Nature Reviews Molecular Cell Biology contents October 2016 Volume 17 Number 10 pp 605-673

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TABLE OF CONTENTS
October 2016 Volume 17 Number 10		Advertisement
2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30	In this issue Comment Research Highlights Reviews Also this month Article series: Adult stem cells  Featured article: Mechanisms and regulation of endothelial VEGF receptor signalling Michael Simons, Emma Gordon & Lena Claesson-Welsh	nature.com webcasts Springer Nature presents a custom webcast on: Defining the immune system at single cell resolution with Seurat Date: Tuesday October 4, 2016 Time: 11AM PDT, 2PM EDT Speaker: Dr Rahul Satija, Assistant Professor, NYU Center for Genomics and Systems Biology  Register for FREE at: And learn how to control for heterogeneity in sequencing depth and cell cycle. Sponsored by:  10x Genomics, Inc.
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Comment: Coenzyme A: to make it or uptake it? Ody C.M. Sibon & Erick Strauss p605 | doi:10.1038/nrm.2016.110 Sibon and Strauss discuss literature suggesting that cells can obtain intracellular coenzyme A by pathways in addition to de novo biosynthesis. Abstract | Full Text | PDF | Supplementary information
RESEARCH HIGHLIGHTS Top Metabolism: Mitophagy turns beige adipocytes white p607 | doi:10.1038/nrm.2016.125 A new study shows that the beige-to-white adipocyte transition requires mitophagy. PDF p53: Understanding the actions of 53BP1 p608 | doi:10.1038/nrm.2016.120 A new study shows that 53BP1 modulates p53-mediated transcription independently of its functions in DNA repair. PDF Cell migration: Fascin and 3D nuclear moves p608 | doi:10.1038/nrm.2016.123 Fascin promotes cell invasion by functioning as a mechanotransducer that binds to nesprin-2 and couples F-actin to the nuclear envelope. PDF Mechanisms of disease: Intracellular tunnels spread disease p608 | doi:10.1038/nrm.2016.124 Fibrillar α-synuclein is transferred between neuronal cells within lysosomes in tunelling nanotubes. PDF Post-translational modifications: Extension of the tubulin code p609 | doi:10.1038/nrm.2016.117 The histone methyltransferase SETD2 methylates microtubules during mitosis, thereby preventing mitotic errors and genomic instability. PDF Cancer biology: Hypoxia as an off switch for gene expression p610 | doi:10.1038/nrm.2016.119 A new study shows that hypoxia interferes with DNA demethylation, resulting in DNA hypermethylation and repression of gene expression, which in tumours leads to the silencing of tumour suppressors. PDF IN BRIEF Chromosome biology: Mitotic chromatin condensin' | Mechanisms of disease: Metabolic reprogramming cures liver disease | Mechanotransduction: Stretching chromatin promotes transcription PDF Molecular Cell Biology JOBS of the week Postdoctoral Fellow -- Molecular and Cell Biology University of Texas Health Science Center at Houston More Science jobs from
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Mechanisms and regulation of endothelial VEGF receptor signalling Michael Simons, Emma Gordon & Lena Claesson-Welsh p611 | doi:10.1038/nrm.2016.87 Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for the formation and remodelling of blood vessels. VEGFR2, which is the main endothelial VEGFR, is regulated by receptor-interacting proteins, endocytosis and trafficking. Recent insights have been gained into these layers of regulation and the crosstalk between VEGFR2 signalling and other endothelial signalling cascades. Abstract | Full Text | PDF
Structural insights into the catalysis and regulation of E3 ubiquitin ligases Lori Buetow & Danny T. Huang p626 | doi:10.1038/nrm.2016.91 Protein ubiquitylation has important regulatory functions, influencing protein-protein interactions and protein stability. The final step of ubiquitylation is catalysed by ubiquitin ligases (E3s), a diverse group of proteins that operate with distinct mechanisms. Recent structural data have provided insights into these mechanisms, extending our understanding of E3 function and regulation. Abstract | Full Text | PDF | Supplementary information
Article series: Adult stem cells Epigenetic control of adult stem cell function Alexandra Avgustinova & Salvador Aznar Benitah p643 | doi:10.1038/nrm.2016.76 The role of epigenetic regulation in adult stem cell function depends on the specific tissue and factor, but it commonly affects stem cell maintenance, self-renewal and differentiation without disrupting germ-layer fate. Abstract | Full Text | PDF | Supplementary information
Subversion of host genome integrity by bacterial pathogens Cindrilla Chumduri, Rajendra Kumar Gurumurthy, Rike Zietlow & Thomas F. Meyer p659 | doi:10.1038/nrm.2016.100 The DNA of mammalian cells can be damaged by various endogenous and exogenous insults, leading, if unrepaired, to genomic instability. Recently it has become apparent that bacterial pathogens can be a source of genomic instability, owing to their combined capacity to incur DNA damage and to interfere with DNA repair pathways. Abstract | Full Text | PDF
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*2015 Journal Citation Reports (Thomson Reuters, 2016)

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