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A*STAR Research - Highlighting the best of research at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization Recent Highlights Autoimmunity: Immune cells upset the kidney | Immunology: The journey from blood to tonsils | Immunology: Early deciders
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TABLE OF CONTENTS
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October 2016 Volume 17, Issue 10 |
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 | Meeting Report News and Views Research Highlights Review Articles Resources Corrigenda Errata |  | Advertisement |  |  |  | For essential cell health data you need on a routine basis, there isn't always time for the relaxed pace of the Western. Apoptosis. Oxidative stress. Cell cycle effects. Viability. Get quantitative, single-cell results in a fraction of the time needed for traditional immunoassays. Simple, rapid assessment of critical cell events on your benchtop with the Muse® cell analyzer. See how it works—Watch video | | |
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FACULTY POSITION IN IMMUNOLOGY
The Department of Immunology seeks applicants for a Tenure - Track Assistant Professor faculty position. Candidates working in all areas of immunology are invited to apply. The successful applicant will join a highly interactive group within the Department of Immunology at Duke University Medical Center.
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Open for Submissions
npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.
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nature.com webcasts
Springer Nature presents a custom webcast on Pure protein: optimal resin selection to maximize purification efficiency
Date: Thursday September 29, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST
Register at:
An expert panel will answer all your questions regarding resin selection strategies following the webinar.
Sponsored by: Thermo Fisher Scientific | | | |
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Meeting Report | Top |
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Progress on thymic function from Maui pp1129 - 1132 Jennifer Cowan and Avinash Bhandoola doi:10.1038/ni.3555 |
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News and Views | Top |
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Research Highlights | Top |
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The survival factor | Macrophage core program | Fueling IgA production | Shaping the healthy repertoire | Neutrophilic tumor suppressors | Germline TCR contributions |
Review | Top |
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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing pp1142 - 1149 Qi Chen, Lijun Sun and Zhijian J Chen doi:10.1038/ni.3558 In this Review, Chen and colleagues discuss recent advances in understanding of the cGAS-STING pathway, focusing on the regulatory mechanisms and roles of this pathway in heath and disease. |
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nature.com webcasts
Springer Nature presents a custom webcast on: Defining the immune system at single cell resolution with Seurat
Date: Tuesday October 4, 2016 Time: 11AM PDT, 2PM EDT
Speaker: Dr Rahul Satija, Assistant Professor, NYU Center for Genomics and Systems Biology R
Register for FREE at
And learn how to control for heterogeneity in sequencing depth and cell cycle.
Sponsored by:
10x Genomics, Inc. | | | |
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Articles | Top |
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The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors pp1150 - 1158 Claudine Neyen, Christopher Runchel, Fanny Schupfer, Pascal Meier and Bruno Lemaitre doi:10.1038/ni.3536 The immune system tailors its responses according to the level of threat. Lemaitre and colleagues identify a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria.
See also: News and Views by Tomé-Poderti & Saleh |
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CD1a on Langerhans cells controls inflammatory skin disease pp1159 - 1166 Ji Hyung Kim, Yu Hu, Tang Yongqing, Jessica Kim, Victoria A Hughes et al. doi:10.1038/ni.3523 Human Langerhans cells express CD1a, but those in mice do not, which makes determination of its function on these cells challenging in vivo. Through the use of a transgenic mouse that expresses CD1a, Winau and colleagues demonstrate that Langerhans cells use CD1a to present contact allergens and self lipid antigens and thereby worsen inflammatory skin conditions.
See also: News and Views by Amagai |
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The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation pp1167 - 1175 Yuanyuan Ding, Zhenhong Guo, Yiqi Liu, Xia Li, Qian Zhang et al. doi:10.1038/ni.3535 CD8α+ DCs are specialized at cross-presentation, but the mechanisms that bestow this ability have not been fully characterized. Cao and colleagues show that the lectin Siglec-G negatively regulates cross-presentation and that its expression is lower in CD8α+ DCs. |
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NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations pp1176 - 1186 Leanne Mortimer, France Moreau, Justin A MacDonald and Kris Chadee doi:10.1038/ni.3538 Dysregulated inflammasome activation is associated with auto-inflammatory diseases. Chadee and colleagues show that prostaglandin E2 triggers rapid inhibition of the inflammasome component NLRP3 by the kinase PKA. Patients with the inflammatory disease CAPS who have mutations in NLPR3 escape this negative regulation.
See also: News and Views by Swanson & Ting |
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CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles pp1187 - 1196 Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man et al. doi:10.1038/ni.3543 B cells and follicular helper T cells in B cell follicles can act as important reservoirs for chronic infection by viruses such as HIV or EBV. Yu and colleagues show that a specialized subpopulation of cytotoxic T cells can enter the B cell follicles to eliminate such virus-infected cells. |
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TFH cells progressively differentiate to regulate the germinal center response pp1197 - 1205 Jason S Weinstein, Edward I Herman, Begoña Lainez, Paula Licona-Limón, Enric Esplugues et al. doi:10.1038/ni.3554 Craft and colleagues show that follicular helper T cells progress through transcriptionally and functionally distinct stages that provide specific signals for germinal center regulation.
See also: News and Views by Belanger & Crotty |
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Resources | Top |
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Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells pp1206 - 1215 Saulius Žuklys, Adam Handel, Saule Zhanybekova, Fatima Govani, Marcel Keller et al. doi:10.1038/ni.3537 Hollander and colleagues provide a map of genes that are direct targets of the transcription factor Foxn1 in thymic epithelial cells and show that Foxn1 controls genes encoding products involved in thymocyte development, antigen processing and thymocyte selection. |
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Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation pp1216 - 1225 Benjamin G Barwick, Christopher D Scharer, Alexander P R Bally and Jeremy M Boss doi:10.1038/ni.3519 Boss and colleagues provide mechanistic insight into cell-division-coupled transcriptional and epigenetic reprogramming events during plasma cell differentiation. |
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Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination pp1226 - 1234 Ali H Ellebedy, Katherine J L Jackson, Haydn T Kissick, Helder I Nakaya, Carl W Davis et al. doi:10.1038/ni.3533 Immunologic memory promotes faster and more-efficient responses after re-exposure to pathogens. Ahmed and colleagues characterize a subset of human B cells that arise after vaccination against or exposure to influenza or Ebola virus and contribute to the memory cell pool. |
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Corrigenda | Top |
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Corrigendum: Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells p1235 Xugang Qiao, Bing He, April Chiu, Daniel M Knowles, Amy Chadburn et al. doi:10.1038/ni1016-1235a |
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Corrigendum: Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease p1235 Nathan D Mathewson, Robert Jenq, Anna V Mathew, Mark Koenigsknecht, Alan Hanash et al. doi:10.1038/ni1016-1235b |
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Errata | Top |
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Erratum: CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis p1235 Danay Cibrian, María Laura Saiz, Hortensia de la Fuente, Raquel Sánchez-Díaz, Olga Moreno-Gonzalo et al. doi:10.1038/ni1016-1235c |
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Erratum: Activin A programs the differentiation of human TFH cells p1235 Michela Locci, Jennifer E Wu, Fortuna Arumemi, Zbigniew Mikulski, Carol Dahlberg et al. doi:10.1038/ni1016-1235d |
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