The authors propose a novel mechanism, termed Activity‐DEPendent Transpositon (ADEPT), in which epigenetic drift and the preferential use of homologous‐directed repair allows transposable elements to hijack activity‐induced double‐strand breaks in aged neurons, contributing to neurodegenerative disease.
Andrew G Newman, Paraskevi Bessa, Victor Tarabykin, and Prim B Singh
Controversial decisions to ban athletes and the Russian doping scandal have raised doubts about the reliability of doping controls in professional sports. To ensure fairness and due process, doping tests must be transparent and adhere to the best scientific standards.
Erik Boye, Tore Skotland, Bjarne Østerud, and Jon Nissen‐Meyer
The Asilomar meeting on recombinant DNA technology and the Napa meeting on genome editing of the human germline are examples of self‐regulation by the scientific community. What can we learn from these cases to improve self‐regulation so as to ensure public trust and inform regulation of new technologies?
Daniel Gregorowius, Nikola Biller‐Andorno, and Anna Deplazes‐Zemp
Music unfolds over time and music perception has much to do with making temporal predictions. But how does the brain interpret upcoming auditory events, and why are humans better at it than most other animals?
For decades, biomimicry was a heralded concept of copying nature's inventions, but it yielded only few results. A recent shift towards more systematic ways to trawl nature's inventions and to understand their function before mimicking them could lead to new innovations.
Damaged and aggregated proteins accumulate during aging and increased proteotoxic stress. This review describes the spatial and temporal quality control systems that operate to limit toxicity and the inheritance of damage by succeeding cell generations.
Sandra Malmgren Hill, Sarah Hanzén, and Thomas Nyström
This study reveals the structural basis for how a single motif interacting with ubiquitin (MIU) at the C‐terminus of MINDY‐1 mediates selective binding to K48‐linked polyUb. Weak ubiquitin interactions from an adjacent MIU motif enhance binding to polyubiquitin.
Yosua Adi Kristariyanto, Syed Arif Abdul Rehman, Simone Weidlich, Axel Knebel, and Yogesh Kulathu
Human RIF1 protein forms a complex with PP1 that limits phosphorylation of MCM proteins to control S‐phase progression. RIF1‐PP1 also protects ORC1 from phosphorylation‐dependent degradation, to ensure full origin licensing in G1 phase.
Shin‐ichiro Hiraga, Tony Ly, Javier Garzón, Zuzana Hořejší, Yoshi‐nobu Ohkubo, Akinori Endo, Chikashi Obuse, Simon J Boulton, Angus I Lamond, and Anne D Donaldson
Hippo signaling regulates tissue size and aberrations in the pathway can lead to cancer. This study identifies MARK family kinases as negative regulators of Hippo signaling by promoting the activity of YAP and TAZ via the inhibition of the Hippo kinase cascade.
Emad Heidary Arash, Ahmed Shiban, Siyuan Song, and Liliana Attisano
CIP2A promotes malignancy by inhibiting the tumor suppressor activity of the protein phosphatase PP2A. This study presents the first crystal structure of CIP2A and characterizes the structural requirements for the binding of CIP2A to the B56 subunits of PP2A.
Jiao Wang, Juha Okkeri, Karolina Pavic, Zhizhi Wang, Otto Kauko, Tuuli Halonen, Grzegorz Sarek, Päivi M Ojala, Zihe Rao, Wenqing Xu, and Jukka Westermarck
Mitochondrial pH flashes are matrix pH responses to drops in mitochondrial potential. This study shows that these mitopHlashes are not detectable in cristae and intermembrane space and require OPA1 independently of mitochondrial fusion.
Manon Rosselin, Jaime Santo‐Domingo, Flavien Bermont, Marta Giacomello, and Nicolas Demaurex
This study identifies an incoherent type‐4 feed‐forward loop (I4‐FFL) consisting of jasmonate, PAD4, and EDS5 in Arabidopsis. This I4‐FFL ensures robust and tunable accumulation of salicylic acid during immune activation through flagellin sensing.
Akira Mine, Tatsuya Nobori, Maria C Salazar‐Rondon, Thomas M Winkelmüller, Shajahan Anver, Dieter Becker, and Kenichi Tsuda
In human, the initial steps of cytochrome c oxidase (CIV) assembly and their coordination with mitochondrial protein synthesis remain to be fully understood. This study characterizes the twin CX9C protein CMC1 function in CIV subunit 1 (COX1) biogenesis.