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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | A dendritic disinhibitory circuit mechanism for pathway-specific gating OPEN | | | Guangyu Robert Yang, John D. Murray and Xiao-Jing Wang | | | Cortical circuits receive simultaneous inputs from multiple pathways and are able to flexibly select the appropriate inputs for processing. Here the authors propose a network model in which dendritic branch-specific disinhibition established through synaptic plasticity achieves pathway-specific gating. | | | 20 September 2016 | doi: 10.1038/ncomms12815 | | |
| Windblown Pliocene diatoms and East Antarctic Ice Sheet retreat OPEN | | | Reed P. Scherer, Robert M. DeConto, David Pollard and Richard B. Alley | | | A long-standing debate regarding the Pliocene history of the East Antarctic Ice Sheet was spurred by the discovery of marine diatoms in the Transantarctic Mountains. Here the authors show that the diatoms were emplaced by wind following a retreat of the ice sheet into coastal basins and subsequent isostatic emergence. | | | 20 September 2016 | doi: 10.1038/ncomms12957 | | |
| A physical zero-knowledge object-comparison system for nuclear warhead verification OPEN | | | Sébastien Philippe, Robert J. Goldston, Alexander Glaser and Francesco d’Errico | | | Zero-knowledge proofs can be used to prove that a statement is true without revealing why it is. Here the authors demonstrate a non-electronic fast neutron radiography technique to confirm that two objects are identical without revealing any details about their design or composition. | | | 20 September 2016 | doi: 10.1038/ncomms12890 | | |
| Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein OPEN | | | Takuma Hashimoto, Daiki D. Horikawa, Yuki Saito, Hirokazu Kuwahara, Hiroko Kozuka-Hata, Tadasu Shin-I, Yohei Minakuchi, Kazuko Ohishi, Ayuko Motoyama, Tomoyuki Aizu, Atsushi Enomoto, Koyuki Kondo, Sae Tanaka, Yuichiro Hara, Shigeyuki Koshikawa, Hiroshi Sagara, Toru Miura, Shin-ichi Yokobori, Kiyoshi Miyagawa, Yutaka Suzuki et al. | | | Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade protein Dsup which suppresses DNA damage. | | | 20 September 2016 | doi: 10.1038/ncomms12808 | | |
| Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels OPEN | | | Martina Rangl, Atsushi Miyagi, Julia Kowal, Henning Stahlberg, Crina M. Nimigean and Simon Scheuring | | | Some ion channels are modulated by binding of cyclic nucleotide to a cyclic nucleotide-binding domain. Here, the authors use high-speed atomic force microscopy to directly monitor the conformational changes induced by ligand binding to a cyclic nucleotide-modulated channel from Mesorhizobium loti. | | | 20 September 2016 | doi: 10.1038/ncomms12789 | | |
| Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair OPEN | | | Volker Middel, Lu Zhou, Masanari Takamiya, Tanja Beil, Maryam Shahid, Urmas Roostalu, Clemens Grabher, Sepand Rastegar, Markus Reischl, Gerd Ulrich Nienhaus and Uwe Strähle | | | Sarcolemma lesions are sealed by a repair patch of lipids and proteins that prevents cell death and myopathy. Here the authors show that the "eat-me" signal phosphatidylserine is sorted from adjacent sarcolemma to the repair patch in a Dysferlin dependent process in zebrafish and human cells. | | | 19 September 2016 | doi: 10.1038/ncomms12875 | | |
| Local microRNA delivery targets Palladin and prevents metastatic breast cancer OPEN | | | Avital Gilam, João Conde, Daphna Weissglas-Volkov, Nuria Oliva, Eitan Friedman, Natalie Artzi and Noam Shomron | | | MicroRNAs represent potential therapeutic targets to control metastasis progression. Here the authors show that miR-96 and miR-182 regulate invasion via Palladin and demonstrate that local delivery of miR-96 and miR-182 may serve as a potential anti-metastatic drug in breast cancer. | | | 19 September 2016 | doi: 10.1038/ncomms12868 | | |
| Structural basis of synaptic vesicle assembly promoted by α-synuclein OPEN | | | Giuliana Fusco, Tillmann Pape, Amberley D. Stephens, Pierre Mahou, Ana Rita Costa, Clemens F. Kaminski, Gabriele S. Kaminski Schierle, Michele Vendruscolo, Gianluigi Veglia, Christopher M. Dobson and Alfonso De Simone | | | α-synuclein, a protein associated to Parkinson's disease, is involved in synaptic vesicle interaction and assembly. Here, the authors use NMR spectroscopy and super-resolution microscopy to unveil the nature and molecular mechanism of α-synuclein-mediated synaptic vesicle clustering. | | | 19 September 2016 | doi: 10.1038/ncomms12563 | | |
| Cortical dynamics during cell motility are regulated by CRL3KLHL21 E3 ubiquitin ligase OPEN | | | Thibault Courtheoux, Radoslav I. Enchev, Fabienne Lampert, Juan Gerez, Jochen Beck, Paola Picotti, Izabela Sumara and Matthias Peter | | | Although focal adhesions (FAs) and microtubules (MTs) are known to associate, the underlying regulation of this dynamic interaction is not understood. Here the authors discover that the CRL3KLHL21 E3 ubiquitin ligase localises to FAs and ubiquitinates the MT plus-tip binding protein EB1, thereby promoting MT and FA dynamics and cell migration. | | | 19 September 2016 | doi: 10.1038/ncomms12810 | | |
| Mechanosensory neurons control sweet sensing in Drosophila OPEN | | | Yong Taek Jeong, Soo Min Oh, Jaewon Shim, Jeong Taeg Seo, Jae Young Kwon and Seok Jun Moon | | | How different sensory modalities interact to control feeding is poorly understood. Here, authors show that in Drosophila, activation of labellar mechanosensory neurons causes inhibition of sweet-sensing gustatory receptor neurons, as a result, Drosophila prefer soft food at the expense of sweetness. | | | 19 September 2016 | doi: 10.1038/ncomms12872 | | |
| PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells OPEN | | | Corina T. Madreiter-Sokolowski, Christiane Klec, Warisara Parichatikanond, Sarah Stryeck, Benjamin Gottschalk, Sergio Pulido, Rene Rost, Emrah Eroglu, Nicole A. Hofmann, Alexander I. Bondarenko, Tobias Madl, Markus Waldeck-Weiermair, Roland Malli and Wolfgang F. Graier | | | MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+ uptake activity. | | | 19 September 2016 | doi: 10.1038/ncomms12897 | | |
| Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks OPEN | | | Pauline Chanut, Sébastien Britton, Julia Coates, Stephen P. Jackson and Patrick Calsou | | | Homologous recombination requires end resection of the DNA at the site of the break, however the Ku dimer can sequester single-ended double-strand breaks. Here the authors show that ATM-dependent phosphorylation of CtIP, along with the actions of Mre11, impair the stable loading of Ku onto DNA. | | | 19 September 2016 | doi: 10.1038/ncomms12889 | | |
| Close-packed polymer crystals from two-monomer-connected precursors OPEN | | | Hong-Joon Lee, Yong-Ryun Jo, Santosh Kumar, Seung Jo Yoo, Jin-Gyu Kim, Youn-Joong Kim, Bong-Joong Kim and Jae-Suk Lee | | | Crystalline polymers with functionalities along the backbone can store and transfer electrons, ions and gases and thus can be used in devices. However, the formation of such materials can be difficult. Here, Lee and others have produced highly crystalline conjugated polymers via two-monomer-connected precursors. | | | 19 September 2016 | doi: 10.1038/ncomms12803 | | |
| N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold OPEN | | | Andreas J. W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka and Markus Engstler | | | How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N-linked glycans help to prevent retarding intermolecular interactions. | | | 19 September 2016 | doi: 10.1038/ncomms12870 | | |
| CDK1 phosphorylates WRN at collapsed replication forks OPEN | | | Valentina Palermo, Sara Rinalducci, Massimo Sanchez, Francesca Grillini, Joshua A. Sommers, Robert M. Brosh, Lello Zolla, Annapaola Franchitto and Pietro Pichierri | | | End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks. | | | 16 September 2016 | doi: 10.1038/ncomms12880 | | |
| Gold nanocrystals with DNA-directed morphologies OPEN | | | Xingyi Ma, June Huh, Wounjhang Park, Luke P. Lee, Young Jik Kwon and Sang Jun Sim | | | Bottom-up synthesis of colloidal metallic nanomaterials with a designable structure is challenging. Here, the authors report the directed crystallisation of gold by a single DNA molecular regulator, using it to synthesise gold nanocrystals with defined complex morphologies. | | | 16 September 2016 | doi: 10.1038/ncomms12873 | | |
| Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes OPEN | | | John A. Lees, Minna Vehkala, Niko Välimäki, Simon R. Harris, Claire Chewapreecha, Nicholas J. Croucher, Pekka Marttinen, Mark R. Davies, Andrew C. Steer, Steven Y. C. Tong, Antti Honkela, Julian Parkhill, Stephen D. Bentley and Jukka Corander | | | Plasticity and clonal population structure in bacterial genomes can hinder traditional SNP-based genetic association studies. Here, Corander and colleagues present a method to identify variable-length sequence elements enriched in a phenotype of interest, and demonstrate its use in human pathogens. | | | 16 September 2016 | doi: 10.1038/ncomms12797 | | |
| Determining crystal structures through crowdsourcing and coursework OPEN | | | Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A. Winburn, Seth Cooper, Jeff Flatten, David S. Rogawski, Nicole M. Koropatkin, Tsinatkeab T. Hailu, Neha Jain, Philipp Koldewey, Logan S. Ahlstrom, Matthew R. Chapman, Andrew P. Sikkema, Meredith A. Skiba, Finn P. Maloney, Felix R. M. Beinlich, null null, Ahmet Caglar et al. | | | Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure, and find that crowdsourcing model-building works. | | | 16 September 2016 | doi: 10.1038/ncomms12549 | | |
| Efficient hydrogen evolution by ternary molybdenum sulfoselenide particles on self-standing porous nickel diselenide foam OPEN | | | Haiqing Zhou, Fang Yu, Yufeng Huang, Jingying Sun, Zhuan Zhu, Robert J. Nielsen, Ran He, Jiming Bao, William A. Goddard III, Shuo Chen and Zhifeng Ren | | | There is on-going research into efficient noble metal-free materials for electrocatalytic hydrogen evolution. Here, the authors prepare ternary molybdenum sulfoselenide particles supported on three-dimensional porous nickel selenide foam, and demonstrate the high efficiency of the hydrogen evolving composite. | | | 16 September 2016 | doi: 10.1038/ncomms12765 | | |
| Air-stable superparamagnetic metal nanoparticles entrapped in graphene oxide matrix OPEN | | | Jiří Tuček, Zdeněk Sofer, Daniel Bouša, Martin Pumera, Kateřina Holá, Aneta Malá, Kateřina Poláková, Markéta Havrdová, Klára Čépe, Ondřej Tomanec and Radek Zbořil | | | Zero-valent metallic nanoparticles can exhibit superparamagnetism, due to quantum effects in magnetic nanomaterials, but their syntheses can be hindered by chemical instability. Here, the authors prepare air-stable superparamagnetic nanoparticles trapped between thermally reduced graphene oxide nanosheets. | | | 15 September 2016 | doi: 10.1038/ncomms12879 | | |
| Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS OPEN | | | Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa and Shuji Kaneko | | | The transient receptor potential ankyrin 1 (TRPA1) is a cation channel that is involved in nociceptive pain sensing. Here, the authors show that hydroxylation of a proline in the N terminus of TRPA1 renders it sensitive to reactive oxygen species resulting from noxious cold. | | | 15 September 2016 | doi: 10.1038/ncomms12840 | | |
| Metastatic progression is associated with dynamic changes in the local microenvironment OPEN | | | Nicole M. Aiello, David L. Bajor, Robert J. Norgard, Amine Sahmoud, Neha Bhagwat, Minh N. Pham, Toby C. Cornish, Christine A. Iacobuzio-Donahue, Robert H. Vonderheide and Ben Z. Stanger | | | Metastatic colonization—the growth of single metastatic cells or small lesions into gross metastases—is poorly understood. Here, the authors characterize the natural history of metastatic growth and assess the impact of chemotherapy in an autochthonous model of pancreatic cancer. | | | 15 September 2016 | doi: 10.1038/ncomms12819 | | |
| Nonlinear spectra of spinons and holons in short GaAs quantum wires OPEN | | | M Moreno, C. J. B. Ford, Y. Jin, J. P. Griffiths, I. Farrer, G. A. C. Jones, D. A. Ritchie, O. Tsyplyatyev and A. J. Schofield | | | Recently, theories have emerged that describe the nonlinear high-energy excitations of one-dimensional electronic fluids. Here, the authors report experimental evidence of their existence and behaviour in tunnelling spectra of short GaAs quantum wires. | | | 15 September 2016 | doi: 10.1038/ncomms12784 | | |
| A second DNA binding site in human BRCA2 promotes homologous recombination OPEN | | | Catharina von Nicolai, Åsa Ehlén, Charlotte Martin, Xiaodong Zhang and Aura Carreira | | | BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair. | | | 15 September 2016 | doi: 10.1038/ncomms12813 | | |
| An experimental phylogeny to benchmark ancestral sequence reconstruction OPEN | | | Ryan N. Randall, Caelan E. Radford, Kelsey A. Roof, Divya K. Natarajan and Eric A. Gaucher | | | Methods for ancestral sequence reconstruction are currently tested with computer simulations, since true biological phylogenies are unknown. Here, Randall et al. build an experimental phylogeny to benchmark the performance of alternate ancestral sequence reconstruction algorithms in inferring ancestral genotypes and phenotypes. | | | 15 September 2016 | doi: 10.1038/ncomms12847 | | |
| Self-assembly of biomorphic carbon/sulfur microstructures in sulfidic environments OPEN | | | Julie Cosmidis and Alexis S. Templeton | | | Organic materials mineralized with sulfur are considered to be a product of biological activity in natural environments and the fossil record. Here, Cosmidis and Templeton show that sulfide can abiotically drive the self-assembly of organic carbon microstructures mineralized with elemental sulfur. | | | 15 September 2016 | doi: 10.1038/ncomms12812 | | |
| The sources of atmospheric black carbon at a European gateway to the Arctic OPEN | | | P Winiger, A Andersson, S Eckhardt, A Stohl and Ö. Gustafsson | | | Black carbon (BC) contributes positively to the radiation budget, yet models are unable to correctly capture its seasonal variability in the Arctic. Here, the authors demonstrate improved model skill in simulating BC concentration and sources when including estimates of BC emissions from fires. | | | 15 September 2016 | doi: 10.1038/ncomms12776 | | |
| MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C OPEN | | | Khaled Thabet, Anastasia Asimakopoulos, Maryam Shojaei, Manuel Romero-Gomez, Alessandra Mangia, William L. Irving, Thomas Berg, Gregory J. Dore, Henning Grønbæk, David Sheridan, Maria Lorena Abate, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Janett Fischer, Ulrich Spengler, Jacob Nattermann, Ahmed Wahid et al. | | | Chronic Hepatitis C infection is associated with a broad spectrum of liver pathologies, ranging from inflammation to fibrosis and liver cancer. Here Thabet et al. identified a polymorphism in the gene MBOAT7 that is associated with increased hepatic inflammation and higher risk of fibrosis development and progression. | | | 15 September 2016 | doi: 10.1038/ncomms12757 | | |
| IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses OPEN | | | Chang-Min Lee, Chuan Hua He, Adel M. Nour, Yang Zhou, Bing Ma, Jin Wook Park, Kyung Hee Kim, Charles Dela Cruz, Lokesh Sharma, Mahmoud L. Nasr, Yorgo Modis, Chun Geun Lee and Jack A. Elias | | | Chitinase 3-like 1 regulates cell death, inflammation and tissue remodelling via IL-13receptorα2. Here, the authors show that TMEM219 is a IL-13Rα2 co-receptor and modulates oxidant-induced apoptosis and lung injury, melanoma metastasis and TGF-β1 signalling, downstream of Chi3l1-IL-13Rα2. | | | 15 September 2016 | doi: 10.1038/ncomms12752 | | |
| PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development OPEN | | | Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez and Pierre Val | | | The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development. | | | 14 September 2016 | doi: 10.1038/ncomms12751 | | |
| Towards optical polarization control of laser-driven proton acceleration in foils undergoing relativistic transparency OPEN | | | Bruno Gonzalez-Izquierdo, Martin King, Ross J. Gray, Robbie Wilson, Rachel J. Dance, Haydn Powell, David A. Maclellan, John McCreadie, Nicholas M. H. Butler, Steve Hawkes, James S. Green, Chris D. Murphy, Luca C. Stockhausen, David C. Carroll, Nicola Booth, Graeme G. Scott, Marco Borghesi, David Neely and Paul McKenna | | | Intense laser pulse interaction with ultra-thin foils constitutes a promising approach for proton acceleration. Here the authors show that the degree of ellipticity in the laser beam polarization can be used to control the proton beam profile. | | | 14 September 2016 | doi: 10.1038/ncomms12891 | | |
| Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9 OPEN | | | Digvijay Singh, Samuel H. Sternberg, Jingyi Fei, Jennifer A. Doudna and Taekjip Ha | | | CRISPR-Cas9 has enabled an unprecedented ability to manipulate the genome yet it is still poorly understood how target recognition functions at a molecular level. Here the authors use single-molecule FRET to probe Cas9-target interaction and identify distinct search and proofreading states. | | | 14 September 2016 | doi: 10.1038/ncomms12778 | | |
| Hidden lattice instabilities as origin of the conductive interface between insulating LaAlO3 and SrTiO3 OPEN | | | P. W. Lee, V. N. Singh, G. Y. Guo, H.-J. Liu, J.-C. Lin, Y.-H. Chu, C. H. Chen and M.-W. Chu | | | The origin of interfacial conductivity between two insulating oxides, LaAlO3 and SrTiO3, remains elusive despite a long time research. Here, Lee et al. report atomic-scale observation of electron-gas formation for screening hidden ferroelectric-like lattice instabilities, discounting the role of polar catastrophe and cation intermixing. | | | 14 September 2016 | doi: 10.1038/ncomms12773 | | |
| The NF-YC–RGL2 module integrates GA and ABA signalling to regulate seed germination in Arabidopsis OPEN | | | Xu Liu, Pengwei Hu, Mingkun Huang, Yang Tang, Yuge Li, Ling Li and Xingliang Hou | | | Crosstalk between gibberellic acid (GA) and abscisic acid (ABA) regulates seed germination. Here the authors show that NF-YC transcription factors can interact with the RGL2 DELLA protein to regulate expression of ABI5 and therefore modulate ABA- and GA-responsive gene expression. | | | 14 September 2016 | doi: 10.1038/ncomms12768 | | |
| The electrophotonic silicon biosensor OPEN | | | José Juan-Colás, Alison Parkin, Katherine E. Dunn, Mark G. Scullion, Thomas F. Krauss and Steven D. Johnson | | | A label-free and low-cost sensor capable of detecting several biomarkers in parallel is a sought-after medical tool. Here, the authors describe an approach exploiting both photonic and electrochemical properties of silicon to build a multi-domain biosensor for label-free and multiplexed detection. | | | 14 September 2016 | doi: 10.1038/ncomms12769 | | |
| Observation of acceleration and deceleration in gigaelectron-volt-per-metre gradient dielectric wakefield accelerators OPEN | | | B. D. O’Shea, G. Andonian, S. K. Barber, K. L. Fitzmorris, S. Hakimi, J. Harrison, P. D. Hoang, M. J. Hogan, B. Naranjo, O. B. Williams, V. Yakimenko and J. B. Rosenzweig | | | Wakefield accelerators are a cheaper and compact alternative to conventional particle accelerators for high-energy physics and coherent x-ray sources. Here, the authors demonstrate a field gradient in excess of a gigaelectron-volt-per-metre using a terahertz-frequency wakefield supported by a dielectric lined-waveguide. | | | 14 September 2016 | doi: 10.1038/ncomms12763 | | |
| Neurons in the primate dorsal striatum signal the uncertainty of object–reward associations OPEN | | | J. Kael White and Ilya E. Monosov | | | The dorsal striatum (DS) is a brain region that is thought to aim actions at certain or known rewards. Here, the authors show that an internal-capsule bordering region of the primate DS signals the uncertainty of object-reward associations, suggesting a novel role for the DS in behavior under uncertainty. | | | 14 September 2016 | doi: 10.1038/ncomms12735 | | |
| Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis OPEN | | | Hong-Yu Wang, Chang-Wu Zheng, Zhuo Chai, Jia-Xing Zhang and Gang Zhao | | | The Strecker reaction is a power method for the synthesis of cyano-substituted compounds. Here the authors report a dual-reagent system for asymmetric Strecker reactions, where an in situ formed organocatalyst/methyl acrylate zwitterionic adduct activates both the cyanide source and the electrophile. | | | 14 September 2016 | doi: 10.1038/ncomms12720 | | |
| The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway OPEN | | | Mélissa Carbonneau, Laurence M. Gagné, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E. Vincent, Anthony Tumber, Laura Hulea, Jonathan Bergeman, Udo Oppermann, Russell G. Jones, Mathieu Laplante, Ivan Topisirovic, Kevin Petrecca, Marc-Étienne Huot and Frédérick A. Mallette | | | Oncogenic mutations of isocitrate dehydrogenases 1 and 2 result in the production of the oncometabolite R-2-hydroxyglutarate. Here the authors show that the oncometabolite promotes mTOR activation in a PTEN/PI3K-independent manner by regulating DEPTOR stability via inhibition of KDM4A activity. | | | 14 September 2016 | doi: 10.1038/ncomms12700 | | |
| A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells OPEN | | | Giulia Bertolin, Florian Sizaire, Gaëtan Herbomel, David Reboutier, Claude Prigent and Marc Tramier | | | Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stability. | | | 14 September 2016 | doi: 10.1038/ncomms12674 | | | | | | | | | | |
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