This review discusses concepts for establishment of cellular heterogeneity in tissues, and proposes that cell identity is dynamically maintained in a cognitive manner, rather than intrinsically predetermined.
Terminally differentiated macrophages displaying a Raf/MEK/ERK pathway‐dependent G1‐like cell cycle expression profile are permissive to HIV‐1 infection due to deactivation of the host HIV‐1 restriction factor SAMHD1.
Petra Mlcochova, Katherine A Sutherland, Sarah A Watters, Cosetta Bertoli, Rob AM de Bruin, Jan Rehwinkel, Stuart J Neil, Gina M Lenzi, Baek Kim, Asim Khwaja, Matthew C Gage, Christiana Georgiou, Alexandra Chittka, Simon Yona, Mahdad Noursadeghi, Greg J Towers, and Ravindra K Gupta
Why certain loci are able to stably switch between alternative epigenetic states (forming heritable epialleles), while others remain resistant to such switches seems to be predetermined by their genetic features, such as DNA sequence composition and repetitiveness.
Marco Catoni, Jayne Griffiths, Claude Becker, Nicolae Radu Zabet, Carlos Bayon, Mélanie Dapp, Michal Lieberman‐Lazarovich, Detlef Weigel, and Jerzy Paszkowski
Proteomics‐based identification of distinct molecular interactions and modifications of wild‐type and melanoma‐associated mutant BRAF reveals the effects of BRAF activators and inhibitors on the quaternary structure of this major therapeutic target.
Britta Diedrich, Kristoffer TG Rigbolt, Michael Röring, Ricarda Herr, Stephanie Kaeser‐Pebernard, Christine Gretzmeier, Robert F Murphy, Tilman Brummer, and Jörn Dengjel
Distinct conformations of Chandipura virus glycoprotein reveal the chronological order of fusion‐associated structural changes, including an early‐stage requirement for antiparallel fusion domain interactions.
Eduard Baquero, Aurélie A Albertini, Hélène Raux, Abbas Abou‐Hamdan, Elisabetta Boeri‐Erba, Malika Ouldali, Linda Buonocore, John K Rose, Jean Lepault, Stéphane Bressanelli, and Yves Gaudin
Folding of proteins entering the secretory pathway in mammalian cells necessitates disulfide bond formation in the ER. This study shows that cytosolic thioredoxin reductase 1 and NADPH are required to reduce non‐native disulfides in such proteins.
Greg J Poet, Ojore BV Oka, Marcel van Lith, Zhenbo Cao, Philip J Robinson, Marie Anne Pringle, Elias SJ Arnér, and Neil J Bulleid