Nature Reviews Cancer contents January 2017 Volume 17 Number 1 pp1-74

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TABLE OF CONTENTS
January 2017 Volume 17 Number 1
Impact Factor 34.244 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Cancer origins  Featured article: The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia Adam S. Sperling, Christopher J. Gibson & Benjamin L. Ebert
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RESEARCH HIGHLIGHTS Top Immunotherapy: Switching off immune suppression p1 | doi:10.1038/nrc.2016.144 Two papers have shown in mouse tumour models that targeting PI3Kγ in myeloid cells can reduce immune suppression and increase the efficacy of immune checkpoint inhibitors. PDF Cell migration: Caged for protection p2 | doi:10.1038/nrc.2016.141 Skau et al. demonstrate that the actin nucleating protein FMN2 generates a perinuclear actin and focal adhesion-based structure to protect the nucleus from damage during cell migration through confining 3D microenvironments. PDF Lymphoma: Now you see it... p2 | doi:10.1038/nrc.2016.146 Scherer et al. show that analysis of circulating tumour DNA can provide prognostic information and predict relapse in patients with diffuse large B-cell lymphoma. PDF IN BRIEF Tumour-Initiating cells: The cell that rocks the tumour | Leukaemia: Don't let sleeping cells lie | Chemotherapy: Less is more | Cancer genetics: X-inactivation and cancer incidence PDF Cancer JOBS of the week Cancer Epigenetic Postdoctoral Position Gustave Roussy Cancer Campus Head of Data Analysis King's College London Exciting PhD Positions in Molecular Medicine CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Staff Scientist Wellcome Trust Sanger Institute Post-doctoral position Molecular Cancer Biology GIGA More Science jobs from Cancer EVENT American Association for Cancer Research - AACR Annual Meeting 2017 01.04.17 Washington, USA More science events from
REVIEWS		Top
The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia Adam S. Sperling, Christopher J. Gibson & Benjamin L. Ebert p5 | doi:10.1038/nrc.2016.112 This Review discusses the molecular processes and clonal evolution that lead to myelodysplastic syndrome (MDS) and secondary acute myeloid leukaemia, highlighting the ways in which these insights are shaping the clinical management of MDS. Abstract | Full Text | PDF
Cancer nanomedicine: progress, challenges and opportunities Jinjun Shi, Philip W. Kantoff, Richard Wooster & Omid C. Farokhzad p20 | doi:10.1038/nrc.2016.108 This Review summarizes progress in applying nanotechnology to cancer treatment and discusses the challenges of clinical translation and opportunities to develop more effective nanotherapeutics through our increasing understanding of tumour biology and nano–bio interactions. Abstract | Full Text | PDF
TIMPs: versatile extracellular regulators in cancer Hartland W. Jackson, Virginie Defamie, Paul Waterhouse & Rama Khokha p38 | doi:10.1038/nrc.2016.115 The four tissue inhibitors of metalloproteinases (TIMPs) regulate proteolysis of a vast range of matrix and cell surface proteins, affecting tumour architecture and cell signalling. This Review article analyses the role of TIMPs in cancer and their potential as targets and biomarkers. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Deciphering the divergent roles of progestogens in breast cancer Jason S. Carroll, Theresa E. Hickey, Gerard A. Tarulli, Michael Williams & Wayne D. Tilley p54 | doi:10.1038/nrc.2016.116 This Opinion article discusses many controversial issues surrounding the connections of progestogens, which stimulate the progesterone receptor, to breast cancer risk and their possible therapeutic use in breast cancer. Abstract | Full Text | PDF
OPINION Article series: Cancer origins The disparate origins of ovarian cancers: pathogenesis and prevention strategies Anthony N. Karnezis, Kathleen R. Cho, C. Blake Gilks, Celeste Leigh Pearce & David G. Huntsman p65 | doi:10.1038/nrc.2016.113 Ovarian cancer comprises a broad range of histologically and genetically different tumours. In this Opinion article, Karnezis et al. explore the different origins of ovarian cancers and how these contribute to our understanding of genetic and environmental risk to better prevent and treat these tumours. Abstract | Full Text | PDF
Corrigendum: Gap junctions and cancer: communicating for 50 years Trond Aasen, Marc Mesnil, Christian C. Naus, Paul D. Lampe & Dale W. Laird p74 | doi:10.1038/nrc.2016.142 Full Text | PDF
Correction: That gut feeling Anna Dart p74 | doi:10.1038/nrc.2016.147 Full Text | PDF
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