Nikon is offering special pricing on our award winning Eclipse Ts2 inverted tissue culture microscope with phase contrast optics. The Ts2 features intuitive controls, a compact body, LED illumination, and smart accessories such as the Contrast Shield which allows fluorescent samples to be easily observed in brightly lit labs. For more information, go to www.nikoninstruments.com/ts2-promo
Bioprocessing Technologies in Stem Cell Research: Challenges and Chances for Commercialization The 1st Stem Cell Community Day brings together experts from industry and academia to discuss recent achievements, challenges, and chances in stem cell bioprocessing for research and commercial manufacturing. Register now and submit your abstract! www.stemcellday.de/
ELECTRON MICROSCOPY FOR MATERIALS - THE NEXT TEN YEARS Presented by: Zhejiang University | Nature | Nature Materials
The conference will feature sessions on nanomaterials, functional materials, structural material, soft matter and biomaterials, and techniques development.
The scientist citizen: time to become political p145 doi:10.1038/ncb3489 Shifting political landscapes in the United States and European Union have seeded uncertainty in the scientific community. Intellectual freedom, funding and scientist mobility must be protected to secure the future of biological research.
Pulling cells out of tumours pp147 - 149 Andrew J. Ewald doi:10.1038/ncb3484 Tumours are highly complex and contain multiple cell types. Cancer-associated fibroblasts are now shown to have a critical role in directly leading cancer cell invasion. This intercellular interaction relies on a mechanically active cadherin-based junction, and CAF-led invasion is demonstrated to require E-cadherin in the cancer cell.
G1 cyclins protect pluripotency pp149 - 150 Julia Arand and Julien Sage doi:10.1038/ncb3480 G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.
Inheritance of protection from osmotic stress pp151 - 152 Kiyomi R. Kaneshiro and Susan Strome doi:10.1038/ncb3483 Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygotic gpdh-2, a rate-limiting enzyme in glycerol biosynthesis.
Twist of fate for skeletal muscle mesenchymal cells pp153 - 154 Natalya A. Goloviznina and Michael Kyba doi:10.1038/ncb3482 Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.
From the industry leaders in sequencing and Droplet Digital™ technologies, Illumina and Bio-Rad provide a robust, scalable, and user-friendly workflow enabling transcriptome profiling of hundreds to tens of thousands of single cells.
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