Nature Immunology Contents: October 2016 Volume 17 pp 1129 - 1235

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Advertisement A*STAR Research - Highlighting the best of research at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization   Recent Highlights Autoimmunity: Immune cells upset the kidney | Immunology: The journey from blood to tonsils | Immunology: Early deciders  Download the A*STAR Research app now! TABLE OF CONTENTS October 2016 Volume 17, Issue 10 Meeting Report News and Views Research Highlights Review Articles Resources Corrigenda Errata Advertisement For essential cell health data you need on a routine basis, there isn't always time for the relaxed pace of the Western. Apoptosis. Oxidative stress. Cell cycle effects. Viability. Get quantitative, single-cell results in a fraction of the time needed for traditional immunoassays. Simple, rapid assessment of critical cell events on your benchtop with the Muse® cell analyzer. See how it works—Watch video Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement FACULTY POSITION IN IMMUNOLOGY The Department of Immunology seeks applicants for a Tenure - Track Assistant Professor faculty position. Candidates working in all areas of immunology are invited to apply. The successful applicant will join a highly interactive group within the Department of Immunology at Duke University Medical Center.  Click here for more    Advertisement Open for Submissions  npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota. Explore the benefits of submitting your manuscript >>   Advertisement nature.com webcasts Springer Nature presents a custom webcast on Pure protein: optimal resin selection to maximize purification efficiency Date: Thursday September 29, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST  Register at: An expert panel will answer all your questions regarding resin selection strategies following the webinar. Sponsored by: Thermo Fisher Scientific     Meeting Report Top Progress on thymic function from Maui   pp1129 - 1132 Jennifer Cowan and Avinash Bhandoola doi:10.1038/ni.3555 News and Views Top Cracking the code of skin inflammation with CD1a   pp1133 - 1134 Masayuki Amagai doi:10.1038/ni.3557 CD1a on Langerhans cells in the epidermis is the lipid receptor for the plant-derived allergen urushiol and self lipids and is a key amplifier of inflammatory responses in urushiol-induced contact dermatitis as well as in psoriasis. See also: Article by Kim et al. Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells   pp1135 - 1136 Simon Bélanger and Shane Crotty doi:10.1038/ni.3561 Follicular helper T cells (TFH cells) sequentially acquire the potential to secrete interleukin 21 (IL-21) and IL-4. The shift from secretion of IL-21 to that of IL-4 modifies the nature of the 'help' signals delivered by TFH cells to germinal center (GC) B cells. See also: Article by Weinstein et al. Reining in uncontrolled inflammasome with PKA   pp1137 - 1138 Karen V Swanson and Jenny P-Y Ting doi:10.1038/ni.3556 New findings show that the NLRP3 inflammasome is inactivated by disassembly of the inflammasome mediated by the kinase PKA and that this regulation might be negated in NLRP3-gain-of-function diseases. See also: Article by Mortimer et al. R.I.P. dead bacteria, you will not be attacked   pp1138 - 1140 Lorena Tomé-Poderti and Maria-Carla Saleh doi:10.1038/ni.3562 The Drosophila immune system distinguishes live, and potentially harmful, bacteria from harmless dead bacteria through the use of a splice variant of the receptor PGRP-LC. See also: Article by Neyen et al. Immunology JOBS of the week Postdoctoral opportunities in Immunology, Keck School of Medicine Keck School of Medicine Postdoctoral researcher position in skin immunology University Hospital Lausanne (CHUV) Assistant Professorship for Clinical Tumor Immunology University of Zurich Postdoctoral Fellow in Immunology Icahn School of Medicine at Mount Sinai Postdoctoral Fellowship in Immunology / Cancer Immunotherapy Oslo University Hospital Radiumhospitalet More Science jobs from Immunology EVENT Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology 19th - 23rd March 2017 Whistler, Canada More science events from Research Highlights Top The survival factor | Macrophage core program | Fueling IgA production | Shaping the healthy repertoire | Neutrophilic tumor suppressors | Germline TCR contributions Review Top Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing   pp1142 - 1149 Qi Chen, Lijun Sun and Zhijian J Chen doi:10.1038/ni.3558 In this Review, Chen and colleagues discuss recent advances in understanding of the cGAS-STING pathway, focusing on the regulatory mechanisms and roles of this pathway in heath and disease. Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Defining the immune system at single cell resolution with Seurat Date: Tuesday October 4, 2016 Time: 11AM PDT, 2PM EDT Speaker: Dr Rahul Satija, Assistant Professor, NYU Center for Genomics and Systems Biology R Register for FREE at And learn how to control for heterogeneity in sequencing depth and cell cycle. Sponsored by:  10x Genomics, Inc.     Articles Top The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors   pp1150 - 1158 Claudine Neyen, Christopher Runchel, Fanny Schupfer, Pascal Meier and Bruno Lemaitre doi:10.1038/ni.3536 The immune system tailors its responses according to the level of threat. Lemaitre and colleagues identify a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria. See also: News and Views by Tomé-Poderti & Saleh CD1a on Langerhans cells controls inflammatory skin disease   pp1159 - 1166 Ji Hyung Kim, Yu Hu, Tang Yongqing, Jessica Kim, Victoria A Hughes et al. doi:10.1038/ni.3523 Human Langerhans cells express CD1a, but those in mice do not, which makes determination of its function on these cells challenging in vivo. Through the use of a transgenic mouse that expresses CD1a, Winau and colleagues demonstrate that Langerhans cells use CD1a to present contact allergens and self lipid antigens and thereby worsen inflammatory skin conditions. See also: News and Views by Amagai The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation   pp1167 - 1175 Yuanyuan Ding, Zhenhong Guo, Yiqi Liu, Xia Li, Qian Zhang et al. doi:10.1038/ni.3535 CD8α+ DCs are specialized at cross-presentation, but the mechanisms that bestow this ability have not been fully characterized. Cao and colleagues show that the lectin Siglec-G negatively regulates cross-presentation and that its expression is lower in CD8α+ DCs. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations   pp1176 - 1186 Leanne Mortimer, France Moreau, Justin A MacDonald and Kris Chadee doi:10.1038/ni.3538 Dysregulated inflammasome activation is associated with auto-inflammatory diseases. Chadee and colleagues show that prostaglandin E2 triggers rapid inhibition of the inflammasome component NLRP3 by the kinase PKA. Patients with the inflammatory disease CAPS who have mutations in NLPR3 escape this negative regulation. See also: News and Views by Swanson & Ting CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles   pp1187 - 1196 Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man et al. doi:10.1038/ni.3543 B cells and follicular helper T cells in B cell follicles can act as important reservoirs for chronic infection by viruses such as HIV or EBV. Yu and colleagues show that a specialized subpopulation of cytotoxic T cells can enter the B cell follicles to eliminate such virus-infected cells. TFH cells progressively differentiate to regulate the germinal center response   pp1197 - 1205 Jason S Weinstein, Edward I Herman, Begoña Lainez, Paula Licona-Limón, Enric Esplugues et al. doi:10.1038/ni.3554 Craft and colleagues show that follicular helper T cells progress through transcriptionally and functionally distinct stages that provide specific signals for germinal center regulation. See also: News and Views by Belanger & Crotty Advertisement Celebrating 15 years of high-quality Reviews! October 2016 marks the 15th anniversary of the launch of Nature Reviews Immunology! See what's been publishing and view the current issue.   Resources Top Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells   pp1206 - 1215 Saulius Žuklys, Adam Handel, Saule Zhanybekova, Fatima Govani, Marcel Keller et al. doi:10.1038/ni.3537 Hollander and colleagues provide a map of genes that are direct targets of the transcription factor Foxn1 in thymic epithelial cells and show that Foxn1 controls genes encoding products involved in thymocyte development, antigen processing and thymocyte selection. Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation   pp1216 - 1225 Benjamin G Barwick, Christopher D Scharer, Alexander P R Bally and Jeremy M Boss doi:10.1038/ni.3519 Boss and colleagues provide mechanistic insight into cell-division-coupled transcriptional and epigenetic reprogramming events during plasma cell differentiation. Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination   pp1226 - 1234 Ali H Ellebedy, Katherine J L Jackson, Haydn T Kissick, Helder I Nakaya, Carl W Davis et al. doi:10.1038/ni.3533 Immunologic memory promotes faster and more-efficient responses after re-exposure to pathogens. Ahmed and colleagues characterize a subset of human B cells that arise after vaccination against or exposure to influenza or Ebola virus and contribute to the memory cell pool. Corrigenda Top Corrigendum: Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells   p1235 Xugang Qiao, Bing He, April Chiu, Daniel M Knowles, Amy Chadburn et al. doi:10.1038/ni1016-1235a Corrigendum: Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease   p1235 Nathan D Mathewson, Robert Jenq, Anna V Mathew, Mark Koenigsknecht, Alan Hanash et al. doi:10.1038/ni1016-1235b Errata Top Erratum: CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis   p1235 Danay Cibrian, María Laura Saiz, Hortensia de la Fuente, Raquel Sánchez-Díaz, Olga Moreno-Gonzalo et al. doi:10.1038/ni1016-1235c Erratum: Activin A programs the differentiation of human TFH cells   p1235 Michela Locci, Jennifer E Wu, Fortuna Arumemi, Zbigniew Mikulski, Carol Dahlberg et al. doi:10.1038/ni1016-1235d Top Advertisement An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms. 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