsiang Chang, Keisuke Sekine, Hsiao-Mei Chao et al.


Cancer stem cells (CSCs), a small population of cancer cells, have been considered to be the origin of cancer initiation, recurrence, and metastasis. Tumor microenvironment …


Cholinesterase-like organocatalysis by imidazole and imidazole-bearing molecules


Paola Nieri, Sara Carpi, Stefano Fogli et al.


Organocatalysis, which is mostly explored for its new potential industrial applications, also represents a chemical event involved in endogenous processes. In the present study, …


Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities


Hui Xie, Zhenxing Wang, Liming Zhang et al.


Vascularization is crucial for bone regeneration after the transplantation of tissue-engineered bone grafts in the clinical setting. Growing evidence suggests that mesenchymal …


Use of banker plant system for sustainable management of the most important insect pest in rice fields in China


Xusong Zheng, Yanhui Lu, Pingyang Zhu et al.


To meet the World’s food demand, there is a growing need for sustainable pest management practices. This study describes the results from complementary laboratory and field …


Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA


Katsuhiro Nakanishi, Shota Morikane, Shiori Ichikawa et al.


Shiga toxin is a major virulence factor of food-poisoning caused by Escherichia coli such as O157:H7. Secretory immunoglobulin (Ig) A (SIgA) is supposed to prevent infection of …


Tenofovir Inhibits Wound Healing of Epithelial Cells and Fibroblasts from the Upper and Lower Human Female Reproductive Tract


Marta Rodriguez-Garcia, Mickey V. Patel, Zheng Shen et al.


Disruption of the epithelium in the female reproductive tract (FRT) is hypothesized to increase HIV infection risk by interfering with barrier protection and facilitating …


DOSCATs: Double standards for protein quantification


Richard J. Bennett, Deborah M. Simpson, Stephen W. Holman et al.


The two most common techniques for absolute protein quantification are based on either mass spectrometry (MS) or on immunochemical techniques, such as western blotting (WB). …


TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1


Jia-chun Yang, Yi Zhang, Si-jia He et al.


Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. …


Use of 3D faces facilitates facial expression recognition in children


Lamei Wang, Wenfeng Chen, Hong Li


This study assessed whether presenting 3D face stimuli could facilitate children’s facial expression recognition. Seventy-one children aged between 3 and 6 participated in the …


Risk assessment of ‘Candidatus Liberibacter solanacearum’ transmission by the psyllids Bactericera trigonica and B. tremblayi from Apiaceae crops to potato


C. A. Antolinez, A. Fereres, A. Moreno


Candidatus Liberibacter solanacearum (Lso) is bacterium transmitted by psyllids to Solanaceae and Apiaceae plants. So far, Lso is found in Europe affecting Apiaceae. In the …


Oil adsorption ability of three-dimensional epicuticular wax coverages in plants


Elena V. Gorb, Philipp Hofmann, Alexander E. Filippov et al.


Primary aerial surfaces of terrestrial plants are very often covered with three-dimensional epicuticular waxes. Such wax coverages play an important role in insect-plant …


Rapid, simple and direct detection of Meloidogyne hapla from infected root galls using loop-mediated isothermal amplification combined with FTA technology


Huan Peng, Haibo Long, Wenkun Huang et al.


The northern root-knot nematode (Meloidogyne hapla) is a damaging nematode that has caused serious economic losses worldwide. In the present study, a sensitive, simple and rapid …


Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic Ca2+ spike


Guosheng Yi, Jiang Wang, Xile Wei et al.


Dendritic Ca2+ spike endows cortical pyramidal cell with powerful ability of synaptic integration, which is critical for neuronal computation. Here we propose a two-compartment …


Protein-coding genes in B chromosomes of the grasshopper Eyprepocnemis plorans


Beatriz Navarro-Domínguez, Francisco J. Ruiz-Ruano, Josefa Cabrero et al.


For many years, parasitic B chromosomes have been considered genetically inert elements. Here we show the presence of ten protein-coding genes in the B chromosome of the …


High-resolution RNA allelotyping along the inactive X chromosome: evidence of RNA polymerase III in regulating chromatin configuration


Ru Hong, Bingqing Lin, Xinyi Lu et al.


We carried out padlock capture, a high-resolution RNA allelotyping method, to study X chromosome inactivation (XCI). We examined the gene reactivation pattern along the inactive …


A furoviral replicase recruits host HSP70 to membranes for viral RNA replication


Jian Yang, Fen Zhang, Nian-Jun Cai et al.


Many host factors have been identified to be involved in viral infection. However, although furoviruses cause important diseases of cereals worldwide, no host factors have yet …


Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics


Otoya Ueda, Naoko A. Wada, Yasuko Kinoshita et al.


T cell–mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key molecules to …


Proteomic signature of muscle fibre hyperplasia in response to faba bean intake in grass carp


Er-Meng Yu, Hao-Fang Zhang, Zhi-Fei Li et al.


Fish muscle growth is important for the rapidly developing global aquaculture industry, particularly with respect to production and quality. Changes in muscle fibre size are …


Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue


Takeichiro Nakane, Hidetoshi Masumoto, Joseph P. Tinney et al.


The current study describes a scalable, porous large-format engineered cardiac tissue (LF-ECT) composed of human induced pluripotent stem cells (hiPSCs) derived multiple lineage …


Improving “color rendering” of LED lighting for the growth of lettuce


Tao Han, Vitaliy Vaganov, Shixiu Cao et al.


Light plays a vital role on the growth and development of plant. On the base of white light with high color rendering to the benefit of human survival and life, we proposed to …


Identification and expression of cuticular protein genes based on Locusta migratoria transcriptome


Xiaoming Zhao, Xin Gou, Zhongyu Qin et al.


Many types of cuticular proteins are found in a single insect species, and their number and features are very diversified among insects. The cuticle matrix consists of many …


The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization


Giovanni Messina, Maria Teresa Atterrato, Yuri Prozzillo et al.


The human Cranio Facial Development Protein 1 (Cfdp1) gene maps to chromosome 16q22.2-q22.3 and encodes the CFDP1 protein, which belongs to the evolutionarily conserved Bucentaur …


Perfluorodecanoic acid stimulates NLRP3 inflammasome assembly in gastric cells


Xiangyu Zhou, Tianyi Dong, Ziyan Fan et al.


Perfluorodecanoic acid (PFDA), a perfluorinated carboxylic acid, presents in the environment and accumulates in human blood and organs, but its association with tumor promotion …


Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice


Chun Yang, Yuko Fujita, Qian Ren et al.


Accumulating evidence suggests that abnormalities in the composition of the gut microbiota may play a role in the pathogenesis of depression. Although approximately 30% mice are …


Successful lichen translocation on disturbed gypsum areas: A test with adhesives to promote the recovery of biological soil crusts


M. Ballesteros, J. Ayerbe, M. Casares et al.


The loss of biological soil crusts represents a challenge for the restoration of disturbed environments, specifically in particular substrates hosting unique lichen communities. …


Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases


Faran Sabeti, Andrew C. James, Corinne F. Carle et al.


Multifocal pupillographic objective perimetry (mfPOP) shows regions of slight hypersensitivity away from retinal regions damaged by diabetes or age-related macular degeneration …


Eukaryotic Life Inhabits Rhodolith-forming Coralline Algae (Hapalidiales, Rhodophyta), Remarkable Marine Benthic Microhabitats


Sherry Krayesky-Self, William E. Schmidt, Delena Phung et al.


Rhodoliths are benthic calcium carbonate nodules accreted by crustose coralline red algae which recently have been identified as useful indicators of biomineral changes resulting …


Fermented milk containing Lactobacillus paracasei subsp. paracasei CNCM I-1518 reduces bacterial translocation in rats treated with carbon tetrachloride


Elisabet Sánchez, Juan C. Nieto, Silvia Vidal et al.


Probiotics can prevent pathological bacterial translocation by modulating intestinal microbiota and improving the gut barrier. The aim was to evaluate the effect of a fermented …


Decreased Amount of Supporting Alveolar Bone at Single-Rooted Premolars Is Under Estimated by 2D Examinations


Hsiang-Hsi Hong, Chung-Chieh Chang, Adrienne Hong et al.


The purpose of this study was to relate the proportions of bone-supported root length of a 2D view into the amount of a 3D bone-attached root surface area (BA-RSA) by using a …


Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state


Diniz M. Sena Jr, Xiaojing Cong, Alejandro Giorgetti et al.


G-protein coupled receptors (GPCRs) are the largest and most pharmaceutically relevant family of membrane proteins. Here, fully unbiased, enhanced sampling simulations of a …


On the determination of elastic moduli of cells by AFM based indentation


Yue Ding, Guang-Kui Xu, Gang-Feng Wang


The atomic force microscopy (AFM) has been widely used to measure the mechanical properties of biological cells through indentations. In most of existing studies, the cell is …


Generation of Aptamers from A Primer-Free Randomized ssDNA Library Using Magnetic-Assisted Rapid Aptamer Selection


Shih-Ming Tsao, Ji-Ching Lai, Horng-Er Horng et al.


Aptamers are oligonucleotides that can bind to specific target molecules. Most aptamers are generated using random libraries in the standard systematic evolution of ligands by …


Polymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level


Wei Liu, Bing Han, Wenjiao Zhu et al.


Selective splicing is a feature of luteinizing hormone receptor (LHCGR). A cryptic exon (LHCGR-exon 6A) was found to be derived from alternative splicing in intron 6 of the LHCGR


Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation


Liang-Jen Wang, Wen-Ching Chan, Miao-Chun Chou et al.


This study examined the relationships among polymorphisms of the STS gene and SULT2A1 gene, dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S), and characteristics of …


Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography


Kengyeh K. Chu, Mark E. Kusek, Linbo Liu et al.


A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting …


Bioenergetic Impairment in Congenital Muscular Dystrophy Type 1A and Leigh Syndrome Muscle Cells


Cibely C. Fontes-Oliveira, Maarten Steinz, Peter Schneiderat et al.


Skeletal muscle has high energy requirement and alterations in metabolism are associated with pathological conditions causing muscle wasting and impaired regeneration. Congenital …


Herbicidal properties of antimalarial drugs


Maxime G. Corral, Julie Leroux, Keith A. Stubbs et al.


The evolutionary relationship between plants and the malarial parasite Plasmodium falciparum is well established and underscored by the P. falciparum apicoplast, an essential …


HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma


Shoutaro Tsuji, Kota Washimi, Taihei Kageyama et al.


The absence of highly specific markers for malignant mesothelioma (MM) has served an obstacle for its diagnosis and development of molecular-targeting therapy against MM. Here, …


Follistatin-like 1 protects against hypoxia-induced pulmonary hypertension in mice


Wei Zhang, Wang Wang, Jie Liu et al.


Pulmonary hypertension (PH) remains a life-limiting disease characterized by pulmonary vascular remodelling due to aberrant proliferation and migration of pulmonary artery smooth …


Degradation of neural representations in higher visual cortex by sleep deprivation


Jia-Hou Poh, Michael W. L. Chee


A night of total sleep deprivation (TSD) impairs selective attention and is accompanied by attenuated activation within ventral visual cortex (VVC). However, finer details of how …


Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor


Nikita Abraham, Michael Healy, Lotten Ragnarsson et al.


Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been …


Migration phenology and breeding success are predicted by methylation of a photoperiodic gene in the barn swallow


Nicola Saino, Roberto Ambrosini, Benedetta Albetti et al.


Individuals often considerably differ in the timing of their life-cycle events, with major consequences for individual fitness, and, ultimately, for population dynamics. …


Rediscovery and reclassification of the dipteran taxon Nothomicrodon Wheeler, an exclusive endoparasitoid of gyne ant larvae


Gabriela Pérez-Lachaud, Benoit J. B. Jahyny, Gunilla Ståhls et al.


The myrmecophile larva of the dipteran taxon Nothomicrodon Wheeler is rediscovered, almost a century after its original description and unique report. The systematic position of …


Stable mucus-associated bacterial communities in bleached and healthy corals of Porites lobata from the Arabian Seas


Ghaida Hadaidi, Till Röthig, Lauren K. Yum et al.


Coral reefs are subject to coral bleaching manifested by the loss of endosymbiotic algae from coral host tissue. Besides algae, corals associate with bacteria. In particular, …


MicroRNAs Associated with Caste Determination and Differentiation in a Primitively Eusocial Insect


David H. Collins, Irina Mohorianu, Matthew Beckers et al.


In eusocial Hymenoptera (ants, bees and wasps), queen and worker adult castes typically arise via environmental influences. A fundamental challenge is to understand how a single …


Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection


Sarah J. Wassmer, Livia S. Carvalho, Bence György et al.


Widespread gene transfer to the retina is challenging as it requires vector systems to overcome physical and biochemical barriers to enter and diffuse throughout retinal tissue. …


Mapping ECoG channel contributions to trajectory and muscle activity prediction in human sensorimotor cortex


Yasuhiko Nakanishi, Takufumi Yanagisawa, Duk Shin et al.


Studies on brain-machine interface techniques have shown that electrocorticography (ECoG) is an effective modality for predicting limb trajectories and muscle activity in humans. …


Cell-to-cell transfer of SAA1 protein in a cell culture model of systemic AA amyloidosis


Stephanie Claus, Ioana Puscalau-Girtu, Paul Walther et al.


Systemic AA amyloidosis arises from the misfolding of serum amyloid A1 (SAA1) protein and the deposition of AA amyloid fibrils at multiple sites within the body. Previous …


PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study


Chun-Chung Chen, XianXiu Chen, Tsai-Chung Li et al.


PG2 is an infusible polysaccharide extracted from Astragalus membranaceus, which is a Chinese herb traditionally used for stroke treatment. We investigated the effect of PG2 on …


Comparative Transcriptomic Analysis of Vernalization- and Cytokinin-Induced Floral Transition in Dendrobium nobile


Zhenzhen Wen, Wenzhong Guo, Jinchi Li et al.


Vernalization is required for floral initiation in Dendrobium. Interestingly, those beneficial effects can also be achieved by exogenous cytokinin application in greenhouses. …


Control strategy of hand movement depends on target redundancy


Shunta Togo, Toshinori Yoshioka, Hiroshi Imamizu


Reaching toward a point target has been intensively studied in human motor control. However, little is known about reaching toward a redundant target, such as grasping a bar, in …


Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing


Haruhiko Takeda, Yoshihide Ueda, Tadashi Inuzuka et al.


Resistance-associated variant (RAV) is one of the most significant clinical challenges in treating HCV-infected patients with direct-acting antivirals (DAAs). We investigated the …


Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity


Yasmine M. Cissé, Kathryn L.G. Russart, Randy J. Nelson


Exposure to dim light at night (dLAN) disrupts natural light/dark cycles and impairs endogenous circadian rhythms necessary to maintain optimal biological function, including the …


Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients


Liqiang Zhi, Shuxin Yao, Wenlong Ma et al.


Rheumatoid arthritis (RA) is a common, chronic autoimmune disease affecting 0.5–1.0% of adults worldwide, including approximately 4.5–5.0 million patients in China. The genetic …


Label-free quantification of calcium-sensor targeting to photoreceptor guanylate cyclase and rhodopsin kinase by backscattering interferometry


Stefan Sulmann, Amanda Kussrow, Darryl J. Bornhop et al.


Quantification of protein binding to membrane proteins is challenging and a limited set of methods is available to study such systems. Here we employed backscattering …


Transcriptomics and proteomic studies reveal acaricidal mechanism of octadecanoic acid-3, 4 - tetrahydrofuran diester against Sarcoptes scabiei var. cuniculi


Xu Song, Zhenzhen Chen, Renyong Jia et al.


In our previous study, a new compound, octadecanoic acid-3, 4-tetrahydrofuran diester, possessing potent acaricidal activity was obtained from neem oil. This study performed …


Individual Differences in Moral Disgust Do Not Predict Utilitarian Judgments, Sexual and Pathogen Disgust Do


Michael Laakasuo, Jukka Sundvall, Marianna Drosinou


The role of emotional disgust and disgust sensitivity in moral judgment and decision-making has been debated intensively for over 20 years. Until very recently, there were two …


Mechanisms of social buffering of fear in zebrafish


Ana I. Faustino, André Tacão-Monteiro, Rui F. Oliveira


Some humans thrive whereas others resign when exposed to threatening situations throughout life. Social support has been identified as an important modulator of these …


Photodynamic dye adsorption and release performance of natural zeolite


Vladimir Hovhannisyan, Chen-Yuan Dong, Shean-Jen Chen


Clinoptilolite type of zeolite (CZ) is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional …


Sustained delivery of calcium and orthophosphate ions from amorphous calcium phosphate and poly(L-lactic acid)-based electrospinning nanofibrous scaffold


Xufeng Niu, Zhongning Liu, Feng Tian et al.


The purpose of this study is to investigate electrospinning poly(L-lactic acid) (PLLA) nanofibrous scaffold with different contents of amorphous calcium phosphate (ACP), which is …


Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers


Yulei Chang, Xiaodan Li, Li Zhang et al.


Recent advances in upconversion nanophotosensitizers (UCNPs-PS) excited by near-infrared (NIR) light have led to substantial progress in improving photodynamic therapy (PDT) of …


Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model


Satoshi Koyama, Shinji Matsunaga, Masaki Imanishi et al.


Blood vessels are important tissue structures that deliver oxygen and nutrition. In tumour tissue, abnormal blood vessels, which are hyperpermeable and immature, are often …


Corticosterone activity during early weaning reprograms molecular markers in rat gastric secretory cells


Juliana Guimarães Zulian, Larissa Yukari Massarenti Hosoya, Priscila Moreira Figueiredo et al.


Gastric epithelial cells differentiate throughout the third postnatal week in rats, and become completely functional by weaning time. When suckling is interrupted by early …


Atomic resolution structure of serine protease proteinase K at ambient temperature


Tetsuya Masuda, Mamoru Suzuki, Shigeyuki Inoue et al.


Atomic resolution structures (beyond 1.20 Å) at ambient temperature, which is usually hampered by the radiation damage in synchrotron X-ray crystallography (SRX), will add to our …


Increased mitochondrial coupling and anaerobic capacity minimizes aerobic costs of trout in the sea


Jeroen Brijs, Erik Sandblom, Henrik Sundh et al.


Anadromy is a distinctive life-history strategy in fishes that has evolved independently many times. In an evolutionary context, the benefits of anadromy for a species or …


IgE binds asymmetrically to its B cell receptor CD23


Balvinder Dhaliwal, Marie O. Y. Pang, Anthony H. Keeble et al.


The antibody IgE plays a central role in allergic disease mechanisms. Its effector functions are controlled through interactions between the Fc region and two principal cell …


Comparative Subcellular Proteomics Analysis of Susceptible and Near-isogenic Resistant Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV infection


Xue-yang Wang, Hai-zhong Yu, Jia-ping Xu et al.


The molecular mechanism of silkworm resistance to Bombyx mori nucleopolyhedrovirus (BmNPV) infection remains largely unclear. Accumulating evidence suggests that subcellular …


Effects of atmospheric-pressure non-thermal bio-compatible plasma and plasma activated nitric oxide water on cervical cancer cells


Ying Li, Min Ho Kang, Han Sup Uhm et al.


Atmospheric-pressure non-thermal bio-compatible plasma is a partially ionized gas with electrically charged particles. Previous studies demonstrated that dielectric barrier …


Y14 governs p53 expression and modulates DNA damage sensitivity


Chia-Chen Lu, Chi-Chieh Lee, Ching-Tzu Tseng et al.


Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 causes G2/M arrest, DNA damage and …


PCTK3/CDK18 regulates cell migration and adhesion by negatively modulating FAK activity


Shinya Matsuda, Kohei Kawamoto, Kenji Miyamoto et al.


PCTAIRE kinase 3 (PCTK3) is a member of the cyclin dependent kinase family, but its physiological function remains unknown. We previously reported that PCTK3-knockdown HEK293T …


Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types


Ying-Jiun J. Chen, Brad A. Friedman, Connie Ha et al.


Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA …


Prion-like characteristics of the bacterial protein Microcin E492


Mohammad Shahnawaz, Kyung-Won Park, Abhisek Mukherjee et al.


Microcin E492 (Mcc) is a pore-forming bacteriotoxin. Mcc activity is inhibited at the stationary phase by formation of amyloid-like aggregates in the culture. Here we report …


Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response


Haoyang Li, Sheng Wang, Yonggui Chen et al.


p53 is a transcription factor with capability of regulating diverse NF-κB dependent biological progresses such as inflammation and host defense, but the actual mechanism remains …


The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans


Thaila Fernanda dos Reis, Benjamin M. Nitsche, Pollyne Borborema Almeida de Lima et al.


One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is the accumulation of glucose, the preferred carbon source of microorganisms, …


Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer’s mouse model by controlling β-amyloid production


Sandra Colié, Sara Sarroca, Rocío Palenzuela et al.


Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the …


Genomic structure of the horse major histocompatibility complex class II region resolved using PacBio long-read sequencing technology


Agnese Viļuma, Sofia Mikko, Daniela Hahn et al.


The mammalian Major Histocompatibility Complex (MHC) region contains several gene families characterized by highly polymorphic loci with extensive nucleotide diversity, copy …


The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption


Manon F. Pritchard, Lydia C. Powell, Saira Khan et al.


Concerns about acquisition of antibiotic resistance have led to increasing demand for new antimicrobial therapies. OligoG CF-5/20 is an alginate oligosaccharide previously shown …


Microvascular vasodilator properties of the angiotensin II type 2 receptor in a mouse model of type 1 diabetes


Marc-Antoine Begorre, Abdallah Dib, Khalil Habchi et al.


Diabetes Mellitus is associated with severe cardiovascular disorders involving the renin-angiotensin system, mainly through activation of the angiotensin II type 1 receptor …


Hidden Markov models reveal complexity in the diving behaviour of short-finned pilot whales


Nicola J. Quick, Saana Isojunno, Dina Sadykova et al.


Diving behaviour of short-finned pilot whales is often described by two states; deep foraging and shallow, non-foraging dives. However, this simple classification system ignores …


Rational mutagenesis by engineering disulphide bonds improves Kluyveromyces lactis beta-galactosidase for high-temperature industrial applications


Agustín Rico-Díaz, María-Efigenia Álvarez-Cao, Juan-José Escuder-Rodríguez et al.


Kluyveromyces lactis β-galactosidase (Kl-β-Gal) is one of the most important enzymes in the dairy industry. The poor stability of this enzyme limits its use in the synthesis of …


International incidence and mortality trends of liver cancer: a global profile


Martin C. S. Wong, Johnny Y. Jiang, William B Goggins et al.


We examined the global incidence and mortality rates of liver cancer, and evaluated the association between incidence/mortality and socioeconomic development (Human Development …


Sequence analysis of pooled bacterial samples enables identification of strain variation in group A streptococcus


Rigbe G. Weldatsadik, Jingwen Wang, Kai Puhakainen et al.


Knowledge of the genomic variation among different strains of a pathogenic microbial species can help in selecting optimal candidates for diagnostic assays and vaccine …


Surface Acoustic Waves to Drive Plant Transpiration


Eliot F. Gomez, Magnus Berggren, Daniel T. Simon


Emerging fields of research in electronic plants (e-plants) and agro-nanotechnology seek to create more advanced control of plants and their products. Electronic/nanotechnology …


Nonlinear responses of soil respiration to precipitation changes in a semiarid temperate steppe


Yuan Miao, Hongyan Han, Yue Du et al.


Extreme precipitation events are predicted to occur more frequently and will have significant influences on terrestrial ecosystem carbon (C) cycling in the future. However, …


A novel method for non-destructive determination of hair photo-induced damage based on multispectral imaging technology


Yue Cao, Hao Qu, Can Xiong et al.


Extended exposure to sunlight may give rise to chemical and physical damages of human hairs. In this work, we report a novel method for non-destructive quantification of hair …


Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R1a activity: evidence for target cell-induced acylation


Anna L. Hopkins, Timothy A. S. Nelson, Irina A. Guschina et al.


Despite being unable to activate the cognate ghrelin receptor (GHS-R), unacylated ghrelin (UAG) possesses a unique activity spectrum that includes promoting bone marrow …


Cross-talk among metabolic parameters, esophageal microbiota, and host gene expression following chronic exposure to an obesogenic diet


Nadeem O. Kaakoush, Virginie Lecomte, Christopher A. Maloney et al.


Unhealthy diets, and ensuing weight gain, predispose individuals to the development of esophageal adenocarcinoma. We examined the effect of chronic high fat diet (HFD) on the …


AT-RvD1 Promotes Resolution of Inflammation in NOD/ShiLtJ mice


Ching-Shuen Wang, Christina L. Maruyama, Justin T. Easley et al.


Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Treatments for hyposalivation are …


Testis Transcriptome Modulation in Klinefelter Patients with Hypospermatogenesis


Marco D’Aurora, Alberto Ferlin, Andrea Garolla et al.


The main genetic cause of male infertility is represented by the Klinefelter Syndrome (KS), a condition accounting for 3% of all cases of infertility and up to15% of cases of …


Inhibitory Potential of Constituents from Osmanthus fragrans and Structural Analogues Against Advanced Glycation End Products, α-Amylase, α-Glucosidase, and Oxidative Stress


Ji-Yeon Yang, Jun-Hwan Park, Namhyun Chung et al.


Inhibition of α-amylase and α-glucosidase, advanced glycation end products (AGEs) formation, and oxidative stress by isolated active constituents of Osmanthus fragrans flowers …


Association Study of Reported Significant Loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with Urolithiasis in Chinese Han Ethnicity


Lujia Wang, Chenchen Feng, Guanxiong Ding et al.


In this study, we aimed to validate the association of 8 reported significant loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with urolithiasis in Chinese Han population. We …


Multi-scale radiomic analysis of sub-cortical regions in MRI related to autism, gender and age


Ahmad Chaddad, Christian Desrosiers, Matthew Toews


We propose using multi-scale image textures to investigate links between neuroanatomical regions and clinical variables in MRI. Texture features are derived at multiple scales of …


Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue


Khaled Alsayegh, Katsuhisa Matsuura, Hidekazu Sekine et al.


Induced pluripotent stem (iPS) cells hold great potential for being a major source of cells for regenerative medicine. One major issue that hinders their advancement to clinic is …


Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease


Isabel Gameiro, Patrycja Michalska, Giammarco Tenti et al.


The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer’s disease (AD), the most …


Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers


Shengyong Ng, Sandra March, Ani Galstian et al.


The malaria liver stage is an attractive target for antimalarial development, and preclinical malaria models are essential for testing such candidates. Given ethical concerns and …


Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation


Xiaozhao Lu, Danna Bai, Xiangwei Liu et al.


Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism …


Patterns in the skin microbiota differ in children and teenagers between rural and urban environments


Jenni Lehtimäki, Antti Karkman, Tiina Laatikainen et al.


The composition of human microbiota is affected by a multitude of factors. Understanding the dynamics of our microbial communities is important for promoting human health because …


Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice


Stephanie Wiegand, Silke S. Zakrzewski, Miriam Eichner et al.


Zinc homoeostasis exerts protective effects in inflammatory intestinal diseases and zinc supplementation has been successfully used for treating infectious diarrhoea. This study …


Enzyme-dependent fluorescence recovery of NADH after photobleaching to assess dehydrogenase activity of isolated perfused hearts


Angel Moreno, Sarah Kuzmiak-Glancy, Rafael Jaimes 3rd et al.


Reduction of NAD+ by dehydrogenase enzymes to form NADH is a key component of cellular metabolism. In cellular preparations and isolated mitochondria suspensions, …


Erratum: Insights into functional and evolutionary analysis of carbaryl metabolic pathway from Pseudomonas sp. strain C5pp


Vikas D. Trivedi, Pramod Kumar Jangir, Rakesh Sharma et al.



Corrigendum: Effects of Nitrogen and Shading on Root Morphologies, Nutrient Accumulation, and Photosynthetic Parameters in Different Rice Genotypes


Shenggang Pan, Haidong Liu, Zhaowen Mo et al.



MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium


Camilla Cerutti, Laura J. Edwards, Helga E. de Vries et al.


Leukocyte adhesion to brain endothelial cells, the blood-brain barrier main component, is a critical step in the pathogenesis of neuroinflammatory diseases such as multiple …


Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes


Lurlène Akendengue, Sylvain Trépout, Martín Graña et al.


Bacterial kinesin light chain is a TPR domain-containing protein encoded by the bklc gene, which co-localizes with the bacterial tubulin (btub) genes in a conserved operon in


Visual deprivation selectively reshapes the intrinsic functional architecture of the anterior insula subregions


Lihua Liu, Congcong Yuan, Hao Ding et al.


The anterior insula (AI) is the core hub of salience network that serves to identify the most relevant stimuli among vast sensory inputs and forward them to higher cognitive …


Tubular Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells Generate Pulse Pressure In Vivo


Hiroyoshi Seta, Katsuhisa Matsuura, Hidekazu Sekine et al.


Human induced pluripotent stem (iPS) cell-derived cardiac cells provide the possibility to fabricate cardiac tissues for transplantation. However, it remains unclear human …


MicroRNA exocytosis by large dense-core vesicle fusion


Alican Gümürdü, Ramazan Yildiz, Erden Eren et al.


Neurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates …


Corrigendum: Defective Acetylcholine Receptor Subunit Switch Precedes Atrophy of Slow-Twitch Skeletal Muscle Fibers Lacking ERK1/2 Kinases in Soleus Muscle


Shuo Wang, Bonnie Seaberg, Ximena Paez-Colasante et al.



Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD


Svenning Rune Møller, Xueying Yi, Silvia Melina Velásquez et al.


Extensins are plant cell wall glycoproteins that act as scaffolds for the deposition of the main wall carbohydrate polymers, which are interlocked into the supramolecular wall …


Corrigendum: Host-ant specificity of endangered large blue butterflies (Phengaris spp., Lepidoptera: Lycaenidae) in Japan


Shouhei Ueda, Takashi Komatsu, Takao Itino et al.



Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity


Wenwei Luo, Hong Yi, Jeannette Taylor et al.


The middle ear conducts sound to the cochlea for hearing. Otitis media (OM) is the most common illness in childhood. Moreover, chronic OM with effusion (COME) is the leading …


A Raf-like protein kinase BHP mediates blue light-dependent stomatal opening


Maki Hayashi, Shin-ichiro Inoue, Yoshihisa Ueno et al.


Stomata in the plant epidermis open in response to blue light and affect photosynthesis and plant growth by regulating CO2 uptake and transpiration. In stomatal guard cells under …


Fluorescence based real time monitoring of fouling in process chromatography


Mili Pathak, Katherine Lintern, Viki Chopda et al.


A real time monitoring of fouling in liquid chromatography has been presented. The versatility of the approach has been proven by successful implementation in three case studies …


Method for detection of hydrogen peroxide in HT22 cells


Dagmara Jacewicz, Kamila Siedlecka-Kroplewska, Joanna Drzeżdżon et al.


We have proposed a new method which can be applied in assessing the intracellular production of hydrogen peroxide. Using this assay we have examined the hydrogen peroxide …


Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii


Mohd Hafidz Mahamad Maifiah, Darren J. Creek, Roger L. Nation et al.


Combination therapy is deployed for the treatment of multidrug-resistant Acinetobacter baumannii, as it can rapidly develop resistance to current antibiotics. This is the first …


Cultivar-specific gene modulation in Vitis vinifera: analysis of the promoters regulating the expression of WOX transcription factors


Paolo Boccacci, Anita Mela, Catalina Pavez Mina et al.


The family of Wuschel-related Homeobox (WOX) genes is a class of transcription factors involved in the early stages of embryogenesis and organ development in plants. Some of …


Carbon nanotube filled with magnetic iron oxide and modified with polyamidoamine dendrimers for immobilizing lipase toward application in biodiesel production


Yanli Fan, Feng Su, Kai Li et al.


Superparamagnetic multi-walled carbon nanotubes (mMWCNTs) were prepared by filling multi-walled carbon nanotubes (MWCNTs) with iron oxide, and further modified by linking …


Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging


Yi-fan Jiang, Shao-syuan Lin, Jing-min Chen et al.


Within mitochondria, the ability to produce energy relies upon the architectural hallmarks of double membranes and cristae invaginations. Herein, we describe novel features of …


Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2


María Isabel Niemeyer, L. Pablo Cid, Marc Paulais et al.


Two-pore domain K2P K+ channels responsible for the background K+ conductance and the resting membrane potential, are also finely regulated by a variety of chemical, physical and …


Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance


Tiago N. Figueira, João M. Freire, Catarina Cunha-Santos et al.


Understanding the interplay between molecules and lipid membranes is fundamental when studying cellular and biotechnological phenomena. Partition between aqueous media and lipid …


Serine protease SP105 activates prophenoloxidase in Asian corn borer melanization, and is regulated by serpin-3


Yuan Chu, Fang Hong, Qizhi Liu et al.


Melanization reaction, resulting from the activation of prophenoloxidase, is a vital immune response in insects for encapsulating and killing the invasive organisms. …


Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells


Shahidul Alam, Merrina Anugraham, Yen-Lin Huang et al.


The (neo-) lacto series glycosphingolipids (nsGSLs) comprise of glycan epitopes that are present as blood group antigens, act as primary receptors for human pathogens and are …


CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases


Kiah L. Butler, Eleanor Clancy-Thompson, David W. Mullins


We present a new foundational role for CXCR3+ monocytes/macrophages in the process of tumor engraftment in the lung. CXCR3 is associated with monocytic and lymphocytic …


Synthesis and biological evaluation of novel ursolic acid analogues as potential α-glucosidase inhibitors


Pan-Pan Wu, Bing-Jie Zhang, Xi-Ping Cui et al.


Ursolic acid (UA) is a major pentacyclic triterpenoid in plants, vegetables and fruits, which has been reported to have a potential anti-diabetic activity. Despite various …


Candidate Genes for Inherited Autism Susceptibility in the Lebanese Population


Silva Kourtian, Jihane Soueid, Nadine J. Makhoul et al.


Autism spectrum disorder (ASD) is characterized by ritualistic-repetitive behaviors and impaired verbal/non-verbal communication. Many ASD susceptibility genes implicated in …


Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans


Jesús Rodríguez-Díaz, Izaskun García-Mantrana, Susana Vila-Vicent et al.


Host genetic factors, such as histo-blood group antigens (HBGAs), are associated with susceptibility to norovirus (NoV) and rotavirus (RV) infections. Recent advances point to …


Integrating Sequence-based GWAS and RNA-Seq Provides Novel Insights into the Genetic Basis of Mastitis and Milk Production in Dairy Cattle


Lingzhao Fang, Goutam Sahana, Guosheng Su et al.


Connecting genome-wide association study (GWAS) to biological mechanisms underlying complex traits is a major challenge. Mastitis resistance and milk production are complex …


STITCHER 2.0: primer design for overlapping PCR applications


Damien M. O’Halloran, Isabel Uriagereka-Herburger, Katrin Bode


Overlapping polymerase chain reaction (PCR) is a common technique used by researchers in very diverse fields that enables the user to ‘stitch’ individual pieces of DNA together. …


A new tyrannosaur with evidence for anagenesis and crocodile-like facial sensory system


Thomas D. Carr, David J. Varricchio, Jayc C. Sedlmayr et al.


A new species of tyrannosaurid from the upper Two Medicine Formation of Montana supports the presence of a Laramidian anagenetic (ancestor-descendant) lineage of Late Cretaceous …


SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation


Vincenzo Dattilo, Lucia D’Antona, Cristina Talarico et al.


The serum- and glucocorticoid-regulated kinase (SGK1) controls cell transformation and tumor progression. SGK1 affects mitotic stability by regulating the expression of …


Evaluation and use of disaccharides as energy source in protein-free mammalian cell cultures


Dawn Sow Zong Leong, Janice Gek Ling Tan, Christine Lin Chin et al.


Mammalian cells are generally considered to be unable to utilize polysaccharides for cell growth because the phospholipid bilayer in the cell membrane has very low permeability …


Corrigendum: Direct coupling: a possible strategy to control fruit production in alternate bearing


Awadhesh Prasad, Kenshi Sakai, Yoshinobu Hoshino



ATHB17 enhances stress tolerance by coordinating photosynthesis associated nuclear gene and ATSIG5 expression in response to abiotic stress


Ping Zhao, Rong Cui, Ping Xu et al.


Photosynthesis is sensitive to environmental stress and must be efficiently modulated in response to abiotic stress. However, the underlying mechanisms are not well understood. …


Molecular characterization reveals the complexity of previously overlooked coral-exosymbiont interactions and the implications for coral-guild ecology


H. Rouzé, M. Leray, H. Magalon et al.


Several obligate associate crabs and shrimps species may co-occur and interact within a single coral host, leading to patterns of associations that can provide essential …


Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment


Sergey O. Bachurin, Elena F. Shevtsova, Galina F. Makhaeva et al.


A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and …


HIVed, a knowledgebase for differentially expressed human genes and proteins during HIV infection, replication and latency


Chen Li, Sri H. Ramarathinam, Jerico Revote et al.


Measuring the altered gene expression level and identifying differentially expressed genes/proteins during HIV infection, replication and latency is fundamental for broadening …


Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs


Long-Jyun Su, Meng-Shiue Wu, Yuen Yung Hui et al.


Cell therapy is a promising strategy for the treatment of human diseases. While the first use of cells for therapeutic purposes can be traced to the 19th century, there has been …


Combined effects of temperature and the herbicide diuron on Photosystem II activity of the tropical seagrass Halophila ovalis


Adam D. Wilkinson, Catherine J. Collier, Florita Flores et al.


Tropical seagrasses are at their highest risk of exposure to photosystem II (PSII) herbicides when elevated rainfall and runoff from farms transports these toxicants into coastal …


Chemical interaction mechanism of 10-MDP with zirconia


Noriyuki Nagaoka, Kumiko Yoshihara, Victor Pinheiro Feitosa et al.


Currently, the functional monomer 10-methacryloyloxy-decyl-dihydrogen-phosphate (10-MDP) was documented to chemically bond to zirconia ceramics. However, little research has been …


Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer


Kenji Ohshima, Satoshi Nojima, Shinichiro Tahara et al.


Argininosuccinate synthetase 1 (ASS1) is a rate-limiting enzyme in arginine biosynthesis. Although ASS1 expression levels are often reduced in several tumors and low ASS1 …


Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi


Juan Li, Fei Gu, Runian Wu et al.


Subtilases belong to a superfamily of serine proteases which are ubiquitous in fungi and are suspected to have developed distinct functional properties to help fungi adapt to …


Downregulation of LIMK1–ADF/cofilin by DADS inhibits the migration and invasion of colon cancer


Jian Su, Yujuan Zhou, Zhibing Pan et al.


This study aimed to explore whether the downregulation of LIM kinase 1 (LIMK1)-actin depolymerization factor (ADF, also known as destrin)/cofilin by diallyl disulfide (DADS) …


Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia


Carlos Alvarez-Moreno, Rose-Anne Lavergne, Ferry Hagen et al.


Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to …


CombiROC: an interactive web tool for selecting accurate marker combinations of omics data


Saveria Mazzara, Riccardo L. Rossi, Renata Grifantini et al.


Diagnostic accuracy can be improved considerably by combining multiple markers, whose performance in identifying diseased subjects is usually assessed via receiver operating …


Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques


Hongqin Yang, Jiuyang Liu, Yanmei Huang et al.


Alisertib (MLN8237) is an orally administered inhibitor of Aurora A kinase. This small-molecule inhibitor is under clinical or pre-clinical phase for the treatment of advanced …


A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys


PeiMin Dai, Hui Huang, Lin Zhang et al.


Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to …


Rheotaxis in the Ediacaran epibenthic organism Parvancorina from South Australia


John R. Paterson, James G. Gehling, Mary L. Droser et al.


Diverse interpretations of Ediacaran organisms arise not only from their enigmatic body plans, but also from confusion surrounding the sedimentary environments they inhabited and …


A novel pathway for amyloids self-assembly in aggregates at nanomolar concentration mediated by the interaction with surfaces


Siddhartha Banerjee, Mohtadin Hashemi, Zhengjian Lv et al.


A limitation of the amyloid hypothesis in explaining the development of neurodegenerative diseases is that the level of amyloidogenic polypeptide in vivo is below the critical …


Disparities in correlating microstructural to nanostructural preservation of dinosaur femoral bones


Jung-Kyun Kim, Yong-Eun Kwon, Sang-Gil Lee et al.


Osteohistological researches on dinosaurs are well documented, but descriptions of direct correlations between the bone microstructure and corresponding nanostructure are …


NMDA receptor antagonism with novel indolyl, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy


Hussin A. Rothan, Elham Amini, Fadihl L. Faraj et al.


N-methyl-D-aspartate receptors (NMDAR) play a central role in epileptogensis and NMDAR antagonists have been shown to have antiepileptic effects in animals and humans. Despite …


Microbial reduction of Fe(III)-bearing clay minerals in the presence of humic acids


Guangfei Liu, Shuang Qiu, Baiqing Liu et al.


Both Fe(III)-bearing clay minerals and humic acids (HAs) are abundant in the soils and sediments. Previous studies have shown that bioreduction of structural Fe(III) in clay …


Suppression of FOXM1 Transcriptional Activities via a Single-Stranded DNA Aptamer Generated by SELEX


Qin Xiang, Guixiang Tan, Xia Jiang et al.


The transcription factor FOXM1 binds to its consensus sequence at promoters through its DNA binding domain (DBD) and activates proliferation-associated genes. The aberrant …


Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection


Qiang Liu, Changfa Fan, Qianqian Li et al.


Passive immunotherapy with monoclonal antibodies (mAbs) is an efficacious treatment for Ebola virus (EBOV) infections in animal models and humans. Understanding what constitutes …


Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus


Ajay Matta, M. Zia Karim, David E. Isenman et al.


Degenerative disc disease (DDD) is associated with spinal pain often leading to long-term disability. However, the non-chondrodystrophic canine intervertebral disc is protected …


NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats


Jingjing Xu, Xujuan Zheng, Kian-Kai Cheng et al.


Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture …


Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase


Alexander Minges, Daniel Ciupka, Christian Winkler et al.


Pyruvate phosphate dikinase (PPDK) is a vital enzyme in cellular energy metabolism catalyzing the ATP- and Pi-dependent formation of phosphoenolpyruvate from pyruvate in C4


STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer


Rui Li, Fang Fang, Ming Jiang et al.


Tumour-induced dendritic cell (DC) dysfunction plays an important role in cancer immune escape. However, the underlying mechanisms are not yet fully understood, reflecting the …


Effect of Size and Surface Charge of Gold Nanoparticles on their Skin Permeability: A Molecular Dynamics Study


Rakesh Gupta, Beena Rai


Molecular level understanding of permeation of nanoparticles through human skin establishes the basis for development of novel transdermal drug delivery systems and design and …


Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt/+Q111/+ model of Huntington’s disease


Robert M. Bragg, Sydney R. Coffey, Rory M. Weston et al.



Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo


Nils Blüthgen, Mirjam van Bentum, Barbara Merz et al.


Activity-dependent alteration of the transcriptional program is central for shaping neuronal connectivity. Constitutively expressed transcription factors orchestrate the initial …


Corrigendum: The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice


Hyejin Shin, Soyoung Bang, Jiyeon Kim et al.



Spatial transcriptome analysis provides insights of key gene(s) involved in steroidal saponin biosynthesis in medicinally important herb Trillium govanianum


Pradeep Singh, Gagandeep Singh, Abhishek Bhandawat et al.


Trillium govanianum, an endangered medicinal herb native to the Himalaya, is less studied at the molecular level due to the non-availability of genomic resources. To facilitate …


Corrigendum: Two novel mutations in PRPF3 causing autosomal dominant retinitis pigmentosa


Zilin Zhong, Ming Yan, Wan Sun et al.



A platform for high-throughput bioenergy production phenotype characterization in single cells


Laimonas Kelbauskas, Honor Glenn, Clifford Anderson et al.


Driven by an increasing number of studies demonstrating its relevance to a broad variety of disease states, the bioenergy production phenotype has been widely characterized at …


The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly


Justyna Broniarczyk, David Pim, Paola Massimi et al.


Human Papillomavirus (HPV) infection involves multiple steps, from cell attachment, through endocytic trafficking towards the trans-Golgi network, and, ultimately, the entry into …


Neural Crest Cells Contribute an Astrocyte-like Glial Population to the Spleen


Amanda J. Barlow-Anacker, Ming Fu, Christopher S. Erickson et al.


Neural crest cells (NCC) are multi-potent cells of ectodermal origin that colonize diverse organs, including the gastrointestinal tract to form the enteric nervous system (ENS) …


Structural Basis for pH-mediated Regulation of F-actin Severing by Gelsolin Domain 1


Jing-song Fan, Honzhen Goh, Ke Ding et al.


Six-domain gelsolin regulates actin structural dynamics through its abilities to sever, cap and uncap F-actin. These activities are modulated by various cellular parameters like …


Conditional Deletion of the Phd2 Gene in Articular Chondrocytes Accelerates Differentiation and Reduces Articular Cartilage Thickness


Shaohong Cheng, Sheila Pourteymoor, Catrina Alarcon et al.


Based on our findings that PHD2 is a negative regulator of chondrocyte differentiation and that hypoxia signaling is implicated in the pathogenesis of osteoarthritis, we …


Potential of MALDI-TOF MS as an alternative approach for capsular typing Streptococcus pneumoniae isolates


Tatiana C. A. Pinto, Natalia S. Costa, Luciana F. S. Castro et al.


Streptococcus pneumoniae can be classified in more than 90 capsular types, as traditionally determined by serological methods and more recently by PCR-based techniques. Such …


Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis


Timo Rademakers, Emiel P. C. van der Vorst, Isabelle T. M. N. Daissormont et al.


During plaque progression, inflammatory cells progressively accumulate in the adventitia, paralleled by an increased presence of leaky vasa vasorum. We here show that next to …


Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage


Lanlan Ge, Wenhui Zhang, Gao Zhou et al.


To systematically study the chemical constituents in Magnolia officinalis var. biloba fruits, nine phenylethanoid glycosides were isolated by solvent extraction, silica gel, and …


Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells


Nobuhiko Yokoyama, Tomoya Matsunobu, Yoshihiro Matsumoto et al.


Synovial sarcoma (SS) is a rare high-grade malignant mesenchymal tumour with a relatively poor prognosis despite intensive multimodal therapy. Although pazopanib, a multi-kinase …


Development of a multiplex loop-mediated isothermal amplification method for the simultaneous detection of Salmonella spp. and Vibrio parahaemolyticus


Ningwei Liu, Dayang Zou, Derong Dong et al.


Rapid detection of food-borne pathogens is important in the food industry, to monitor and prevent the spread of these pathogens through contaminated food products. We therefore …


Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways


Lara Macchioni, Magdalena Davidescu, Katia Fettucciari et al.


Enteric glial cells (EGCs) are components of the intestinal epithelial barrier essential for regulating the enteric nervous system. Clostridium difficile is the most common cause …


Frugivore-Mediated Selection in A Habitat Transformation Scenario


Francisco E. Fontúrbel, Rodrigo Medel


Plant-animal interactions are strong drivers of phenotypic evolution. However, the extent to which anthropogenic habitat transformation creates new selective scenarios for …


Gut metagenomic analysis reveals prominent roles of Lactobacillus and cecal microbiota in chicken feed efficiency


Wei Yan, Congjiao Sun, Jingwei Yuan et al.


Interactions between the host and gut microbiota can affect gut metabolism. In this study, the individual performances of 252 hens were recorded to evaluate feed efficiency. Hens …


Mitochondrial DNA and trade data support multiple origins of Helicoverpa armigera (Lepidoptera, Noctuidae) in Brazil


Wee Tek Tay, Thomas K. Walsh, Sharon Downes et al.


The Old World bollworm Helicoverpa armigera is now established in Brazil but efforts to identify incursion origin(s) and pathway(s) have met with limited success due to the …


Corrigendum: Antigen distribution of TMUV and GPV are coincident with the expression profiles of CD8α-positive cells and goose IFNγ


Hao Zhou, Shun Chen, Mingshu Wang et al.



Evidence for salicylic acid signalling and histological changes in the defence response of Eucalyptus grandis to Chrysoporthe austroafricana


Lizahn Zwart, Dave Kenneth Berger, Lucy Novungayo Moleleki et al.


Eucalyptus species are cultivated for forestry and are of economic importance. The fungal stem canker pathogen Chrysoporthe austroafricana causes disease of varying severity on


Engineering Structurally Interacting RNA (sxRNA)


Francis Doyle, Sameer Lapsia, Salvatore Spadaro et al.


RNA-based three-way junctions (3WJs) are naturally occurring structures found in many functional RNA molecules including rRNA, tRNA, snRNA and ribozymes. 3WJs are typically …


E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells


Qingqiang Xu, Naiwei Zhu, Shenglin Chen et al.


Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes the most prevalent viral encephalitis in Asia. Since JEV is a neurotropic virus, it is important to …


Characterisation of male breast cancer: a descriptive biomarker study from a large patient series


Matthew P. Humphries, Sreekumar Sundara Rajan, Hedieh Honarpisheh et al.


Male breast cancer (MBC) is rare. We assembled 446 MBCs on tissue microarrays and assessed clinicopathological information, together with data from 15 published studies, …


Erratum: Targeted RNA-Seq profiling of splicing pattern in the DMD gene: exons are mostly constitutively spliced in human skeletal muscle


Anne-Laure Bougé, Eva Murauer, Emmanuelle Beyne et al.



Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit


Tomoya Kubota, Ana M. Correa, Francisco Bezanilla


The voltage-gated potassium channel subfamily A member 3 (Kv1.3) dominantly expresses on T cells and neurons. Recently, the interaction between Kv1.3 and NavBeta1 subunits has …


Corrigendum: Human behaviour can trigger large carnivore attacks in developed countries


Vincenzo Penteriani, María del Mar Delgado, Francesco Pinchera et al.



Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion


Arata Honda, Yoshihiro Kawano, Haruna Izu et al.


Experimental animal models have played an indispensable role in the development of human induced pluripotent stem cell (iPSC) research. The derivation of high-quality (so-called …


Organization of prefrontal network activity by respiration-related oscillations


Jonatan Biskamp, Marlene Bartos, Jonas-Frederic Sauer


The medial prefrontal cortex (mPFC) integrates information from cortical and sub-cortical areas and contributes to the planning and initiation of behaviour. A potential mechanism …


Gene expression-based biomarkers for discriminating early and late stage of clear cell renal cancer


Sherry Bhalla, Kumardeep Chaudhary, Ritesh Kumar et al.


In this study, an attempt has been made to identify expression-based gene biomarkers that can discriminate early and late stage of clear cell renal cell carcinoma (ccRCC) …


Patterns of correlation of facial shape with physiological measurements are more integrated than patterns of correlation with ratings


S. Windhager, F. L. Bookstein, E. Millesi et al.


This article exploits a method recently incorporated in the geometric morphometric toolkit that complements previous approaches to quantifying the facial features associated with …


Checking behavior in rhesus monkeys is related to anxiety and frontal activity


Marion Bosc, Bernard Bioulac, Nicolas Langbour et al.


When facing doubt, humans can go back over a performed action in order to optimize subsequent performance. The present study aimed to establish and characterize physiological …


Preparation and characterization of (−)-Epigallocatechin-3-gallate (EGCG)-loaded nanoparticles and their inhibitory effects on Human breast cancer MCF-7 cells


Liang Zeng, Jingna Yan, Liyong Luo et al.


We were employing nanotechnology to improve the targeting ability of (−)-Epigallocatechin-3-gallate (EGCG) towards MCF-7 cells, and two kinds of EGCG nanoparticles (FA-NPS-PEG …


Corrigendum: Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma


Peipei Xu, Huaqin Zuo, Bing Chen et al.



Touch and Hearing Mediate Osseoperception


Francesco Clemente, Bo Håkansson, Christian Cipriani et al.


Osseoperception is the sensation arising from the mechanical stimulation of a bone-anchored prosthesis. Here we show that not only touch, but also hearing is involved in this …


Albino T-DNA tomato mutant reveals a key function of 1-deoxy-D-xylulose-5-phosphate synthase (DXS1) in plant development and survival


Manuel García-Alcázar, Estela Giménez, Benito Pineda et al.


Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the …


Calcium regulation of the human mitochondrial ATP-Mg/Pi carrier SLC25A24 uses a locking pin mechanism


Steven P. D. Harborne, Martin S. King, Paul G. Crichton et al.


Mitochondrial ATP-Mg/Pi carriers import adenine nucleotides into the mitochondrial matrix and export phosphate to the cytosol. They are calcium-regulated to control the size of …


Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability


Mark C. Julian, Lijuan Li, Shekhar Garde et al.


The ability of antibodies to accumulate affinity-enhancing mutations in their complementarity-determining regions (CDRs) without compromising thermodynamic stability is critical …


Strain-specific estimation of epidemic success provides insights into the transmission dynamics of tuberculosis


Jean-Philippe Rasigade, Maxime Barbier, Oana Dumitrescu et al.


The transmission dynamics of tuberculosis involves complex interactions of socio-economic and, possibly, microbiological factors. We describe an analytical framework to infer …


Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury


Haolu Wang, Run Zhang, Kim R. Bridle et al.


Oxidative stress reflects an imbalance between reactive oxygen species (ROS) and antioxidants, which has been reported as an early unifying event in the development and …


Proteome dynamics during postnatal mouse corpus callosum development


Alexander I. Son, Xiaoqin Fu, Fumikazu Suto et al.


Formation of cortical connections requires the precise coordination of numerous discrete phases. This is particularly significant with regard to the corpus callosum, whose …


Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications


Raghib Ashraf, Hamidullah, Mohammad Hasanain et al.


S009-131, a coumarin-chalcone hybrid, had been shown to possess anti-proliferative and anti-tumour effect by triggering apoptosis. In this report, we investigated role of DNA …


Antiproliferative effects of ruthenium-based nucleolipidic nanoaggregates in human models of breast cancer in vitro: insights into their mode of action


Carlo Irace, Gabriella Misso, Antonella Capuozzo et al.


Looking for new metal-based anticancer treatments, in recent years many ruthenium complexes have been proposed as effective and safe potential drugs. In this context we have …


The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass


Kazuaki Mito, Yuiko Sato, Tami Kobayashi et al.


The nicotinic receptor α7nAchR reportedly regulates vagal nerve targets in brain and cardiac tissue. Here we show that nAchR7−/− mice exhibit increased bone mass due to decreased …


Land-use types and soil chemical properties influence soil microbial communities in the semiarid Loess Plateau region in China


Qin Tian, Takeshi Taniguchi, Wei-Yu Shi et al.


Similar land-use types usually have similar soil properties, and, most likely, similar microbial communities. Here, we assessed whether land-use types or soil chemical properties …


SERS detection of the biomarker hydrogen cyanide from Pseudomonas aeruginosa cultures isolated from cystic fibrosis patients


Rikke Kragh Lauridsen, Lea M. Sommer, Helle Krogh Johansen et al.


Pseudomonas aeruginosa is the primary cause of chronic airway infections in cystic fibrosis (CF) patients. Persistent infections are seen from the first P. aeruginosa culture in …


A new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells


Dong-Peng Li, Zhao-Yang Wang, Jie Cui et al.


A new ratiometric fluorescent probe was constructed with hemicyanine and 7-nitrobenzofurazan for detection of sulfur dioxide derivatives (HSO3/SO32−). The ratiometric response …


Soil classification predicts differences in prokaryotic communities across a range of geographically distant soils once pH is accounted for


Rachel Kaminsky, Blandine Trouche, Sergio E. Morales


Agricultural land is typically managed based on visible plant life at the expense of the belowground majority. However, microorganisms mediate processes sustaining plant life and …


Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development


Ganive Bhinder, Joannie M. Allaire, Cyrielle Garcia et al.


Breast milk has many beneficial properties and unusual characteristics including a unique fat component, termed milk fat globule membrane (MFGM). While breast milk yields …


Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder


Lorena Coretti, Claudia Cristiano, Ermanno Florio et al.


Alterations of microbiota-gut-brain axis have been invoked in the pathogenesis of autism spectrum disorders (ASD). Mouse models could represent an excellent tool to understand …


Biodegradable Polymeric Nanocapsules Prevent Cardiotoxicity of Anti-Trypanosomal Lychnopholide


Renata Tupinambá Branquinho, Jérôme Roy, Charlotte Farah et al.


Chagas disease is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi. New antitrypanosomal options are desirable to prevent complications, including a high …


Nerve regeneration by human corneal stromal keratocytes and stromal fibroblasts


Gary Hin-Fai Yam, Geraint P. Williams, Melina Setiawan et al.


Laser refractive surgeries reshape corneal stroma to correct refractive errors, but unavoidably affect corneal nerves. Slow nerve regeneration and atypical neurite morphology …


Applying Taguchi design and large-scale strategy for mycosynthesis of nano-silver from endophytic Trichoderma harzianum SYA.F4 and its application against phytopathogens


Shahira H. EL-Moslamy, Marwa F. Elkady, Ahmed H. Rezk et al.


Development of reliable and low-cost requirement for large-scale eco-friendly biogenic synthesis of metallic nanoparticles is an important step for industrial applications of …


Discriminating cognitive status in Parkinson’s disease through functional connectomics and machine learning


Alexandra Abós, Hugo C. Baggio, Bàrbara Segura et al.


There is growing interest in the potential of neuroimaging to help develop non-invasive biomarkers in neurodegenerative diseases. In this study, connection-wise patterns of …

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