The EMBO Journal Table of Contents for 4 October 2016; Vol. 35, No. 19

4 October 2016 | Volume 35, Number 19 Submit Table of Contents News & Views Articles Resource Volume 35, Number 19 News & Views A plant solution to the CDK conundrum in the DNA damage response Halting the cell cycle yet allowing CDK stimulation of DNA repair creates a catch‐22 situation that can be solved by specialized cyclin‐CDK complexes. Bénédicte Desvoyes and Crisanto Gutierrez Published online 29.08.2016 A code within a code: how codons influence mRNA stability Recent work in fish, flies, and mice has identified a conserved pattern of codon optimality, highlighting the regulatory effect of translation rates on mRNA stability in both development and homeostasis. Javier Martinez and Bojan Zagrovic Published online 25.08.2016 Methionine on the rise: how mitochondria changed their codon usage The discovery that NSUN3 and ABH1 specifically modify mt‐tRNAMet sheds light on the basis for efficient translation in mitochondria. Felix Boos, Michael Wollin, and Johannes M Herrmann Published online 30.08.2016 Articles The plant‐specific CDKB1‐CYCB1 complex mediates homologous recombination repair in Arabidopsis A division‐of‐labor strategy allows plants to provide repair‐stimulating CDK activity while still blocking mitosis‐driving cyclin‐dependent kinases upon DNA damage. Annika K Weimer, Sascha Biedermann, Hirofumi Harashima, Farshad Roodbarkelari, Naoki Takahashi, Julia Foreman, Yonsheng Guan, Gaëtan Pochon, Maren Heese, Daniël Van Damme, Keiko Sugimoto, Csaba Koncz, Peter Doerner, Masaaki Umeda, and Arp Schnittger Published online 05.08.2016 Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition In addition to spelling out protein sequence, mRNA codon triplets contain translation‐dependent regulatory information that influences transcript stability and contributes to controlled turnover of maternal mRNAs in frogs, mice, and flies. Ariel A Bazzini, Florencia del Viso, Miguel A Moreno‐Mateos, Timothy G Johnstone, Charles E Vejnar, Yidan Qin, Jun Yao, Mustafa K Khokha, and Antonio J Giraldez Published online 19.07.2016 NSUN3 and ABH1 modify the wobble position of mt‐tRNAMet to expand codon recognition in mitochondrial translation RNA methyltransferase NSUN3 acts specifically on mitochondrial tRNAMet, allowing different codons to be recognised by this single tRNA and offering insight on the consequence of reported disease mutations. Sara Haag, Katherine E Sloan, Namit Ranjan, Ahmed S Warda, Jens Kretschmer, Charlotte Blessing, Benedikt Hübner, Jan Seikowski, Sven Dennerlein, Peter Rehling, Marina V Rodnina, Claudia Höbartner, and Markus T Bohnsack Published online 05.08.2016 Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes Lysosomes containing α‐synuclein fibrils can transfer between primary neurons via tunneling nanotubes. Saïda Abounit, Luc Bousset, Frida Loria, Seng Zhu, Fabrice de Chaumont, Laura Pieri, Jean‐Christophe Olivo‐Marin, Ronald Melki, and Chiara Zurzolo Published online 22.08.2016 Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator Co‐crystallization of the Hrr25 kinase and its monopolin complex binding partner Mam1 shows the mechanism of Hrr25 recruitment to kinetochores in meiosis I and suggests a conserved mode of CK1‐family kinase regulation. Qiaozhen Ye, Sarah N Ur, Tiffany Y Su, and Kevin D Corbett Published online 04.08.2016 Resource Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging A combination of quantitative approaches allows to estimate the absolute and relative abundance of key centrosomal and centriolar proteins in human cells. Manuel Bauer, Fabien Cubizolles, Alexander Schmidt, and Erich A Nigg Published online 18.08.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.