Scientific Reports Biology Table of Contents e-alert: 08 November 2016

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08 November 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               WEBINAR TOMORROW: Achieve 90% Efficiency with CRISPR Editing Join us for an exclusive webinar where you'll learn how to get started with a successful CRISPR experiment. You'll see the results of CRISPR editing from collaborators/researchers who have been working with Synthego guide RNA products.  All attendees will receive 3 Free Synthetic Guide RNAs! Reserve Your Seat                 Biological Sciences               EEG Spectral Dynamics of Video Commercials: Impact of the Narrative on the Branding Product Preference ▶     Regina W. Y. Wang, Yu-Ching Chang, Shang-Wen Chuang     Neuromarketing has become popular and received a lot of attention. The quality of video commercials and the product information they convey to consumers is a hotly debated topic …             Circadian rhythms of European and African-Americans after a large delay of sleep as in jet lag and night work ▶     Charmane I. Eastman, Victoria A. Tomaka, Stephanie J. Crowley     Jet travel and night shift work produce large changes in when people sleep, work and eat; a challenge that was not encountered during most of our evolution. Successful adaptation …             Sustained synchronized neuronal network activity in a human astrocyte co-culture system ▶     Jacobine Kuijlaars, Tutu Oyelami, Annick Diels et al.     Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer’s disease and is typically …             Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs ▶     Feng Li, Liang Cheng, Christopher M. Murphy et al.     Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stopping treatment from the stable HBV …             Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks ▶     Suyu Mei, Kun Zhang     Protein-protein interaction (PPI) networks are naturally viewed as infrastructure to infer signalling pathways. The descriptors of signal events between two interacting proteins …             Engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using unrelated carbon sources ▶     Kajan Srirangan, Xuejia Liu, Tam T. Tran et al.     While poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] is a biodegradable commodity plastic with broad applications, its microbial synthesis is hindered by high …             Variant responses of tree seedling to seasonal drought stress along an elevational transect in tropical montane forests ▶     Xiaoyang Song, Jieqiong Li, Wenfu Zhang et al.     Seasonal drought is a common phenomenon in many forests predominated by monsoon climate. The impact of seasonal drought, however, may vary with elevations, and tree species of …             The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy ▶     Chang Soon Choi, Edson Luck Gonzales, Ki Chan Kim et al.     Autism spectrum disorder (ASD) is a heterogeneously pervasive developmental disorder in which various genetic and environmental factors are believed to underlie its development. …             Comparative morphological trade-offs between pre- and post-copulatory sexual selection in Giant hissing cockroaches (Tribe: Gromphadorhini) ▶     Kate L. Durrant, Ian M. Skicko, Craig Sturrock et al.     Sperm competition theory predicts that animals face a trade-off between investment in weaponry and investment in ejaculate composition. Within the Madagascan giant hissing …             Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice ▶     Ting Zhao, Baihong Pan, Hasan B. Alam et al.     Production of innate and adaptive immune cells from hematopoietic stem cells, and maturation of T lymphocytes are effective immune responses to fight severe microbial infection. …             Global Changes in Lipid Profiles of Mouse Cortex, Hippocampus, and Hypothalamus Upon p53 Knockout ▶     Sang Tak Lee, Jong Cheol Lee, Jong Whi Kim et al.     Comprehensive lipidomic profiling in three different brain tissues (cortex, hippocampus, and hypothalamus) of mouse with p53 deficiency was performed by nanoflow liquid …             The prion protein family member Shadoo induces spontaneous ionic currents in cultured cells ▶     Antal Nyeste, Claudia Stincardini, Petra Bencsura et al.     Some mutant forms of the cellular prion protein (PrPC) carrying artificial deletions or point mutations associated with familial human prion diseases are capable of inducing …             A Shorter Route to Antibody Binders via Quantitative in vitro Bead-Display Screening and Consensus Analysis ▶     Sylwia A. Mankowska, Pietro Gatti-Lafranconi, Matthieu Chodorge et al.     Affinity panning of large libraries is a powerful tool to identify protein binders. However, panning rounds are followed by the tedious re-screening of the clones obtained to …             Nuclear import of dimerized ribosomal protein Rps3 in complex with its chaperone Yar1 ▶     Valentin Mitterer, Nadine Gantenbein, Ruth Birner-Gruenberger et al.     After their cytoplasmic synthesis, ribosomal proteins need to be transported into the nucleus, where they assemble with ribosomal RNA into pre-ribosomal particles. Due to their …             PEPlife: A Repository of the Half-life of Peptides ▶     Deepika Mathur, Satya Prakash, Priya Anand et al.     Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like …             Silver nanoparticles-containing dual-function hydrogels based on a guar gum-sodium borohydride system ▶     Lei Dai, Ben Nadeau, Xingye An et al.     Dual-function hydrogels, possessing both stimuli-responsive and self-healing properties, have recently attracted attention of both chemists and materials scientists. Here we …             Transcriptomic analysis on the formation of the viable putative non-culturable state of beer-spoilage Lactobacillus acetotolerans ▶     Junyan Liu, Yang Deng, Brian M. Peters et al.     Lactic acid bacteria (LAB) are the most common beer-spoilage bacteria regardless of beer type, and thus pose significant problems for the brewery industry. The aim of this study …             Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation ▶     Mark C. Dessing, Jesper Kers, Jeffrey Damman et al.     NLRP3 (NOD-like receptor family, pyrin domain containing 3) is a member of the inflammasome family and is of special interest in renal disease. Experimental studies have shown …             The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair ▶     Elizabeth A. Vuono, Ananda Mukherjee, David A. Vierra et al.     Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and increased cancer risk. The FA proteins function primarily in DNA interstrand crosslink (ICL) …             Ovule positions within linear fruit are correlated with nonrandom mating in Robinia pseudoacacia ▶     Cunquan Yuan, Yuhan Sun, Peng Sun et al.     Post-pollination processes can lead to nonrandom mating among compatible pollen donors. Moreover, morphological patterns of ovule development within linear fruits are reportedly …             Big genomics and clinical data analytics strategies for precision cancer prognosis ▶     Ghim Siong Ow, Vladimir A. Kuznetsov     The field of personalized and precise medicine in the era of big data analytics is growing rapidly. Previously, we proposed our model of patient classification termed Prognostic …             Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction ▶     Kyle P. Quinn, Kelly E. Sullivan, Zhiyi Liu et al.     Understanding the organization and mechanical function of the extracellular matrix (ECM) is critical for the development of therapeutic strategies that regulate wound healing …             α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue ▶     Lu Gan, Zhenjiang Liu, Yizhe Chen et al.     Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid …             Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations ▶     Daphne Sun, Simona Dalin, Michael T. Hemann et al.     Recent drug discovery and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for precision medicine. However, drug resistance remains a major …             Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp ▶     Liis Andresen, Tanel Tenson, Vasili Hauryliuk     The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new …             Diversity of bacteriome associated with Phlebotomus chinensis (Diptera: Psychodidae) sand flies in two wild populations from China ▶     Kaili Li, Huiying Chen, Jinjin Jiang et al.     Sand fly Phlebotomus chinensis is a primary vector of transmission of visceral leishmaniasis in China. The sand flies have adapted to various ecological niches in distinct …             TALEN-mediated knock-in via non-homologous end joining in the crustacean Daphnia magna ▶     Takashi Nakanishi, Yasuhiko Kato, Tomoaki Matsuura et al.     Transcription activator-like effector nucleases (TALENs) are versatile tools that enable the insertion of DNA into different organisms. Here, we confirmed TALEN-mediated knock-in …             An active IGF-1R-AKT signaling imparts functional heterogeneity in ovarian CSC population ▶     Ram K. Singh, Ajit Dhadve, Asmita Sakpal et al.     Deregulated IGF-1R-AKT signaling influences multiple nodes of cancer cell physiology and assists in migration, metastasis and acquirement of radio/chemoresistance. Enrichment of …             ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons ▶     Kyung-Tai Kim, Namhee Kim, Hwan-Ki Kim et al.     LIM-homeodomain (HD) transcription factors form a multimeric complex and assign neuronal subtype identities, as demonstrated by the hexameric ISL1-LHX3 complex which gives rise …             A rapid, automated surface protein profiling of single circulating exosomes in human blood ▶     Golam Kibria, Erika K. Ramos, Katelyn E. Lee et al.     Circulating exosomes provide a promising approach to assess novel and dynamic biomarkers in human disease, due to their stability, accessibility and representation of molecules …             Comparative analyses of longevity and senescence reveal variable survival benefits of living in zoos across mammals ▶     Morgane Tidière, Jean-Michel Gaillard, Vérane Berger et al.     While it is commonly believed that animals live longer in zoos than in the wild, this assumption has rarely been tested. We compared four survival metrics (longevity, baseline …             Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R ▶     Toshiyuki Kojima, Kiichiro Tsuchiya, Shinji Ikemizu et al.     CD200R is an inhibitory receptor expressed on myeloid cells and some lymphoid cells, and plays important roles in negatively regulating immune responses. CD200 is the only known …             Anti-tumor activity of SL4 against breast cancer cells: induction of G2/M arrest through modulation of the MAPK-dependent p21 signaling pathway ▶     Li-Hui Wang, Xiao-Rui Jiang, Guo-Liang Chen et al.     SL4, a chalcone-based compound, has been shown to retard tumor invasion and angiogenesis by suppressing HIF1 activity and to induce apoptosis by promoting ROS release. Here, we …             Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library– Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene ▶     Sandeep Kumar, In-hwan Jang, Chan Woo Kim et al.     Disturbed blood flow (d-flow) induces atherosclerosis by altering the expression of mechanosensitive genes in the arterial endothelium. Previously, we identified >580 …             Sequencing of long stretches of repetitive DNA ▶     Alfredo De Bustos, Angeles Cuadrado, Nicolás Jouve     Repetitive DNA is widespread in eukaryotic genomes, in some cases making up more than 80% of the total. SSRs are a type of repetitive DNA formed by short motifs repeated in …             Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2 ▶     Amine Saad, Krikor Bijian, Dinghong Qiu et al.     Fascin 1 (FSCN1) is a cytoskeleton-associated protein recognized to function primarily in the regulation of cytoskeleton structure and formation of plasma membrane protrusions. …             IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection ▶     Matthew G. Booty, Palmira Barreira-Silva, Stephen M. Carpenter et al.     IL-21 is produced predominantly by activated CD4+ T cells and has pleiotropic effects on immunity via the IL-21 receptor (IL-21R), a member of the common gamma chain (γc) …             Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity ▶     Amira Latif-Hernandez, Disha Shah, Tariq Ahmed et al.     Intracerebral injection of the excitotoxic, endogenous tryptophan metabolite, quinolinic acid (QA), constitutes a chemical model of neurodegenerative brain disease. Complementary …             Stathmin-like 4 is critical for the maintenance of neural progenitor cells in dorsal midbrain of zebrafish larvae ▶     Meng-Ju Lin, Shyh-Jye Lee     A delicate balance between proliferating and differentiating signals is necessary to ensure proper growth and neuronal specification. By studying the developing zebrafish brain, …             Automatic detection and measurement of viral replication compartments by ellipse adjustment ▶     Yasel Garcés, Adán Guerrero, Paloma Hidalgo et al.     Viruses employ a variety of strategies to hijack cellular activities through the orchestrated recruitment of macromolecules to specific virus-induced cellular micro-environments. …             A microfluidic device for measuring cell migration towards substrate-bound and soluble chemokine gradients ▶     Jan Schwarz, Veronika Bierbaum, Jack Merrin et al.     Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, …             Combination of OipA, BabA, and SabA as candidate biomarkers for predicting Helicobacter pylori-related gastric cancer ▶     Yu-Lin Su, Hsiang-Ling Huang, Bo-Shih Huang et al.     Helicobacter pylori (H. pylori ) infection is a major cause of chronic gastritis and is highly related to duodenal ulcer (DU) and gastric cancer (GC). To identify H. pylori…             RNA-seq based transcriptomic analysis uncovers α-linolenic acid and jasmonic acid biosynthesis pathways respond to cold acclimation in Camellia japonica ▶     Qingyuan Li, Sheng Lei, Kebing Du et al.     Camellia is a well-known ornamental flower native to Southeast of Asia, including regions such as Japan, Korea and South China. However, most species in the genus Camellia are …             Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior ▶     Gregory D. Smith, Jessika White, Joaquin N. Lugo     We evaluated the effects of superimposing seizures on a genetic mutation with known involvement in both Autism Spectrum Disorder and in epilepsy. Neuron-subset specific (NS)-Pten …             Concurrent profiling of polar metabolites and lipids in human plasma using HILIC-FTMS ▶     Xiaoming Cai, Ruibin Li     Blood plasma is the most popularly used sample matrix for metabolite profiling studies, which aim to achieve global metabolite profiling and biomarker discovery. However, most of …             Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow ▶     Kenji Yumoto, Matthew R. Eber, Jingcheng Wang et al.     Disseminated prostate cancer (PCa) cells in the marrow survive for years without evidence of proliferation, while maintaining the capacity to develop into metastatic lesions. …             On the behaviour of lung tissue under tension and compression ▶     Pinelopi Andrikakou, Karthik Vickraman, Hari Arora     Lung injuries are common among those who suffer an impact or trauma. The relative severity of injuries up to physical tearing of tissue have been documented in clinical studies. …             Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion ▶     Weihong Zeng, Zhicui Liu, Siming Zhang et al.     A deeper understanding of the immunological events during pregnancy will provide novel insights into the pathogenesis of pregnancy complications. The fundamental function of T …             Possible existence of optical communication channels in the brain ▶     Sourabh Kumar, Kristine Boone, Jack Tuszyński et al.     Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have …             Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6 ▶     Marcelo Franchin, David F. Colón, Marcos G. da Cunha et al.     Isoflavonoids have been largely studied due to their distinct biological activities identified thus far. Herein, we evaluated the activity of neovestitol, an isoflavonoid …             Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury ▶     Hui Liu, Lei Yang, Hui-Jun Wu et al.     The morbidity and mortality of patients with ischemic cardiomyopathy resulted from ischemia/reperfusion injury are very high. The present study investigates whether our …             SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity ▶     Xiaoqiang Tang, Han Ma, Lei Han et al.     The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the …             Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology ▶     Juha P. Väyrynen, Shivaprakash J. Mutt, Karl-Heinz Herzig et al.     Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of …             Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin ▶     Christina Engels, Clarissa Schwab, Jianbo Zhang et al.     Glycerol/diol dehydratases catalyze the conversion of glycerol to 3-hydroxypropionaldehyde (3-HPA), the basis of a multi-component system called reuterin. Reuterin has …             Cyanobacteria in lakes on Yungui Plateau, China are assembled via niche processes driven by water physicochemical property, lake morphology and watershed land-use ▶     Jingqiu Liao, Lei Zhao, Xiaofeng Cao et al.     Plateau lakes are important ecosystems with diverse ecological functions. Cyanobacteria play a key role in plateau lakes as primary producers. However, they are threatening when …             Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5 ▶     Xueqing Xu, Bei Zhang, Shilong Yang et al.     Naturally occurring toxins have been invaluable tools for the study of structural and functional relationships of voltage-gated sodium channels (VGSC). Few studies have been made …             Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin ▶     Bang-li Hu, Cheng Shi, Rong-e Lei et al.     IL-22 ameliorates liver fibrosis by inhibiting hepatic stellate cells (HSC), and loss of miR-200a is associated with the development of liver fibrosis. The study aimed to …             HepaCAM associates with connexin 43 and enhances its localization in cellular junctions ▶     Meihui Wu, Mei Chung Moh, Herbert Schwarz     HepaCAM (GlialCAM) is frequently deleted in carcinomas, and reintroduction of hepaCAM into transformed cell lines reduces cellular growth and induces senescence. Mutations in …             Recombinant spider silk from aqueous solutions via a bio-inspired microfluidic chip ▶     Qingfa Peng, Yaopeng Zhang, Li Lu et al.     Spiders achieve superior silk fibres by controlling the molecular assembly of silk proteins and the hierarchical structure of fibres. However, current wet-spinning process for …             Relation between brain temperature and white matter damage in subacute carbon monoxide poisoning ▶     Shunrou Fujiwara, Yoshichika Yoshioka, Tsuyoshi Matsuda et al.     In the previous studies, carbon monoxide (CO) poisoning showed an imbalance between cerebral perfusion and metabolism in the acute phase and the brain temperature (BT) in these …             mTOR Overactivation in Mesenchymal cells Aggravates CCl4− Induced liver Fibrosis ▶     Lanlan Shan, Yan Ding, You Fu et al.     Hepatic stellate cells are of mesenchymal cell type located in the space of Disse. Upon liver injury, HSCs transactivate into myofibroblasts with increase in expression of …             The role of gibberellins in improving the resistance of tebuconazole-coated maize seeds to chilling stress by microencapsulation ▶     Lijuan Yang, Daibin Yang, Xiaojing Yan et al.     Chilling stress during germination often causes severe injury. In the present study, maize seed germination and shoot growth under chilling stress were negatively correlated with …             IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma ▶     Qi Huang, limin Duan, Xin Qian et al.     Inflammation and angiogenesis are two hallmarks of carcinoma. The proinflammatory cytokine interleukin-17 (IL-17) facilitates angiogenesis in lung cancer; however, the underlying …             Serum neurofilament light protein predicts clinical outcome in traumatic brain injury ▶     Pashtun Shahim, Magnus Gren, Victor Liman et al.     Axonal white matter injury is believed to be a major determinant of adverse outcomes following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament …             Phase transitions and self-organized criticality in networks of stochastic spiking neurons ▶     Ludmila Brochini, Ariadne de Andrade Costa, Miguel Abadi et al.     Phase transitions and critical behavior are crucial issues both in theoretical and experimental neuroscience. We report analytic and computational results about phase transitions …             Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth ▶     Peck Yin Chin, Camilla L. Dorian, Mark R. Hutchinson et al.     Toll-like receptor 4 (TLR4) activation by bacterial infection, or by sterile inflammatory insult is a primary trigger of spontaneous preterm birth. Here we utilize mouse models …             A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity In vivo ▶     Elena Pastor-Cavada, Leticia M. Pardo, Dalia Kandil et al.     Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. …             Mycelia as a focal point for horizontal gene transfer among soil bacteria ▶     Tom Berthold, Florian Centler, Thomas Hübschmann et al.     Horizontal gene transfer (HGT) is a main mechanism of bacterial evolution endowing bacteria with new genetic traits. The transfer of mobile genetic elements such as plasmids …             The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells ▶     Vijesh J. Bhute, Yan Ma, Xiaoping Bao et al.     Breast tumors are characterized into subtypes based on their surface marker expression, which affects their prognosis and treatment. Poly (ADP-ribose) polymerase (PARP) …             Graded Mirror Self-Recognition by Clark’s Nutcrackers ▶     Dawson Clary, Debbie M. Kelly     The traditional ‘mark test’ has shown some large-brained species are capable of mirror self-recognition. During this test a mark is inconspicuously placed on an animal’s body …             Self-assembly of keratin peptides: Its implication on the performance of electrospun PVA nanofibers ▶     Kavitha Kadirvelu, Nishter Nishad Fathima     Drawing inspiration from the field of designer self-assembling materials, this work is aimed to focus on the self-assembling nature of extracted peptides. Hair keratin, a …             Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes ▶     Jonah D. Hocum, Ian Linde, Dustin T. Rae et al.     Retroviral gene therapy offers immense potential to treat many genetic diseases and has already shown efficacy in clinical trials. However, retroviral vector mediated …             Eliciting maize defense pathways aboveground attracts belowground biocontrol agents ▶     Camila Cramer Filgueiras, Denis S. Willett, Ramom Vasconcelos Pereira et al.     Plant defense pathways mediate multitrophic interactions above and belowground. Understanding the effects of these pathways on pests and natural enemies above and belowground …             Membrane glycerolipidome of soybean root hairs and its response to nitrogen and phosphate availability ▶     Fang Wei, Brian Fanella, Liang Guo et al.     Root hairs are tubular extensions of specific root epidermal cells important in plant nutrition and water absorption. To determine membrane glycerolipids in root hairs and roots …             Genome-Wide Analysis and Functional Characterization of the Polyadenylation Site in Pigs Using RNAseq Data ▶     Hongyang Wang, Rui Li, Xiang Zhou et al.     Polyadenylation, a critical step in the production of mature mRNA for translation in most eukaryotes, involves cleavage and poly(A) tail addition at the 3′ end of mRNAs at the …             Cytological basis of sterility in male and female hybrids between sibling species of grey voles Microtus arvalis and M. levis ▶     Anna A. Torgasheva, Pavel M. Borodin     To make insight into the cytological basis of reproductive isolation, we examined chromosome synapsis and recombination in sterile male and female hybrids between Microtus arvalis…             Environmental Topology and Water Availability Modulates the Catalytic Activity of β-Galactosidase Entrapped in a Nanosporous Silicate Matrix ▶     M. Ines Burgos, Manuel I. Velasco, Rodolfo H. Acosta et al.     In the present work we studied the catalytic activity of E. coli β-Gal confined in a nanoporous silicate matrix (Eβ-Gal) at different times after the beginning of the sol-gel …             Enhancing succinic acid biosynthesis in Escherichia coli by engineering its global transcription factor, catabolite repressor/activator (Cra) ▶     Li-Wen Zhu, Shi-Tao Xia, Li-Na Wei et al.     This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis …             The first complete mitochondrial genome of Dacus longicornis (Diptera: Tephritidae) using next-generation sequencing and mitochondrial genome phylogeny of Dacini tribe ▶     Fan Jiang, Xubin Pan, Xuankun Li et al.     The genus Dacus is one of the most economically important tephritid fruit flies. The first complete mitochondrial genome (mitogenome) of Dacus species – D. longicornis was …             A critical role of solute carrier 22a14 in sperm motility and male fertility in mice ▶     Shin-ya Maruyama, Momoe Ito, Yuusuke Ikami et al.     We previously identified solute carrier 22a14 (Slc22a14) as a spermatogenesis-associated transmembrane protein in mice. Although Slc22a14 is a member of the organic anion/cation …             Surveillance for highly pathogenic H5 avian influenza virus in synanthropic wildlife associated with poultry farms during an acute outbreak ▶     Susan A. Shriner, J. Jeffrey Root, Mark W. Lutman et al.     In November 2014, a Eurasian strain H5N8 highly pathogenic avian influenza virus was detected in poultry in Canada. Introduced viruses were soon detected in the United States and …             Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress ▶     Nan Xie, Liwei Ma, Feng Zhu et al.     Nucleolar proteins play an important role in the regulation of the MDM2–p53 pathway, which coordinates cellular response to stress. However, the mechanism underlying this …             Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L ▶     Chunbin Tan, Zhaoming Liu, Senhua Chen et al.     Three novel 2,3-diaryl indone derivatives, ascomindones A−C (1−3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6−9) …             Instrumental Divergence and the Value of Control ▶     Prachi Mistry, Mimi Liljeholm     A critical aspect of flexible choice is that alternative actions yield distinct consequences: Only when available action alternatives produce distinct outcome states does …             A sequence variant associating with educational attainment also affects childhood cognition ▶     Bjarni Gunnarsson, Guðrún A. Jónsdóttir, Gyða Björnsdóttir et al.     Only a few common variants in the sequence of the genome have been shown to impact cognitive traits. Here we demonstrate that polygenic scores of educational attainment predict …             Smart Nanocomposites of Cu-Hemin Metal-Organic Frameworks for Electrochemical Glucose Biosensing ▶     Juan He, Han Yang, Yayun Zhang et al.     Herein, a smart porous material, Cu-hemin metal-organic-frameworks (Cu-hemin MOFs), was synthesized via assembling of Cu2+ with hemin to load glucose oxidase (GOD) for …             Effects of NDRG1 family proteins on photoreceptor outer segment morphology in zebrafish ▶     Shimpei Takita, Yasutaka Wada, Satoru Kawamura     Rods and cones are functionally and morphologically distinct. We previously identified N-myc downstream-regulated gene 1b (ndrg1b) in carp as a cone-specific gene. Here, we show …             Understanding the Antifungal Mechanism of Ag@ZnO Core-shell Nanocomposites against Candida krusei ▶     Bhaskar Das, Md. Imran Khan, R. Jayabalan et al.     In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis …             IL-25 attenuates rheumatoid arthritis through suppression of Th17 immune responses in an IL-13-dependent manner ▶     Dan Liu, Tuanping Cao, Na Wang et al.     IL-25, a new member of the IL-17 cytokine family, is involved in type 2 immunity initiation and has been associated with the pathogenesis of rheumatoid arthritis (RA). However, …             An Investigation of the Differences and Similarities between Generated Small-World Networks for Right- and Left-Hand Motor Imageries ▶     Jiang Zhang, Yuyao Li, Huafu Chen et al.     In this study, small-world network analysis was performed to identify the similarities and differences between functional brain networks for right- and left-hand motor imageries …             Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population ▶     Pei Zhang, Qingzhi Wang, Fengjuan Jiao et al.     Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may …             Spatiotemporal neurodynamics of automatic temporal expectancy in 9-month old infants ▶     Giovanni Mento, Eloisa Valenza     Anticipating events occurrence (Temporal Expectancy) is a crucial capacity for survival. Yet, there is little evidence about the presence of cortical anticipatory activity from …             Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma ▶     Ruoyu Zhang, Kiichi Nakahira, Xiaoxian Guo et al.     Cell free DNA (cfDNA) has received increasing attention and has been studied in a broad range of clinical conditions. However, few studies have focused on mitochondrial DNA …             Direct evidence for the semipersistent transmission of Cucurbit chlorotic yellows virus by a whitefly vector ▶     Jingjing Li, Xiangzhi Liang, Xueli Wang et al.     Cucurbit chlorotic yellows virus (CCYV) (genus Crinivirus, family Closteroviridae) is an emerging plant virus, and is now spreading and causing severe economic losses to cucurbit …             In Vivo Bioluminescence Tomography for Monitoring Breast Tumor Growth and Metastatic Spreading: Comparative Study and Mathematical Modeling ▶     Séverine Mollard, Raphaelle Fanciullino, Sarah Giacometti et al.     This study aimed at evaluating the reliability and precision of Diffuse Luminescent Imaging Tomography (DLIT) for monitoring primary tumor and metastatic spreading in breast …             Differences in Bacterial Diversity and Communities Between Glacial Snow and Glacial Soil on the Chongce Ice Cap, West Kunlun Mountains ▶     Guang Li Yang, Shu Gui Hou, Ri Le Baoge et al.     A detailed understanding of microbial ecology in different supraglacial habitats is important due to the unprecedented speed of glacier retreat. Differences in bacterial …             Ultra-low activities of a common radioisotope for permission-free tracking of a drosophilid fly in its natural habitat ▶     Wolfgang Arthofer, Clemens Decristoforo, Birgit C. Schlick-Steiner et al.     Knowledge of a species’ ecology, including its movement in time and space, is key for many questions in biology and conservation. While numerous tools for tracking larger animals …             Constitutive cyclic GMP accumulation in Arabidopsis thaliana compromises systemic acquired resistance induced by an avirulent pathogen by modulating local signals ▶     Jamshaid Hussain, Jian Chen, Vittoria Locato et al.     The infection of Arabidopsis thaliana plants with avirulent pathogens causes the accumulation of cGMP with a biphasic profile downstream of nitric oxide signalling. However, …             Diversity and function of the Antarctic krill microorganisms from Euphausia superba ▶     Xiaoqiu Cui, Guoliang Zhu, Haishan Liu et al.     The diversity and ecological function of microorganisms associated with Euphausia superba, still remain unknown. This study identified 75 microbial isolates from E. superba, that …             A combination of genome-wide association and transcriptome analysis reveals candidate genes controlling harvest index-related traits in Brassica napus ▶     Kun Lu, Zhongchun Xiao, Hongju Jian et al.     Harvest index (HI), the ratio of seed mass to total biomass of the aboveground plant parts, is an important trait for harvestable yield of crops. Unfortunately, HI of Brassica …             On-chip, multisite extracellular and intracellular recordings from primary cultured skeletal myotubes ▶     Noha Rabieh, Silviya M. Ojovan, Nava Shmoel et al.     In contrast to the extensive use of microelectrode array (MEA) technology in electrophysiological studies of cultured neurons and cardiac muscles, the vast field of skeletal …             A simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics ▶     Hao Yuan Kueh, Yanting Zhu, Jue Shi     Anti-mitotic drugs constitute a major class of cytotoxic chemotherapeutics used in the clinic, killing cancer cells by inducing prolonged mitotic arrest that activates intrinsic …             Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps ▶     Manjunath B Joshi, Guruprasad Baipadithaya, Aswath Balakrishnan et al.     Constitutively active neutrophil extracellular traps (NETs) and elevated plasma homocysteine are independent risk factors for Type 2 Diabetes (T2D) associated vascular diseases. …             Predicting Subtype Selectivity for Adenosine Receptor Ligands with Three-Dimensional Biologically Relevant Spectrum (BRS-3D) ▶     Song-Bing He, Ben Hu, Zheng-Kun Kuang et al.     Adenosine receptors (ARs) are potential therapeutic targets for Parkinson’s disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important …             Diagnosis trajectories of prior multi-morbidity predict sepsis mortality ▶     Mette K. Beck, Anders Boeck Jensen, Annelaura Bach Nielsen et al.     Sepsis affects millions of people every year, many of whom will die. In contrast to current survival prediction models for sepsis patients that primarily are based on data from …             Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions ▶     Taro Misaki, Shuhei Naka, Rina Hatakeyama et al.     Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of …             Mechanisms of arrhythmogenesis related to calcium-driven alternans in a model of human atrial fibrillation ▶     Kelly C. Chang, Natalia A. Trayanova     The occurrence of atrial fibrillation (AF) is associated with progressive changes in the calcium handling system of atrial myocytes. Calcium cycling instability has been …             In vivo online magnetic resonance quantification of absolute metabolite concentrations in microdialysate ▶     Stefan Glöggler, Silvia Rizzitelli, Noël Pinaud et al.     In order to study metabolic processes in animal models of diseases and in patients, microdialysis probes have evolved as powerful tools that are minimally invasive. However, …             Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9 ▶     Murali M. S. Balla, Sejal Desai, Pallavi Purwar et al.     Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for …             Fluorimetric Mercury Test Strips with Suppressed “Coffee Stains” by a Bio-inspired Fabrication Strategy ▶     Yuchun Qiao, Jizhen Shang, Shuying Li et al.     A fluorimetric Hg2+ test strip has been developed using a lotus-inspired fabrication method for suppressing the “coffee stains” toward the uniform distribution of probe materials …             Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3 ▶     Su M. Phyu, Chih-Chung Tseng, Ian N. Fleming et al.     Akt is an intracellular signalling pathway that serves as an essential link between cell surface receptors and cellular processes including proliferation, development and …             The mutation p.E113K in the Schiff base counterion of rhodopsin is associated with two distinct retinal phenotypes within the same family ▶     Charlotte Reiff, Marta Owczarek-Lipska, Georg Spital et al.     The diagnoses of retinitis pigmentosa (RP) and stationary night blindness (CSNB) are two distinct clinical entities belonging to a group of clinically and genetically …             Measurement of in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device ▶     Chien-Han Lin, Chien-Kai Wang, Yu-An Chen et al.     In various physiological activities, cells experience stresses along their in-plane direction when facing substrate deformation. Capability of continuous monitoring elasticity of …             Strand-Exchange Nucleic Acid Circuitry with Enhanced Thermo-and Structure- Buffering Abilities Turns Gene Diagnostics Ultra-Reliable and Environmental Compatible ▶     Zhentong Zhu, Yidan Tang, Yu Sherry Jiang et al.     Catalytic hairpin assembly (CHA) is one of the most promising nucleic acid amplification circuits based on toehold-mediated strand exchange reactions. But its performance is …             DHA-supplemented diet increases the survival of rats following asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation ▶     Junhwan Kim, Tai Yin, Koichiro Shinozaki et al.     Accumulating evidence illustrates the beneficial effects of dietary docosahexaenoic acid (DHA) on cardiovascular diseases. However, its effects on cardiac arrest (CA) remain …             EGFR tyrosine kinase inhibitors versus chemotherapy as first-line therapy for non-small cell lung cancer patients with the L858R point mutation ▶     Jianlin Xu, Haitang Yang, Bo Jin et al.     The efficacy of EGFR tyrosine kinase inhibitors (TKIs) varies among different EGFR mutations. Here, we directly compared the efficacy of first-line TKIs to chemotherapy for …             The endotracheal tube microbiome associated with Pseudomonas aeruginosa or Staphylococcus epidermidis ▶     An Hotterbeekx, Basil B. Xavier, Kenny Bielen et al.     Ventilator-associated pneumonia (VAP) is one of the commonest hospital-acquired infections associated with high mortality. VAP pathogenesis is closely linked to organisms …             Differential Canalograms Detect Outflow Changes from Trabecular Micro-Bypass Stents and Ab Interno Trabeculectomy ▶     Hardik A. Parikh, Ralitsa T. Loewen, Pritha Roy et al.     Recently introduced microincisional glaucoma surgeries that enhance conventional outflow offer a favorable risk profile over traditional surgeries, but can be unpredictable. Two …             Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model ▶     R. Alan Harris, Callison E. Alcott, Elinor L. Sullivan et al.     Maternal obesity contributes to an increased risk of lifelong morbidity and mortality for both the mother and her offspring. In order to better understand the molecular …             Strain dependent differences in glucocorticoid-induced bone loss between C57BL/6J and CD-1 mice ▶     Adel Ersek, Ana I. Espirito Santo, Youridies Vattakuzhi et al.     We have investigated the effect of long-term glucocorticoid (GC) administration on bone turnover in two frequently used mouse strains; C57BL/6J and CD1, in order to assess the …             Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues ▶     Qing Chang, Olga I. Ornatsky, Iram Siddiqui et al.     Imaging mass cytometry was used for direct visualization of platinum localization in tissue sections from tumor and normal tissues of cisplatin-treated mice bearing pancreas …             Biopsy variability of lymphocytic infiltration in breast cancer subtypes and the ImmunoSkew score ▶     Adnan Mujahid Khan, Yinyin Yuan     The number of tumour biopsies required for a good representation of tumours has been controversial. An important factor to consider is intra-tumour heterogeneity, which can vary …             Complete integrability of information processing by biochemical reactions ▶     Elena Agliari, Adriano Barra, Lorenzo Dello Schiavo et al.     Statistical mechanics provides an effective framework to investigate information processing in biochemical reactions. Within such framework far-reaching analogies are established …             Long-term exposure to Myozyme results in a decrease of anti-drug antibodies in late-onset Pompe disease patients ▶     Elisa Masat, Pascal Laforêt, Marie De Antonio et al.     Immunogenicity of recombinant human acid-alpha glucosidase (rhGAA) in enzyme replacement therapy (ERT) is a safety and efficacy concern in the management of late-onset Pompe …             Identification of G8969>A in mitochondrial ATP6 gene that severely compromises ATP synthase function in a patient with IgA nephropathy ▶     Shuzhen Wen, Katarzyna Niedzwiecka, Weiwei Zhao et al.     Here we elucidated the pathogenesis of a 14-year-old Chinese female who initially developed an isolated nephropathy followed by a complex clinical presentation with brain and …             Anticipation of guilt for everyday moral transgressions: The role of the anterior insula and the influence of interpersonal psychopathic traits ▶     Ana Seara-Cardoso, Catherine L. Sebastian, Eamon McCrory et al.     Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge …             Corrigendum: Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy ▶     Libo Yuan, Tian Tian, Yuqi Chen et al.                 Faster poleward range shifts in moths with more variable colour patterns ▶     Anders Forsman, Per-Eric Betzholtz, Markus Franzén     Range shifts have been documented in many organisms, and climate change has been implicated as a contributing driver of latitudinal and altitudinal range modifications. However, …             Structural basis of the high thermal stability of the histone-like HU protein from the mollicute Spiroplasma melliferum KC3 ▶     Konstantin M. Boyko, Tatiana V. Rakitina, Dmitry A. Korzhenevskiy et al.     The three-dimensional structure of the histone-like H protein from the mycoplasma Spiroplasma melliferum KC3 (HUSpm) was determined at 1.4 Å resolution, and the thermal stability …             Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word count ▶     Yoshiko Wada, Kennosuke Wada, Yuki Iwasaki et al.     Ebolavirus, MERS coronavirus and influenza virus are zoonotic RNA viruses, which mutate very rapidly. Viral growth depends on many host factors, but human cells may not provide …             Exposure to extremely low frequency electromagnetic fields alters the behaviour, physiology and stress protein levels of desert locusts ▶     Joanna Wyszkowska, Sebastian Shepherd, Suleiman Sharkh et al.     Electromagnetic fields (EMFs) are present throughout the modern world and are derived from many man-made sources including overhead transmission lines. The risks of extremely-low …             SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis ▶     Sergio Pulido-Tamayo, Bram Weytjens, Dries De Maeyer et al.     Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the …             Physiological response and sulfur metabolism of the V. dahliae-infected tomato plants in tomato/potato onion companion cropping ▶     Xuepeng Fu, Chunxia Li, Xingang Zhou et al.     Companion cropping with potato onions (Allium cepa var. agrogatum Don.) can enhance the disease resistance of tomato plants (Solanum lycopersicum) to Verticillium dahliae …             mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling ▶     Roberto Bravo-Sagua, Camila López-Crisosto, Valentina Parra et al.     Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with …             Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization ▶     Lei Dong, Alexandra Helmke, Ari Waisman et al.     Understanding of T helper 17 lineage (TH17) polarization has been significantly promoted by cell culture experiments that reduce the complexity of the in vivo environment. We …             Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML ▶     Morito Kurata, Susan K. Rathe, Natashay J. Bailey et al.     Acute myeloid leukemia (AML) can display de novo or acquired resistance to cytosine arabinoside (Ara-C), a primary component of induction chemotherapy. To identify genes capable …             Adaptive capacities from survival to stress responses of two isogenic lines of rainbow trout fed a plant-based diet ▶     B. Sadoul, A. Foucard, C. Valotaire et al.     The composition of feed for farmed salmonids has strongly evolved during the last decades due to the substitution of fishery-derived fish oil and fishmeal by ingredients of plant …             Past climate changes facilitated homoploid speciation in three mountain spiny fescues (Festuca, Poaceae) ▶     I. Marques, D. Draper, M. L. López-Herranz et al.     Apart from the overwhelming cases of allopolyploidization, the impact of speciation through homoploid hybridization is becoming more relevant than previously thought. Much less …             Mitochondrial genomes and comparative genomics of Aphanomyces astaci and Aphanomyces invadans ▶     Jenny Makkonen, Arto Vesterbacka, Frank Martin et al.     The genus Aphanomyces (Saprolegniales, Oomycetes) includes species with a variety of ecologies from saprotrophs to plant and animal parasites. Two important species in this genus …             Changeover from signalling to energy-provisioning lipids during transition from colostrum to mature milk in the giant panda (Ailuropoda melanoleuca) ▶     Tong Zhang, David G. Watson, Rong Zhang et al.     Among the large placental mammals, ursids give birth to the most altricial neonates with the lowest neonatal:maternal body mass ratios. This is particularly exemplified by giant …             Trends for isolated amino acids and dipeptides: Conformation, divalent ion binding, and remarkable similarity of binding to calcium and lead ▶     M. Ropo, V. Blum, C. Baldauf     We derive structural and binding energy trends for twenty amino acids, their dipeptides, and their interactions with the divalent cations Ca2+, Ba2+, Sr2+, Cd2+, Pb2+, and Hg2+. …             Molecular Characterization of A Novel Effector Expansin-like Protein from Heterodera avenae that Induces Cell Death in Nicotiana benthamiana ▶     Jing Liu, Huan Peng, Jiangkuan Cui et al.     Cereal cyst nematodes are sedentary biotrophic endoparasites that maintain a complex interaction with their host plants. Nematode effector proteins are synthesized in the …             Essential Oils and Eugenols Inhibit Biofilm Formation and the Virulence of Escherichia coli O157:H7 ▶     Yong-Guy Kim, Jin-Hyung Lee, Giyeon Gwon et al.     Enterohemorrhagic Escherichia coli O157:H7 (EHEC) has caused foodborne outbreaks worldwide and the bacterium forms antimicrobial-tolerant biofilms. We investigated the abilities …             Remote in vivo stress assessment of aquatic animals with microencapsulated biomarkers for environmental monitoring ▶     Anton Gurkov, Ekaterina Shchapova, Daria Bedulina et al.     Remote in vivo scanning of physiological parameters is a major trend in the development of new tools for the fields of medicine and animal physiology. For this purpose, a variety …             HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells ▶     Rong Jia, Si Zhang, Miaomiao Liu et al.     Oral squamous cell carcinoma (OSCC) is the leading cause of death related to oral diseases. The mechanisms of OSCC development remain largely unknown. Heterogeneous nuclear …             Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics ▶     Bartosz Szczesny, Michela Marcatti, John R. Zatarain et al.     Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H2S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung …             Identification of candidate genes for congenital heart defects on proximal chromosome 8p ▶     Tingting Li, Chunjie Liu, Yuejuan Xu et al.     With the application of advanced molecular cytogenetic techniques, the number of patients identified as having abnormal chromosome 8p has increased progressively. Individuals …             In vitro membrane protein synthesis inside Sec translocon-reconstituted cell-sized liposomes ▶     Naoki Ohta, Yasuhiko Kato, Hajime Watanabe et al.     Protein synthesis using an in vitro transcription-translation system (IVTT) inside cell-sized liposomes has become a valuable tool to study the properties of biological systems …             Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt’s lymphoma (BL) Daudi cells by NMR spectroscopy ▶     Paul D. Madge, Andrea Maggioni, Mauro Pascolutti et al.     Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, …             Digital barcodes of suspension array using laser induced breakdown spectroscopy ▶     Qinghua He, Yixi Liu, Yonghong He et al.     We show a coding method of suspension array based on the laser induced breakdown spectroscopy (LIBS), which promotes the barcodes from analog to digital. As the foundation of …             Genomic analysis reveals selection in Chinese native black pig ▶     Yuhua Fu, Cencen Li, Qianzi Tang et al.     Identification of genomic signatures that help reveal mechanisms underlying desirable traits in domesticated pigs is of significant biological, agricultural and medical …             Recombinant production of influenza hemagglutinin and HIV-1 GP120 antigenic peptides using a cleavable self-aggregating tag ▶     Wanghui Xu, Qing Zhao, Lei Xing et al.     The increasing demand for antigenic peptides in the development of novel serologic diagnostics and epitope-based vaccines requires rapid and reliable peptide synthesis …             A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticated chicken ▶     Xinzheng Jia, Huiran Lin, Qinghua Nie et al.     Body weight is one of the most important quantitative traits with high heritability in chicken. We previously mapped a quantitative trait locus (QTL) for body weight by …             Multi-phasic bi-directional chemotactic responses of the growth cone ▶     Honda Naoki, Makoto Nishiyama, Kazunobu Togashi et al.     The nerve growth cone is bi-directionally attracted and repelled by the same cue molecules depending on the situations, while other non-neural chemotactic cells usually show …             Bioinspired seeding of biomaterials using three dimensional microtissues induces chondrogenic stem cell differentiation and cartilage formation under growth factor free conditions ▶     J. Leijten, L. S. Moreira Teixeira, J. Bolander et al.     Cell laden biomaterials are archetypically seeded with individual cells and steered into the desired behavior using exogenous stimuli to control growth and differentiation. In …             ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer ▶     Lídia Cedó, Annabel García-León, Lucía Baila-Rueda et al.     Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with …             Evaluation of uttroside B, a saponin from Solanum nigrum Linn, as a promising chemotherapeutic agent against hepatocellular carcinoma ▶     Lekshmi R. Nath, Jaggaiah N. Gorantla, Arun Kumar T. Thulasidasan et al.     We report, for the first time, the remarkable efficacy of uttroside B, a potent saponin from Solanum nigrum Linn, against liver cancer. The compound has been isolated and …             Analysis of codon usage patterns in Ginkgo biloba reveals codon usage tendency from A/U-ending to G/C-ending ▶     Bing He, Hui Dong, Cong Jiang et al.     As one of the most ancient tree species, the codon usage pattern analysis of Ginkgo biloba is a useful way to understand its evolutionary and genetic mechanisms. Several studies …             Integrative omics connects N-glycoproteome-wide alterations with pathways and regulatory events in induced pluripotent stem cells ▶     Putty-Reddy Sudhir, Madireddy Pavana Kumari, Wei-Ting Hsu et al.     Molecular-level differences ranging from genomes to proteomes, but not N-glycoproteomes, between human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) …             Improving virus production through quasispecies genomic selection and molecular breeding ▶     Francisco J. Pérez-Rodríguez, Lucía D’Andrea, Montserrat de Castellarnau et al.     Virus production still is a challenging issue in antigen manufacture, particularly with slow-growing viruses. Deep-sequencing of genomic regions indicative of efficient …             How many papillomavirus species can go undetected in papilloma lesions? ▶     Cíntia Daudt, Flavio R. C. da Silva, André F. Streck et al.     A co-infection comprising to at least seven papillomavirus (PV) types was detected by next generation sequencing (NGS) of randomly primed rolling circle amplification (RCA) …             Think global, act local: Preserving the global commons ▶     Oliver P. Hauser, Achim Hendriks, David G. Rand et al.     Preserving global public goods, such as the planet’s ecosystem, depends on large-scale cooperation, which is difficult to achieve because the standard reciprocity mechanisms …             Population assessment of tropical tuna based on their associative behavior around floating objects ▶     M. Capello, J. L. Deneubourg, M. Robert et al.     Estimating the abundance of pelagic fish species is a challenging task, due to their vast and remote habitat. Despite the development of satellite, archival and acoustic tagging …             Transcriptome Analysis of the Signalling Networks in Coronatine-Induced Secondary Laticifer Differentiation from Vascular Cambia in Rubber Trees ▶     Shaohua Wu, Shixin Zhang, Jinquan Chao et al.     The secondary laticifer in rubber tree (Hevea brasiliensis Muell. Arg.) is a specific tissue within the secondary phloem. This tissue differentiates from the vascular cambia, and …             Host-ant specificity of endangered large blue butterflies (Phengaris spp., Lepidoptera: Lycaenidae) in Japan ▶     Shouhei Ueda, Takashi Komatsu, Takao Itino et al.     Large blue butterflies, Phengaris (Maculinea), are an important focus of endangered-species conservation in Eurasia. Later-instar Phengaris caterpillars live in Myrmica ant nests …             Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells ▶     Sarah Vogel, Simon Arnoldini, Stephanie Möller et al.     Extracellular matrix (ECM) composition and structural integrity is one of many factors that influence cellular differentiation. Fibronectin (FN) which is in many tissues the most …             Limited mitogenomic degradation in response to a parasitic lifestyle in Orobanchaceae ▶     Weishu Fan, Andan Zhu, Melisa Kozaczek et al.     In parasitic plants, the reduction in plastid genome (plastome) size and content is driven predominantly by the loss of photosynthetic genes. The first completed mitochondrial …             Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1 ▶     Faiza Baameur, Pooja Singhmar, Yong Zhou et al.     Exchange protein directly activated by cAMP-1 (Epac1) is a cAMP sensor that regulates multiple cellular functions including cellular migration, proliferation and differentiation. …             C2-domain mediated nano-cluster formation increases calcium signaling efficiency ▶     Mike Bonny, Xin Hui, Julia Schweizer et al.     Conventional protein kinase Cs (cPKCs) are key signaling proteins for transducing intracellular Ca2+ signals into downstream phosphorylation events. However, the lifetime of …             Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions ▶     Betty Hebecker, Sebastian Vlaic, Theresia Conrad et al.     Candida albicans is a common cause of life-threatening fungal bloodstream infections. In the murine model of systemic candidiasis, the kidney is the primary target organ while …             N-acetyl ornithine deacetylase is a moonlighting protein and is involved in the adaptation of Entamoeba histolytica to nitrosative stress ▶     Preeti Shahi, Meirav Trebicz-Geffen, Shruti Nagaraja et al.     Adaptation of the Entamoeba histolytica parasite to toxic levels of nitric oxide (NO) that are produced by phagocytes may be essential for the establishment of chronic amebiasis …             Characterization of the starch-acting MaAmyB enzyme from Microbacterium aurum B8.A representing the novel subfamily GH13_42 with an unusual, multi-domain organization ▶     Vincent Valk, Rachel M. van der Kaaij, Lubbert Dijkhuizen     The bacterium Microbacterium aurum strain B8.A degrades granular starches, using the multi-domain MaAmyA α-amylase to initiate granule degradation through pore formation. This …             Decoding of top-down cognitive processing for SSVEP-controlled BMI ▶     Byoung-Kyong Min, Sven Dähne, Min-Hee Ahn et al.     We present a fast and accurate non-invasive brain-machine interface (BMI) based on demodulating steady-state visual evoked potentials (SSVEPs) in electroencephalography (EEG). …             Voluntary control of intracortical oscillations for reconfiguration of network activity ▶     Juliana Corlier, Mario Valderrama, Miguel Navarrete et al.     Voluntary control of oscillatory activity represents a key target in the self-regulation of brain function. Using a real-time closed-loop paradigm and simultaneous macro- and …             Identification of a two-component Class IIb bacteriocin in Streptococcus pyogenes by recombinase-based in vivo expression technology ▶     Brent D. Armstrong, Christine A. Herfst, Nicholas C. Tonial et al.     Streptococcus pyogenes is a globally prominent bacterial pathogen that exhibits strict tropism for the human host, yet bacterial factors responsible for the ability of S. pyogenes…             Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies ▶     Nan Wu, Yu-Long Song, Bei Wang et al.     The gut-associated lymphoid tissue, connected with liver via bile and blood, constructs a local immune environment of both defense and tolerance. The gut-liver immunity has been …             Cassava brown streak virus has a rapidly evolving genome: implications for virus speciation, variability, diagnosis and host resistance ▶     Titus Alicai, Joseph Ndunguru, Peter Sseruwagi et al.     Cassava is a major staple food for about 800 million people in the tropics and sub-tropical regions of the world. Production of cassava is significantly hampered by cassava brown …             LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development ▶     Deanna Acosta, Susmita Bagchi, Pilib Ó Broin et al.     During pregnancy, luminal and basal epithelial cells of the adult mammary gland proliferate and differentiate resulting in remodeling of the adult gland. While pathways that …             β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces ▶     James W. P. Brown, Alexander K. Buell, Thomas C. T. Michaels et al.     α-Synuclein is an intrinsically disordered protein that is associated with the pathogenesis of Parkinson’s disease through the processes involved in the formation of amyloid …             Periodic protein adsorption at the gold/biotin aqueous solution interface: evidence of kinetics with time delay ▶     H. Neff, H. M. Laborde, A. M. N. Lima     An oscillatory molecular adsorption pattern of the protein neutravidin from aqueous solution onto gold, in presence of a pre-deposited self assembled mono-molecular biotin film, …             Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly ▶     Tomasz Kochańczyk, Michał Nowakowski, Dominika Wojewska et al.     The binding of metal ions at the interface of protein complexes presents a unique and poorly understood mechanism of molecular assembly. A remarkable example is the Rad50 zinc …             The role of pericytic laminin in blood brain barrier integrity maintenance ▶     Jyoti Gautam, Xuanming Zhang, Yao Yao     Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, …             Effects of sedimentation on soil physical and chemical properties and vegetation characteristics in sand dunes at the Southern Dongting Lake region, China ▶     Ying Pan, Hao Zhang, Xu Li et al.     Sedimentation is recognized as a major factor determining the ecosystem processes of lake beaches; however, the underlying mechanisms, especially in freshwater sand dunes, have …             Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation ▶     Xiaodong Lin, Liangcai Zhao, Shengli Tang et al.     The fibroblast growth factors (FGFs) family shows a great potential in the treatment of diabetes, but little attention is paid to basic FGF (bFGF). In this study, to explore the …             α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses ▶     Naoto Sugeno, Sandra Jäckel, Aaron Voigt et al.     α-Synuclein (αS) is a protein linked to Parkinson’s disease (PD) and related neurodegenerative disorders. It is mostly localized within synapses, but αS has also been suggested …             Significant glial alterations in response to iron loading in a novel organotypic hippocampal slice culture model ▶     Sinead Healy, Jill McMahon, Peter Owens et al.     Aberrant iron deposition in the brain is associated with neurodegenerative disorders including Multiple Sclerosis, Alzheimer’s disease and Parkinson’s disease. To study the …             Few Ramachandran Angle Changes Provide Interaction Strength Increase in Aβ42 versus Aβ40 Amyloid Fibrils ▶     Oscar H. Bastidas, Benjamin Green, Mary Sprague et al.     The pathology of Alzheimer’s disease can ultimately be traced to the increased aggregation stability of Aβ42 peptides which possess two extra residues (Ile 41 & Ala 42) that the …             Physical interactions between DNA and sepiolite nanofibers, and potential application for DNA transfer into mammalian cells ▶     Fidel Antonio Castro-Smirnov, Olivier Piétrement, Pilar Aranda et al.     Nanofibers of sepiolite, a natural silicate belonging to the clay minerals family, might constitute a potential promising nanocarrier for the non-viral transfer of bio-molecules. …             Interaction of benzo[a]pyrene diol epoxide isomers with human serum albumin: Site specific characterisation of adducts and associated kinetics ▶     Hitesh V. Motwani, Emelie Westberg, Margareta Törnqvist     Carcinogenicity of benzo[a]pyrene {B[a]P, a polycyclic aromatic hydrocarbon (PAH)} involves DNA-modification by B[a]P diol epoxide (BPDE) metabolites. Adducts to serum albumin …             Regulation of RNA-binding proteins affinity to export receptors enables the nuclear basket proteins to distinguish and retain aberrant mRNAs ▶     M. Soheilypour, M. R. K. Mofrad     Export of messenger ribonucleic acids (mRNAs) into the cytoplasm is a fundamental step in gene regulation processes, which is meticulously quality controlled by highly efficient …             An open-hardware platform for optogenetics and photobiology ▶     Karl P. Gerhardt, Evan J. Olson, Sebastian M. Castillo-Hair et al.     In optogenetics, researchers use light and genetically encoded photoreceptors to control biological processes with unmatched precision. However, outside of neuroscience, the …             Coral Reef Resilience, Tipping Points and the Strength of Herbivory ▶     Sally J. Holbrook, Russell J. Schmitt, Thomas C. Adam et al.     Coral reefs increasingly are undergoing transitions from coral to macroalgal dominance. Although the functional roles of reef herbivores in controlling algae are becoming better …             Tumour microenvironment-responsive lipoic acid nanoparticles for targeted delivery of docetaxel to lung cancer ▶     Fenfen Gu, Chuling Hu, Zhongguang Tai et al.     In the present study, we developed a novel type of reduction-sensitive nanoparticles (NPs) for docetaxel (DTX) delivery based on cross-linked lipoic acid NPs (LANPs). The …             Functional insights into the testis transcriptome of the edible sea urchin Loxechinus albus ▶     Juan Diego Gaitán-Espitia, Roland Sánchez, Paulina Bruning et al.     The edible sea urchin Loxechinus albus (Molina, 1782) is a keystone species in the littoral benthic systems of the Pacific coast of South America. The international demand for …             Experimental piscine alphavirus RNA recombination in vivo yields both viable virus and defective viral RNA ▶     Elin Petterson, Tz-Chun Guo, Øystein Evensen et al.     RNA recombination in non-segmented RNA viruses is important for viral evolution and documented for several virus species through in vitro studies. Here we confirm viral RNA …             Genome-wide analyses reveal a highly conserved Dengue virus envelope peptide which is critical for virus viability and antigenic in humans ▶     Renata C. Fleith, Francisco P. Lobo, Paula F. dos Santos et al.     Targeting regions of proteins that show a high degree of structural conservation has been proposed as a method of developing immunotherapies and vaccines that may bypass the wide …             The peacock train does not handicap cursorial locomotor performance ▶     Nathan K. Thavarajah, Peter G. Tickle, Robert L. Nudds et al.     Exaggerated traits, like the peacock train, are recognized as classic examples of sexual selection. The evolution of sexual traits is often considered paradoxical as, although …             Understanding the immune system architecture and transcriptome responses to southern rice black-streaked dwarf virus in Sogatella furcifera ▶     Lin Wang, Nan Tang, Xinlei Gao et al.     Sogatella furcifera, the white-backed planthopper (WBPH), has become one of the most destructive pests in rice production owing to its plant sap-sucking behavior and efficient …             Coenzyme Engineering of a Hyperthermophilic 6-Phosphogluconate Dehydrogenase from NADP+ to NAD+ with Its Application to Biobatteries ▶     Hui Chen, Zhiguang Zhu, Rui Huang et al.     Engineering the coenzyme specificity of redox enzymes plays an important role in metabolic engineering, synthetic biology, and biocatalysis, but it has rarely been applied to …             Large-scale identification of adverse drug reaction-related proteins through a random walk model ▶     Xiaowen Chen, Hongbo Shi, Feng Yang et al.     Adverse drug reactions (ADRs) are responsible for drug failure in clinical trials and affect life quality of patients. The identification of ADRs during the early phases of drug …             Legionella pneumophila prevents proliferation of its natural host Acanthamoeba castellanii ▶     Luce Mengue, Matthieu Régnacq, Willy Aucher et al.     Legionella pneumophila is a ubiquitous, pathogenic, Gram-negative bacterium responsible for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists …             Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine ▶     Masashi Maekawa, Minhyoung Lee, Kuiru Wei et al.     Accumulation of phosphatidylserine in the inner leaflet of the plasma membrane is a hallmark of eukaryotes. Sublethal levels of staurosporine and related compounds deplete …             Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis ▶     Tao Nie, Xiaoyan Hui, Liufeng Mao et al.     Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we reveal that harmine …             Comprehensive DNA methylation analysis of the Aedes aegypti genome ▶     Cassandra Falckenhayn, Vitor Coutinho Carneiro, Anderson de Mendonça Amarante et al.     Aedes aegypti mosquitoes are important vectors of viral diseases. Mosquito host factors play key roles in virus control and it has been suggested that dengue virus replication is …             Identification of DNA primase inhibitors via a combined fragment-based and virtual screening ▶     Stefan Ilic, Sabine R. Akabayov, Haribabu Arthanari et al.     The structural differences between bacterial and human primases render the former an excellent target for drug design. Here we describe a technique for selecting small molecule …             Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments ▶     Aleksandra Badura, Claudia Clopath, Martijn Schonewille et al.     Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal …             Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy ▶     Teemu D. Laajala, Heikki Seikkula, Fatemeh Seyednasrollah sadat et al.     Ultrasensitive prostate-specific antigen (u-PSA) remains controversial for follow-up after radical prostatectomy (RP). The aim of this study was to model PSA doubling times …             Surface micro- and nano-texturing of stainless steel by femtosecond laser for the control of cell migration ▶     M. Martínez-Calderon, M. Manso-Silván, A. Rodríguez et al.     The precise control over the interaction between cells and the surface of materials plays a crucial role in optimizing the integration of implanted biomaterials. In this regard, …             A murine model of early Pseudomonas aeruginosa lung disease with transition to chronic infection ▶     H. K. Bayes, N. Ritchie, S. Irvine et al.     Pseudomonas aeruginosa (PA) remains an important pathogen in patients with cystic fibrosis (CF) lung disease as well as non-CF bronchiectasis and chronic obstructive airways …             Kisspeptin and RFRP-3 differentially regulate food intake and metabolic neuropeptides in the female desert jerboa ▶     Rajae Talbi, Marie-Pierre Laran-Chich, Rabia Magoul et al.     Jerboas are wild rodents exhibiting exceptional adaptation to their desert environment. Under harsh autumn conditions, they shut down reproduction, increase body weight and …             Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain ▶     Zexu Ma, Ying Yu, Yueqiang Xiao et al.     Porcine reproductive and respiratory syndrome virus (PRRSV) strain A2MC2 induces type I interferons in cultured cells. The objective of this study was to attenuate this strain by …             Rapid gamma oscillations in the inferior occipital gyrus in response to eyes ▶     Wataru Sato, Takanori Kochiyama, Shota Uono et al.     Eyes are an indispensable communication medium for human social interactions. Although previous neuroscientific evidence suggests the activation of the inferior occipital gyrus …             H2O2 and Ca2+-based signaling and associated ion accumulation, antioxidant systems and secondary metabolism orchestrate the response to NaCl stress in perennial ryegrass ▶     Tao Hu, Ke Chen, Longxing Hu et al.     Little is known about the interplay between Ca2+ and H2O2 signaling in stressed cool-season turfgrass. To understand better how Ca2+ and H2O2 signals are integrated to enhance …             The Seminal fluid proteome of the polyandrous Red junglefowl offers insights into the molecular basis of fertility, reproductive ageing and domestication ▶     Kirill Borziak, Aitor Álvarez-Fernández, Timothy L. Karr et al.     Seminal fluid proteins (SFPs) are emerging as fundamental contributors to sexual selection given their role in post-mating reproductive events, particularly in polyandrous …             Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells ▶     Ryo Ohta, Akira Niwa, Yukimasa Taniguchi et al.     Obtaining highly purified differentiated cells via directed differentiation from human pluripotent stem cells (hPSCs) is an essential step for their clinical application. Among …             Shell properties of commercial clam Chamelea gallina are influenced by temperature and solar radiation along a wide latitudinal gradient ▶     Francesca Gizzi, Maria Giulia Caccia, Ginevra Allegra Simoncini et al.     Phenotype can express different morphologies in response to biotic or abiotic environmental influences. Mollusks are particularly sensitive to different environmental parameters, …             Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer’s Disease ▶     Yen-Ching Chen, Chi-Jung Hsiao, Chien-Cheng Jung et al.     Previous genome-wide association studies using P-values to select single nucleotide polymorphisms (SNPs) have suffered from high false-positive and false-negative results. This …             Isolation and mass spectrometry analysis of urinary extraexosomal proteins ▶     Siri Hildonen, Ellen Skarpen, Trine Grønhaug Halvorsen et al.     The aim of the present study was to develop a LC-MS/MS-based proteomic analysis method of urinary exosomal proteins that has the potential to discover disease biomarkers. In …             Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins ▶     Fuliang He, Hongwei Zhao, Shan Dai et al.     Either acute or sub-acute Budd–Chiari syndrome (BCS) with diffuse occlusion of hepatic veins has a high mortality rate and remains challenging for clinical treatment. We aimed to …             An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities ▶     O. N. Silva, C. de la Fuente-Núñez, E. F. Haney et al.     Antibiotic-resistant infections are predicted to kill 10 million people per year by 2050, costing the global economy $100 trillion. Therefore, there is an urgent need to develop …             Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila ▶     Estefania Cerro-Herreros, Juan M. Fernandez-Costa, María Sabater-Arcis et al.     Myotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in …             Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain ▶     Stéphanie Ventéo, Sophie Laffray, Christiane Wetzel et al.     Identification of the molecular mechanisms governing sensory neuron subtype excitability is a key requisite for the development of treatments for somatic sensory disorders. Here, …             Turmeric powder and its derivatives from Curcuma longa rhizomes: Insecticidal effects on cabbage looper and the role of synergists ▶     Wagner de Souza Tavares, Yasmin Akhtar, Gabriel Luiz Padoan Gonçalves et al.     Curcuma longa has well-known insecticidal and repellent effects on insect pests, but its impact on Trichoplusia ni is unknown. In this study, the compound ar-turmerone, extracted …             Distinct sets of locomotor modules control the speed and modes of human locomotion ▶     Hikaru Yokoyama, Tetsuya Ogawa, Noritaka Kawashima et al.     Although recent vertebrate studies have revealed that different spinal networks are recruited in locomotor mode- and speed-dependent manners, it is unknown whether humans share …             Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems ▶     Dola Sengupta, Sandip Kar     Bone morphogenetic protein 2 (BMP2), differentially regulates the developmental lineage commitment of neural stem cells (NSC’s) in central and peripheral nervous systems. …             Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release ▶     Guang Xin, Zeliang Wei, Chengjie Ji et al.     Thrombosis and its complications are the leading cause of death in patients with diabetes. Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to …             Overexpression of soluble RAGE in mesenchymal stem cells enhances their immunoregulatory potential for cellular therapy in autoimmune arthritis ▶     Min-Jung Park, Seung Hoon Lee, Su-Jin Moon et al.     Mesenchymal stem cells (MSCs) are attractive agents for cellular therapy in rheumatoid arthritis (RA). The receptor for advanced glycation end products (RAGE) serves as a pattern …             Subdiffusion in Membrane Permeation of Small Molecules ▶     Christophe Chipot, Jeffrey Comer     Within the solubility–diffusion model of passive membrane permeation of small molecules, translocation of the permeant across the biological membrane is traditionally assumed to …             Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine ▶     Melissa Nyendak, Gwendolyn M. Swarbrick, Amanda Duncan et al.     The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by the absence of correlates of protective immunity. One correlate would be the ability of …             AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes ▶     Yuanyuan Guo, Cai Lin, Peng Xu et al.     Autophagy is essential in physiological and pathological processes, however, the role of autophagy in cutaneous wound healing and the underlying molecular mechanism remain …             Evidence of the presence of nucleic acids and β-glucan in the matrix of non-typeable Haemophilus influenzae in vitro biofilms ▶     Mirian Domenech, Elena Pedrero-Vega, Alicia Prieto et al.     Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative bacterium that frequently colonizes the human nasopharynx; it is a common cause of chronic and recurrent otitis …             Coral symbioses under prolonged environmental change: living near tolerance range limits ▶     Eugenia M. Sampayo, Tyrone Ridgway, Lorenzo Franceschinis et al.     As climate change progresses, understanding the long-term response of corals and their endosymbionts (Symbiodinium) to prolonged environmental change is of immediate importance. …             A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes ▶     Maria Allhorn, Sabine Arve, Holger Brüggemann et al.     The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated …             Systems-wide analysis of manganese deficiency-induced changes in gene activity of Arabidopsis roots ▶     Jorge Rodríguez-Celma, Yi-Hsiu Tsai, Tuan-Nan Wen et al.     Manganese (Mn) is pivotal for plant growth and development, but little information is available regarding the strategies that evolved to improve Mn acquisition and cellular …             Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan ▶     Xifeng Wu, Chi Pang Wen, Yuanqing Ye et al.     The objective of this study was to develop markedly improved risk prediction models for lung cancer using a prospective cohort of 395,875 participants in Taiwan. Discriminatory …             Microbial community dynamics in the rhizosphere of a cadmium hyper-accumulator ▶     J. L. Wood, C. Zhang, E. R. Mathews et al.     Phytoextraction is influenced by the indigenous soil microbial communities during the remediation of heavy metal contaminated soils. Soil microbial communities can affect plant …             Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies ▶     Federico Martinón-Torres, Eileen Png, Chiea Chuen Khor et al.     Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both …             CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells ▶     Paula Ruiz, Marta Martin-Millan, M. C. Gonzalez-Martin et al.     It is well established that activation of Wnt/βcatenin signaling in the osteoblast lineage leads to an increase in bone mass through a dual mechanism: increased …             Pollutant-induced cell death and reactive oxygen species accumulation in the aerial roots of Chinese banyan (Ficus microcarpa) ▶     Nan Liu, Ce Cao, Zhongyu Sun et al.     Industrial pollutants induce the production of toxic reactive oxygen species (ROS) such as O2.−, H2O2, and ·OH in plants, but they have not been well quantified or localized in …             Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown ▶     Masafumi Takaji, Atsushi Takemoto, Chihiro Yokoyama et al.     The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate …             Colour formation on the wings of the butterfly Hypolimnas salmacis by scale stacking ▶     Radwanul Hasan Siddique, Silvia Vignolini, Carolin Bartels et al.     The butterfly genus Hypolimnas features iridescent blue colouration in some areas of its dorsal wings. Here, we analyse the mechanisms responsible for such colouration on the …             ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress ▶     Jing Zhou, Lianping Ge, Changkai Jia et al.     The role of ROS in stem cell biology has not been fully illustrated and understood. Here we compared the different responses and investigated the mechanism underlying oxidative …             INO80 is Required for Osteogenic Differentiation of Human Mesenchymal Stem Cells ▶     Chenchen Zhou, Jing Zou, Shujuan Zou et al.     Bone marrow derived human mesenchymal stem cells (MSC) are a great source in bone tissue engineering. However, how to improve the efficiency of MSC osteogenesis remains a big …             Intraepithelial dendritic cells and sensory nerves are structurally associated and functional interdependent in the cornea ▶     Nan Gao, Patrick Lee, Fu-Shin Yu     The corneal epithelium consists of stratified epithelial cells, sparsely interspersed with dendritic cells (DCs) and a dense layer of sensory axons. We sought to assess the …             A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis ▶     Yating Li, Tao Zhang, Yuncai Zhou et al.     The presenilin-mediated Notch1 cleavage pathway plays a critical role in controlling pancreatic beta cell fate and survival. The aim of the present study was to investigate the …             DPDR-CPI, a server that predicts Drug Positioning and Drug Repositioning via Chemical-Protein Interactome ▶     Heng Luo, Ping Zhang, Xi Hang Cao et al.     The cost of developing a new drug has increased sharply over the past years. To ensure a reasonable return-on-investment, it is useful for drug discovery researchers in both …             Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches ▶     Yingdong Zhu, Pei Wang, Wei Sha et al.     Mounting evidence suggests that whole grain (WG) intake plays an important role in chronic disease prevention. However, numerous human studies have failed to produce clear-cut …             miR-19b Regulates Ventricular Action Potential Duration in Zebrafish ▶     Alexander Benz, Mandy Kossack, Dominik Auth et al.     Sudden cardiac death due to ventricular arrhythmias often caused by action potential duration (APD) prolongation is a common mode of death in heart failure (HF). microRNAs, …             Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease ▶     G. S. M. Sundaram, Dhruva D. Dhavale, Julie L. Prior et al.     Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an earlier …                       nature.com webcasts Join us for our upcoming webcast with live Q&A presented by BioPharma Dealmakers ADVANCES IN PRECISION MEDICINE AND GENOMIC SEQUENCING Sponsored by: Aperiomics Inc. | Bluebee | iNanoBio | Becton Dickinson (BD)               • Careers & Jobs         naturejobs.com Science jobs of the week       Research Associate     University College London (UCL)            Clinical Research Fellow     University of Cambridge            Research Assistant     Queen's University Belfast            Cancer Research 4 Year PhD Studentships 2017     Cancer Research UK Manchester Institute            Research Fellow     University of Brighton            Postdoctoral Researcher     University of British Columbia (UBC)            Research Technician     University of Bristol            Postdoctoral Position     University of Texas Health Science Center at Tyler            Postdoctoral Fellow / Research Associate     Augusta University            Postdoc (m / f)     Ulm University          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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