Journal of Antibiotics - Table of Contents alert Volume 70 Issue 5

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Advertisement April 2017 marks the 25th Anniversary of Nature Genetics! To celebrate, the editors have selected some past papers which are free to read for a limited time.  Click here to read!   Special Issue Dedicated to Satoshi Ōmura: A leader and an inspiration in natural products chemistry, and the Nobel Prize Laureate in Physiology or Medicine 2015 Top We are very honored and pleased to dedicate this May issue of The Journal of Antibiotics to Professor Satoshi Ōmura, in recognition of his 2015 Nobel Prize in Physiology or Medicine and his other great achievements. Accordingly, the issue also includes a list and overview of all 181 new compounds he has discovered in his 50-year career, encompassing nearly 500 compounds total. We are grateful to have received so many contributions from researchers all over the world, who hold Professor Ōmura in high esteem. We would like to thank Managing Editor Dr. Kazuro Shiomi, the coordinator of this issue, for his hard work in planning and coordinating this very special publication. The Journal of Antibiotics TABLE OF CONTENTS Volume 70, Issue 5 (May 2017) In this issue Editorials Perspective Review Articles Correspondence Original Articles Notes Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Editorials Top Foreword celebrating the career of Professor Satoshi Ōmura Kuniaki Tatsuta J Antibiot 2017 70: 455-456; 10.1038/ja.2017.25 Full Text Achievements of Professor Satoshi Ōmura Kazuro Shiomi J Antibiot 2017 70: 457-491; 10.1038/ja.2017.36 Full Text Perspective Top The ups and downs of drug discovery: the early history of Fidaxomicin James B McAlpine J Antibiot 2017 70: 492-494; advance online publication, January 18, 2017; 10.1038/ja.2016.157 Abstract | Full Text Review Articles Top Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations Andy Crump J Antibiot 2017 70: 495-505; advance online publication, February 15, 2017; 10.1038/ja.2017.11 Abstract | Full Text Genus Kitasatospora, taxonomic features and diversity of secondary metabolites Yōko Takahashi J Antibiot 2017 70: 506-513; advance online publication, February 15, 2017; 10.1038/ja.2017.8 Abstract | Full Text Endophytic actinomycetes: promising source of novel bioactive compounds Atsuko Matsumoto and Yōko Takahashi J Antibiot 2017 70: 514-519; advance online publication, March 8, 2017; 10.1038/ja.2017.20 Abstract | Full Text The antibiotic resistance crisis, with a focus on the United States Evan Martens and Arnold L Demain J Antibiot 2017 70: 520-526; advance online publication, March 1, 2017; 10.1038/ja.2017.30 Abstract | Full Text Nature nurtures the design of new semi-synthetic macrolide antibiotics OPEN Prabhavathi Fernandes, Evan Martens and David Pereira J Antibiot 2017 70: 527-533; advance online publication, November 30, 2016; 10.1038/ja.2016.137 Abstract | Full Text The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis Juan F Martín, Antonio Rodríguez-García and Paloma Liras J Antibiot 2017 70: 534-541; advance online publication, March 15, 2017; 10.1038/ja.2017.19 Abstract | Full Text Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2 Isao Momose and Takumi Watanabe J Antibiot 2017 70: 542-550; advance online publication, February 15, 2017; 10.1038/ja.2017.9 Abstract | Full Text Correspondence Top Message from a long-time friend: congratulations on Emeritus Professor Satoshi Ōmura’s accomplishments James B McAlpine J Antibiot 2017 70: 551-552; 10.1038/ja.2017.43 Full Text Original Articles Top Enhanced dereplication of fungal cultures via use of mass defect filtering OPEN Noemi D Paguigan, Tamam El-Elimat, Diana Kao, Huzefa A Raja, Cedric J Pearce and Nicholas H Oberlies J Antibiot 2017 70: 553-561; advance online publication, January 11, 2017; 10.1038/ja.2016.145 Abstract | Full Text Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities Atsushi Fukumoto, Yong-Pil Kim, Atsuko Matsumoto, Yoko Takahashi, Makoto Suzuki, Hideyuki Onodera, Hiroshi Tomoda, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Satoshi Ōmura and Kazuro Shiomi J Antibiot 2017 70: 562-567; advance online publication, March 15, 2017; 10.1038/ja.2017.28 Abstract | Full Text Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation Atsushi Fukumoto, Yong-Pil Kim, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Hideaki Hanaki, Satoshi Ōmura and Kazuro Shiomi J Antibiot 2017 70: 568-573; advance online publication, March 15, 2017; 10.1038/ja.2017.29 Abstract | Full Text Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Ōmura and Toshiaki Sunazuka J Antibiot 2017 70: 574-581; advance online publication, December 7, 2016; 10.1038/ja.2016.141 Abstract | Full Text Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6 Masayuki Igarashi, Ryuichi Sawa, Manabu Yamasaki, Chigusa Hayashi, Maya Umekita, Masaki Hatano, Toshinobu Fujiwara, Kiyohisa Mizumoto and Akio Nomoto J Antibiot 2017 70: 582-589; advance online publication, January 11, 2017; 10.1038/ja.2016.161 Abstract | Full Text Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1 Takashi Fukuda, Misaki Takahashi, Kenichiro Nagai, Enjuro Harunari, Chiaki Imada and Hiroshi Tomoda J Antibiot 2017 70: 590-594; advance online publication, December 21, 2016; 10.1038/ja.2016.152 Abstract | Full Text Antarlides F–H, new members of the antarlide family produced by Streptomyces sp. BB47 Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi and Masaya Imoto J Antibiot 2017 70: 595-600; advance online publication, February 8, 2017; 10.1038/ja.2017.6 Abstract | Full Text Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490  Yixizhuoma, Naoki Ishikawa, Mohamed S Abdelfattah and Masami Ishibashi J Antibiot 2017 70: 601-606; advance online publication, January 11, 2017; 10.1038/ja.2016.158 Abstract | Full Text Simamycin (5′-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp. Yasuhiro Igarashi, Takayuki Kyoso, Youngju Kim and Tsutomu Oikawa J Antibiot 2017 70: 607-610; advance online publication, January 18, 2017; 10.1038/ja.2016.163 Abstract | Full Text Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7 Yasuhiro Takehana, Maya Umekita, Masaki Hatano, Chiaki Kato, Ryuichi Sawa and Masayuki Igarashi J Antibiot 2017 70: 611-615; advance online publication, March 1, 2017; 10.1038/ja.2017.26 Abstract | Full Text Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms Ayako Nara, Takuya Hashimoto, Mamoru Komatsu, Makoto Nishiyama, Tomohisa Kuzuyama and Haruo Ikeda J Antibiot 2017 70: 616-624; advance online publication, March 15, 2017; 10.1038/ja.2017.33 Abstract | Full Text Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate Wayne KW Chou, Colin A Gould and David E Cane J Antibiot 2017 70: 625-631; advance online publication, March 1, 2017; 10.1038/ja.2017.24 Abstract | Full Text Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes Sandip S Shinde, Atsushi Minami, Zhi Chen, Tetsuo Tokiwano, Tomonobu Toyomasu, Nobuo Kato, Takeshi Sassa and Hideaki Oikawa J Antibiot 2017 70: 632-638; advance online publication, March 8, 2017; 10.1038/ja.2017.27 Abstract | Full Text Molecular beacons to identify gifted microbes for genome mining Richard H Baltz J Antibiot 2017 70: 639-646; advance online publication, January 25, 2017; 10.1038/ja.2017.1 Abstract | Full Text Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor Masaki Ohtawa, Shiho Arima, Risa Shimizu, Naomi Hanatani, Eri Shimizu, Kazuro Shiomi, Kiyoshi Kita, Satoshi Ōmura and Tohru Nagamitsu J Antibiot 2017 70: 647-654; advance online publication, February 22, 2017; 10.1038/ja.2017.16 Abstract | Full Text Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Megumi Kumura, Takuji Yoshida and Keiichi Ajito J Antibiot 2017 70: 655-663; advance online publication, December 7, 2016; 10.1038/ja.2016.139 Abstract | Full Text Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci Zsolt Szűcs, Ilona Bereczki, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Eszter Ostorházi, Réka Szatmári and Pál Herczegh J Antibiot 2017 70: 664-670; advance online publication, February 1, 2017; 10.1038/ja.2017.2 Abstract | Full Text Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth, David B Olsen and Katherine Young J Antibiot 2017 70: 671-674; advance online publication, January 18, 2017; 10.1038/ja.2016.165 Abstract | Full Text The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues Takamichi Imaizumi, Hiroshi Nakagawa, Ran Hori, Yasuo Watanabe, Shiro Soga, Kyoichiro Iida and Hideyuki Onodera J Antibiot 2017 70: 675-679; advance online publication, January 18, 2017; 10.1038/ja.2016.166 Abstract | Full Text Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis Naftale Katz, Neusa Araújo, Paulo Marcos Zech Coelho, Carlos Medicis Morel, Ana Rosa Linde-Arias, Takeshi Yamada, Yuki Horimatsu, Koh Suzuki, Toshiaki Sunazuka and Satoshi Ōmura J Antibiot 2017 70: 680-684; advance online publication, March 15, 2017; 10.1038/ja.2017.31 Abstract | Full Text Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis Akiho Yagi, Ryuji Uchida, Hiroshi Hamamoto, Kazuhisa Sekimizu, Ken-ichi Kimura and Hiroshi Tomoda J Antibiot 2017 70: 685-690; 10.1038/ja.2017.23 Abstract | Full Text MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane Yusuke Kanda, Youhei Yamasaki, Satomi Shimura, Shinji Kamisuki, Fumio Sugawara, Yoko Nagumo and Takeo Usui J Antibiot 2017 70: 691-694; advance online publication, January 18, 2017; 10.1038/ja.2016.168 Abstract | Full Text Notes Top γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination Tatsuya Shirahata, Chieko Ino, Fumi Mizuno, Yoshihisa Asada, Masao Hirotani, George A Petersson, Satoshi Ōmura, Takafumi Yoshikawa and Yoshinori Kobayashi J Antibiot 2017 70: 695-698; advance online publication, March 22, 2017; 10.1038/ja.2017.35 Full Text Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4 Hideki Hashizume, Ryuichi Sawa, Kazuma Yamashita, Yoshio Nishimura and Masayuki Igarashi J Antibiot 2017 70: 699-704; advance online publication, March 15, 2017; 10.1038/ja.2017.34 Full Text Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684 Toshihiko Nogawa, Noriko Ogita, Yushi Futamura, Shigenori Negishi, Nobumoto Watanabe and Hiroyuki Osada J Antibiot 2017 70: 705-707; advance online publication, January 18, 2017; 10.1038/ja.2016.167 Full Text Two new sacrolide-class oxylipins from the edible cyanobacterium Aphanothece sacrum Naoya Oku, Sayaka Hana, Miyako Matsumoto, Kohsuke Yonejima, Keijiroh Tansei, Yasuhiro Isogai and Yasuhiro Igarashi J Antibiot 2017 70: 708-709; advance online publication, March 8, 2017; 10.1038/ja.2017.32 Full Text Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D Dong Yang, Mostafa E Rateb, Nan Wang and Ben Shen J Antibiot 2017 70: 710-714; advance online publication, February 15, 2017; 10.1038/ja.2017.13 Full Text Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale Mei Liu, Pei Huang, Qian Wang, Biao Ren, Ayokunmi Oyeleye, Miaomiao Liu, Jingyu Zhang, Xiaolin Li, Xiaoping Zhang, Lixin Zhang and Xueting Liu J Antibiot 2017 70: 715-717; advance online publication, January 11, 2017; 10.1038/ja.2016.160 Full Text Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506 Shan Lu, Shinichi Nishimura, Masashi Ito, Taira Kato and Hideaki Kakeya J Antibiot 2017 70: 718-720; advance online publication, December 21, 2016; 10.1038/ja.2016.153 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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