Poster on effects of new antidiabetic drugs on cardiovascular health
This poster summarizes cardiovascular outcome trials of newly developed glucose-lowering agents. Some of these drugs have shown cardiovascular benefit that might have clinical importance in the management of type 2 diabetes.
Microbiology: Manipulation of the manipulators Wolbachia bacteria infect insects and can cause mating incompatibilities, an outcome that is used to fight insect-transmitted disease. The proposed genes responsible illuminate this process and the disease-control mechanisms.
Cell biology: Sort and destroy Aggregates are aberrant, non-functional forms of protein that often build up in cells in response to stress. Organelles called mitochondria have now been found to be active players in the clearance of these protein aggregates.
Earth’s first stable continents did not form by subduction Phase equilibria modelling of rocks from Western Australia confirms that the ancient continental crust could have formed by multistage melting of basaltic ‘parents’ along high geothermal gradients—a process incompatible with modern-style subduction.
The integral role of iron in ocean biogeochemistry The recent expansion of observational data has changed our understanding of the ocean iron cycle and its linkages with nutrients such as carbon and nitrogen. Alessandro Tagliabue, Andrew R. Bowie, Philip W. Boyd et al.
Whole-genome landscape of pancreatic neuroendocrine tumours The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations. Aldo Scarpa, David K. Chang, Katia Nones et al.
Abiotic tooth enamel Nanometre-scale columnar structures in tooth enamel inspire novel nanocomposites containing layers of vertically aligned nanowires, produced by layer-by-layer fabrication and combining high values of both storage modulus and energy dissipation. Bongjun Yeom, Trisha Sain, Naida Lacevic et al.
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection Introducing chimeric antigen receptors into the endogenous T-cell receptor locus reduces tonic signalling, averts accelerated T-cell differentiation and delays T-cell exhaustion, leading to enhanced function and anti-tumour efficacy compared to random integrations. Justin Eyquem, Jorge Mansilla-Soto, Theodoros Giavridis et al.
Mechanical stretch triggers rapid epithelial cell division through Piezo1 The stretch-activated channel Piezo1 controls homeostatic epithelial cell numbers by activating cells to divide rapidly when under stretch strain from low density, and by activating cells to extrude and die when cells are under crowding strain. S. A. Gudipaty, J. Lindblom, P. D. Loftus et al.
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