Nature Methods Application Notes e-UPDATE: 13 October 2015

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13 October 2015  Application Notes bring you the latest information about innovative tools and technologies and their applications in the lab. We hope that you will find this service useful and informative and encourage you to sign up for future Updates to ensure that you never miss one!

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FEATURED APPLICATION NOTE Rapid screening for protein solubility and expression www.lucigen.com > The Expresso® Solubility and Expression Screening System uses a simple ligase-free cloning strategy and a single PCR product to construct and test seven distinct protein fusion partners in parallel over the course of a few days. This multiplexed system simplifies the screening of fusion partners and greatly increases the chances of obtaining improved expression and solubility of target proteins. PDF

		InnoStamp 40™ and InnoScan 1100AL™: a complete automated platform for microstructured cell arrays www.innopsys.com > Microstructured cell arrays are obtained by patterning of extracellular matrix (ECM) components on a substrate to control cell spread. Because such arrays are of interest to different fields related to cell biology, automatic production and parallelized assays are needed. With complete automation of ECM 2D patterning and whole-slide image acquisition, the InnoStamp 40™ and the InnoScan 1100AL™ are ideal tools for high-throughput assays for the study of cell fate decisions in the presence of external stimuli such as drugs, toxins or mechanical stress. PDF

		Intercalating fluorescence dyes: different kits, high variety www.analytik-jena.com > Using intercalating dyes for quantification assays is one of the most common and popular real-time PCR application. SYBR Green or EvaGreen for example are easy and universally to use. Thus a wide variety of ready-to-use master mixes are available to simplify workflows as much as possible. Analytik Jena's standard real-time thermal cycler qTOWER 2.0/2.2 was used to compare the performance of those mixes. PDF

		Time-resolved fluorescence in the analysis of edible oils www.lambertinstruments.com > Fluorescence spectroscopy is an effective method to obtain a physical or chemical signature for delineating the composition and characteristics of organic matter. It is a major tool for analyzing food security. However, since most organic ingredients have similar fluorescent spectra, it is difficult to distinguish them with high precision by traditional fluorescence analysis. PDF

		RNAdestination™ www.incellart.com > Unlock the potential of messenger RNA to develop novel biotherapeutics. PDF

		Switching between multiple solutions maintaining constant flow-rate www.fluigent.com > In this application, one MFCS™-EZ pressure channel is connected via a manifold to ten separate vials containing different aqueous solutions. Use of the M-Switch™ and ESS™ Control software allows the selection of a specific solution directed to a microfluidic device. PDF

		MAGNETOFECTION™,the tool of choice to reach high transfection andtransduction efficiency with low toxicity on Primary cells www.ozbiosciences.com > Magnetofection is a powerful method for introducing nucleic acids into cells, that successful overcomes the limitations encountered by traditional nucleic acid delivery systems such as low efficiency, toxicity, difficulty to handle. Magnetofection™ has been successfully tested on a broad range of cell lines, hard-to-transfect and primary cells. It is perfect for non-dividing or slowly dividing cells, meaning that the genetic materials can go to the nucleus without cell division. PDF

 

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