The EMBO Journal Table of Contents for 17 January 2017; Vol. 36, No. 2

17 January 2017 | Volume 36, Number 2 Submit Table of Contents News & Views Articles Volume 36, Number 2 News & Views Removing the waste bags: how p97 drives autophagy of lysosomes Upon lysosomal rupture, autophagic clearance—lysophagy—is mediated by the AAA‐ATPase VCP/p97, and this process is compromised in the presence of mutant p97 known to cause inclusion body myopathy and neurodegeneration. Marta Seczynska and Ivan Dikic Published online 28.11.2016 Maintaining hair follicle stem cell identity in a dish Long‐term in vitro expansion of murine skin stem cells without help of heterologous cell types has been achieved by combining 3D culture techniques and distinct growth factor combinations. Adriana Sánchez‐Danés and Cédric Blanpain Published online 21.12.2016 Articles VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy The AAA‐ATPase VCP/p97 governs an endolysosomal damage response pathway (ELDR) that ensures survival after lysosomal rupture and promotes autophagic clearance of the damaged organelles. Chrisovalantis Papadopoulos, Philipp Kirchner, Monika Bug, Daniel Grum, Lisa Koerver, Nina Schulze, Robert Poehler, Alina Dressler, Sven Fengler, Khalid Arhzaouy, Vanda Lux, Michael Ehrmann, Conrad C Weihl, and Hemmo Meyer Published online 17.10.2016 Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny Cell culture conditions for enrichment and long‐term maintenance of multipotent mouse skin stem cells in population equilibrium. Carlos Andrés Chacón‐Martínez, Markus Klose, Catherin Niemann, Ingmar Glauche, and Sara A Wickström Published online 09.12.2016 SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland Adhesion regulator SHARPIN modulates stromal collagen architecture and matrix turnover in mammary gland fibroblasts during puberty and thereby regulates the outgrowth of mammary ducts. Emilia Peuhu, Riina Kaukonen, Martina Lerche, Markku Saari, Camilo Guzmán, Pia Rantakari, Nicola De Franceschi, Anni Wärri, Maria Georgiadou, Guillaume Jacquemet, Elina Mattila, Reetta Virtakoivu, Yuming Liu, Youmna Attieh, Kathleen A Silva, Timo Betz, John P Sundberg, Marko Salmi, Marie‐Ange Deugnier, Kevin W Eliceiri, and Johanna Ivaska Published online 14.12.2016 Endothelial basement membrane laminin 511 is essential for shear stress response Laminin 511 (Laminin α5) is required for adhesion of endothelial cells to their basement membrane and stabilizes junctional VE‐cadherin, and this is required for the shear stress response of resistance arteries. Jacopo Di Russo, Anna‐Liisa Luik, Lema Yousif, Sigmund Budny, Hans Oberleithner, Verena Hofschröer, Juergen Klingauf, Ed van Bavel, Erik NTP Bakker, Per Hellstrand, Anirban Bhattachariya, Sebastian Albinsson, Frederic Pincet, Rupert Hallmann, and Lydia M Sorokin Published online 09.12.2016 Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387 Cyclin‐dependent kinase‐promoted phosphorylation of STAT2 at T387 inhibits type I IFN‐dependent signaling with effects on viral and cell proliferative responses. Yuxin Wang, Jing Nan, Belinda Willard, Xin Wang, Jinbo Yang, and George R Stark Published online 16.11.2016 Unloading of homologous recombination factors is required for restoring double‐stranded DNA at damage repair loci Excessive end resection during DNA repair is prevented by the anti‐recombinase Srs2 forging ahead and paving the way for DNA re‐synthesis polymerases. Yulia Vasianovich, Veronika Altmannova, Oleksii Kotenko, Matthew D Newton, Lumir Krejci, and Svetlana Makovets Published online 08.12.2016 mGluR long‐term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum Activation of metabotropic glutamate receptors (mGluR) drives selective exit of AMPARs from the ER, leading to insertion of GluA2 at the plasma membrane to regulate synaptic plasticity. Joseph E Pick, Latika Khatri, Matheus F Sathler, and Edward B Ziff Published online 17.11.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.