Scientific Reports Biology Table of Contents e-alert: 13 October 2015

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13 October 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Mismatch negativity in common marmosets: Whole-cortical recordings with multi-channel electrocorticograms ▶     Misako Komatsu, Kana Takaura, Naotaka Fujii     Mismatch negativity (MMN) is a component of event-related potentials (ERPs) evoked by violations of regularity in sensory stimulus-series in humans. Recently, the MMN has …             Mutual medication in capuchin monkeys – Social anointing improves coverage of topically applied anti-parasite medicines ▶     Mark Bowler, Emily J. E. Messer, Nicolas Claidière et al.     Wild and captive capuchin monkeys will anoint themselves with a range of strong smelling substances including millipedes, ants, limes and onions. Hypotheses for the function of …             Soybean Hydrophobic Protein is Present in a Matrix Secreted by the Endocarp Epidermis during Seed Development ▶     Daryl E. Enstone, Carol A. Peterson, Mark Gijzen     Hydrophobic protein from soybean (HPS) is present in soybean dust and is an allergen (Gly m 1) that causes asthma in allergic individuals. Past studies have shown that HPS occurs …             Coculture of Primary Motor Neurons and Schwann Cells as a Model for In Vitro Myelination ▶     Sujin Hyung, Bo Yoon Lee, Jong-Chul Park et al.     A culture system that can recapitulate myelination in vitro will not only help us better understand the mechanism of myelination and demyelination, but also find out possible …             Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation ▶     Constanze Schelhorn, Pau Martín-Malpartida, David Suñol et al.     The Cytoplasmic Polyadenylation Element Binding proteins are RNA binding proteins involved in the translational regulation of mRNA. During cell cycle progression, CPEB1 is …             Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy ▶     Savita Devi, Eerappa Rajakumara, Niyaz Ahmed     Evasion of innate immune recognition is one of the key strategies for persistence of Helicobacter pylori, by virtue of its ability to modulate or escape the host innate immune …             Ageing and Caloric Restriction in a Marine Planktonic Copepod ▶     Enric Saiz, Albert Calbet, Kaiene Griffell et al.     Planktonic copepods are a key group in the marine pelagic ecosystem, linking primary production with upper trophic levels. Their abundance and population dynamics are constrained …             Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human ▶     Qingfeng Chen, Weijian Ye, Wei Jian Tan et al.     Understanding of natural killer (NK) cell development in human is incomplete partly because of limited access to appropriate human tissues. We have developed a cytokine-enhanced …             Closely-related taxa influence woody species discrimination via DNA barcoding: evidence from global forest dynamics plots ▶     Nancai Pei, David L. Erickson, Bufeng Chen et al.     To determine how well DNA barcodes from the chloroplast region perform in forest dynamics plots (FDPs) from global CTFS-ForestGEO network, we analyzed DNA barcoding sequences of …             Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels ▶     Youngmee Jung, HaYeun Ji, Zaozao Chen et al.     Tissue-engineered blood vessels (TEBV) can serve as vascular grafts and may also play an important role in the development of organs-on-a-chip. Most TEBV construction involves …             Investigation of Readout RF Pulse Impact on the Chemical Exchange Saturation Transfer Spectrum ▶     Sheng-Min Huang, Meei-Ling Jan, Hsin-Chin Liang et al.     Chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI) is capable of both microenvironment and molecular imaging. The optimization of scanning parameters is …             Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals ▶     Junji Furukawa, Katsuhisa Inoue, Junya Maeda et al.     The purine salvage pathway plays a major role in the nucleotide production, relying on the supply of nucleobases and nucleosides from extracellular sources. Although specific …             HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells ▶     HanLin Ma, Le Su, HongWei Yue et al.     We previously found that Homeobox containing 1 (HMBOX1) was required for bone mesenchymal stem cell (BMSC) and mouse embryonic stem cell (ESC) differentiation into vascular …             Audiovisual temporal recalibration occurs independently at two different time scales ▶     Erik Van der Burg, David Alais, John Cass     Combining signals across the senses improves precision and speed of perception, although this multisensory benefit declines for asynchronous signals. Multisensory events may …             Adrenergic ligands that block oviposition in the cattle tick Rhipicephalus microplus affect ovary contraction ▶     Raquel Cossío-Bayúgar, Estefan Miranda-Miranda, Manuel Fernández-Rubalcaba et al.     The tyraminergic/octopaminergic system is central for the control of arthropod oviposition. Previous works demonstrated that the pharmacological perturbation of this system …             The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts ▶     Hiromi Chikada, Keiichi Ito, Ayaka Yanagida et al.     Hepatic stem/progenitor cells, hepatoblasts, have a high proliferative ability and can differentiate into mature hepatocytes and cholangiocytes. Therefore, these cells are …             Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6 ▶     Hai-Wei Chen, Yong-Kang Yang, Hao Xu et al.     Host cells orchestrate the production of IFN-β upon detecting invading viral pathogens. Here, we report that Ring finger protein 166 (RNF166) potentiates RNA virus-triggered …             Structure of importin-α bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein ▶     Ryohei Nakada, Hidemi Hirano, Yoshiyuki Matsuura     A non-classical nuclear localization signal (ncNLS) of influenza A virus nucleoprotein (NP) is critical for nuclear import of viral genomic RNAs that transcribe and replicate in …             A calmodulin like EF hand protein positively regulates oxalate decarboxylase expression by interacting with E-box elements of the promoter ▶     Ayushi Kamthan, Mohan Kamthan, Avinash Kumar et al.     Oxalate decarboxylase (OXDC) enzyme has immense biotechnological applications due to its ability to decompose anti-nutrient oxalic acid. Flammulina velutipes, an edible wood …             Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries ▶     Chao-Ping Tung, Ing-Chien Chen, Chung-Ming Yu et al.     Broadly neutralizing antibodies developed from the IGHV1–69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence …             Dual mode of action of Bt proteins: protoxin efficacy against resistant insects ▶     Bruce E. Tabashnik, Min Zhang, Jeffrey A. Fabrick et al.     Transgenic crops that produce Bacillus thuringiensis (Bt) proteins for pest control are grown extensively, but insect adaptation can reduce their effectiveness. Established mode …             Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues ▶     Hironori Kawakami, Eiji Ohashi, Shota Kanamoto et al.     In eukaryotes, the origin recognition complex (ORC) heterohexamer preferentially binds replication origins to trigger initiation of DNA replication. Crystallographic studies …             DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs ▶     Cyril Ramathal, Benjamin Angulo, Meena Sukhwani et al.     Deletions of the AZFa region (AZoospermia Factor-a) region of the human Y chromosome cause irreversible spermatogenic failure that presents clinically in men as Sertoli-cell only …             Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity ▶     Jesus Izaguirre-Carbonell, Hirofumi Kawakubo, Hiroshi Murata et al.     SQAP is a novel and promising anticancer agent that was obtained by structural modifications from a natural compound. SQAP inhibits angiogenesis in vivo resulting in increased …             The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset ▶     David Safronetz, Kyle Rosenke, Jonna B. Westover et al.     With up to 500,000 infections annually, Lassa virus (LASV), the cause of Lassa fever, is one of the most prevalent etiological agents of viral hemorrhagic fever (VHF) in humans. …             The development of pressure across membranes in Donnan systems ▶     Asher Ilani     The pressure that develops between the two sides of a Donnan system is equal to the difference between the osmotic values of the two solutions, even though permeant ions may …             Polarization: A Key Difference between Man-made and Natural Electromagnetic Fields, in regard to Biological Activity ▶     Dimitris J. Panagopoulos, Olle Johansson, George L. Carlo     In the present study we analyze the role of polarization in the biological activity of Electromagnetic Fields (EMFs)/Electromagnetic Radiation (EMR). All types of man-made …             Relationships between the resting-state network and the P3: Evidence from a scalp EEG study ▶     Fali Li, Tiejun Liu, Fei Wang et al.     The P3 is an important event-related potential that can be used to identify neural activity related to the cognitive processes of the human brain. However, the relationships, …             Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue ▶     Grzegorz Godlewski, Tony Jourdan, Gergő Szanda et al.     We report an unexpected link between aging, thermogenesis and weight gain via the orphan G protein-coupled receptor GPR3. Mice lacking GPR3 and maintained on normal chow had …             Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population ▶     Lei Cai, Tianlu Chen, Jinglei Yang et al.     Little is known about the trace element profile differences between Schizophrenia patients and healthy controls; previous studies about the association of certain elements with …             Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context ▶     Ella R. Thompson, Kylie L. Gorringe, Simone M. Rowley et al.     The breast cancer predisposition gene, BRCA2, has a large number of genetic variants of unknown effect. The variant rs11571833, an A > T transversion in the final exon of the …             Adiposity and immune-muscle crosstalk in South Asians & Europeans: A cross-sectional study ▶     M.Constantine Samaan, Sonia S. Anand, Arya M. Sharma et al.     South Asians (SA) are at higher risk of cardiometabolic disorders than Europeans (EU), yet the potential determinants of this risk are poorly understood. We tested the hypotheses …             Obesity changes the human gut mycobiome ▶     M. Mar Rodríguez, Daniel Pérez, Felipe Javier Chaves et al.     The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. …             Corrigendum: Tracking of dendritic cell migration into lymph nodes using molecular imaging with sodium iodide symporter and enhanced firefly luciferase genes ▶     Ho Won Lee, Seung Yun Yoon, Thoudam Debraj Singh et al.                 Fluoxetine exposure during adolescence increases preference for cocaine in adulthood ▶     Sergio D. Iñiguez, Lace M. Riggs, Steven J. Nieto et al.     Currently, there is a high prevalence of antidepressant prescription rates within juvenile populations, yet little is known about the potential long-lasting consequences of such …             Erratum: Simultaneous silence organizes structured higher-order interactions in neural populations ▶     Hideaki Shimazaki, Kolia Sadeghi, Tomoe Ishikawa et al.                 Fully automatic and robust 3D registration of serial-section microscopic images ▶     Ching-Wei Wang, Eric Budiman Gosno, Yen-Sheng Li     Robust and fully automatic 3D registration of serial-section microscopic images is critical for detailed anatomical reconstruction of large biological specimens, such as …             Discovery of Novel Anti-prion Compounds Using In Silico and In Vitro Approaches ▶     Jae Wook Hyeon, Jiwon Choi, Su Yeon Kim et al.     Prion diseases are associated with the conformational conversion of the physiological form of cellular prion protein (PrPC) to the pathogenic form, PrPSc. Compounds that inhibit …             The neuropeptide oxytocin modulates consumer brand relationships ▶     Andreas Fürst, Jesko Thron, Dirk Scheele et al.     Each year, companies invest billions of dollars into marketing activities to embellish brands as valuable relationship partners assuming that consumer brand relationships (CBRs) …             A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing ▶     Kangquan Yin, Ting Han, Guang Liu et al.     CRISPR/Cas has emerged as potent genome editing technology and has successfully been applied in many organisms, including several plant species. However, delivery of genome …             Ca2+-regulated cyclic electron flow supplies ATP for nitrogen starvation-induced lipid biosynthesis in green alga ▶     Hui Chen, Jinlu Hu, Yaqin Qiao et al.     We previously showed that both the linear photosynthetic electron transportation rate and the respiration rate dropped significantly during N starvation-induced neutral lipid …             A novel combined RNA-protein interaction analysis distinguishes HIV-1 Gag protein binding sites from structural change in the viral RNA leader ▶     Julia C. Kenyon, Liam J. Prestwood, Andrew M. L. Lever     RNA-protein interactions govern many viral and host cell processes. Conventional ‘footprinting’ to examine RNA-protein complex formation often cannot distinguish between sites of …             Click-crosslinkable and photodegradable gelatin hydrogels for cytocompatible optical cell manipulation in natural environment ▶     Masato Tamura, Fumiki Yanagawa, Shinji Sugiura et al.     This paper describes the generation of “click-crosslinkable“ and “photodegaradable“ gelatin hydrogels from the reaction between dibenzocycloctyl-terminated photoclevable …             Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions ▶     Stéphane Gangnard, Anita Lewit-Bentley, Sébastien Dechavanne et al.     The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …             Maternal intraguild predation risk affects offspring anti-predator behavior and learning in mites ▶     Michael Seiter, Peter Schausberger     Predation risk is a strong selective force shaping prey morphology, life history and behavior. Anti-predator behaviors may be innate, learned or both but little is known about …             Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors ▶     Fang Bai, Chae Ho Lim, Jingyue Jia et al.     Forced expression of defined transcriptional factors has been well documented as an effective method for cellular reprogramming or directed differentiation. However, transgene …             An Intelligent Decision Support System for Leukaemia Diagnosis using Microscopic Blood Images ▶     Siew Chin Neoh, Worawut Srisukkham, Li Zhang et al.     This research proposes an intelligent decision support system for acute lymphoblastic leukaemia diagnosis from microscopic blood images. A novel clustering algorithm with …             Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms ▶     Liang Jing, Ting-Ting Duan, Meng Tian et al.     The emotion of despair that occurs with uncontrollable stressful event is probably retained by memory, termed despair-associated memory, although little is known about the …             Divergent DNA methylation patterns associated with gene expression in rice cultivars with contrasting drought and salinity stress response ▶     Rohini Garg, VVS Narayana Chevala, Rama Shankar et al.     DNA methylation is an epigenetic mechanism that play an important role in gene regulation in response to environmental conditions. The understanding of DNA methylation at the …             Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range ▶     Gemma Henderson, Faith Cox, Siva Ganesh et al.     Ruminant livestock are important sources of human food and global greenhouse gas emissions. Feed degradation and methane formation by ruminants rely on metabolic interactions …             Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect ▶     Chia-Sui Sun, Chi-Chang Lee, Yi-Ni Li et al.     The abundant accumulation of inclusion bodies containing polyglutamine-expanded mutant huntingtin (mHTT) aggregates is considered as the key pathological event in Huntington’s …             Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly ▶     Vladyslava Sokolova, Frances Li, George Polovin et al.     In the proteasome, the proteolytic 20S core particle (CP) associates with the 19S regulatory particle (RP) to degrade polyubiquitinated proteins. Six ATPases (Rpt1-Rpt6) of the …             SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS ▶     Rosa Pujol-Pina, Sílvia Vilaprinyó-Pascual, Roberta Mazzucato et al.     The characterization of amyloid-beta peptide (Aβ) oligomer forms and structures is crucial to the advancement in the field of Alzheimer´s disease (AD). Here we report a critical …             The transfer and transformation of collective network information in gene-matched networks ▶     Takashi Kitsukawa, Takeshi Yagi     Networks, such as the human society network, social and professional networks, and biological system networks, contain vast amounts of information. Information signals in …             Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells ▶     Lianzhong Zhao, Jiping Zhu, Hongbo Zhou et al.     H5N1 influenza A virus (IAV) causes severe respiratory diseases and high mortality rates in animals and humans. MicroRNAs are being increasingly studied to evaluate their …             Role of supplemental foods and habitat structural complexity in persistence and coexistence of generalist predatory mites ▶     Alberto Pozzebon, Gregory M. Loeb, Carlo Duso     Plant traits can influence the interactions between herbivore arthropods and their natural enemies. In these interactions generalist predators are often present, preying on …             Absorption of PCB126 by upper airways impairs G protein-coupled receptor-mediated immune response ▶     Ana Lúcia B. Shimada, Wesley S. Cruz, Rodrigo A. Loiola et al.     PCB126 is a dioxin-like polychlorinated biphenyl (PCB) environmental pollutant with a significant impact on human health, as it bioaccumulates and causes severe toxicity. …             Profiling RNA editing in human tissues: towards the inosinome Atlas ▶     Ernesto Picardi, Caterina Manzari, Francesca Mastropasqua et al.     Adenine to Inosine RNA editing is a widespread co- and post-transcriptional mechanism mediated by ADAR enzymes acting on double stranded RNA. It has a plethora of biological …             Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo ▶     Ping Yang, Yunfei Zhao, Lei Zhao et al.     Insulin resistance is closely related to inflammatory stress and the mammalian target of rapamycin/S6 kinase (mTOR/S6K) pathway. The present study investigated whether rapamycin, …             Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation ▶     Guro F. Giskeødegård, Sarah K. Davies, Victoria L. Revell et al.     Understanding how metabolite levels change over the 24 hour day is of crucial importance for clinical and epidemiological studies. Additionally, the association between sleep …             Exchanging ligand-binding specificity between a pair of mouse olfactory receptor paralogs reveals odorant recognition principles ▶     Olivia Baud, Shuguang Yuan, Luc Veya et al.     A multi-gene family of ~1000 G protein-coupled olfactory receptors (ORs) constitutes the molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable …             Zoophycos macroevolution since 541 Ma ▶     Li-Jun Zhang, Ruo-Ying Fan, Yi-Ming Gong     Zoophycos is one of the most complex and enigmatic trace fossils recorded in marine strata from Cambrian to Quaternary worldwide, which is invaluable for the study of Phanerozoic …             Predominant role of interferon-γ in the host protective effect of CD8+ T cells against Neospora caninum infection ▶     Alexandra Correia, Pedro Ferreirinha, Sofia Botelho et al.     It is well established that CD8+ T cells play an important role in protective immunity against protozoan infections. However, their role in the course of Neospora caninum …             Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse (nsEP) Exposure ▶     Caleb C. Roth, Ronald A. Barnes Jr., Bennett L. Ibey et al.     The mechanism(s) responsible for the breakdown (nanoporation) of cell plasma membranes after nanosecond pulse (nsEP) exposure remains poorly understood. Current theories focus …             Stacked thin layers of metaphase chromatin explain the geometry of chromosome rearrangements and banding ▶     Joan-Ramon Daban     The three-dimensional organization of tightly condensed chromatin within metaphase chromosomes has been one of the most challenging problems in structural biology since the …             Corrigendum: Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime ▶     Paul S. Sharp, Kira Shaw, Luke Boorman et al.                 Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells ▶     Ana Rosa Soares, Tania Martins-Marques, Teresa Ribeiro-Rodrigues et al.                 Corrigendum: Development of a transformation system for Hirsutella spp. and visualization of the mode of nematode infection by GFP-labeled H. minnesotensis ▶     Jingzu Sun, Sook-Young Park, Seogchan Kang et al.                 Intracellular Temperature Sensing: An Ultra-bright Luminescent Nanothermometer with Non-sensitivity to pH and Ionic Strength ▶     Helin Liu, Yanyan Fan, Jianhai Wang et al.     Luminescence thermometry usually suffer from cellular complexity of the biochemical environment (such as pH and ionic strength), and thus the accuracy and reliability of the …             Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus ▶     Marc Monot, Catherine Eckert, Astrid Lemire et al.     The major virulence factors of Clostridium difficile are toxins A and B. These toxins are encoded by tcdA and tcdB genes, which form a pathogenicity locus (PaLoc) together with …             Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative ▶     Fredy Kern, Tobias K. F. Dier, Yogan Khatri et al.     Since their discovery in the soil bacterium Sorangium cellulosum, epothilones have emerged as a valuable substance class with promising anti-tumor activity. Because of their …             A Unified Framework for Reservoir Computing and Extreme Learning Machines based on a Single Time-delayed Neuron ▶     S. Ortín, M. C. Soriano, L. Pesquera et al.     In this paper we present a unified framework for extreme learning machines and reservoir computing (echo state networks), which can be physically implemented using a single …             Integrated transcriptome sequencing and dynamic analysis reveal carbon source partitioning between terpenoid and oil accumulation in developing Lindera glauca fruits ▶     Jun Niu, Yinlei Chen, Jiyong An et al.     Lindera glauca fruits (LGF) with the abundance of terpenoid and oil has emerged as a novel specific material for industrial and medicinal application in China, but the complex …             Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways ▶     Fang Liang, Yuxiang Han, Hao Gao et al.     Natural products are a rich resource for the discovery of therapeutic substances. By directly using 504 fine fractions from isolated traditional Chinese medicine plants, we …             Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress ▶     Ryosuke Nakato, Yu Ohkubo, Akari Konishi et al.     Protein S-nitrosylation modulates important cellular processes, including neurotransmission, vasodilation, proliferation, and apoptosis in various cell types. We have previously …             The antiviral drug ganciclovir does not inhibit microglial proliferation and activation ▶     Thomas Skripuletz, Laura Salinas Tejedor, Chittappen K. Prajeeth et al.     Ganciclovir is effective in the treatment of human infections with viruses of the Herpesviridae family. Beside antiviral properties, recently ganciclovir was described to inhibit …             Phenotypic vulnerability of energy balance responses to sleep loss in healthy adults ▶     Andrea M. Spaeth, David F. Dinges, Namni Goel     Short sleep duration is a risk factor for increased hunger and caloric intake, late-night eating, attenuated fat loss when dieting, and for weight gain and obesity. It is unknown …             Extensible byssus of Pinctada fucata: Ca2+-stabilized nanocavities and a thrombospondin-1 protein ▶     Chuang Liu, Shiguo Li, Jingliang Huang et al.     The extensible byssus is produced by the foot of bivalve animals, including the pearl oyster Pinctada fucata, and enables them to attach to hard underwater surfaces. However, the …             Energy saving strategies of honeybees in dipping nectar ▶     Jianing Wu, Heng Yang, Shaoze Yan     The honeybee’s drinking process has generally been simplified because of its high speed and small scale. In this study, we clearly observed the drinking cycle of the Italian …             Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes ▶     Paola Rebuzzini, Elisa Cebral, Lorenzo Fassina et al.     Chronic arsenic exposure is associated with increased morbidity and mortality for cardiovascular diseases. Arsenic increases myocardial infarction mortality in young adulthood, …             Overexpression of GbRLK, a putative receptor-like kinase gene, improved cotton tolerance to Verticillium wilt ▶     Zhao Jun, Zhiyuan Zhang, Yulong Gao et al.     Verticillium dahliae is a causative fungal pathogen and only a few genes have been identified that exhibit critical roles in disease resistance and few has shown positive effects …             Synthesis of an arrayed sgRNA library targeting the human genome ▶     Tobias Schmidt, Jonathan L. Schmid-Burgk, Veit Hornung     Clustered regularly interspaced short palindromic repeats (CRISPR) in conjunction with CRISPR-associated proteins (Cas) can be employed to introduce double stand breaks into …             Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury ▶     Yuan-Yu Hsueh, Ya-Ju Chang, Chia-Wei Huang et al.     Perinatal cerebral hypoxic-ischemic (HI) injury damages the architecture of neurovascular units (NVUs) and results in neurological disorders. Here, we differentiated …             Real-time imaging of hydrogen peroxide dynamics in vegetative and pathogenic hyphae of Fusarium graminearum ▶     Michael Mentges, Jörg Bormann     Balanced dynamics of reactive oxygen species in the phytopathogenic fungus Fusarium graminearum play key roles for development and infection. To monitor those dynamics, …             Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster ▶     Hua Wang, Kai Wang, Guanjun Xiao et al.     Although High hydrostatic pressure (HHP) as an important physical and chemical tool has been increasingly applied to research of organism, the response mechanisms of organism to …             Highly informative marker sets consisting of genes with low individual degree of differential expression ▶     V. V. Galatenko, M. Yu. Shkurnikov, T. R. Samatov et al.     Genes with significant differential expression are traditionally used to reveal the genetic background underlying phenotypic differences between cancer cells. We hypothesized …             FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells ▶     Lina Sun, Chenming Sun, Zhanfeng Liang et al.     Thymic epithelial cells (TECs) form a 3-dimentional network supporting thymocyte development and maturation. Besides epithelium and thymocytes, heterogeneous fibroblasts are …             A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus ▶     Mia Gi, Kang-Mu Lee, Sang Cheol Kim et al.     Pseudomonas aeruginosa establishes airway infections in Cystic Fibrosis patients. Here, we investigate the molecular interactions between P. aeruginosa and airway mucus …             Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA) ▶     Huinan Li, Cheng Wu, Rodolfo Aramayo et al.     Synaptic vesicles (SVs) are neuronal presynaptic organelles that load and release neurotransmitter at chemical synapses. In addition to classic neurotransmitters, we have found …             Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses ▶     Junko Matsuzaki, Takemasa Tsuji, Immanuel F. Luescher et al.     Tumor antigen-specific CD4+ T cells generally orchestrate and regulate immune cells to provide immune surveillance against malignancy. However, activation of antigen-specific CD4+…             Boletus edulis Nitrite Reductase Reduces Nitrite Content of Pickles and Mitigates Intoxication in Nitrite-intoxicated Mice ▶     Weiwei Zhang, Guoting Tian, Shanshan Feng et al.     Pickles are popular in China and exhibits health-promoting effects. However, nitrite produced during fermentation adversely affects health due to formation of methemoglobin and …             Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets ▶     Junyan Lu, Hanlin Zeng, Zhongjie Liang et al.     The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis …             Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities ▶     Li-Qiang Pan, Wen-Bin Zhao, Jun Lai et al.     Poor pharmacokinetics and resistance within some tumor cell lines have been the major obstacles during the preclinical or clinical application of TRAIL (tumor-necrosis-factor …             Cutoff lensing: predicting catalytic sites in enzymes ▶     Simon Aubailly, Francesco Piazza     Predicting function-related amino acids in proteins with unknown function or unknown allosteric binding sites in drug-targeted proteins is a task of paramount importance in …             Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland ▶     Andrzej T. Slominski, Tae-Kang Kim, Wei Li et al.     To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …             The 82-plex plasma protein signature that predicts increasing inflammation ▶     Martin Tepel, Hans C. Beck, Qihua Tan et al.     The objective of the study was to define the specific plasma protein signature that predicts the increase of the inflammation marker C-reactive protein from index day to next-day …             Design, Synthesis and Structure-Activity Relationship Optimization of Lycorine Derivatives for HCV Inhibition ▶     Duozhi Chen, Jieyun Cai, Junjun Cheng et al.     Lycorine is reported to be a multifunctional compound. We previously showed that lycorine is an HCV inhibitor with strong activity. Further research on the antivirus mechanism …             Tolerance and reward equity predict cooperation in ravens (Corvus corax) ▶     Jorg J. M. Massen, Caroline Ritter, Thomas Bugnyar     Cooperative decision rules have so far been shown experimentally mainly in mammal species that have variable and complex social networks. However, these traits should not …             HDAC inhibitor misprocesses bantam oncomiRNA, but stimulates hid induced apoptotic pathway ▶     Utpal Bhadra, Tanmoy Mondal, Indira Bag et al.     Apoptosis or programmed cell death is critical for embryogenesis and tissue homeostasis. Uncontrolled apoptosis leads to different human disorders including immunodeficiency, …             Light attenuates lipid accumulation while enhancing cell proliferation and starch synthesis in the glucose-fed oleaginous microalga Chlorella zofingiensis ▶     Tianpeng Chen, Jin Liu, Bingbing Guo et al.     The objective of this study was to investigate the effect of light on lipid and starch accumulation in the oleaginous green algae Chlorella zofingiensis supplemented with …             Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast ▶     Xiaolong Deng, Huan Zhou, Guiping Zhang et al.     RNA interference (RNAi) is a widespread gene-silencing mechanism and is required for heterochromatin assembly in a variety of organisms. The RNA-induced transcriptional silencing …             Whole Genome Sequencing demonstrates that Geographic Variation of Escherichia coli O157 Genotypes Dominates Host Association ▶     Norval J. C. Strachan, Ovidiu Rotariu, Bruno Lopes et al.     Genetic variation in an infectious disease pathogen can be driven by ecological niche dissimilarities arising from different host species and different geographical locations. …             Uncoating Mechanism of Carnation Mottle Virus Revealed by Cryo-EM Single Particle Analysis ▶     Chun-Yan Wang, Qin-Fen Zhang, Yuan-Zhu Gao et al.     Genome uncoating is a prerequisite for the successful infection of plant viruses in host plants. Thus far, little is known about the genome uncoating of the Carnation mottle virus…             New reconstruction of the Wiwaxia scleritome, with data from Chengjiang juveniles ▶     Zhifei Zhang, Martin R. Smith, Degan Shu     Wiwaxiids are a problematic group of scale-covered lophotrochozoans known from Cambrian Stages 3–5. Their imbricating dorsal scleritome of leaf-like scales has prompted …             Habitat fragmentation is associated to gut microbiota diversity of an endangered primate: implications for conservation ▶     Claudia Barelli, Davide Albanese, Claudio Donati et al.     The expansion of agriculture is shrinking pristine forest areas worldwide, jeopardizing the persistence of their wild inhabitants. The Udzungwa red colobus monkey (Procolobus …             Target-Driven Evolution of Scorpion Toxins ▶     Shangfei Zhang, Bin Gao, Shunyi Zhu     It is long known that peptide neurotoxins derived from a diversity of venomous animals evolve by positive selection following gene duplication, yet a force that drives their …             An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo ▶     Jonas Wietek, Riccardo Beltramo, Massimo Scanziani et al.     Channelrhodopsins are light-gated cation channels that have been widely used for optogenetic stimulation of electrically excitable cells. Replacement of a glutamic acid in the …             Comparative analyses of fecal microbiota in Tibetan and Chinese Han living at low or high altitude by barcoded 454 pyrosequencing ▶     Long Li, Xin Zhao     Knowledge about the impact of altitude and ethnicity on human gut microbiota is currently limited. In this study, fecal microbiota from 12 Tibetans (T group), 11 Chinese Han …             The network organization of protein interactions in the spliceosome is reproduced by the simple rules of food-web models ▶     Mathias M. Pires, Maurício Cantor, Paulo R. Guimarães et al.     The network structure of biological systems provides information on the underlying processes shaping their organization and dynamics. Here we examined the structure of the …             Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding ▶     Georgina Victoria-Acosta, Karla Vazquez-Santillan, Luis Jimenez-Hernandez et al.     XAF1 is a tumour suppressor gene that compromises cell viability by modulating different cellular events such as mitosis, cell cycle progression and apoptosis. In cancer, the XAF1…             Spillover and pandemic properties of zoonotic viruses with high host plasticity ▶     Christine Kreuder Johnson, Peta L. Hitchens, Tierra Smiley Evans et al.     Most human infectious diseases, especially recently emerging pathogens, originate from animals, and ongoing disease transmission from animals to people presents a significant …             Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica ▶     Ankita Chatterjee, Sudip Kundu     Chlorophyll is one of the most important pigments present in green plants and rice is one of the major food crops consumed worldwide. We curated the existing genome scale …             Microbial metabolic networks in a complex electrogenic biofilm recovered from a stimulus-induced metatranscriptomics approach ▶     Shun’ichi Ishii, Shino Suzuki, Aaron Tenney et al.     Microorganisms almost always exist as mixed communities in nature. While the significance of microbial community activities is well appreciated, a thorough understanding about …             Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1 ▶     Donghui Wu, Hung Yi Kristal Kaan, Xiaoxia Zheng et al.     Ornithine decarboxylase (ODC) catalyzes the first and rate-limiting step of polyamine biosynthesis in humans. Polyamines are essential for cell proliferation and are implicated …             Mapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation ▶     Maria Merkulova, Teodor G. Păunescu, Anie Azroyan et al.     V-ATPases (H+ ATPases) are multisubunit, ATP-dependent proton pumps that regulate pH homeostasis in virtually all eukaryotes. They are involved in key cell biological processes …             Role of JAK-STAT signaling in maturation of phagosomes containing Staphylococcus aureus ▶     Fei Zhu, Yadong Zhou, Chunxia Jiang et al.     Phagocytosis is a required mechanism for the defense against pathogens. Staphylococcus aureus, an important bacterial pathogen, can promptly escape from phagosomes and …             Maximizing oyster-reef growth supports green infrastructure with accelerating sea-level rise ▶     Justin T. Ridge, Antonio B. Rodriguez, F. Joel Fodrie et al.     Within intertidal communities, aerial exposure (emergence during the tidal cycle) generates strong vertical zonation patterns with distinct growth boundaries regulated by …             ScbR- and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor ▶     Xiao Li, Juan Wang, Shanshan Li et al.     In model organism Streptomyces coelicolor, γ-butyrolactones (GBLs) and antibiotics were recognized as signalling molecules playing fundamental roles in intra- and interspecies …             Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells ▶     Naoki Okumura, Ayaka Kusakabe, Hiroatsu Hirano et al.     The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy …             Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity ▶     Shiliang Li, Guoqin Luan, Xiaoli Ren et al.     Human dihydroorotate dehydrogenase (hDHODH) is an attractive therapeutic target for the treatment of rheumatoid arthritis, transplant rejection and other autoimmune diseases. …             A combinatorial approach towards the design of nanofibrous scaffolds for chondrogenesis ▶     Maqsood Ahmed, Tiago André da Silva Ramos, Febriyani Damanik et al.     The extracellular matrix (ECM) is a three-dimensional (3D) structure composed of proteinaceous fibres that provide physical and biological cues to direct cell behaviour. Here, we …             Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis ▶     Hong Wang, Tao Tan, Junfeng Wang et al.     Alcoholic liver disease (ALD) is a significant public health issue with heavy medical and economic burdens. The aetiology of ALD is not yet completely understood. The development …             A strategy to discover decoy chemokine ligands with an anti-inflammatory activity ▶     Dayana Abboud, François Daubeuf, Quoc Tuan Do et al.     Excessive signaling by chemokines has been associated with chronic inflammation or cancer, thus attracting substantial attention as promising therapeutic targets. Inspired by …             Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins ▶     Séverine Ménoret, Anne De Cian, Laurent Tesson et al.     The generation of genetically-modified organisms has been revolutionized by the development of new genome editing technologies based on the use of gene-specific nucleases, such …             Simulating photoacoustic waves produced by individual biological particles with spheroidal wave functions ▶     Yong Li, Hui Fang, Changjun Min et al.     Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and …             Finding cannabinoids in hair does not prove cannabis consumption ▶     Bjoern Moosmann, Nadine Roth, Volker Auwärter     Hair analysis for cannabinoids is extensively applied in workplace drug testing and in child protection cases, although valid data on incorporation of the main analytical …             High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis ▶     Clara V. Perani, Inga D. Neumann, Stefan O. Reber et al.     Maternal obesity is associated with lower basal plasma cortisol levels and increased risk of postpartum psychiatric disorders. Given that both obesity and the peripartum period …             Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls ▶     Changsong Wang, Yue Feng, Mingao Wang et al.     Urinary volatile organic compounds (VOCs) analysis for kidney diseases has attracted a large amount of scientific interest recently, and urinary metabolite analysis has already …             Shifts in leaf N:P stoichiometry during rehabilitation in highly alkaline bauxite processing residue sand ▶     Johnvie B. Goloran, Chengrong Chen, Ian R. Phillips et al.     Large quantities of sodic and alkaline bauxite residue are produced globally as a by-product from alumina refineries. Ecological stoichiometry of key elements [nitrogen (N) and …             Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation ▶     Vijaya Pandey, Vijay Kumar     Sirtuin-7 (SIRT7) deacetylase exhibits a high selectivity for acetylated H3K18 and has been implicated in the maintenance of malignant phenotype. However, it remains unclear if …             Direct regulation of the natural competence regulator gene tfoX by cyclic AMP (cAMP) and cAMP receptor protein (CRP) in Vibrios ▶     Rui Wu, Meng Zhao, Jing Li et al.     TfoX (Sxy) and CRP are two important competence activators. The link between tfoX and CRP has been shown in H. influenza but lacking evidence of direct interaction. Recently a …             Construction of a High-Density Genetic Map and Quantitative Trait Locus Mapping in the Sea Cucumber Apostichopus japonicus ▶     Meilin Tian, Yangping Li, Jing Jing et al.     Genetic linkage maps are critical and indispensable tools in a wide range of genetic and genomic research. With the advancement of genotyping-by-sequencing (GBS) methods, the …             IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3 ▶     Reiner K. W. Mailer, Anne-Laure Joly, Sang Liu et al.     CD4+FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological self-tolerance. Treg cell development and function depend on the transcription factor FOXP3, …             Chemical recognition of fruit ripeness in spider monkeys (Ateles geoffroyi) ▶     Omer Nevo, Rosa Orts Garri, Laura Teresa Hernandez Salazar et al.     Primates are now known to possess well-developed olfactory sensitivity and discrimination capacities that can play a substantial role in many aspects of their interaction with …             Comparative analysis of pentavalent rotavirus vaccine strains and G8 rotaviruses identified during vaccine trial in Africa ▶     Elisabeth Heylen, Mark Zeller, Max Ciarlet et al.     RotaTeqTM is a pentavalent rotavirus vaccine based on a bovine rotavirus genetic backbone in vitro reassorted with human outer capsid genes. During clinical trials of RotaTeqTM …             Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels ▶     Ben Cristofori-Armstrong, Ming S. Soh, Sahil Talwar et al.     For the past 30 years, oocytes from Xenopus laevis have been extensively used to express and characterise ion channels in an easily controlled environment. Here we report the …             CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins ▶     Toru Suzuki, Chisato Kikuguchi, Sahil Sharma et al.     The CCR4-NOT complex is conserved in eukaryotes and is involved in mRNA metabolism, though its molecular physiological roles remain to be established. We show here that …             Characterization of aggregate/aggresome structures formed by polyhedrin of Bombyx mori nucleopolyhedrovirus ▶     Zhong-Jian Guo, Liu-Xing Tao, Xian-Yun Dong et al.     Virus infections often lead to formation of aggregates and aggresomes in host cells. In this study, production of aggregates and aggresomes by the highly expressed protein …             Time-scales of hydrological forcing on the geochemistry and bacterial community structure of temperate peat soils ▶     Flavia L. D. Nunes, Luc Aquilina, Jo de Ridder et al.     Peatlands are an important global carbon reservoir. The continued accumulation of carbon in peatlands depends on the persistence of anoxic conditions, in part induced by water …             Identification of a FOXP3+CD3+CD56+ population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma ▶     Xiaofeng Li, Jirun Peng, Yanli Pang et al.     The liver resident lymphoid population is featured by the presence of a large number of CD3+CD56+ cells referred as natural T cells. In human hepatocellular carcinoma (HCC) …             Transcranial magnetic stimulation facilitates neurorehabilitation after pediatric traumatic brain injury ▶     Hongyang Lu, Tali Kobilo, Courtney Robertson et al.     Traumatic brain injury (TBI) is the leading cause of death and disability among children in the United States. Affected children will often suffer from emotional, cognitive and …             PLD1 participates in BDNF-induced signalling in cortical neurons ▶     Mohamed Raafet Ammar, Tamou Thahouly, André Hanauer et al.     The brain-derived neurotrophic factor BDNF plays a critical role in neuronal development and the induction of L-LTP at glutamatergic synapses in several brain regions. However, …             Soft-tissue and dermal arrangement in the wing of an Early Cretaceous bird: Implications for the evolution of avian flight ▶     Guillermo Navalón, Jesús Marugán-Lobón, Luis M. Chiappe et al.     Despite a wealth of fossils of Mesozoic birds revealing evidence of plumage and other soft-tissue structures, the epidermal and dermal anatomy of their wing’s patagia remain …             Multicopper oxidase-1 is required for iron homeostasis in Malpighian tubules of Helicoverpa armigera ▶     Xiaoming Liu, Chengxian Sun, Xiaoguang Liu et al.     Multicopper oxidases (MCOs) are enzymes that contain 10 conserved histidine residues and 1 cysteine residue. MCO1 has been extensively investigated in the midgut because this MCO …             High resolution structure of an M23 peptidase with a substrate analogue ▶     Maja Grabowska, Elzbieta Jagielska, Honorata Czapinska et al.     LytM is a Staphylococcus aureus autolysin and a homologue of the S. simulans lysostaphin. Both enzymes are members of M23 metallopeptidase family (MEROPS) comprising primarily …             Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods ▶     Nicolette G. Alkema, Tushar Tomar, Evelien W. Duiker et al.     Using patient-derived xenografts (PDXs) for preclinical cancer research demands proper storage of tumour material to facilitate logistics and to reduce the number of animals …             Accurate and Efficient Resolution of Overlapping Isotopic Envelopes in Protein Tandem Mass Spectra ▶     Kaijie Xiao, Fan Yu, Houqin Fang et al.     It has long been an analytical challenge to accurately and efficiently resolve extremely dense overlapping isotopic envelopes (OIEs) in protein tandem mass spectra to confidently …             Ultra-high voltage electron microscopy of primitive algae illuminates 3D ultrastructures of the first photosynthetic eukaryote ▶     Toshiyuki Takahashi, Tomoki Nishida, Chieko Saito et al.     A heterotrophic organism 1–2 billion years ago enslaved a cyanobacterium to become the first photosynthetic eukaryote, and has diverged globally. The primary phototrophs, …             A Nanoparticle-based Sensor Platform for Cell Tracking and Status/Function Assessment ▶     David Yeo, Christian Wiraja, Yon Jin Chuah et al.     Nanoparticles are increasingly popular choices for labeling and tracking cells in biomedical applications such as cell therapy. However, all current types of nanoparticles fail …             IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity ▶     Cohen Idan, Rider Peleg, Voronov Elena et al.     Environmental signals can be translated into chromatin changes, which alter gene expression. Here we report a novel concept that cells can signal chromatin damage from the …             Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain ▶     Yuka Kimura, Yukiko Toyofuku, Shin Koike et al.     Hydrogen polysulfides (H2Sn) have a higher number of sulfane sulfur atoms than hydrogen sulfide (H2S), which has various physiological roles. We recently found H2Sn in the brain. …             Mammalian Host-Versus-Phage immune response determines phage fate in vivo ▶     Katarzyna Hodyra-Stefaniak, Paulina Miernikiewicz, Jarosław Drapała et al.     Emerging bacterial antibiotic resistance draws attention to bacteriophages as a therapeutic alternative to treat bacterial infection. Examples of phage that combat bacteria …             Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay ▶     Megha Aggarwal, Rajesh Sharma, Pravindra Kumar et al.     Chikungunya virus (CHIKV) capsid protein (CVCP) is a serine protease that possesses cis-proteolytic activity essential for the structural polyprotein processing and plays a key …             The C-terminal amyloidogenic peptide contributes to self-assembly of Avibirnavirus viral protease ▶     Xiaojuan Zheng, Lu Jia, Boli Hu et al.     Unlike other viral protease, Avibirnavirus infectious bursal disease virus (IBDV)-encoded viral protease VP4 forms unusual intracellular tubule-like structures during viral …             Alleviation of skin inflammation after Lin− cell transplantation correlates with their differentiation into myeloid-derived suppressor cells ▶     Su Jeong Ryu, Ji-Min Ju, Woojin Kim et al.     To understand the cellular mechanism underlying the therapeutic effects exerted by hematopoietic stem cell transplantation in the repair of tissue damage, we investigated the in …             Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface ▶     Manoranjan Arakha, Sweta Pal, Devyani Samantarrai et al.     Investigating the interaction patterns at nano-bio interface is a key challenge for safe use of nanoparticles (NPs) to any biological system. The study intends to explore the …             Hyperisampsins H–M, Cytotoxic Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii ▶     Hucheng Zhu, Chunmei Chen, Qingyi Tong et al.     Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H–M (1–6), were isolated from the aerial parts of Hypericum sampsonii, together with five …             Phylum-wide analysis of genes/proteins related to the last steps of assembly and export of extracellular polymeric substances (EPS) in cyanobacteria ▶     Sara B. Pereira, Rita Mota, Cristina P. Vieira et al.     Many cyanobacteria produce extracellular polymeric substances (EPS) with particular characteristics (e.g. anionic nature and presence of sulfate) that make them suitable for …             Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmission ▶     Guodong Niu, Bin Wang, Genwei Zhang et al.     Inhibiting Plasmodium development in mosquitoes will block malaria transmission. Fibrinogen-related protein 1 (FREP1) is critical for parasite infection in Anopheles gambiae and …             Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function ▶     Gin-Fu Chen, Varadarajan Sudhahar, Seock-Won Youn et al.     Copper (Cu), an essential micronutrient, plays a fundamental role in inflammation and angiogenesis; however, its precise mechanism remains undefined. 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