EMBO reports Table of Contents for March 2017; Vol. 18, No. 3

March 2017 | Volume 18, Number 3 Submit Table of Contents Editorial Opinion Science & Society Reviews Scientific Report Articles Volume 18, Number 3 Editorial Trump's travel travesty The recent executive order by US President Donald Trump to bar citizens from seven countries from entering the USA has a chilling effect on the free exchange of people and ideas in science. Holger Breithaupt and Bernd Pulverer Published online 08.02.2017 Opinion Activity‐DEPendent Transposition The authors propose a novel mechanism, termed Activity‐DEPendent Transpositon (ADEPT), in which epigenetic drift and the preferential use of homologous‐directed repair allows transposable elements to hijack activity‐induced double‐strand breaks in aged neurons, contributing to neurodegenerative disease. Andrew G Newman, Paraskevi Bessa, Victor Tarabykin, and Prim B Singh Published online 20.02.2017 A pension fund for European scientists Many scientists who work abroad end up loosing out on pension rights in the home country. A pan‐European pension scheme could address this problem and support international mobility in research. Vic Norris Published online 31.01.2017 Science & Society Doping and drug testing: Anti‐doping work must be transparent and adhere to good scientific practices to ensure public trust Controversial decisions to ban athletes and the Russian doping scandal have raised doubts about the reliability of doping controls in professional sports. To ensure fairness and due process, doping tests must be transparent and adhere to the best scientific standards. Erik Boye, Tore Skotland, Bjarne Østerud, and Jon Nissen‐Meyer Published online 06.02.2017 The role of scientific self‐regulation for the control of genome editing in the human germline: The lessons from the Asilomar and the Napa meetings show how self‐regulation and public deliberation can lead to regulation of new biotechnologies The Asilomar meeting on recombinant DNA technology and the Napa meeting on genome editing of the human germline are examples of self‐regulation by the scientific community. What can we learn from these cases to improve self‐regulation so as to ensure public trust and inform regulation of new technologies? Daniel Gregorowius, Nikola Biller‐Andorno, and Anna Deplazes‐Zemp Published online 20.02.2017 Feel the beat: Music exploits our brain's ability to predict and the dopamine‐reward system to instill pleasure Music unfolds over time and music perception has much to do with making temporal predictions. But how does the brain interpret upcoming auditory events, and why are humans better at it than most other animals? Katrin Weigmann Published online 26.01.2017 From imitation to inspiration: Biomimicry experiences a revival driven by a more systematic approach to explore nature's inventions for human use For decades, biomimicry was a heralded concept of copying nature's inventions, but it yielded only few results. A recent shift towards more systematic ways to trawl nature's inventions and to understand their function before mimicking them could lead to new innovations. Philip Hunter Published online 13.02.2017 Reviews Organoid technologies meet genome engineering This review discusses the marriage of 3D organoid and genome engineering technologies, which holds great promise for biomedical research and translational application. Jing Nie and Eri Hashino Published online 15.02.2017 Restricted access: spatial sequestration of damaged proteins during stress and aging Damaged and aggregated proteins accumulate during aging and increased proteotoxic stress. This review describes the spatial and temporal quality control systems that operate to limit toxicity and the inheritance of damage by succeeding cell generations. Sandra Malmgren Hill, Sarah Hanzén, and Thomas Nyström Published online 13.02.2017 Scientific Report A single MIU motif of MINDY‐1 recognizes K48‐linked polyubiquitin chains This study reveals the structural basis for how a single motif interacting with ubiquitin (MIU) at the C‐terminus of MINDY‐1 mediates selective binding to K48‐linked polyUb. Weak ubiquitin interactions from an adjacent MIU motif enhance binding to polyubiquitin. Yosua Adi Kristariyanto, Syed Arif Abdul Rehman, Simone Weidlich, Axel Knebel, and Yogesh Kulathu Published online 12.01.2017 Articles Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation Human RIF1 protein forms a complex with PP1 that limits phosphorylation of MCM proteins to control S‐phase progression. RIF1‐PP1 also protects ORC1 from phosphorylation‐dependent degradation, to ensure full origin licensing in G1 phase. Shin‐ichiro Hiraga, Tony Ly, Javier Garzón, Zuzana Hořejší, Yoshi‐nobu Ohkubo, Akinori Endo, Chikashi Obuse, Simon J Boulton, Angus I Lamond, and Anne D Donaldson Published online 11.01.2017 MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells Hippo signaling regulates tissue size and aberrations in the pathway can lead to cancer. This study identifies MARK family kinases as negative regulators of Hippo signaling by promoting the activity of YAP and TAZ via the inhibition of the Hippo kinase cascade. Emad Heidary Arash, Ahmed Shiban, Siyuan Song, and Liliana Attisano Published online 09.02.2017 Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56 CIP2A promotes malignancy by inhibiting the tumor suppressor activity of the protein phosphatase PP2A. This study presents the first crystal structure of CIP2A and characterizes the structural requirements for the binding of CIP2A to the B56 subunits of PP2A. Jiao Wang, Juha Okkeri, Karolina Pavic, Zhizhi Wang, Otto Kauko, Tuuli Halonen, Grzegorz Sarek, Päivi M Ojala, Zihe Rao, Wenqing Xu, and Jukka Westermarck Published online 07.02.2017 L‐OPA1 regulates mitoflash biogenesis independently from membrane fusion Mitochondrial pH flashes are matrix pH responses to drops in mitochondrial potential. This study shows that these mitopHlashes are not detectable in cristae and intermembrane space and require OPA1 independently of mitochondrial fusion. Manon Rosselin, Jaime Santo‐Domingo, Flavien Bermont, Marta Giacomello, and Nicolas Demaurex Published online 07.02.2017 An incoherent feed‐forward loop mediates robustness and tunability in a plant immune network This study identifies an incoherent type‐4 feed‐forward loop (I4‐FFL) consisting of jasmonate, PAD4, and EDS5 in Arabidopsis. This I4‐FFL ensures robust and tunable accumulation of salicylic acid during immune activation through flagellin sensing. Akira Mine, Tatsuya Nobori, Maria C Salazar‐Rondon, Thomas M Winkelmüller, Shajahan Anver, Dieter Becker, and Kenichi Tsuda Published online 09.01.2017 A CMC1‐knockout reveals translation‐independent control of human mitochondrial complex IV biogenesis In human, the initial steps of cytochrome c oxidase (CIV) assembly and their coordination with mitochondrial protein synthesis remain to be fully understood. This study characterizes the twin CX9C protein CMC1 function in CIV subunit 1 (COX1) biogenesis. Myriam Bourens and Antoni Barrientos Published online 12.01.2017 Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy The E3 ubiquitin ligase MARCH5 targets the mitophagy receptor FUNDC1 for degradation, which desensitizes mitochondrial clearance and fine‐tunes mitophagy under hypoxic stress. Ziheng Chen, Lei Liu, Qi Cheng, Yanjun Li, Hao Wu, Weilin Zhang, Yueying Wang, Sheikh Arslan Sehgal, Sami Siraj, Xiaohui Wang, Jun Wang, Yushan Zhu, and Quan Chen Published online 19.01.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.