EMBO reports Table of Contents for October 2016; Vol. 17, No. 10

October 2016 | Volume 17, Number 10 Submit Table of Contents Science & Society Review Scientific Reports Articles Volume 17, Number 10 Science & Society Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules The social and cultural environment influences the development of the human brain and its synaptic connectivity from birth into adulthood. This knowledge could inspire and inform educational programs to constructively interact with the neuronal architecture of the brain. Kathinka Evers and Jean‐Pierre Changeux Published online 09.09.2016 Editing EU legislation to fit plant genome editing: The use of genome editing technologies in plant breeding requires a novel regulatory approach for new plant varieties that involves farmers New genome editing techniques require a novel approach to regulating genetically modified organisms. This article proposes a product‐based regulatory framework that puts more emphasis on farmers and public acceptance. Agnes E Ricroch, Klaus Ammann, and Marcel Kuntz Published online 14.09.2016 Challenges and options for disease vector control: The outbreak of Zika virus in South America and increasing insecticide resistance among mosquitoes have rekindled efforts for controlling disease vectors Vector control that targets disease‐transmitting insects has been used very efficiently to halt the spread of malaria and dengue fever. Increasing resistance to insecticides and new outbreaks of mosquito‐transmitted diseases has put the focus on both proven and novel sophisticated technologies to control disease vectors. Philip Hunter Published online 05.09.2016 Review The integrated stress response In order to restore cellular homeostasis, stress stimuli activate a common adaptive pathway termed the integrated stress response (ISR). This review highlights the current understanding of ISR pathways and how these regulate cell fate under diverse stress conditions. Karolina Pakos‐Zebrucka, Izabela Koryga, Katarzyna Mnich, Mila Ljujic, Afshin Samali, and Adrienne M Gorman Published online 14.09.2016 Scientific Reports ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules The microcephaly gene ASPM recruits the cytokinesis regulator CITK to the mitotic spindle of neural progenitor cells, where it promotes the nucleation and stabilization of astral microtubules, providing a link between the two microcephaly proteins. Marta Gai, Federico T Bianchi, Cristiana Vagnoni, Fiammetta Vernì, Silvia Bonaccorsi, Selina Pasquero, Gaia E Berto, Francesco Sgrò, Alessandra MA Chiotto, Laura Annaratone, Anna Sapino, Anna Bergo, Nicoletta Landsberger, Jacqueline Bond, Wieland B Huttner, and Ferdinando Di Cunto Published online 25.08.2016 Capture‐C reveals preformed chromatin interactions between HIF‐binding sites and distant promoters Preexisting long‐range interactions between HIF‐binding sites and promoters as well as other enhancers shape the transcriptional architecture of the cellular response to hypoxia. James L Platt, Rafik Salama, James Smythies, Hani Choudhry, James OJ Davies, Jim R Hughes, Peter J Ratcliffe, and David R Mole Published online 08.08.2016 TRPA1 and TRPV1 contribute to iodine antiseptics‐associated pain and allergy This report identifies the cation channel TRPA1 as an endogenous molecular target of iodine in mammals. The iodine‐dependent activation of TRPA1 and also TRPV1 is associated with major iodine antiseptics‐induced adverse reactions such as pain and cutaneous allergy. Deyuan Su, Hong Zhao, Jinsheng Hu, Dan Tang, Jianmin Cui, Ming Zhou, Jian Yang, and Shu Wang Published online 26.08.2016 Structural role of the T94I rhodopsin mutation in congenital stationary night blindness Congenital stationary night blindness (CSNB) is an inherited retinal dysfunction. This study compares the molecular impact of CSNB‐causing rhodopsin mutations T94I and G90D using X‐ray crystallography, molecular dynamic simulations, and kinetic biochemical analysis. Ankita Singhal, Ying Guo, Milos Matkovic, Gebhard Schertler, Xavier Deupi, Elsa CY Yan, and Joerg Standfuss Published online 25.07.2016 Pseudouridylation of 7SK snRNA promotes 7SK snRNP formation to suppress HIV‐1 transcription and escape from latency 7SK snRNA function is regulated by pseudouridylation, which stabilizes P‐TEFb‐sequestering 7SK snRNP and suppresses the transcription of HIV‐1 and cellular genes. Yang Zhao, John Karijolich, Britt Glaunsinger, and Qiang Zhou Published online 24.08.2016 Articles A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two‐cell embryos The ERV‐associated lincRNA, LincGET, is essential for mouse embryonic development beyond the two‐cell stage. LincGET forms an RNA‐protein complex with hnRNP U, FUBP1, and ILF2, participating in transcription regulation and exon skipping splicing activities. Jiaqiang Wang, Xin Li, Leyun Wang, Jingyu Li, Yanhua Zhao, Gerelchimeg Bou, Yufei Li, Guanyi Jiao, Xinghui Shen, Renyue Wei, Shichao Liu, Bingteng Xie, Lei Lei, Wei Li, Qi Zhou, and Zhonghua Liu Published online 05.08.2016 Pharmacological eEF2K activation promotes cell death and inhibits cancer progression Elongation factor 2 kinase (eEF2K) is part of an adaptation pathway that enables cells to cope with nutrient deprivation by regulating translation rates. Pharmacological activation of the eEF2K pathway via the anti‐viral drug nelfinavir rewires this stress adaptation program into a response that is detrimental for tumor growth. Aude De Gassart, Olivier Demaria, Rébecca Panes, Léa Zaffalon, Alexey G Ryazanov, Michel Gilliet, and Fabio Martinon Published online 29.08.2016 SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death Here, SPATA2 is identified as interaction partner of the deubiquitinase CYLD, mediating its recruitment to the TNF receptor signaling complex, and promoting CYLD activity. SPATA2 is essential for TNFR complex II formation, whereas its loss enhances NF‐κB and MAPK signaling and impairs TNF‐dependent cell death. Lisa Schlicher, Manuela Wissler, Florian Preiss, Prisca Brauns‐Schubert, Celia Jakob, Veronica Dumit, Christoph Borner, Joern Dengjel, and Ulrich Maurer Published online 25.07.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.