Thursday, March 2, 2017

Nature Cell Biology contents: March 2017 Volume 19 Number 3, pp 145 - 258

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Nature Cell Biology

ATCC® CRISPR/Cas9 Gene-edited Isogenic Cell Lines 
Isogenic cell lines are engineered from tumor cell lines relevant to diseases and drug targets and possess key mutations, such as EML4-ALK fusion and NRAS Q61K. ATCC isogenic cell lines undergo a thorough molecular validation at the genomic, transcript, and protein levels. We perform additional bio-functional characterization to demonstrate drug-screening applications. 
Start your drug screening studies with the new isogenic cell line!

March 2017 Volume 19, Issue 3

News and Views

Nikon is offering special pricing on our award winning Eclipse Ts2 inverted tissue culture microscope with phase contrast optics. The Ts2 features intuitive controls, a compact body, LED illumination, and smart accessories such as the Contrast Shield which allows fluorescent samples to be easily observed in brightly lit labs. For more information, go to

Recommend to library

Bioprocessing Technologies in Stem Cell Research: Challenges and Chances for Commercialization
The 1st Stem Cell Community Day brings together experts from industry and academia to discuss recent achievements, challenges, and chances in stem cell bioprocessing for research and commercial manufacturing. Register now and submit your abstract!
Presented by: Zhejiang University | Nature | Nature Materials

The conference will feature sessions on nanomaterials, functional materials, structural material, soft matter and biomaterials, and techniques development.

May 27-29, 2016 | Zhenjiang, China 
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The scientist citizen: time to become political   p145
Shifting political landscapes in the United States and European Union have seeded uncertainty in the scientific community. Intellectual freedom, funding and scientist mobility must be protected to secure the future of biological research.

News and Views


Pulling cells out of tumours   pp147 - 149
Andrew J. Ewald
Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.

See also: Article by Labernadie et al.

G1 cyclins protect pluripotency   pp149 - 150
Julia Arand and Julien Sage
G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

See also: Article by Liu et al.

Inheritance of protection from osmotic stress   pp151 - 152
Kiyomi R. Kaneshiro and Susan Strome
Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygotic gpdh-2, a rate-limiting enzyme in glycerol biosynthesis.

See also: Letter by Burton et al.

Twist of fate for skeletal muscle mesenchymal cells   pp153 - 154
Natalya A. Goloviznina and Michael Kyba
Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.

See also: Article by Liu et al.

Nature Cell Biology
JOBS of the week
Postdoctoral position: RNA, Stem Cell and Cancer Biology
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Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice   pp155 - 163
Sangbum Park, David G. Gonzalez, Boris Guirao, Jonathan D. Boucher, Katie Cockburn et al.
Park et al. study individual cell dynamics during mouse wound re-epithelialization in real time and reveal a finely orchestrated interplay between epidermal migration, directional division and differentiation.

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive   pp164 - 176
Nai Yang Fu, Anne C. Rios, Bhupinder Pal, Charity W. Law, Paul Jamieson et al.
Fu et al. define a heterogeneous population of MaSC subsets based on the expression of LGR5 and TSPAN8, with varying anatomical locations in the mouse mammary ductal tree, in vivo repopulating abilities, cell cycle status and molecular signatures.

G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells   pp177 - 188
Lijun Liu, Wojciech Michowski, Hiroyuki Inuzuka, Kouhei Shimizu, Naoe Taira Nihira et al.
Liu et al. show that G1 cyclins and their cyclin-dependent kinases regulate the pluripotent state by driving phosphorylation of Nanog, Oct4 and Sox2, thereby identifying a direct connection between G1 cyclins and pluripotency factors.

See also: News and Views by Arand & Sage

Cell–matrix signals specify bone endothelial cells during developmental osteogenesis   pp189 - 201
Urs H. Langen, Mara E. Pitulescu, Jung Mo Kim, Rocio Enriquez-Gasca, Kishor K. Sivaraj et al.
Langen et al. identify a third capillary endothelial cell subtype, termed type E, that supports embryonic and early postnatal bone formation, and show that endothelial integrin β1 and laminin α5 are required for bone angiogenesis and osteogenesis.

A Twist2-dependent progenitor cell contributes to adult skeletal muscle   pp202 - 213
Ning Liu, Glynnis A. Garry, Stephen Li, Svetlana Bezprozvannaya, Efrain Sanchez-Ortiz et al.
Liu et al. identify an interstitial progenitor cell, characterized by Twist2 expression, that is highly myogenic, forms type IIb/x myofibres and contributes to regeneration in adult skeletal muscle.

See also: News and Views by Goloviznina & Kyba

Differential cytokine contributions of perivascular haematopoietic stem cell niches   pp214 - 223
Noboru Asada, Yuya Kunisaki, Halley Pierce, Zichen Wang, Nicolas F. Fernandez et al.
Asada et al. examine differential effects of CXCL12 and SCF expression by perivascular bone marrow niche cells, such as arteriolar NG2+ vascular smooth muscle cells and sinusoidal LepR+ cells, on haematopoietic stem cell maintenance and mobilization.

A mechanically active heterotypic E–cadherin/N–cadherin adhesion enables fibroblasts to drive cancer cell invasion   pp224 - 237
Anna Labernadie, Takuya Kato, Agustí Brugués, Xavier Serra-Picamal, Stefanie Derzsi et al.
Cancer-associated fibroblasts (CAFs) promote metastasis by creating tracks for cancer cell migration. Labernadie et al. now show that heterotypic adhesions between E-cadherin on cancer cells and N-cadherin on CAFs transmit forces to drive invasion.

See also: News and Views by Ewald

The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors   pp238 - 251
Aifu Lin, Qingsong Hu, Chunlai Li, Zhen Xing, Guolin Ma et al.
Yang and colleagues report that the LINK-A lncRNA binds to the PIP3 phospholipid, leading to enhanced AKT signalling, tumorigenesis and resistance to AKT inhibitors.



Insulin-like signalling to the maternal germline controls progeny response to osmotic stress   pp252 - 257
Nicholas O. Burton, Tokiko Furuta, Amy K. Webster, Rebecca E. W. Kaplan, L. Ryan Baugh et al.
Burton et al. show that Caenorhabditis elegans parental exposure to osmotic stress protects progeny from osmotic stress through insulin-like signalling, linking maternal germline signalling to progeny metabolism.

See also: News and Views by Kaneshiro & Strome



Erratum: Long-range self-organization of cytoskeletal myosin II filament stacks   p258
Shiqiong Hu, Kinjal Dasbiswas, Zhenhuan Guo, Yee-Han Tee, Visalatchi Thiagarajan et al.

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