Wednesday, January 25, 2017

Nature Communications -25 January 2017

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Accelerating the search for the missing proteins in the human proteome OPEN
Mark S. Baker, Seong Beom Ahn, Abidali Mohamedali, Mohammad T. Islam, David Cantor, Peter D. Verhaert, Susan Fanayan, Samridhi Sharma, Edouard C. Nice, Mark Connor and Shoba Ranganathan
The Human Proteome Project aims to catalogue the ∼20,000 proteins encoded by the human genome. In this review, Baker et al. focus on the missing proteins, proteins that lack high stringency proteomic evidence, and launch MissingProteinPedia, a database aimed at accelerating the search for missing proteins.
24 January 2017 | doi: 10.1038/ncomms14271
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A swarm of autonomous miniature underwater robot drifters for exploring submesoscale ocean dynamics OPEN
Jules S. Jaffe, Peter J. S. Franks, Paul L. D. Roberts, Diba Mirza, Curt Schurgers, Ryan Kastner and Adrien Boch
Observing dynamics associated with oceanic submesoscales requires simultaneous sampling at multiple locations. Here, the authors show that a swarm of 16 Mini-Autonomous Underwater Explorers (M-AUEs), whose 3D trajectories are measured near-continuously, can resolve features of the flow at these scales.
24 January 2017 | doi: 10.1038/ncomms14189

Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time OPEN
Bai-Yu Lee, Daniel L. Clemens, Aleidy Silva, Barbara Jane Dillon, Saša Masleša-Galić, Susana Nava, Xianting Ding, Chih-Ming Ho and Marcus A. Horwitz
Current antibiotic therapies for tuberculosis are lengthy and onerous. Here, the authors use an output-driven approach to optimize drug doses for two experimental drug regimens in a mouse model of tuberculosis, leading to improved regimens that reduce treatment time by 75%.
24 January 2017 | doi: 10.1038/ncomms14183

Refined Ordovician timescale reveals no link between asteroid breakup and biodiversification OPEN
A. Lindskog, M. M. Costa, C.M.Ø. Rasmussen, J. N. Connelly and M. E. Eriksson
The high amount of L-type chondrites discovered in Ordovician sediments has previously been linked with the Great Ordovician Biodiversification Event. But here, Lindskog et al. present new zircon ages that date the chondrite dispersion to 468.0±0.3 Ma, showing that the two events may be unrelated.
24 January 2017 | doi: 10.1038/ncomms14066

Market forces influence helping behaviour in cooperatively breeding paper wasps OPEN
Lena Grinsted and Jeremy Field
In cooperatively breeding species, subordinates help to raise the dominant breeders’ offspring in return for benefits associated with group membership. Here, Grinsted and Field show that the amount of help provided by subordinate paper wasps depends on the availability of alternative nesting options, as predicted by biological market theory.
24 January 2017 | doi: 10.1038/ncomms13750

Fractal nematic colloids OPEN
S. M. Hashemi, U. Jagodič, M. R. Mozaffari, M. R. Ejtehadi, I. Muševič and M. Ravnik
Topological defects in nematic liquid crystals can be controlled upon external stimuli for designing novel photonic materials. Here, Hashemi et al. show geometry-induced formation of fractal defects in nematic fluids with the fractal self-similarity more than 90% from micrometers to nanometres.
24 January 2017 | doi: 10.1038/ncomms14026

Superior colliculus neurons encode a visual saliency map during free viewing of natural dynamic video OPEN
Brian J. White, David J. Berg, Janis Y. Kan, Robert A. Marino, Laurent Itti and Douglas P. Munoz
Saliency maps have been proposed to guide visual attention, yet the underlying neural correlates remain undetermined. Here, the authors record from monkeys as they watch videos of natural scenes, and find superior colliculus superficial visual-layer neurons exhibit activity patterns consistent with a visual saliency map.
24 January 2017 | doi: 10.1038/ncomms14263

Scalable high-precision tuning of photonic resonators by resonant cavity-enhanced photoelectrochemical etching OPEN
Eduardo Gil-Santos, Christopher Baker, Aristide Lemaître, Carmen Gomez, Giuseppe Leo and Ivan Favero
Aligning the resonances of sets of optical cavities is necessary for advanced photonics and sensing applications. Here, the authors introduce resonant photoelectrochemical etching as a method to collectively and permanently tune the resonant wavelengths of ensembles of resonators on a photonic chip.
24 January 2017 | doi: 10.1038/ncomms14267

Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast OPEN
Daniel C. Jeffares, Clemency Jolly, Mimoza Hoti, Doug Speed, Liam Shaw, Charalampos Rallis, Francois Balloux, Christophe Dessimoz, Jürg Bähler and Fritz J. Sedlazeck
Fission yeast Schizosaccharomyces pombe has diverse traits. Jeffares et al. characterize large copy number variations (CNVs) and rearrangements in S. pombe, and show that CNVs are transient with effects on quantitative traits and gene expression, whereas rearrangements influence intrinsic reproductive isolation.
24 January 2017 | doi: 10.1038/ncomms14061

Earth’s changing global atmospheric energy cycle in response to climate change OPEN
Yefeng Pan, Liming Li, Xun Jiang, Gan Li, Wentao Zhang, Xinyue Wang and Andrew P. Ingersoll
The long-term Lorenz energy cycle of Earth’s global remains poorly explored. Here, the authors use three independent meteorological data sets from the modern satellite era (1979–2013) to examine the temporal characteristics of such a cycle.
24 January 2017 | doi: 10.1038/ncomms14367

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling OPEN
Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel and Hossein Ardehali
The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.
24 January 2017 | doi: 10.1038/ncomms14095

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids OPEN
Shira Sagie, Shir Toubiana, Stella R. Hartono, Hagar Katzir, Aya Tzur-Gilat, Shany Havazelet, Claire Francastel, Guillaume Velasco, Frédéric Chédin and Sara Selig
ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hybrids
24 January 2017 | doi: 10.1038/ncomms14015

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain OPEN
Stefan A. Berghoff, Nina Gerndt, Jan Winchenbach, Sina K. Stumpf, Leon Hosang, Francesca Odoardi, Torben Ruhwedel, Carolin Böhler, Benoit Barrette, Ruth Stassart, David Liebetanz, Payam Dibaj, Wiebke Möbius, Julia M. Edgar and Gesine Saher
Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.
24 January 2017 | doi: 10.1038/ncomms14241

Temporal and compartment-specific signals coordinate mitotic exit with spindle position OPEN
Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop and Gislene Pereira
The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in the mother cell and that in the absence of FEAR mitotic exit requires daughter cell-confined factors.
24 January 2017 | doi: 10.1038/ncomms14129

Mineral inclusions in diamonds may be synchronous but not syngenetic OPEN
Fabrizio Nestola, Haemyeong Jung and Lawrence A. Taylor
Trapped mineral inclusions in diamonds give information on diamond crystallization and ages, under the assumption that they are syngenetic (formed simultaneously). Here, the authors show evidence that many mineral inclusions are protogenetic (formed at different times) thus undermining previous diamond ages.
24 January 2017 | doi: 10.1038/ncomms14168

MetaSort untangles metagenome assembly by reducing microbial community complexity OPEN
Peifeng Ji, Yanming Zhang, Jinfeng Wang and Fangqing Zhao
Currently available metagenomic data analysis relies on reference genomes. Here, the authors describe a new de novo metagenomic assembly method, metaSort, that constructs bacterial genomes from metagenomic samples to reduce microbial community complexity while increasing genome recovery and assembly.
23 January 2017 | doi: 10.1038/ncomms14306

Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing OPEN
Qing Xie, Yueli Liu, Tao Cai, Corrigan Horton, Joshua Stefanson and Zhu A. Wang
Androgen receptor is an important regulator of prostate development and cancer. In this study, the authors use genetic lineage tracing in mice to clarify the role of AR in different prostate epithelial cells.
23 January 2017 | doi: 10.1038/ncomms14284

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes OPEN
Can Liu, Ruifang Liu, Dingxiao Zhang, Qu Deng, Bigang Liu, Hsueh-Ping Chao, Kiera Rycaj, Yoko Takata, Kevin Lin, Yue Lu, Yi Zhong, John Krolewski, Jianjun Shen and Dean G. Tang
MicroRNAs have important roles in regulating tumor development, progression and metastasis. Here, the authors demonstrate the tumor-suppressive functions of miRNA141 in prostate cancer stem cells mediated by directly targeting CD44, Rho GTPase protein family members, and EZH2.
23 January 2017 | doi: 10.1038/ncomms14270

A metastable liquid melted from a crystalline solid under decompression OPEN
Chuanlong Lin, Jesse S. Smith, Stanislav V. Sinogeikin, Yoshio Kono, Changyong Park, Curtis Kenney-Benson and Guoyin Shen
It is experimentally challenging to observe an intermediate liquid in solid–solid phase transitions due to short lifetimes of the resulting metastable states. Here, Lin et al. show that a metastable bismuth liquid can be formed from a crystalline solid through decompression and maintained for hours.
23 January 2017 | doi: 10.1038/ncomms14260

Wafer-scale integration of sacrificial nanofluidic chips for detecting and manipulating single DNA molecules OPEN
Chao Wang, Sung-Wook Nam, John M. Cotte, Christopher V. Jahnes, Evan G. Colgan, Robert L. Bruce, Markus Brink, Michael F. Lofaro, Jyotica V. Patel, Lynne M. Gignac, Eric A. Joseph, Satyavolu Papa Rao, Gustavo Stolovitzky, Stanislav Polonsky and Qinghuang Lin
The wide use of microfluidics for biological analysis demands scalable preparation methods, yet in practice it is very challenging. Here, Wang et al. show a wafer-scale fabrication of nanofluidic chips with single-digit nanometre dimension, which is compatible with standard semiconductor processing.
23 January 2017 | doi: 10.1038/ncomms14243

Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion OPEN
Peng Yue, Yubo Zhang, Kunrong Mei, Shaoxiao Wang, Johannes Lesigang, Yueyao Zhu, Gang Dong and Wei Guo
Membrane fusion during exocytosis is mediated by interaction between SNARE proteins on vesicles and the cell membrane, but how SNARE complex assembly is initiated remains unknown. Here, the authors show that interaction of Sec3 with Sso2 on the plasma membrane promotes formation of an Sso2–Sec9 complex, an early step in SNARE assembly, likely by inhibiting Sso2 auto-inhibition.
23 January 2017 | doi: 10.1038/ncomms14236

Synchronous deglacial thermocline and deep-water ventilation in the eastern equatorial Pacific OPEN
Natalie E. Umling and Robert C. Thunell
Potential age model problems with marine Δ14C records have obscured our understanding of the role of the deep-ocean in deglacial atmospheric CO2 rise. Here, the authors show that deglacial ventilation of EEP thermocline and deep waters occurred synchronously and was coeval with changes in Atlantic records.
23 January 2017 | doi: 10.1038/ncomms14203

A human immunodeficiency syndrome caused by mutations in CARMIL2 OPEN
T. Schober, T. Magg, M. Laschinger, M. Rohlfs, N. D. Linhares, J. Puchalka, T. Weisser, K. Fehlner, J. Mautner, C. Walz, K. Hussein, G. Jaeger, B. Kammer, I. Schmid, M. Bahia, S. D. Pena, U. Behrends, B. H. Belohradsky, C. Klein and F. Hauck et al.
CARMIL2 (Rltpr) is involved in T-cell function. Here, the authors identify human CARMIL2-deficiency as an autosomal recessive primary immunodeficiency disorder characterized by EBV+ smooth muscle tumours, CD28 co-signalling deficiency and impaired cytoskeletal dynamics.
23 January 2017 | doi: 10.1038/ncomms14209

Transformable topological mechanical metamaterials OPEN
D. Zeb Rocklin, Shangnan Zhou, Kai Sun and Xiaoming Mao
Here Rocklin et al. propose a design principle using operations that cost little energy and realize mechanical metamaterials that can be easily and reversibly transformed between states with different mechanical and acoustic properties.
23 January 2017 | doi: 10.1038/ncomms14201

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites OPEN
David Braig, Tracy L. Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R. Thiele, Craig J. Morton, Johannes Zeller, Jurij Kiefer, Lawrence A. Potempa, Natalie A. Mellett, Luke A. Miles, Xiao-Jun Du, Peter J. Meikle, Markus Huber-Lang, G. Björn Stark, Michael W. Parker, Karlheinz Peter and Steffen U. Eisenhardt
C-reactive protein is a pentameric protein secreted by the liver in response to injury and infection. Here Braig et al. show that conformational changes in CRP on the surface of monocyte-derived microvesicles enable binding of complement C1q and lead to activation of the complement cascade and aggravation of inflammation.
23 January 2017 | doi: 10.1038/ncomms14188

Divergent prion strain evolution driven by PrPC expression level in transgenic mice OPEN
Annick Le Dur, Thanh Lan Laï, Marie-George Stinnakre, Aude Laisné, Nathalie Chenais, Sabine Rakotobe, Bruno Passet, Fabienne Reine, Solange Soulier, Laetitia Herzog, Gaëlle Tilly, Human Rézaei, Vincent Béringue, Jean-Luc Vilotte and Hubert Laude
PrPC protein plays a key role in prion transmission across species. Here, the authors compare transmission of a representative scrapie isolate to transgenic mice expressing variable levels of the same Prnp allele as the donor sheep, and find divergent strain propagation regulated by PrPC gene dosage.
23 January 2017 | doi: 10.1038/ncomms14170

Prehistorical and historical declines in Caribbean coral reef accretion rates driven by loss of parrotfish OPEN
Katie L. Cramer, Aaron O’Dea, Tara R. Clark, Jian-xin Zhao and Richard D. Norris
Fishing of keystone herbivores such as parrotfish is thought to negatively impact corals. Here, Cramer and colleagues analyse the sedimentary record for the last 3,000 years from three coral reef sites in the Caribbean and show that indeed coral declines are linked to parrotfish declines.
23 January 2017 | doi: 10.1038/ncomms14160

Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation OPEN
Démosthène Mitrossilis, Jens-Christian Röper, Damien Le Roy, Benjamin Driquez, Aude Michel, Christine Ménager, Gorky Shaw, Simon Le Denmat, Laurent Ranno, Frédéric Dumas-Bouchiat, Nora M. Dempsey and Emmanuel Farge
Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in the Drosophila embryonic epithelia and show this triggers apical pulsations, in turn stabilizing Myosin-II, resulting in mesoderm invagination.
23 January 2017 | doi: 10.1038/ncomms13883

Spatially integrative metrics reveal hidden vulnerability of microtidal salt marshes OPEN
Neil K. Ganju, Zafer Defne, Matthew L. Kirwan, Sergio Fagherazzi, Andrea D’Alpaos and Luca Carniello
Point measurements have historically been used to assess salt marsh vulnerability; however, these metrics do not integrate over the necessary spatiotemporal scales. Here, the authors show that two geomorphic-based, spatiotemporally integrative metrics reveal vulnerability not captured by traditional metrics.
23 January 2017 | doi: 10.1038/ncomms14156

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation OPEN
Victor H. Villar, Tra Ly Nguyen, Vanessa Delcroix, Silvia Terés, Marion Bouchecareilh, Bénédicte Salin, Clément Bodineau, Pierre Vacher, Muriel Priault, Pierre Soubeyran and Raúl V. Durán
Inhibitors of the mTORC1 pathway are considered anti-cancer drugs. Here, the authors show that on nutrient restriction, glutaminolysis-induced activation of mTORC1 induces apoptosis via inhibiting autophagy, highlighting that under such conditions inhibition of mTORC1 results in survival of cancer cells.
23 January 2017 | doi: 10.1038/ncomms14124

A cell-based computational model of early embryogenesis coupling mechanical behaviour and gene regulation OPEN
Julien Delile, Matthieu Herrmann, Nadine Peyriéras and René Doursat
Embryonic development is a complex process where genetic and biochemical information direct morphogenesis. Here the authors describe MecaGen, an agent-based model and simulation platform of multicellular development designed to allow a quantitative comparison between simulations and real biological data.
23 January 2017 | doi: 10.1038/ncomms13929

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme OPEN
Ang Li, Seth Figueroa, Ting-Xin Jiang, Ping Wu, Randall Widelitz, Qing Nie and Cheng-Ming Chuong
Asymmetric feather vane shape was a critical innovation in feather evolution and adaptation for flight. Here, Li and colleagues characterize the multi-module regulatory network that controls feather vane shape and underlies feather diversification.
20 January 2017 | doi: 10.1038/ncomms14139

Humans rather than climate the primary cause of Pleistocene megafaunal extinction in Australia OPEN
Sander van der Kaars, Gifford H. Miller, Chris S. M. Turney, Ellyn J. Cook, Dirk Nürnberg, Joachim Schönfeld, A. Peter Kershaw and Scott J. Lehman
Megafaunal extinction in Australia has been attributed to both climate change and human causation. Here, van der Kaars et al. present a 150,000 year record offshore southwest Australia in which they refine the timing and nature of regional ecosystem changes and megafaunal population collapse.
20 January 2017 | doi: 10.1038/ncomms14142

Rapid adaptive phenotypic change following colonization of a newly restored habitat OPEN
Camilla Lo Cascio Sætre, Charles Coleiro, Martin Austad, Mark Gauci, Glenn-Peter Sætre, Kjetil Lysne Voje and Fabrice Eroukhmanoff
Rapid local adaptation could potentially facilitate the recolonization of restored habitats. Here, the authors show that reed warblers have undergone substantial adaptive change in body mass in only 19 years after colonizing a restored wetland in Malta.
20 January 2017 | doi: 10.1038/ncomms14159

Extremely broadband, on-chip optical nonreciprocity enabled by mimicking nonlinear anti-adiabatic quantum jumps near exceptional points OPEN
Youngsun Choi, Choloong Hahn, Jae Woong Yoon, Seok Ho Song and Pierre Berini
Nonreciprocal optical devices can be designed based on symmetry breaking at singular points associated with non-Hermitian physics. Here, Choi et al. theoretically show that encircling of exceptional points enables the broadband operation and chip integration of such devices.
20 January 2017 | doi: 10.1038/ncomms14154

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein OPEN
Maoxue Tang, Guangping Gao, Carlos B. Rueda, Hang Yu, David N. Thibodeaux, Tomoyuki Awano, Kristin M. Engelstad, Maria-Jose Sanchez-Quintero, Hong Yang, Fanghua Li, Huapeng Li, Qin Su, Kara E. Shetler, Lynne Jones, Ryan Seo, Jonathan McConathy, Elizabeth M. Hillman, Jeffrey L. Noebels, Darryl C. De Vivo and Umrao R. Monani et al.
Glut1-deficiency syndrome is a severe neurodevelopmental disorder characterized by low brain glucose and epileptic seizures. Tang et al. show that in model mice, low Glut1 leads to defects of the brain vasculature, and that AAV9-based gene therapy at pre- or early-symptomatic stages prevents the defects and mitigates disease.
20 January 2017 | doi: 10.1038/ncomms14152

Imperfect two-dimensional topological insulator field-effect transistors OPEN
William G. Vandenberghe and Massimo V. Fischetti
A challenge of using 2D materials for nanoelectronic devices is the need for defect-free lattice supporting efficient carrier transport. Here, the authors show theoretically that 2D topological insulators enable high-performance, low-power field-effect transistors without requiring defect-free materials.
20 January 2017 | doi: 10.1038/ncomms14184

Esterase mutation is a mechanism of resistance to antimalarial compounds OPEN
Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler and Daniel E. Goldberg
Pepstatin is a known inhibitor of malarial proteases, but its activity varies between sources. Here, Istvan et al. identify a pepstatin ester as the active component of pepstatin preparations and show that this prodrug is activated by a Plasmodium esterase, mutation of which can confer resistance to pepstatin and other compounds.
20 January 2017 | doi: 10.1038/ncomms14240

Selective gating to vibrational modes through resonant X-ray scattering OPEN
Rafael C. Couto, Vinícius V. Cruz, Emelie Ertan, Sebastian Eckert, Mattis Fondell, Marcus Dantz, Brian Kennedy, Thorsten Schmitt, Annette Pietzsch, Freddy F. Guimarães, Hans Ågren, Faris Gel’mukhanov, Michael Odelius, Victor Kimberg and Alexander Föhlisch
Investigating dynamics of polyatomic molecules is difficult as their potential energy surfaces are multidimensional due to coupled degrees of freedom. Here the authors demonstrate a spatial selective gating technique to probe the different vibrational modes of water upon core-level excitation with X-rays.
20 January 2017 | doi: 10.1038/ncomms14165

Anthropogenic ecosystem disturbance and the recovery debt OPEN
David Moreno-Mateos, Edward B. Barbier, Peter C. Jones, Holly P. Jones, James Aronson, José A. López-López, Michelle L. McCrackin, Paula Meli, Daniel Montoya and José M. Rey Benayas
Recovery of damaged ecosystems can vary in time and extent. Here, Moreno-Mateos and colleagues perform a meta-analysis to describe and quantify what they call recovery debt, an interim reduction in biodiversity, populations, and biogeochemical function of ecosystems during the recovery process.
20 January 2017 | doi: 10.1038/ncomms14163

A robust and tuneable mid-infrared optical switch enabled by bulk Dirac fermions OPEN
Chunhui Zhu, Fengqiu Wang, Yafei Meng, Xiang Yuan, Faxian Xiu, Hongyu Luo, Yazhou Wang, Jianfeng Li, Xinjie Lv, Liang He, Yongbing Xu, Junfeng Liu, Chao Zhang, Yi Shi, Rong Zhang and Shining Zhu
Mid-infrared pulsed sources are technologically important for sensing and spectroscopy but their implementation is challenging due to the lack of a tuneable optical switch. Here, the authors address this limitation by engineering the band structure of an emerging Dirac semimetal, Cd3As2.
20 January 2017 | doi: 10.1038/ncomms14111

Improper electric polarization in simple perovskite oxides with two magnetic sublattices OPEN
Hong Jian Zhao, L. Bellaiche, Xiang Ming Chen and Jorge Íñiguez
Magnetically-driven ferroelectricity holds the key for novel multiferroic effects in perovskite oxides, but it remains poorly understood. Here, Zhao et al. determine the dominant magnetostructural couplings that yield improper ferroelectricity in a generic perovskite with two spin sublattices.
20 January 2017 | doi: 10.1038/ncomms14025

Rapid generation of hypomorphic mutations OPEN
Laura L. Arthur, Joyce J. Chung, Preetam Jankirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath and Sergej Djuranovic
Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to modulate expression of a target protein.
20 January 2017 | doi: 10.1038/ncomms14112

Acoustic-optical phonon up-conversion and hot-phonon bottleneck in lead-halide perovskites OPEN
Jianfeng Yang, Xiaoming Wen, Hongze Xia, Rui Sheng, Qingshan Ma, Jincheol Kim, Patrick Tapping, Takaaki Harada, Tak W. Kee, Fuzhi Huang, Yi-Bing Cheng, Martin Green, Anita Ho-Baillie, Shujuan Huang, Santosh Shrestha, Robert Patterson and Gavin Conibeer
Slow cooling of hot charge carriers in lead halide perovskite could be used in photovoltaics devices. Here, Yang et al. study hot carrier dynamics by transient absorption spectroscopy. They relate the phonon bottleneck to the up-conversion of low-energy phonons, facilitated by the presence of organic cations.
20 January 2017 | doi: 10.1038/ncomms14120

The shape of telephone cord blisters OPEN
Yong Ni, Senjiang Yu, Hongyuan Jiang and Linghui He
Telephone cord blisters constitute a well-known example of patterns generated following buckling in thin films. Here the authors develop an analytical approach that can model the sectional height profiles along the blisters that they measure experimentally and simulate numerically.
20 January 2017 | doi: 10.1038/ncomms14138

Quantum interference between transverse spatial waveguide modes OPEN
Aseema Mohanty, Mian Zhang, Avik Dutt, Sven Ramelow, Paulo Nussenzveig and Michal Lipson
Practical implementations of quantum photonic circuits consist primarily of large waveguide networks to path-encode information. Here, Mohanty et al. demonstrate quantum interference between transverse spatial modes in a single silicon nitride waveguide, enabling robust quantum information processing.
20 January 2017 | doi: 10.1038/ncomms14010

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action OPEN
Ning Chai, Lee R. Swem, Summer Park, Gerald Nakamura, Nancy Chiang, Alberto Estevez, Rina Fong, Lynn Kamen, Elviza Kho, Mike Reichelt, Zhonghua Lin, Henry Chiu, Elizabeth Skippington, Zora Modrusan, Jeremy Stinson, Min Xu, Patrick Lupardus, Claudio Ciferri and Man-Wah Tan
Influenza B virus (IBV) co-circulates with influenza A virus to cause annual epidemics. Here, Chai et al. isolate a human monoclonal antibody that binds to a conserved epitope in the viral HA protein, neutralizes IBV strains in vitro, and protects mice against IBV infection.
19 January 2017 | doi: 10.1038/ncomms14234

Storing single photons emitted by a quantum memory on a highly excited Rydberg state OPEN
Emanuele Distante, Pau Farrera, Auxiliadora Padrón-Brito, David Paredes-Barato, Georg Heinze and Hugues de Riedmatten
The state of a single photon can be stored as a Rydberg excitation using electromagnetically induced transparency, and this enables nonlinear interactions at the single-photon level. Here, the authors store a paired photon emitted by a quantum memory in an ensemble-based, highly nonlinear medium.
19 January 2017 | doi: 10.1038/ncomms14072

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression OPEN
Chongbiao Huang, Na Li, Zengxun Li, Antao Chang, Yanan Chen, Tiansuo Zhao, Yang Li, Xiuchao Wang, Wei Zhang, Zhimin Wang, Lin Luo, Jingjing Shi, Shengyu Yang, He Ren and Jihui Hao
Interleukin-35 (IL-35) is an immune suppressive cytokine produced by T-cells. Here, the authors show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL-35 promotes metastasis in an autocrine/paracrine manner via induction of ICAM-1 expression.
19 January 2017 | doi: 10.1038/ncomms14035

Indefinitely stable iron(IV) cage complexes formed in water by air oxidation OPEN
Stefania Tomyn, Sergii I. Shylin, Dmytro Bykov, Vadim Ksenofontov, Elzbieta Gumienna-Kontecka, Volodymyr Bon and Igor O. Fritsky
High-valent iron compounds do not form spontaneously under ambient conditions and those that are synthetically available are rarely stable. Here, the authors synthesize stable iron(IV) hexahydrazide clathrochelate complexes in aqueous media via a metal-templated reaction accompanied by aerobic oxidation.
19 January 2017 | doi: 10.1038/ncomms14099

Optimality and sub-optimality in a bacterial growth law OPEN
Benjamin D. Towbin, Yael Korem, Anat Bren, Shany Doron, Rotem Sorek and Uri Alon
Organisms improve their fitness by adjusting their gene expression to the environment, for example bacteria scale the expression of metabolic enzymes near linearly to their growth rate. Here, the authors show that such linear scaling often maximizes growth rate, but that linear scaling is suboptimal under some conditions.
19 January 2017 | doi: 10.1038/ncomms14123

α3 Chains of type V collagen regulate breast tumour growth via glypican-1 OPEN
Guorui Huang, Gaoxiang Ge, Valerio Izzi and Daniel S. Greenspan
Collagen has a role in cancer and is particularly important for breast cancer. Here the authors show that the expression of α3 type V collagen and one of its receptors- glipican-1- in the same cell, contributes to a deregulated growth of breast cancer cells.
19 January 2017 | doi: 10.1038/ncomms14351

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers OPEN
Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar and Michael G. Roth
Lung cancers often harbour loss-of-function mutations in SMARCA4. Here, the authors demonstrate a vulnerability of SMARCA4-deficient lung cancers for Aurora kinase A inhibition associated with mitotic defects.
19 January 2017 | doi: 10.1038/ncomms14098

Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway OPEN
Mengrui Wu, Wei Chen, Yun Lu, Guochun Zhu, Liang Hao and Yi-Ping Li
Osteoclasts are bone resorptive cells and an attractive target to treat diseases characterized by excessive bone loss, but little is known about osteoclast inhibition. Here the authors identify Gα13 as an intracellular inhibitor of osteoclastogenesis that can prevent bone loss in mice via Akt activation and inhibition of RhoA signalling.
19 January 2017 | doi: 10.1038/ncomms13700

Drosophila FIT is a protein-specific satiety hormone essential for feeding control OPEN
Jinghan Sun, Chang Liu, Xiaobing Bai, Xiaoting Li, Jingyun Li, Zhiping Zhang, Yunpeng Zhang, Jing Guo and Yan Li
Protein feeding is known to induce strong inhibition on further food intake, though the underlying mechanisms remain poorly understood. Here, the authors identify a protein-specific satiety hormone in Drosophila, and show that it suppresses feeding via promoting DILP2 release in the central nervous system.
19 January 2017 | doi: 10.1038/ncomms14161

Glucocorticoid receptor signalling activates YAP in breast cancer OPEN
Giovanni Sorrentino, Naomi Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, Carolina Marotta, Carmelo Neri, Elisa Cappuzzello, Mattia Forcato, Antonio Rosato, Miguel Mano, Silvio Bicciato and Giannino Del Sal
Activation of YAP contributes to tumorigenesis in several tissues. Here, the authors show that in breast cancer cells glucocorticoids induce expression of fibronectin that in turn activates focal adhesion kinase/Src signalling to promote YAP nuclear translocation and transcriptional activity.
19 January 2017 | doi: 10.1038/ncomms14073

Whole-brain 3D mapping of human neural transplant innervation OPEN
Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn and Oliver Brüstle
Transplantation of cells into the central nervous system has developed into a major avenue for replacing neurons lost to neurodegenerative disease. Here the authors develop an approach combining viral-based transynaptic tracing labeling and whole brain imaging to trace synaptic innervation of human neurons transplanted into a mouse background.
19 January 2017 | doi: 10.1038/ncomms14162

The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells OPEN
Gennaro Gambardella, Annamaria Carissimo, Amy Chen, Luisa Cutillo, Tomasz J. Nowakowski, Diego di Bernardo and Robert Blelloch
MicroRNAs can posttranscriptionally repress multiple targets in a cell population. Here the authors use single-cell sequencing to investigate the effects of an individual miRNA on transcriptional heterogeneity and gene co-expression
19 January 2017 | doi: 10.1038/ncomms14126

Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung OPEN
Hattie Chung, Tami D. Lieberman, Sara O. Vargas, Kelly B. Flett, Alexander J. McAdam, Gregory P. Priebe and Roy Kishony
The authors sequence the genomes of 552 bacterial isolates sampled across 23 sites of the lungs of a patient with cystic fibrosis, and identify bacterial genes under global and location-specific adaptation.
19 January 2017 | doi: 10.1038/ncomms14078

Consistent negative response of US crops to high temperatures in observations and crop models OPEN
Bernhard Schauberger, Sotirios Archontoulis, Almut Arneth, Juraj Balkovic, Philippe Ciais, Delphine Deryng, Joshua Elliott, Christian Folberth, Nikolay Khabarov, Christoph Müller, Thomas A. M. Pugh, Susanne Rolinski, Sibyll Schaphoff, Erwin Schmid, Xuhui Wang, Wolfram Schlenker and Katja Frieler
Future agricultural productivity is threatened by high temperatures. Here, using 9 crop models, Schauberger et al. find that yield losses due to temperatures >30 °C are captured by current models where yield losses by mild heat stress occur mainly due to water stress and can be buffered by irrigation.
19 January 2017 | doi: 10.1038/ncomms13931

Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter OPEN
Andreas Anderluh, Tina Hofmaier, Enrico Klotzsch, Oliver Kudlacek, Thomas Stockner, Harald H. Sitte and Gerhard J. Schütz
The human serotonin transporter (SERT) mediates the uptake of neurotransmitters to terminate neuronal signalling. Here the authors use single-molecule imaging to get insight into the molecular origin of SERT oligomerization and their pre-set stoichiometry at the plasma membrane.
19 January 2017 | doi: 10.1038/ncomms14089

Shape-dependent ordering of gold nanocrystals into large-scale superlattices OPEN
Jianxiao Gong, Richmond S. Newman, Michael Engel, Man Zhao, Fenggang Bian, Sharon C. Glotzer and Zhiyong Tang
Ordered self-assembly is a promising way to realize collective properties in nanocrystals, but reliable routes to such macroscopic structures are missing. Here the authors make cm-scale ordered superlattice films from gold nanoclusters, correlating film properties with the shape of the building blocks
19 January 2017 | doi: 10.1038/ncomms14038

Fibronectin-guided migration of carcinoma collectives OPEN
Sandeep Gopal, Laurence Veracini, Dominique Grall, Catherine Butori, Sébastien Schaub, Stéphane Audebert, Luc Camoin, Emilie Baudelet, Agata Radwanska, Stéphanie Beghelli-de la Forest Divonne, Shelia M. Violette, Paul H. Weinreb, Samah Rekima, Marius Ilie, Anne Sudaka, Paul Hofman and Ellen Van Obberghen-Schilling
Tumour microenvironment influences the migration of cancer cells. Here the authors analyse the proteomic constitution of the extracellular matrix and identify a role for fibronectin in regulating the collective migration of squamous cell carcinoma cells.
19 January 2017 | doi: 10.1038/ncomms14105

p-wave triggered superconductivity in single-layer graphene on an electron-doped oxide superconductor OPEN
A. Di Bernardo, O. Millo, M. Barbone, H. Alpern, Y. Kalcheim, U. Sassi, A. K. Ott, D. De Fazio, D. Yoon, M. Amado, A. C. Ferrari, J. Linder and J. W. A. Robinson
Unconventional superconductivity may be triggered when graphene is deposited on a high temperature superconductor. Here, Di Bernardo et al. observe spectroscopic evidence for p-wave superconductivity in single layer graphene on an electron-doped cuprate superconductor.
19 January 2017 | doi: 10.1038/ncomms14024

MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice OPEN
Keerthi Krishnan, Billy Y. B. Lau, Gabrielle Ewall, Z. Josh Huang and Stephen D. Shea
Rett syndrome is associated with impaired synaptic connectivity beginning in early development. Here the authors show in female mice heterozygous for Mecp2, a model of Rett syndrome, that during adulthood, auditory cortex plasticity associated with a learned maternal behaviour is also impaired.
18 January 2017 | doi: 10.1038/ncomms14077

Highly thermal-stable ferromagnetism by a natural composite OPEN
Tianyu Ma, Junming Gou, Shanshan Hu, Xiaolian Liu, Chen Wu, Shuai Ren, Hui Zhao, Andong Xiao, Chengbao Jiang, Xiaobing Ren and Mi Yan
Magnetism deterioration is usually expected in all ferromagnetic materials with increasing temperature. Here, Ma et al. report a Fe-Ga alloy with highly thermal-stable magnetization up to 880 K and with nearly no deterioration over a wide temperature range in magnetostriction.
18 January 2017 | doi: 10.1038/ncomms13937

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations OPEN
Yvonne Y Li, Grace T. Y. Chung, Vivian W. Y. Lui, Ka-Fai To, Brigette B. Y. Ma, Chit Chow, John K, S. Woo, Kevin Y. Yip, Jeongsun Seo, Edwin P. Hui, Michael K. F. Mak, Maria Rusan, Nicole G. Chau, Yvonne Y. Y. Or, Marcus H. N. Law, Peggy P. Y. Law, Zoey W. Y. Liu, Hoi-Lam Ngan, Pok-Man Hau, Krista R. Verhoeft et al.
Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.
18 January 2017 | doi: 10.1038/ncomms14121

Origin and evolution of the deep thermochemical structure beneath Eurasia OPEN
N. Flament, S. Williams, R. D. Müller, M. Gurnis and D. J. Bower
The Perm anomaly is found in the lower mantle beneath Eurasia, but how this structure formed has remained unclear. Here, the authors show that the anomaly has been mobile since it formed in isolation within a closed subduction network and propose that the anomaly is linked to the Emeishan volcanics.
18 January 2017 | doi: 10.1038/ncomms14164

Dynamical observations on the crack tip zone and stress corrosion of two-dimensional MoS2 OPEN
Thuc Hue Ly, Jiong Zhao, Magdalena Ola Cichocka, Lain-Jong Li and Young Hee Lee
How well the linear elastic fracture picture holds at small length scales and systems with reduced dimensionality remains an active area of inquiry. Here authors use in situ electron microscopy to study fracture in MoS2 monolayers and report dislocation emission rates greater than expected accompanying crack propagation.
18 January 2017 | doi: 10.1038/ncomms14116

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages OPEN
Lin Luo, Nilesh J. Bokil, Adam A. Wall, Ronan Kapetanovic, Natalie M. Lansdaal, Faustine Marceline, Belinda J. Burgess, Samuel J. Tong, Zhong Guo, Kirill Alexandrov, Ian L. Ross, Margaret L. Hibbs, Jennifer L. Stow and Matthew J. Sweet
Toll-like receptors engage TIR domain-containing adaptors to control proinflammatory gene expression in response to pathogens and tissue damage. Here the authors show that the non-TIR domain-containing transmembrane protein SCIMP is a previously unrecognized TLR adaptor expressed by macrophages.
18 January 2017 | doi: 10.1038/ncomms14133

Expression of the novel maternal centrosome assembly factor Wdr8 is required for vertebrate embryonic mitoses OPEN
Daigo Inoue, Manuel Stemmer, Thomas Thumberger, Thomas Ruppert, Felix Bärenz, Joachim Wittbrodt and Oliver J. Gruss
The assembly of the first centrosome occurs upon fertilisation when male centrioles recruit pericentriolar material from the egg cytoplasm. Here the authors identify Wdr8 as a maternally essential protein that is required for centrosome assembly during embryonic mitoses of medaka.
18 January 2017 | doi: 10.1038/ncomms14090

Nanoparticle-induced unusual melting and solidification behaviours of metals OPEN
Chao Ma, Lianyi Chen, Chezheng Cao and Xiaochun Li
A material with a deep melted zone (MZ) but small heat-affected zone (HAZ) is ideal for manufacturing, but improving one zone comes at the expense of the other. Here, the authors resolve this contradiction in metals by adding nanoparticles, which change the metals’ properties in such a way that both expands MZ and minimizes HAZ.
18 January 2017 | doi: 10.1038/ncomms14178

Novel genetic loci associated with hippocampal volume OPEN
Derrek P. Hibar, Hieab H. H. Adams, Neda Jahanshad, Ganesh Chauhan, Jason L. Stein, Edith Hofer, Miguel E. Renteria, Joshua C. Bis, Alejandro Arias-Vasquez, M. Kamran Ikram, Sylvane Desrivières, Meike W. Vernooij, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S. Aribisala, Nicola J. Armstrong, Lavinia Athanasiu et al.
The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.
18 January 2017 | doi: 10.1038/ncomms13624

Sixfold improved single particle measurement of the magnetic moment of the antiproton OPEN
H. Nagahama, C. Smorra, S. Sellner, J. Harrington, T. Higuchi, M. J. Borchert, T. Tanaka, M. Besirli, A. Mooser, G. Schneider, K. Blaum, Y. Matsuda, C. Ospelkaus, W. Quint, J. Walz, Y. Yamazaki and S. Ulmer
High-precision measurements could disclose fundamental dissimilarities between matter and antimatter, which are found imbalanced in the Universe. Here, the authors measure the magnetic moment of the antiproton with six-fold higher accuracy than before, finding it consistent with that of the proton.
18 January 2017 | doi: 10.1038/ncomms14084

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product OPEN
Jaeok Park, Michal Zielinski, Alexandr Magder, Youla S. Tsantrizos and Albert M. Berghuis
Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an allosteric effector of the enzyme.
18 January 2017 | doi: 10.1038/ncomms14132

Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification OPEN
Frédéric Lamoliatte, Francis P. McManus, Ghizlane Maarifi, Mounira K. Chelbi-Alix and Pierre Thibault
Ubiquitylation and SUMOylation are two important related post-translational modifications. Here the authors present an approach for the simultaneous identification and quantification of protein-wide SUMO and ubiquitin sites from a single sample, uncovering widespread crosstalk between the two modifications.
18 January 2017 | doi: 10.1038/ncomms14109

Carbon translocation from a plant to an insect-pathogenic endophytic fungus OPEN
Scott W. Behie, Camila C. Moreira, Irina Sementchoukova, Larissa Barelli, Paul M. Zelisko and Michael J. Bidochka
The endophytic fungus Metarhizium robertsii is also an insect pathogen and can facilitate transfer of insect-derived nitrogen to host plants. Here, the authors show that carbon is transferred from plant to fungus suggesting a tripartite interaction where nitrogen is exchanged for photosynthate.
18 January 2017 | doi: 10.1038/ncomms14245

The geometric nature of weights in real complex networks OPEN
Antoine Allard, M. Ángeles Serrano, Guillermo García-Pérez and Marián Boguñá
Complex networks have been conjectured to be hidden in metric spaces, which offer geometric interpretation of networks’ topologies. Here the authors extend this concept to weighted networks, providing empirical evidence on the metric natures of weights, which are shown to be reproducible by a gravity model.
18 January 2017 | doi: 10.1038/ncomms14103

Structural basis of ligand interaction with atypical chemokine receptor 3 OPEN
Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva and Tracy M. Handel
The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ligand-induced conformational changes in ACKR3.
18 January 2017 | doi: 10.1038/ncomms14135

Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes OPEN
Zhen Liang, Kunling Chen, Tingdong Li, Yi Zhang, Yanpeng Wang, Qian Zhao, Jinxing Liu, Huawei Zhang, Cuimin Liu, Yidong Ran and Caixia Gao
Protocols for crop genome editing would ideally be quick, efficient and specific while avoiding integration of transgenes into the genome of edited plants. Here, Liang et al. show that CRISPR/Cas9 ribonucleoproteins can be used to generate genome edited wheat plants in as little as nine weeks.
18 January 2017 | doi: 10.1038/ncomms14261

Annual time-series analysis of aqueous eDNA reveals ecologically relevant dynamics of lake ecosystem biodiversity OPEN
Iliana Bista, Gary R. Carvalho, Kerry Walsh, Mathew Seymour, Mehrdad Hajibabaei, Delphine Lallias, Martin Christmas and Simon Creer
DNA from macrobial taxa can be extracted from environmental samples, including water, and be used to assess biodiversity in the region. Here, Bista and colleagues show that temporal shifts in the biodiversity of a lake invertebrate community can be detected by analysis of environmental DNA (eDNA).
18 January 2017 | doi: 10.1038/ncomms14087

Infrared laser-induced gene expression for tracking development and function of single C. elegans embryonic neurons OPEN
Anupriya Singhal and Shai Shaham
Tools to label single neurons and track their development in C. elegans have been lacking. Singhal et al. optimized a method, which applies infrared laser to induce heat-dependent gene expression at cellular resolution in developing C. elegans embryos, and show that it can uncover new aspects of embryo morphogenesis.
18 January 2017 | doi: 10.1038/ncomms14100

Fluid shear stress activates YAP1 to promote cancer cell motility OPEN
Hyun Jung Lee, Miguel F. Diaz, Katherine M. Price, Joyce A. Ozuna, Songlin Zhang, Eva M. Sevick-Muraca, John P. Hagan and Pamela L. Wenzel
Fluid frictional forces around cancer cells influence chemokine production and delivery of chemotherapeutic drugs but it is unclear if they directly impact tumour biology through biomechanical effects. Here, the authors show that wall shear stress stimulates cancer cell migration through a ROCK–LIMK–YAP axis.
18 January 2017 | doi: 10.1038/ncomms14122

One million years of glaciation and denudation history in west Greenland OPEN
Astrid Strunk, Mads Faurschou Knudsen, David L. Egholm, John D. Jansen, Laura B. Levy, Bo H. Jacobsen and Nicolaj K. Larsen
Erosion rates and ice cover extent of present day fjords and summit plateau landscapes beyond the last deglaciation are virtually unknown. Here, the authors constrain the long-term denudation rates and glaciation history in west Greenland based on cosmogenic nuclides.
18 January 2017 | doi: 10.1038/ncomms14199

Metal/oxide interfacial effects on the selective oxidation of primary alcohols OPEN
Guofeng Zhao, Fan Yang, Zongjia Chen, Qingfei Liu, Yongjun Ji, Yi Zhang, Zhiqiang Niu, Junjie Mao, Xinhe Bao, Peijun Hu and Yadong Li
Metals supported on metal oxides are common heterogeneous catalysts. Here the authors show that metal/oxide interfacial sites are highly active for alcohol oxidation—independent of the particle sizes—and use this information to design inverse oxide-on-metal particles with high activity and stability.
18 January 2017 | doi: 10.1038/ncomms14039
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Corrigendum: Making brain-machine interfaces robust to future neural variability OPEN
David Sussillo, Sergey D. Stavisky, Jonathan C. Kao, Stephen I. Ryu and Krishna V. Shenoy
20 January 2017 | doi: 10.1038/ncomms14490
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18 January 2017 | doi: 10.1038/ncomms14299

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