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TABLE OF CONTENTS |
May 2017 Volume 19, Issue 5 |
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| Editorial News and Views Articles Letters Resource Technical Report
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nature.com webcasts Springer Nature presents a custom webcast on: Perturb-seq: High Throughput CRISPR Screening via Single-Cell RNA Sequencing Date: Wednesday May 10, 2017 Time: 11AM PDT | 2PM EDT Register FREE Sponsored by: 10x Genomics | | | |
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NATURE CONFERENCE ON INFLAMMATORY DISEASES Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer. September 17-20, 2017 | Beijing, China REGISTER NOW! | | | |
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Editorial | Top |
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Science in the age of Trump p409 doi:10.1038/ncb3526 The steep cuts in science funding proposed in the 2018 US budget blueprint have raised alarm in scientific quarters, and signal the current administration's disregard for the significance of science and research in modern society.
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News and Views | Top |
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Articles | Top |
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ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes pp421 - 432 Georgia Chatzinikolaou, Zivkos Apostolou, Tamara Aid-Pavlidis, Anna Ioannidou, Ismene Karakasilioti et al. doi:10.1038/ncb3499 Chatzinikolaou et al. show that the nucleotide excision repair complex ERCC1–XPF cooperates with the chromatin organizer CTCF, cohesin subunits and ATRX to facilitate the silencing of a subset of imprinted genes in the developing liver.
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Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling pp433 - 444 Amy Reilein, David Melamed, Karen Sophia Park, Ari Berg, Elisa Cimetta et al. doi:10.1038/ncb3505 Reilein et al. demonstrate that Drosophila ovarian follicle stem cells (FSCs) produce either proliferative follicle cells or quiescent escort cells, depending on which position they occupy in the germarium and in response to graded Wnt signalling.
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Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis pp445 - 456 Young Cha, Min-Joon Han, Hyuk-Jin Cha, Janet Zoldan, Alison Burkart et al. doi:10.1038/ncb3517 Cha et al. show that SIRT2 suppression by miR-200c enhances acetylation levels and enzymatic activities of glycolytic enzymes and contributes to metabolic reprogramming of human induced pluripotent stem cells and human embryonic stem cells.
See also: News and Views by Liu & Shyh-Chang |
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Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche pp457 - 467 Erich W. Damm and Wilson K. Clements doi:10.1038/ncb3508 Damm et al. demonstrate that trunk neural crest cell migration to the dorsal aorta in zebrafish is regulated by platelet-derived growth factor (PDGF) signalling and required for haematopoietic stem cell (HSC) specification.
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CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis pp468 - 479 Remi Sonneville, Sara Priego Moreno, Axel Knebel, Clare Johnson, C. James Hastie et al. doi:10.1038/ncb3500 The Cdc45–MCM–GINS (CMG) complex is needed for DNA replication, but how CMG dissociates from DNA in higher eukaryotes is not clear. Sonneville et al. now characterize pathways for CMG dissociation and replication termination in worm and frog.
See also: News and Views by Gaggioli & Zegerman |
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Microtubule minus-end regulation at spindle poles by an ASPM–katanin complex pp480 - 492 Kai Jiang, Lenka Rezabkova, Shasha Hua, Qingyang Liu, Guido Capitani et al. doi:10.1038/ncb3511 Jiang et al. show that the microcephaly-associated protein ASPM and katanin form a complex that binds microtubule minus ends and can sever microtubules and block microtubule minus-end elongation to control spindle pole dynamics.
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Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division pp493 - 503 Murielle Saade, Elena Gonzalez-Gobartt, Rene Escalona, Susana Usieto and Elisa Marti doi:10.1038/ncb3512 Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
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SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis pp504 - 517 Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra et al. doi:10.1038/ncb3514 Sah and colleagues show that the volume-sensitive ion channel SWELL1 regulates adipocyte insulin-PI(3)K-AKT2 signalling, glucose uptake and lipid content through interactions with GRB2/Cav1.
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The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer pp518 - 529 Angela M. Krebs, Julia Mitschke, Maria Lasierra Losada, Otto Schmalhofer, Melanie Boerries et al. doi:10.1038/ncb3513 Adding to the recent debate on the role of epithelial–mesenchymal transition (EMT) in cancer cell invasion and metastasis, Brabletz and colleagues show that the EMT-inducing transcription factor Zeb1 drives pancreatic tumorigenesis and metastasis.
See also: News and Views by Nieto |
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Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes pp530 - 541 Shunsuke Kon, Kojiro Ishibashi, Hiroto Katoh, Sho Kitamoto, Takanobu Shirai et al. doi:10.1038/ncb3509 Fujita et al. find that normal epithelial cells induce metabolic changes in adjacent transformed cells, causing their apical extrusion. The effect is conveyed non-cell-autonomously and relies on PDK4-mediated inhibition of mitochondrial function.
See also: News and Views by Coloff & Brugge |
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Letters | Top |
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A three-dimensional model of human lung development and disease from pluripotent stem cells pp542 - 549 Ya-Wen Chen, Sarah Xuelian Huang, Ana Luisa Rodrigues Toste de Carvalho, Siu-Hong Ho, Mohammad Naimul Islam et al. doi:10.1038/ncb3510 Chen et al. generate lung bud organoids from human pluripotent stem cells that recapitulate early lung development, such as branching airway formation and early alveolar structures, which could potentially be used to model lung disease.
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Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling pp550 - 557 Chih-Chun Janet Lin and Meng C. Wang doi:10.1038/ncb3515 Lin and Wang show that methionine deprivation reprogrammes bacterial metabolism to regulate host mitochondrial dynamics and lipid metabolism in Caenorhabditis elegans through nuclear receptor and Hedgehog signalling.
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Resource | Top |
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High-resolution myogenic lineage mapping by single-cell mass cytometry pp558 - 567 Ermelinda Porpiglia, Nikolay Samusik, Andrew Tri Van Ho, Benjamin D. Cosgrove, Thach Mai et al. doi:10.1038/ncb3507 Porpiglia et al. use single-cell mass cytometry to analyse surface markers and key myogenic transcription factors of skeletal muscle stem cells during homeostasis and repair, and identify previously unrecognized myogenic progenitor cell populations.
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Technical Report | Top |
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Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium pp568 - 577 Margherita Y. Turco, Lucy Gardner, Jasmine Hughes, Tereza Cindrova-Davies, Maria J. Gomez et al. doi:10.1038/ncb3516 Turco et al. derive long-term genetically stable organoids from normal endometrium and the decidua that recapitulate characteristics of in vivo uterine glands, respond to hormones and differentiate into secretory and ciliated endometrial cells.
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April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time. Click here to read! | | | |
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| | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | |
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