Nature Cell Biology contents: October 2016 Volume 18 Number 10, pp 1025 - 1109

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Advertisement OPENING NEW DOORS TO A WHOLE NEW VIEW OF BIOLOGY  Go beyond snapshots and analyze global protein dynamics more deeply by harnessing the true power of accurate TMT-based quantitative proteomics. A new web resource highlighting critical advances across the entire workflow is now available! TABLE OF CONTENTS October 2016 Volume 18, Issue 10 News and Views Articles Letter Erratum Advertisement   Contamination with microorganisms such as mycoplasma or cross-contamination with other eukaryotic cells continues to present the most severe challenges for cell culture laboratories worldwide. Get some background information about this topic and some tips and tricks from the Eppendorf cell handling experts to master this daily challenge in your lab. Click here     Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Therapeutic approaches to enhance natural killer cell cytotoxicity: the force awakens This Poster discusses the growing armamentarium of Natural Killer cell based anticancer approaches and provides an overview of the strategies and agents in preclinical and clinical research.  Download the Poster free online Produced with support from Lonza Bioscience Solutions     Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Automating Continuous Cell Culture Date: Tuesday October 11, 2016 Time: 7AM PDT, 10AM EDT, 3PM BST, 4PM CEST Speaker: Oliver Gaßmann, Application Specialist, Beckman Coulter Life Sciences Register for the webcast and live Q&A session Sponsored by: Beckman Coulter Life Sciences     News and Views Top Turn up the lysosome   pp1025 - 1027 Paul Saftig and Albert Haas doi:10.1038/ncb3409 Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal digestive functions can be promoted in isolated cells and mice by pharmacologically stimulating the autophagy- and lysosome-regulating transcription factors TFEB and ZKSCAN3 through previously unrecognized mTORC1-independent pathways acting via PKC. See also: Article by Li et al. Regional tumour glutamine supply affects chromatin and cell identity   pp1027 - 1029 Jonas W. Højfeldt and Kristian Helin doi:10.1038/ncb3414 Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells. See also: Article by Pan et al. Cell Biology JOBS of the week Interdisciplinary Professorship for Quantitative Cell Biology Westfälische Wilhelms-Universität Münster Postdoctoral Fellow -- Molecular and Cell Biology University of Texas Health Science Center at Houston Chair, Cell Biology, Neurobiology and Anatomy Medical College of Wisconsin Assistant Professor - Eukaryotic Cell Biology Department of Biochemistry University of Toronto More Science jobs from Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Defining the immune system at single cell resolution with Seurat Date: Tuesday October 4, 2016 Time: 11AM PDT, 2PM EDT Speaker: Dr Rahul Satija, Assistant Professor, NYU Center for Genomics and Systems Biology  Register for FREE at And learn how to control for heterogeneity in sequencing depth and cell cycle. Sponsored by: 10x Genomics, Inc.     Articles Top iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy   pp1031 - 1042 Kazuki Kodo, Sang-Ging Ong, Fereshteh Jahanbani, Vittavat Termglinchan, Keiichi Hirono et al. doi:10.1038/ncb3411 Kodo et al. show that patient-specific iPSC-derived cardiomyocytes recapitulate the proliferative defects associated with the disease, which are a result of TBX20 mutations and abnormal TGF-β signalling. Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling   pp1043 - 1053 Sanguk Yun, Madhusudhan Budatha, James E. Dahlman, Brian G. Coon, Ryan T. Cameron et al. doi:10.1038/ncb3405 Using a chimaeric integrin α5 (where the tail is replaced by that of α2), Yun et al. show that in endothelial cells, integrin α5 interacts with the cAMP-specific phosphodiesterase PDE4D5 to reduce cAMP levels and inflammation both in vitro and in vivo. Self-repair promotes microtubule rescue   pp1054 - 1064 Charlotte Aumeier, Laura Schaedel, Jérémie Gaillard, Karin John, Laurent Blanchoin et al. doi:10.1038/ncb3406 Microtubules can self-repair in vitro in response to stress. Théry and colleagues now show that such repair can occur in cells, as free tubulin dimers can be incorporated into a damaged microtubule lattice to promote rescue events. Protein kinase C controls lysosome biogenesis independently of mTORC1   pp1065 - 1077 Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song et al. doi:10.1038/ncb3407 Using a chemical screening approach, Yang and colleagues identify PKC as a regulator of lysosome biogenesis, which controls the subcellular localization of TFEB and ZKSCAN3 through parallel signalling pathways and independently of mTORC1. See also: News and Views by Saftig & Haas Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow   pp1078 - 1089 Rachelle W. Johnson, Elizabeth C. Finger, Monica M. Olcina, Marta Vilalta, Todd Aguilera et al. doi:10.1038/ncb3408 Johnson et al. report that loss of leukaemia inhibitory factor receptor (LIFR) signalling reduces the expression of genes associated with dormancy in metastatic breast cancer cells, and promotes bone marrow colonization and osteoclastogenesis. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation   pp1090 - 1101 Min Pan, Michael A. Reid, Xazmin H. Lowman, Rajan P. Kulkarni, Thai Q. Tran et al. doi:10.1038/ncb3410 Pan et al. find that regional glutamine deficiency in melanoma tumours induces tumour cell dedifferentiation and confers therapeutic resistance through histone methylation changes. See also: News and Views by Højfeldt & Helin Advertisement Nature Plants is now accepting submissions! Do you have something in the pipeline? Consider us for your next research paper. Find out how to submit in the Guide to Authors. Submit your research.   Letter Top EB1 interacts with outwardly curved and straight regions of the microtubule lattice   pp1102 - 1108 Audrey Guesdon, Franck Bazile, Rubén M. Buey, Renu Mohan, Solange Monier et al. doi:10.1038/ncb3412 Guesdon et al. characterize the microtubule-end-binding region of EB1 using cryo-electron tomography, providing insights into the mechanism of this interaction and the architectural changes in the GTP-cap region during microtubule growth. Erratum Top Erratum: Sex hormones establish a reserve pool of adult muscle stem cells   p1109 Ji-Hoon Kim, Gi-Chan Han, Ji-Yun Seo, Inkuk Park, Wookjin Park et al. doi:10.1038/ncb3416 Top Advertisement AGRICULTURAL GENOMICS 2016 — FROM VARIATION TO IMPROVED PRODUCTION  Hosting Organizations: Institute of Plant Physiology and Ecology, SIBS, CAS | Nature Genetics November 6-8, 2016  Crowne Plaza Shanghai|Xiayang Lake, China REGISTER NOW!    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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