Nature Communications - 30 September 2015

Advertisement Accelerating Neuroscience Research  A major challenge in neuroscience research and drug discovery is the lack of easy access to relevant animal models for use in screening drug candidates.  The Advanced Neuroscience Mouse Model Portfolio provides simplified access to models and services for the study of neuronal disease and signaling. Learn about extensive phenotyping data, and aging services to help accelerate research outcomes.  Learn More     Weekly Content Alert Nature Communications is now fully open access. Read more. 30 September 2015  Featured image: Schnitsar et al. show that motile cilia formation is dependent on regulation of the protein Dishevelled by the protein PTEN. Latest content: Articles Erratum Journal homepage Recommend to library Web feed   Advertisement Primers in your inbox Nature Reviews Disease Primers launched in April 2015 and publishes Primers — introductory review articles that provide overviews of diseases and disorders. Primer articles describe all aspects of a condition: epidemiology; disease mechanisms; diagnosis, screening and prevention; management; and quality of life.  Stay updated on the latest Primers published.       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     A recursive vesicle-based model protocell with a primitive model cell cycle OPEN Kensuke Kurihara, Yusaku Okura, Muneyuki Matsuo, Taro Toyota, Kentaro Suzuki and Tadashi Sugawara The synthetic production of model protocells, which represent potential intermediates between nonliving material and living cells, may help to explain the origin of cellular life. Here, Kurihara et al. develop a giant vesicle-based model protocell that is able to self-proliferate recursively in response to external stimuli. 29 September 2015 | doi: 10.1038/ncomms9352 Biological Sciences  Biophysics  Cell biology  Ablation of hippocampal neurogenesis in mice impairs the response to stress during the dark cycle OPEN Cheng-Yu Tsai, Ching-Yen Tsai, Sebastian J. Arnold and Guo-Jen Huang Adult hippocampal neurogenesis is involved in the response to stress but whether it exerts a positive or negative effect remains unclear. Here the authors ablate hippocampal neurogenesis in mice and find that the effects on anxiety behaviour depend on the time of day, and that neurogenesis specifically impairs the response to stress during the dark cycle. 29 September 2015 | doi: 10.1038/ncomms9373 Biological Sciences  Neuroscience  Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK–STAT pathway in Sézary syndrome OPEN Mark J. Kiel, Anagh A. Sahasrabuddhe, Delphine C. M. Rolland, Thirunavukkarasu Velusamy, Fuzon Chung, Matthew Schaller, Nathanael G. Bailey, Bryan L. Betz, Roberto N. Miranda, Pierluigi Porcu, John C. Byrd, L. Jeffrey Medeiros, Steven L. Kunkel, David W. Bahler, Megan S. Lim and Kojo S. J. Elenitoba-Johnson Sézary syndrome is a T cell malignancy that has been poorly characterized at the genome level. In this study, Kiel et al. perform whole-genome analyses and identify mutations in the JAK–STAT pathway and show that primary cells are sensitive to JAK inhibitors. 29 September 2015 | doi: 10.1038/ncomms9470 Biological Sciences  Cancer  Genetics  Ultrahigh volumetric capacitance and cyclic stability of fluorine and nitrogen co-doped carbon microspheres OPEN Junshuang Zhou, Jie Lian, Li Hou, Junchuan Zhang, Huiyang Gou, Meirong Xia, Yufeng Zhao, Timothy A. Strobel, Lu Tao and Faming Gao Carbon-based supercapacitors often suffer from poor volumetric capacitance due to the low packing density which arises from attempts to increase the electrode surface area. Here, in contrast, the authors fabricate N and F co-doped non-porous solid carbon spheres and achieve exceptional performances. 29 September 2015 | doi: 10.1038/ncomms9503 Physical Sciences  Materials science  Physical chemistry  A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement OPEN Nagendran Ramalingam, Christof Franke, Evelin Jaschinski, Moritz Winterhoff, Yao Lu, Stefan Brühmann, Alexander Junemann, Helena Meier, Angelika A. Noegel, Igor Weber, Hongxia Zhao, Rudolf Merkel, Michael Schleicher and Jan Faix Amoeboid motility is driven by actomyosin-based contraction and exploits differences in the mechanical properties of the cortical cytoskeleton. Here the authors discover that mDia1-like formin A is responsible for generating a subset of actin filaments at the rear of Dictyostelium that suppresses lateral protrusions and blebbing during 2D-confined migration. 29 September 2015 | doi: 10.1038/ncomms9496 Biological Sciences  Cell biology  Entropy-stabilized oxides OPEN Christina M. Rost, Edward Sachet, Trent Borman, Ali Moballegh, Elizabeth C. Dickey, Dong Hou, Jacob L. Jones, Stefano Curtarolo and Jon-Paul Maria The composition of oxide compounds controls many of their properties and electronic phases. Here, the authors show that entropy and configurational disorder can stabilize new phases of oxides, potentially enabling a better engineering of their properties. 29 September 2015 | doi: 10.1038/ncomms9485 Physical Sciences  Condensed matter  Materials science  Exciton dynamics of C60-based single-photon emitters explored by Hanbury Brown–Twiss scanning tunnelling microscopy OPEN P. Merino, C. Große, A. Rosławska, K. Kuhnke and K. Kern Electrons and holes trapped in a molecular crystal couple to form excitons. Here, the authors use scanning tunnelling microscopy to inject current with submolecular precision into structural defects in solid C60 and demonstrate single photon emission from the excitons trapped there. 29 September 2015 | doi: 10.1038/ncomms9461 Physical Sciences  Materials science  Nanotechnology  Optical physics  Macroscopic ordering of helical pores for arraying guest molecules noncentrosymmetrically OPEN Chunji Li, Joonil Cho, Kuniyo Yamada, Daisuke Hashizume, Fumito Araoka, Hideo Takezoe, Takuzo Aida and Yasuhiro Ishida Helical nanostructures often exhibit intriguing physical phenomena. Here, the authors fabricate a helical porous material exhibiting both controlled handedness and macroscopic orientation, which promises applications in a wide array of disciplines. 29 September 2015 | doi: 10.1038/ncomms9418 Chemical Sciences  Materials science  Optical physics  Organic chemistry  Carbon-bridged oligo(p-phenylenevinylene)s for photostable and broadly tunable, solution-processable thin film organic lasers OPEN Marta Morales-Vidal, Pedro G. Boj, José M. Villalvilla, José A. Quintana, Qifan Yan, Nai-Ti Lin, Xiaozhang Zhu, Nopporn Ruangsupapichat, Juan Casado, Hayato Tsuji, Eiichi Nakamura and María A. Díaz-García Thin film organic solid-state lasers are low-cost flexible devices which require efficient, stable, colour-tunable, solution-processable materials. Here, the authors show that oligo(p-phenylenevinylene)s simultaneously possess all such properties, as demonstrated by their use in laser devices. 29 September 2015 | doi: 10.1038/ncomms9458 Physical Sciences  Applied physics  Condensed matter  Atomic-level characterization of transport cycle thermodynamics in the glycerol-3-phosphate:phosphate antiporter OPEN Mahmoud Moradi, Giray Enkavi and Emad Tajkhorshid Membrane transporters transition between inward- and outward-facing conformations to translocate substrates across membranes but mechanistic details of this process remain scarce. Here Moradi et al. use an advanced molecular simulation approach to describe the complete thermodynamic cycle of the GlpT transporter at atomic-level detail. 29 September 2015 | doi: 10.1038/ncomms9393 Biological Sciences  Biophysics  Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera OPEN Zhihong Sun, Hugh M. B. Harris, Angela McCann, Chenyi Guo, Silvia Argimón, Wenyi Zhang, Xianwei Yang, Ian B Jeffery, Jakki C. Cooney, Todd F. Kagawa, Wenjun Liu, Yuqin Song, Elisa Salvetti, Agnieszka Wrobel, Pia Rasinkangas, Julian Parkhill, Mary C. Rea, Orla O’Sullivan, Jarmo Ritari, François P. Douillard et al. Lactobacillus is a lactic acid bacteria and has a wide range of application from use in probiotic food production to biotherapeutics. Here, the authors sequence and compare the genomes of 213 different Lactobacillus strains and related genera, and provide new insight into phylogenomic organization and adaptive immunity elements in this bacteria family. 29 September 2015 | doi: 10.1038/ncomms9322 Biological Sciences  Bioinformatics  Biotechnology  Microbiology  Maternal bile acid transporter deficiency promotes neonatal demise OPEN Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhong-ze Fang, Matthew W. Frank, Christopher Calabrese, Kristopher W. Krausz, Geoffrey Neale, Sharon Frase, Peter Vogel, Charles O. Rock, Frank J. Gonzalez and John D. Schuetz The mechanisms underlying perinatal mortality due to intrahepatic cholestasis of pregnancy are not fully understood. Here, the authors show that absence of the nuclear receptor and bile acid regulator Nrli2 and the biliary transporter Abcb11 strongly reduces maternal serum bile acid levels, improving neonatal survival. 29 September 2015 | doi: 10.1038/ncomms9186 Biological Sciences  Medical research  Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies OPEN Nicholas E. Webb, David C. Montefiori and Benhur Lee Potencies of HIV broadly neutralizing antibodies are usually defined by their in vitro IC50 and IC80 values, but much higher levels will be required for successful immunotherapies. Here, Webb et al. predict antibody potency at therapeutic levels by analyzing dose–response curve slopes, which correlate with epitope class. 29 September 2015 | doi: 10.1038/ncomms9443 Biological Sciences  Immunology  Medical research  Virology  Coordinating activation strategy for C(sp3)–H/C(sp3)–H cross-coupling to access β-aromatic α-amino acids OPEN Kaizhi Li, Qian Wu, Jingbo Lan and Jingsong You Oxidative coupling of two C(sp3)-H groups is an attractive approach for the formation of carbon-carbon bonds, building structural complexity while avoiding the formation of waste salts. Here, the authors report such a transformation, using a nickel catalyst to functionalise amino acids with benzylic radicals. 29 September 2015 | doi: 10.1038/ncomms9404 Chemical Sciences  Catalysis  Organic chemistry  Lower glycolysis carries a higher flux than any biochemically possible alternative OPEN Steven J. Court, Bartlomiej Waclaw and Rosalind J. Allen The biochemical pathways of central carbon metabolism are highly conserved across all domains of life. Here, Court et al. use a computational approach to test all possible pathways of glycolysis and gluconeogenesis and find that the existing trunk pathways may represent a maximal flux solution selected for during evolution. 29 September 2015 | doi: 10.1038/ncomms9427 Biological Sciences  Bioinformatics  Evolution  Systems biology  Flexible coherent control of plasmonic spin-Hall effect OPEN Shiyi Xiao, Fan Zhong, Hui Liu, Shining Zhu and Jensen Li Conventional methods to control surface plasmon polaritons with light offer limited tunability or complex design parameters. Here, Xiao et al. demonstrate coherent and independent control of surface plasmon polariton orbitals for two opposite spins using multiple rings of nano-slots on a metasurface 29 September 2015 | doi: 10.1038/ncomms9360 Physical Sciences  Materials science  Optical physics  Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle OPEN Darren J. Parker, Christopher B. Cunningham, Craig A. Walling, Clare E. Stamper, Megan L. Head, Eileen M. Roy-Zokan, Elizabeth C. McKinney, Michael G. Ritchie and Allen J. Moore The burying beetle shows flexible parenting behaviour. Here, the authors show that offspring fare equally well regardless of the sex or number of parents present and find similar gene expression profiles in uniparental and biparental females and in uniparental males, which suggests no specialization in parenting. 29 September 2015 | doi: 10.1038/ncomms9449 Biological Sciences  Evolution  Genetics  Zoology  Raman spectroscopy as probe of nanometre-scale strain variations in graphene OPEN C. Neumann, S. Reichardt, P. Venezuela, M. Drögeler, L. Banszerus, M. Schmitz, K. Watanabe, T. Taniguchi, F. Mauri, B. Beschoten, S. V. Rotkin and C. Stampfer Raman spectroscopy has become an invaluable tool for graphene characterisation, yet the nature of the broadening of the Raman 2D line remains unclear. Here, Stampfer et al. show that the Raman 2D line width is a measure of nanometre-scale strain variations in graphene on insulating substrates. 29 September 2015 | doi: 10.1038/ncomms9429 Physical Sciences  Materials science  Nanotechnology  Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis OPEN Peter Zanvit, Joanne E. Konkel, Xue Jiao, Shimpei Kasagi, Dunfang Zhang, Ruiqing Wu, Cheryl Chia, Nadim J. Ajami, Daniel P. Smith, Joseph F. Petrosino, Brittany Abbatiello, Hiroko Nakatsukasa, Qianming Chen, Yasmine Belkaid, Zi-Jiang Chen and WanJun Chen Commensal microbes are necessary for proper development of the immune system. Here Zanvit et al. show that neonatal antibiotics treatment causes long-term changes in the gut and skin microbiomes, and exacerbates immune-mediated skin pathology at adult age in mouse experimental models of psoriasis. 29 September 2015 | doi: 10.1038/ncomms9424 Biological Sciences  Immunology  Microbiology  Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome OPEN Felix R. Day, David A. Hinds, Joyce Y. Tung, Lisette Stolk, Unnur Styrkarsdottir, Richa Saxena, Andrew Bjonnes, Linda Broer, David B. Dunger, Bjarni V. Halldorsson, Debbie A. Lawlor, Guillaume Laval, Iain Mathieson, Wendy L. McCardle, Yvonne Louwers, Cindy Meun, Susan Ring, Robert A. Scott, Patrick Sulem, André G. Uitterlinden et al. This paper describes the largest genome-wide association study to date on polycystic ovary syndrome (PCOS), a common reproductive disorder in women. Six genetic loci—including known targets of cancer chemotherapy—were identified, and the authors infer causal and balancing selection mechanisms involved in PCOS risk and susceptibility. 29 September 2015 | doi: 10.1038/ncomms9464 Biological Sciences  Genetics  Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis OPEN Harriet Corvol, Scott M. Blackman, Pierre-Yves Boëlle, Paul J. Gallins, Rhonda G. Pace, Jaclyn R. Stonebraker, Frank J. Accurso, Annick Clement, Joseph M. Collaco, Hong Dang, Anthony T. Dang, Arianna Franca, Jiafen Gong, Loic Guillot, Katherine Keenan, Weili Li, Fan Lin, Michael V. Patrone, Karen S. Raraigh, Lei Sun et al. Cystic fibrosis imposes a decline in quality of life but new treatments are being developed that target specific CFTR variants. Here the authors identify five genome loci significantly associated with variation in disease severity in a meta-analysis, which may provide targets for individualized treatment of cystic fibrosis. 29 September 2015 | doi: 10.1038/ncomms9382 Biological Sciences  Genetics  NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation Emi Murayama, Milka Sarris, Michael Redd, Dorothée Le Guyader, Catherine Vivier, Wyatt Horsley, Nikolaus Trede and Philippe Herbomel How do stromal cells contribute to the haematopoietic stem cell (HSC) niche? In zebrafish, Murayama et al. identify somite-derived stromal cells in the first niche where HSCs home, and depletion of the nascent polypeptide-associated complex alpha subunit in these cells prevents HSC maturation. 28 September 2015 | doi: 10.1038/ncomms9375 Biological Sciences  Cell biology  Developmental biology  An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products OPEN Chad W. Johnston, Michael A. Skinnider, Morgan A. Wyatt, Xiang Li, Michael R. M. Ranieri, Lian Yang, David L. Zechel, Bin Ma and Nathan A. Magarvey Microbial natural products represent a large reservoir of potential pharmaceutical agents. Here, Johnston et al. describe a computer-automated programme for connecting genome sequences with identified and isolated natural products. 28 September 2015 | doi: 10.1038/ncomms9421 Biological Sciences  Biochemistry  Microbiology  Organic chemistry  The structural origin of the hard-sphere glass transition in granular packing OPEN Chengjie Xia, Jindong Li, Yixin Cao, Binquan Kou, Xianghui Xiao, Kamel Fezzaa, Tiqiao Xiao and Yujie Wang Glass transition shows dramatic dynamic slowdown, but its origin remains unclear. Here, Xia et al. observe in granular systems the rapid growth of a geometrically frustrated polytetrahedral order with packing fraction, which is spatially correlated with the slow dynamics. 28 September 2015 | doi: 10.1038/ncomms9409 Physical Sciences  Condensed matter  Materials science  Multiplex lithography for multilevel multiscale architectures and its application to polymer electrolyte membrane fuel cell OPEN Hyesung Cho, Sang Moon Kim, Yun Sik Kang, Junsoo Kim, Segeun Jang, Minhyoung Kim, Hyunchul Park, Jung Won Bang, Soonmin Seo, Kahp-Yang Suh, Yung-Eun Sung and Mansoo Choi Multiplex lithography is a technique that can be used to fabricate complex soft materials. Here, the authors develop a method to prepare multilevel multiscale structures and demonstrate its application on polymer electrolyte membrane fuel cells which display decreased membrane resistance and increased electrochemical active surface area. 28 September 2015 | doi: 10.1038/ncomms9484 Physical Sciences  Applied physics  Materials science  Structure of the native Sec61 protein-conducting channel OPEN Stefan Pfeffer, Laura Burbaum, Pia Unverdorben, Markus Pech, Yuxiang Chen, Richard Zimmermann, Roland Beckmann and Friedrich Förster The protein-conducting channel Sec61 is responsible for protein transport and membrane insertion at the endoplasmic reticulum. Here, the authors determine the structure of ribosome-bound Sec61 in a native context, in which it adopts a laterally open conformation, irrespective of its functional state. 28 September 2015 | doi: 10.1038/ncomms9403 Biological Sciences  Biochemistry  Cell biology  Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer OPEN Yi Sun, Zhen Sheng, Chao Ma, Kailin Tang, Ruixin Zhu, Zhuanbin Wu, Ruling Shen, Jun Feng, Dingfeng Wu, Danyi Huang, Dandan Huang, Jian Fei, Qi Liu and Zhiwei Cao Predicting combinations of chemotherapeutic drugs that act synergistically is challenging. Here the authors take a computational approach to predict synergistic pairs, validate novel pairs using several cancer cell lines, and assess toxicity in a zebrafish xenograft model. 28 September 2015 | doi: 10.1038/ncomms9481 Biological Sciences  Bioinformatics  Cancer  CPI motif interaction is necessary for capping protein function in cells OPEN Marc Edwards, Patrick McConnell, Dorothy A. Schafer and John A. Cooper Capping protein regulates actin filament dynamics by binding to barbed ends and preventing their growth. Edwards et al. show that capping protein also requires interactions with proteins containing a capping protein interaction motif to promote its proper localization and regulation of actin dynamics. 28 September 2015 | doi: 10.1038/ncomms9415 Biological Sciences  Biochemistry  Cell biology  Optodynamic simulation of β-adrenergic receptor signalling OPEN Edward R. Siuda, Jordan G. McCall, Ream Al-Hasani, Gunchul Shin, Sung Il Park, Martin J. Schmidt, Sonya L. Anderson, William J. Planer, John A. Rogers and Michael R. Bruchas Optogenetic activation of β2-adrenergic receptors (β2-AR) has been achieved, but not characterized in detail. Here, Siuda et al. show that light-controlled opto-β2AR mimics endogenous β2AR activity in vitro and in vivo, and develop novel, optically active, functionally selective receptors to bias β2AR intracellular signaling mechanisms. 28 September 2015 | doi: 10.1038/ncomms9480 Biological Sciences  Cell biology  Medical research  Neuroscience  Carrier separation and transport in perovskite solar cells studied by nanometre-scale profiling of electrical potential OPEN Chun-Sheng Jiang, Mengjin Yang, Yuanyuan Zhou, Bobby To, Sanjini U. Nanayakkara, Joseph M. Luther, Weilie Zhou, Joseph J. Berry, Jao van de Lagemaat, Nitin P. Padture, Kai Zhu and Mowafak M. Al-Jassim Carrier separation and transport in solar cells need to be understood to improve efficiency. Here, Jiang et al. study the junction structure in perovskite solar cells using Kelvin probe force microscopy, showing that solar cells have a p–n junction and carrier mobility is a limiting factor for device efficiency improvement. 28 September 2015 | doi: 10.1038/ncomms9397 Physical Sciences  Condensed matter  Materials science  Sunlight-powered kHz rotation of a hemithioindigo-based molecular motor OPEN Manuel Guentner, Monika Schildhauer, Stefan Thumser, Peter Mayer, David Stephenson, Peter J. Mayer and Henry Dube Although photodriven molecular motors—capable of converting light into unidirectional motion—hold promise for many applications, these typically require ultraviolet light. Here, the authors design and analyse a motor that can operate at high speeds (kHz) under visible light at ambient temperature. 28 September 2015 | doi: 10.1038/ncomms9406 Chemical Sciences  Nanotechnology  Organic chemistry  Physical chemistry  Multiple-exciton generation in lead selenide nanorod solar cells with external quantum efficiencies exceeding 120% OPEN Nathaniel J. L. K. Davis, Marcus L. Böhm, Maxim Tabachnyk, Florencia Wisnivesky-Rocca-Rivarola, Tom C. Jellicoe, Caterina Ducati, Bruno Ehrler and Neil C. Greenham One-dimensional nanostructures have been shown to increase multiple-exciton generation, offering a pathway to breaking the Shockley–Queisser limit. Here, Davis et al. have fabricated working photovoltaic devices based on high-quality PbSe nanorods and a maximum external quantum efficiency of 122 % was demonstrated. 28 September 2015 | doi: 10.1038/ncomms9259 Physical Sciences  Materials science  Nanotechnology  All-passive nonreciprocal metastructure OPEN Ahmed M. Mahmoud, Arthur R. Davoyan and Nader Engheta The design of all-passive nonreciprocal metastructures is a challenging task as there are trade-offs between the nonreciprocal transmission ratio and insertion loss. Here, Mahmoud et al. propose a concept for all-passive, high-throughput metastructures that exhibit nonreciprocal properties and wave-flow isolation. 28 September 2015 | doi: 10.1038/ncomms9359 Physical Sciences  Materials science  Optical physics  Femtosecond structural transformation of phase-change materials far from equilibrium monitored by coherent phonons OPEN Muneaki Hase, Paul Fons, Kirill Mitrofanov, Alexander V. Kolobov and Junji Tominaga Chalcogenide-based phase-change materials such as Ge2Sb2Te5 could be useful for optical data storage, but the mechanism that ultimately limits their switching speed is unclear. Here, the authors use coherent phonon spectroscopy to better understand the non-thermal pathways between the two different phases. 25 September 2015 | doi: 10.1038/ncomms9367 Physical Sciences  Condensed matter  Medical research  A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families OPEN Oriol Calvete, Paula Martinez, Pablo Garcia-Pavia, Carlos Benitez-Buelga, Beatriz Paumard-Hernández, Victoria Fernandez, Fernando Dominguez, Clara Salas, Nuria Romero-Laorden, Jesus Garcia-Donas, Jaime Carrillo, Rosario Perona, Juan Carlos Triviño, Raquel Andrés, Juana María Cano, Bárbara Rivera, Luis Alonso-Pulpon, Fernando Setien, Manel Esteller, Sandra Rodriguez-Perales et al. Genetic factors that cause cardiac angiosarcoma are unknown. Calvete et al. show that a missense mutation in protection of telomeres 1 (POT1) gene causes cardiac angiosarcoma by affecting the POT1 function and, consequently, telomere length and stability. 25 September 2015 | doi: 10.1038/ncomms9383 Biological Sciences  Cancer  Genetics  Medical research  Functional classification of memory CD8+ T cells by CX3CR1 expression OPEN Jan P. Böttcher, Marc Beyer, Felix Meissner, Zeinab Abdullah, Jil Sander, Bastian Höchst, Sarah Eickhoff, Jan C. Rieckmann, Caroline Russo, Tanja Bauer, Tobias Flecken, Dominik Giesen, Daniel Engel, Steffen Jung, Dirk H. Busch, Ulrike Protzer, Robert Thimme, Matthias Mann, Christian Kurts, Joachim L. Schultze et al. The function of memory CD8+ T cells is often believed to be directly correlated with their localization in tissues. Here the authors show that CD8+ T cells with different proliferative and cytotoxic properties can be distinguished based on their expression of CX3CR1, independently of their tissue localization. 25 September 2015 | doi: 10.1038/ncomms9306 Biological Sciences  Immunology  EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma OPEN Haiou Liu, Yidong Liu, Weisi Liu, Weijuan Zhang and Jiejie Xu Chemokines and their receptors have key roles in tumorigenesis. Here, the authors demonstrate that CXRC4 is overexpressed in hepatocellular carcinoma and is associated with poor prognosis and, mechanistically CXCR4 is increased in expression via EZH2 repression of microRNA-622. 25 September 2015 | doi: 10.1038/ncomms9494 Biological Sciences  Cancer  Medical research  Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike OPEN Jeong Hyun Lee, Daniel P. Leaman, Arthur S. Kim, Alba Torrents de la Peña, Kwinten Sliepen, Anila Yasmeen, Ronald Derking, Alejandra Ramos, Steven W. de Taeye, Gabriel Ozorowski, Florian Klein, Dennis R. Burton, Michel C. Nussenzweig, Pascal Poignard, John P. Moore, Per Johan Klasse, Rogier W. Sanders, Michael B. Zwick, Ian A. Wilson and Andrew B. Ward et al. The envelope glycoprotein (Env) trimer is the only antigenic target for broadly neutralizing antibodies on the surface of the HIV-1 virus. Here the authors show that two related monoclonal antibodies bind between gp41 protomers and neutralize HIV-1 by accelerating Env trimer decay. 25 September 2015 | doi: 10.1038/ncomms9167 Biological Sciences  Biochemistry  Biophysics  Standards and figure-of-merits for quantifying the performance of triboelectric nanogenerators OPEN Yunlong Zi, Simiao Niu, Jie Wang, Zhen Wen, Wei Tang and Zhong Lin Wang Triboelectric nanogenerators are a technology for converting mechanical energy into electricity, but standards for quantifying their performance is lacking. Here, the authors present figure-of-merits to quantitatively evaluate the performance of triboelectric nanogenerators and establish a foundation for further development. 25 September 2015 | doi: 10.1038/ncomms9376 Physical Sciences  Applied physics  Materials science  TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression Ken-ichi Takayama, Aya Misawa, Takashi Suzuki, Kiyoshi Takagi, Yoshihide Hayashizaki, Tetsuya Fujimura, Yukio Homma, Satoru Takahashi, Tomohiko Urano and Satoshi Inoue The epigenetic mark 5-hmC alters gene expression and is known to be regulated by TET proteins. Here, the authors show that 5-hmC and TET2 are reduced in prostate cancer via androgen receptor-dependent miRNA expression and are inversely correlated with prognosis. 25 September 2015 | doi: 10.1038/ncomms9219 Biological Sciences  Cancer  An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses Xiangqiang Zhan, Bilian Qian, Fengqiu Cao, Wenwu Wu, Lan Yang, Qingmei Guan, Xianbin Gu, Pengcheng Wang, Temiloluwa A. Okusolubo, Stephanie L. Dunn, Jian-Kang Zhu and Jianhua Zhu The phytohormone ABA plays a critical role in plant stress responses. Here, using a forward-genetic screen, Zhan et al. discover a splicing factor that plays an important role in splicing HAB1 phosphatase and fine-tuning ABA sensitivity in Arabidopsis. 25 September 2015 | doi: 10.1038/ncomms9139 Biological Sciences  Plant sciences  ABA signalling is fine-tuned by antagonistic HAB1 variants Zhijuan Wang, Hongtao Ji, Bingjian Yuan, Shuangfeng Wang, Chao Su, Bin Yao, Hongtao Zhao and Xia Li Protein phosphatases are central regulators of abscisic acid (ABA) signalling and stress responses in plants. Here, Wang et al. show that different splice variants of the phosphatase HAB1 antagonistically influence ABA sensitivity in Arabidopsis and propose that alternative splicing fine tunes ABA signalling. 25 September 2015 | doi: 10.1038/ncomms9138 Biological Sciences  Plant sciences  Local and bulk 13C hyperpolarization in nitrogen-vacancy-centred diamonds at variable fields and orientations OPEN Gonzalo A. Álvarez, Christian O. Bretschneider, Ran Fischer, Paz London, Hisao Kanda, Shinobu Onoda, Junichi Isoya, David Gershoni and Lucio Frydman Hyperpolarization of nuclear spins for enhancing the sensitivity of magnetic resonance can typically be achieved at low temperatures. Here, the authors demonstrate room-temperature polarization of 13C derived from optically pumped electrons of nitrogen vacancies in diamonds with arbitrary orientations. 25 September 2015 | doi: 10.1038/ncomms9456 Physical Sciences  Applied physics  Condensed matter  Light-induced pyroelectric effect as an effective approach for ultrafast ultraviolet nanosensing OPEN Zhaona Wang, Ruomeng Yu, Caofeng Pan, Zhaoling Li, Jin Yang, Fang Yi and Zhong Lin Wang Zinc oxide is potentially a useful material for ultraviolet detectors, but a relatively long response time hinders practical implementation. Here, the authors demonstrate a zinc oxide nanowire/perovskite heterostructure detector with a five orders of magnitude improvement in both rising and falling edge time. 25 September 2015 | doi: 10.1038/ncomms9401 Physical Sciences  Applied physics  Materials science  Optical physics  Hot-carrier cooling and photoinduced refractive index changes in organic–inorganic lead halide perovskites OPEN Michael B. Price, Justinas Butkus, Tom C. Jellicoe, Aditya Sadhanala, Anouk Briane, Jonathan E. Halpert, Katharina Broch, Justin M. Hodgkiss, Richard H. Friend and Felix Deschler The use of organic–inorganic metal-halide perovskites in hot-carrier devices depends on deepening the understanding of photoexcitations in these materials. Here, Price et al. use transient absorption spectroscopy to study hot-carrier distributions in CH3NH3PbI3 and quantify key semiconductors parameters. 25 September 2015 | doi: 10.1038/ncomms9420 Physical Sciences  Applied physics  Materials science  Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function Parveen Sharma, Cynthia Abbasi, Savo Lazic, Allen C. T. Teng, Dingyan Wang, Nicole Dubois, Vladimir Ignatchenko, Victoria Wong, Jun Liu, Toshiyuki Araki, Malte Tiburcy, Cameron Ackerley, Wolfram H. Zimmermann, Robert Hamilton, Yu Sun, Peter P. Liu, Gordon Keller, Igor Stagljar, Ian C. Scott, Thomas Kislinger et al. Mechanical and electrical activity in the heart is propagated through unique cardiomyocyte membrane structures, the intercalated discs (ID). Sharma et al. identify a novel ID protein, Tmem65, that controls Ca2+ signalling and electrical coupling by interacting with and functionally regulating the gap junction protein Cx43. 25 September 2015 | doi: 10.1038/ncomms9391 Biological Sciences  Cell biology  Developmental biology  Metal oxide-resistive memory using graphene-edge electrodes OPEN Seunghyun Lee, Joon Sohn, Zizhen Jiang, Hong-Yu Chen and H.-S. Philip Wong Increasing memory performance and density will require new breakthroughs in atomic-scale technology and three-dimensional device architectures. Here, the authors demonstrate a memory just 3 Å thick that can be stacked by exploiting the atomically thin edge of monolayer graphene. 25 September 2015 | doi: 10.1038/ncomms9407 Physical Sciences  Applied physics  Materials science  TrkB/BDNF signalling patterns the sympathetic nervous system OPEN Jennifer C. Kasemeier-Kulesa, Jason A. Morrison, Frances Lefcort and Paul M. Kulesa The signals that pattern the sympathetic nervous system are not fully understood. Here the authors show that the dorsal migration of the primary sympathetic ganglia in chick embryos is orchestrated by BDNF/TrkB signalling and requires contact with preganglionic axons. 25 September 2015 | doi: 10.1038/ncomms9281 Biological Sciences  Cell biology  Developmental biology  CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis OPEN Masanori A. Murayama, Shigeru Kakuta, Asuka Inoue, Naoto Umeda, Tomo Yonezawa, Takumi Maruhashi, Koichiro Tateishi, Harumichi Ishigame, Rikio Yabe, Satoshi Ikeda, Akimasa Seno, Hsi-Hua Chi, Yuriko Hashiguchi, Riho Kurata, Takuya Tada, Sachiko Kubo, Nozomi Sato, Yang Liu, Masahira Hattori, Shinobu Saijo et al. The complement system contributes to chronic inflammatory diseases. Here the authors show that CRTP6 suppresses the alternative complement pathway and reverses rheumatoid arthritis in a mouse model of the disease. 25 September 2015 | doi: 10.1038/ncomms9483 Biological Sciences  Immunology  Swarming bacteria migrate by Lévy Walk OPEN Gil Ariel, Amit Rabani, Sivan Benisty, Jonathan D. Partridge, Rasika M. Harshey and Avraham Be'er Lévy walks have been found in the motion of large animals such as birds and fish in search of sparsely and randomly distributed food. Here, Ariel et al. observe, by tracking long-duration trajectories of fluorescently labelled bacteria, similar walks in bacterial swarms for the first time. 25 September 2015 | doi: 10.1038/ncomms9396 Biological Sciences  Biophysics  Microbiology  Macroscopic and high-throughput printing of aligned nanostructured polymer semiconductors for MHz large-area electronics OPEN Sadir G. Bucella, Alessandro Luzio, Eliot Gann, Lars Thomsen, Christopher R. McNeill, Giuseppina Pace, Andrea Perinot, Zhihua Chen, Antonio Facchetti and Mario Caironi Semiconducting polymers with high mobility are essential for the development of high-frequency flexible electronics, whose fabrications rely on robust printing techniques. Bucella et al. report the fabrication of n-type polymer field-effect transistors, with mobility up to 6.4 cm2 V−1s operated at 3.3 MHz, by room temperature bar-coating technique. 25 September 2015 | doi: 10.1038/ncomms9394 Physical Sciences  Applied physics  Materials science  Sub-10-fs population inversion in N2+ in air lasing through multiple state coupling OPEN Huailiang Xu, Erik Lötstedt, Atsushi Iwasaki and Kaoru Yamanouchi Remote generation of population-inverted gain media in air is a step towards the realization of bright and coherent atmospheric lasers. Here, the authors verify population inversion in N2+ and demonstrate the generation of air lasing by acting on it as the gain medium. 25 September 2015 | doi: 10.1038/ncomms9347 Physical Sciences  Atomic and molecular physics  Optical physics  PTEN regulates cilia through Dishevelled OPEN Iryna Shnitsar, Mikhail Bashkurov, Glenn R. Masson, Abiodun A. Ogunjimi, Sherly Mosessian, Eduardo Aguiar Cabeza, Calley L. Hirsch, Daniel Trcka, Gerald Gish, Jing Jiao, Hong Wu, Rudolf Winklbauer, Roger L. Williams, Laurence Pelletier, Jeffrey L. Wrana and Miriam Barrios-Rodiles The formation of motile cilia is regulated by Dishevelled (DVL), a central component in WNT signalling and planar cell polarity (PCP). Here the authors identify DVL as a novel substrate of the phosphatase PTEN, coupling PTEN to cilia dynamics and PCP. 24 September 2015 | doi: 10.1038/ncomms9388 Biological Sciences  Cell biology  The foundations of the human cultural niche OPEN Maxime Derex and Robert Boyd Our understanding of how humans produce complex technologies is limited. Here, the authors use a computer-based experiment to show that the production of complex innovations results from a population process that relies on efficient social learning mechanisms and specific population structures. 24 September 2015 | doi: 10.1038/ncomms9398 Biological Sciences  Evolution  Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation OPEN Adeel Asghar, Audrey Lajeunesse, Kalyan Dulla, Guillaume Combes, Philippe Thebault, Erich A. Nigg and Sabine Elowe Bub1 kinase phosphorylates histone H2A-T120 at the centromere to recruit shugoshin proteins and promote sister chromatid cohesion during mitosis. Here the authors show that Bub1 autophosphorylation on T589 influences Bub1 dynamics at the kinetochore and restricts H2A-T120 phosphorylation to centromeres. 24 September 2015 | doi: 10.1038/ncomms9364 Biological Sciences  Cell biology  Electronic cooling via interlayer Coulomb coupling in multilayer epitaxial graphene OPEN Momchil T. Mihnev, John R. Tolsma, Charles J. Divin, Dong Sun, Reza Asgari, Marco Polini, Claire Berger, Walt A. de Heer, Allan H. MacDonald and Theodore B. Norris The coupling between layers plays an important role in the properties of stacked two-dimensional materials. Here, the authors show that Coulomb interactions between electrons in different layers of graphene induce thermal transport even though all electronic states are confined to individual layers. 24 September 2015 | doi: 10.1038/ncomms9105 Physical Sciences  Condensed matter  Materials science  Adaptive rewiring aggravates the effects of species loss in ecosystems David Gilljam, Alva Curtsdotter and Bo Ebenman The formation of new feeding links by consumers adapting to the loss of prey is thought to buffer food webs against cascading extinctions. However, Ebenman et al. show that adaptive rewiring can still cause extinction cascades if predators are efficient at capturing rare prey, leading to overexploitation of resources. 24 September 2015 | doi: 10.1038/ncomms9412 Biological Sciences  Ecology  High charge mobility in two-dimensional percolative networks of PbSe quantum dots connected by atomic bonds OPEN Wiel H. Evers, Juleon M. Schins, Michiel Aerts, Aditya Kulkarni, Pierre Capiod, Maxime Berthe, Bruno Grandidier, Christophe Delerue, Herre S. J. van der Zant, Carlo van Overbeek, Joep L. Peters, Daniel Vanmaekelbergh and Laurens D. A. Siebbeles The effect of nanocrystal structure on electronic properties is of considerable interest for optoelectronic devices. Here, Evers et al. study the charge transport in two-dimensional percolative networks of PbSe and find excellent terahertz mobility of charge carriers. 24 September 2015 | doi: 10.1038/ncomms9195 Physical Sciences  Materials science  Nanotechnology  Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1 OPEN Lorenza Ciani, Aude Marzo, Kieran Boyle, Eleanna Stamatakou, Douglas M. Lopes, Derek Anane, Faye McLeod, Silvana B. Rosso, Alasdair Gibb and Patricia C. Salinas The mechanisms by which signalling proteins dynamically modulate neurotransmitter release remain poorly understood. Here, Ciani et al. show Wnt signalling influences vesicle pool availability in an activity-dependent manner via direct interactions with Dishevelled-1 and the synaptic vesicle calcium sensor Synaptotagmin-1. 24 September 2015 | doi: 10.1038/ncomms9302 Biological Sciences  Cell biology  Neuroscience  Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection OPEN Samia Akthar, Dhiren F. Patel, Rebecca C. Beale, Teresa Peiró, Xin Xu, Amit Gaggar, Patricia L. Jackson, J. Edwin Blalock, Clare M. Lloyd and Robert J. Snelgrove Proteases degrade extracellular matrix during inflammation, releasing peptides that can recruit neutrophils. Here the authors show that degradation of such bioactive peptide by the enzyme leukotriene A4 hydrolase is critical to limit pulmonary inflammation during bacterial infection in mice. 24 September 2015 | doi: 10.1038/ncomms9423 Biological Sciences  Immunology  Trophic network architecture of root-associated bacterial communities determines pathogen invasion and plant health OPEN Zhong Wei, Tianjie Yang, Ville-Petri Friman, Yangchun Xu, Qirong Shen and Alexandre Jousset Species-rich communities are thought to be more resistant to pathogen invasion. Here, Wei et al. show that the resource competition network architecture of root-associated bacterial communities are better predictors of plant pathogen invasion resistance than measures of community diversity. 24 September 2015 | doi: 10.1038/ncomms9413 Biological Sciences  Ecology  Microbiology  Plant sciences  Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins OPEN Niclas Gimber, Georgi Tadeus, Tanja Maritzen, Jan Schmoranzer and Volker Haucke Neurotransmission is mediated by synaptic vesicles (SVs) fusion with the plasma membrane near active zones. Here, Gimber et al. observe that rapid diffusional spread and confinement is followed by slow reclustering of SV proteins at the periactive endocytic zone through SV protein association with the clathrin-based machinery. 24 September 2015 | doi: 10.1038/ncomms9392 Biological Sciences  Biophysics  Cell biology  Neuroscience  Herbivory increases diversification across insect clades OPEN John J. Wiens, Richard T. Lapoint and Noah K. Whiteman Insects include most living species, yet the causes of this remarkable diversity remain unclear. Here, the authors show a positive relationship between herbivory and diversification among insect orders, which suggests that herbivory helps explain insect diversity. 24 September 2015 | doi: 10.1038/ncomms9370 Biological Sciences  Ecology  Evolution  Ultra-low-power hybrid light–matter solitons OPEN P. M. Walker, L. Tinkler, D. V. Skryabin, A. Yulin, B. Royall, I. Farrer, D. A. Ritchie, M. S. Skolnick and D. N. Krizhanovskii Harnessing nonlinear optics in optoelectronic devices requires a platform that exhibits both giant optical nonlinearity and is compatible with photonic-circuit fabrication. Here, the authors demonstrate such a system that uses strong light–matter coupling between waveguide photons and quantum-well excitons. 24 September 2015 | doi: 10.1038/ncomms9317 Physical Sciences  Applied physics  Materials science  Optical physics  Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method OPEN Jia-Ren Lin, Mohammad Fallahi-Sichani and Peter K. Sorger Multiplexed single cell measurements provide insight into connections between cell state and phenotype. Here Lin et al. present CycIF, a high throughput, public domain immunofluorescence method for multiplexed single-cell analysis of adherent cells following live-cell imaging. 24 September 2015 | doi: 10.1038/ncomms9390 Biological Sciences  Biotechnology  Convergent capture of retroviral superantigens by mammalian herpesviruses OPEN Amr Aswad and Aris Katzourakis Horizontal gene transfer from retroviruses to mammals is rare between unrelated viruses. Here the authors show the convergent acquisition by herpesviruses of a virulence gene of ancient retroviruses, which occurred at least twice from different donor lineages, to distinct herpesviruses that infect mammals. 24 September 2015 | doi: 10.1038/ncomms9299 Biological Sciences  Evolution  Virology  Oscillation of p38 activity controls efficient pro-inflammatory gene expression OPEN Taichiro Tomida, Mutsuhiro Takekawa and Haruo Saito The prolonged presence of cytokines is necessary to produce a robust pro-inflammatory response through the activation of p38 MAPK. Here, Tomida et al. show that asynchronous oscillatory activation of p38 MAPK occurs at the single-cell level and is necessary for the proper expression of pro-inflammatory genes. 24 September 2015 | doi: 10.1038/ncomms9350 Biological Sciences  Biochemistry  Chemical biology  Systems biology  HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling OPEN Rachel P. J. Lai, Graeme Meintjes, Katalin A. Wilkinson, Christine M. Graham, Suzaan Marais, Helen Van der Plas, Armin Deffur, Charlotte Schutz, Chloe Bloom, Indira Munagala, Esperanza Anguiano, Rene Goliath, Gary Maartens, Jacques Banchereau, Damien Chaussabel, Anne O’Garra and Robert J. Wilkinson Some patients with HIV-associated tuberculosis develop an immune reconstitution inflammatory syndrome (TB-IRIS) in response to antiretroviral therapy. Here the authors identify genes differentially expressed in patients likely to progress to TB-IRIS and find activation of Toll-like receptor and inflammasome pathways. 24 September 2015 | doi: 10.1038/ncomms9451 Biological Sciences  Immunology  Medical research  Microbiology  Rapid biotic homogenization of marine fish assemblages OPEN Anne E. Magurran, Maria Dornelas, Faye Moyes, Nicholas J. Gotelli and Brian McGill The response of marine fish assemblages to global change is not fully understood. Analysing a 29-year time-series, Magurran et al. show that despite little change in species richness, high species turnover is leading to North Atlantic groundfish assemblages becoming spatially homogenized, likely as a result of climatic change. 24 September 2015 | doi: 10.1038/ncomms9405 Biological Sciences  Ecology  Oceanography  High damage tolerance of electrochemically lithiated silicon OPEN Xueju Wang, Feifei Fan, Jiangwei Wang, Haoran Wang, Siyu Tao, Avery Yang, Yang Liu, Huck Beng Chew, Scott X. Mao, Ting Zhu and Shuman Xia Mechanical degradation is an undesired behaviour for battery electrode materials such as lithiated silicon. Here, the authors perform in situ nanomechanical experiments and atomistic modelling to reveal the damage tolerance of electrochemically lithiated silicon. 24 September 2015 | doi: 10.1038/ncomms9417 Chemical Sciences  Materials science  Nanotechnology  Current-driven dynamics of skyrmions stabilized in MnSi nanowires revealed by topological Hall effect OPEN Dong Liang, John P. DeGrave, Matthew J. Stolt, Yoshinori Tokura and Song Jin Magnetic skyrmions are topologically protected magnetization textures which can arise in helical magnets and present promise for low-power nanoscale magnetic storage device applications. Here, the authors demonstrate extended phase stability and current-driven dynamics of skyrmions in nanowires of MnSi. 24 September 2015 | doi: 10.1038/ncomms9217 Physical Sciences  Applied physics  Condensed matter  Climate constrains the evolutionary history and biodiversity of crocodylians OPEN Philip D. Mannion, Roger B. J. Benson, Matthew T. Carrano, Jonathan P. Tennant, Jack Judd and Richard J. Butler Crocodylians and their relatives have a rich evolutionary history. Here the authors show long-term decline of terrestrial crocodylians driven by decreasing temperatures but no relationship between temperature and biodiversity for marine crocodylians over their 250 million year history. 24 September 2015 | doi: 10.1038/ncomms9438 Biological Sciences  Ecology  Evolution  Palaeontology  O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth OPEN Xiongjian Rao, Xiaotao Duan, Weimin Mao, Xuexia Li, Zhonghua Li, Qian Li, Zhiguo Zheng, Haimiao Xu, Min Chen, Peng G. Wang, Yingjie Wang, Binghui Shen and Wen Yi The pentose phosphate pathway is aberrantly activated in cancer cells but the mechanism is unclear. Here, the authors show that G6PD, the rate-limiting enzyme in the pathway, is post-translationally modified with a sugar moiety under hypoxic conditions leading to increased production of precursors for macromolecular synthesis and antioxidants. 24 September 2015 | doi: 10.1038/ncomms9468 Biological Sciences  Cancer  Medical research  STIM1 dimers undergo unimolecular coupling to activate Orai1 channels OPEN Yandong Zhou, Xizhuo Wang, Xianming Wang, Natalia A. Loktionova, Xiangyu Cai, Robert M. Nwokonko, Erin Vrana, Youjun Wang, Brad S. Rothberg and Donald L. Gill STIM1, the endoplasmic reticulum calcium sensor, is activated in response to calcium store depletion and translocates to the ER–plasma membrane junctions to activate Orai1 channels. Here the authors present a new model of unimolecular coupling between STIM1 and Orai1 whereby STIM1 dimers may be involved in crosslinking Orai1 channels. 24 September 2015 | doi: 10.1038/ncomms9395 Biological Sciences  Biochemistry  Biophysics  Cell biology  Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma OPEN Chang-Lung Lee, Katherine D. Castle, Everett J. Moding, Jordan M. Blum, Nerissa Williams, Lixia Luo, Yan Ma, Luke B. Borst, Yongbaek Kim and David G. Kirsch p53 can be activated by oncogenic stress to suppress tumourigenesis, but its role in radiation carcinogenesis has not been studied in p53 wild-type mice. Here, Lee et al. show that knocking down p53 during total-body irradiation not only reduces acute toxicity, but prevents the formation of radiation-induced lymphoma. 24 September 2015 | doi: 10.1038/ncomms9477 Biological Sciences  Cancer  Medical research  Direct view on the phase evolution in individual LiFePO4 nanoparticles during Li-ion battery cycling OPEN Xiaoyu Zhang, Martijn van Hulzen, Deepak P. Singh, Alex Brownrigg, Jonathan P. Wright, Niels H. van Dijk and Marnix Wagemaker Understanding phase transitions in electrodes under realistic conditions is important for future battery design. Here, the authors use synchrotron micro-beam diffraction to reveal the phase transition mechanism within individual particles of LiFePO4, revealing a cycling rate transformation mechanism. 23 September 2015 | doi: 10.1038/ncomms9333 Chemical Sciences  Applied physics  Materials science  NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures Paolo Carrega, Fabrizio Loiacono, Emma Di Carlo, Angelo Scaramuccia, Marco Mora, Romana Conte, Roberto Benelli, Grazia Maria Spaggiari, Claudia Cantoni, Stefania Campana, Irene Bonaccorsi, Barbara Morandi, Mauro Truini, Maria Cristina Mingari, Lorenzo Moretta and Guido Ferlazzo NCR+ type 3 innate lymphoid cells display lymphoid tissue-inducing ability. Here the authors show that these cells are increased in early-stage human lung cancer, respond to cancer cells and associated fibroblasts by producing cytokines and are associated to intratumoural ectopic lymphoid structures. 23 September 2015 | doi: 10.1038/ncomms9280 Biological Sciences  Cancer  Immunology  Medical research  Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes OPEN Ineke Brouwer, Asiya Giniatullina, Niels Laurens, Jan R. T. van Weering, Dirk Bald, Gijs J. L. Wuite and Alexander J. Groffen Membrane fusion in cells is triggered by an increase in Ca2+ and involves SNARE complexes and calcium-sensing proteins, but the mechanism underlying the Ca2+-sensors’ role in fusion remains unclear. Here the authors show in vitro that the Ca2+-sensor Doc2b acts directly on membranes and induces a hemifusion intermediate in the presence of calcium. 23 September 2015 | doi: 10.1038/ncomms9387 Biological Sciences  Biochemistry  Biophysics  Proposal for a room-temperature diamond maser OPEN Liang Jin, Matthias Pfender, Nabeel Aslam, Philipp Neumann, Sen Yang, Jörg Wrachtrup and Ren-Bao Liu Maser applications are hindered by their demanding working conditions. Here, Jin et al. theoretically propose a room-temperature maser based on nitrogen vacancy centres in diamond. This numerical study demonstrates that the operation of the maser under readily accessible conditions is feasible. 23 September 2015 | doi: 10.1038/ncomms9251 Physical Sciences  Applied physics  Materials science  Optical physics  Atomistic understandings of reduced graphene oxide as an ultrathin-film nanoporous membrane for separations OPEN Li-Chiang Lin and Jeffrey C. Grossman Ultrathin-film nanoporous membranes promise low-cost and high-performance separation for applications such as water desalination and the purification of natural gas. Here, the authors adopt a molecular dynamics approach to assess the potential of reduced grapheme oxide as such a material. 23 September 2015 | doi: 10.1038/ncomms9335 Physical Sciences  Materials science  Nanotechnology  Physical chemistry  In silico prediction and screening of modular crystal structures via a high-throughput genomic approach OPEN Yi Li, Xu Li, Jiancong Liu, Fangzheng Duan and Jihong Yu High-throughput computation aids design of new functional materials. Here, Yu et al. develop a high-throughput screening method for a group of zeolites with crystalline modular structures which are viewed as having gene-like stacking codes, and identify the most promising structures with desired properties. 23 September 2015 | doi: 10.1038/ncomms9328 Chemical Sciences  Inorganic chemistry  Materials science  Symmetry-protected transport in a pseudospin-polarized waveguide OPEN Wen-Jie Chen, Zhao-Qing Zhang, Jian-Wen Dong and C. T. Chan Designing robust electromagnetic channels where transport is unidirectional is still a challenge. Here, the authors propose a new paradigm for spin-filtered waveguides in air, avoiding the use of special bulk materials. 23 September 2015 | doi: 10.1038/ncomms9183 Physical Sciences  Optical physics  Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice OPEN Rebecca Deprez-Poulain, Nathalie Hennuyer, Damien Bosc, Wenguang G. Liang, Emmanuelle Enée, Xavier Marechal, Julie Charton, Jane Totobenazara, Gonzague Berte, Jouda Jahklal, Tristan Verdelet, Julie Dumont, Sandrine Dassonneville, Eloise Woitrain, Marion Gauriot, Charlotte Paquet, Isabelle Duplan, Paul Hermant, François- Xavier Cantrelle, Emmanuel Sevin et al. Inhibiting insulin-degrading enzyme (IDE) has been proposed as a potential therapeutic strategy for the treatment of patients with diabetes. Here, the authors develop a novel IDE inhibitor but find that, surprisingly, IDE inhibition has negative effects on glucose tolerance in mice. 23 September 2015 | doi: 10.1038/ncomms9250 Biological Sciences  Medical research  Calcium ions open a selectivity filter gate during activation of the MthK potassium channel OPEN David J. Posson, Radda Rusinova, Olaf S. Andersen and Crina M. Nimigean Ion channels open and close to allow the regulated passage of ions through the membrane. Here the authors use selective ion channel blockers to analyse this regulation in a potassium channel and show that the gate is in the selectivity filter, past the entrance to the channel. 23 September 2015 | doi: 10.1038/ncomms9342 Biological Sciences  Biophysics  Multiply periodic states and isolated skyrmions in an anisotropic frustrated magnet OPEN A. O. Leonov and M. Mostovoy Skyrmions—magnetic vortices with an additional twist—have only been observed in a small number of chiral magnets, all with specific non-centrosymmetric structure. Here, the authors suggest that skyrmions can be found in many frustrated magnets as long as they meet a specific set of criteria. 23 September 2015 | doi: 10.1038/ncomms9275 Physical Sciences  Condensed matter  Theoretical physics  SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes OPEN Ken Tajima, Toshifumi Yae, Sarah Javaid, Oliver Tam, Valentine Comaills, Robert Morris, Ben S. Wittner, Mingzhu Liu, Amanda Engstrom, Fumiyuki Takahashi, Joshua C. Black, Sridhar Ramaswamy, Toshihiro Shioda, Molly Hammell, Daniel A. Haber, Johnathan R. Whetstine and Shyamala Maheswaran The p53-inducible antiproliferative gene BTG2 is suppressed in many cancers, in the absence of inactivating gene mutations. Here the authors show that the histone lysine methyltransferase SETD1A suppresses the expression of several p53 target genes including BTG2 by inducing a network of microRNAs. 23 September 2015 | doi: 10.1038/ncomms9257 Biological Sciences  Cancer  Cell biology  Cosmochemical fractionation by collisional erosion during the Earth’s accretion OPEN Asmaa Boujibar, Denis Andrault, Nathalie Bolfan-Casanova, Mohamed Ali Bouhifd and Julien Monteux Collisions in the early Solar System affected the final composition of the terrestrial planets, and enstatite chondrites (EC) are thought to represent the primordial Earth’s precursors. Here, the authors show that differences between Earth and EC are due to impact erosion of >15% of the early Earth’s mass. 23 September 2015 | doi: 10.1038/ncomms9295 Earth Sciences  Geology and geophysics  Planetary sciences  Longitudinal spin Seebeck effect contribution in transverse spin Seebeck effect experiments in Pt/YIG and Pt/NFO OPEN Daniel Meier, Daniel Reinhardt, Michael van Straaten, Christoph Klewe, Matthias Althammer, Michael Schreier, Sebastian T. B. Goennenwein, Arunava Gupta, Maximilian Schmid, Christian H. Back, Jan-Michael Schmalhorst, Timo Kuschel and Günter Reiss Measurements of the spin Seebeck effect, the generation of spin current in a ferromagnet due to a temperature gradient, are often hindered by parasitic effects. Here, the authors use ferromagnetic insulators to show how transverse spin Seebeck measurements can be explained by the longitudinal spin Seebeck. 23 September 2015 | doi: 10.1038/ncomms9211 Physical Sciences  Applied physics  Condensed matter    Nature Communications JOBS of the week Research Fellow (Cell Biology) University of Edinburgh Lab manager Karolinska Institutet (KI) Tenure-Track Faculty Position University of California Los Angeles Postdoctoral Fellow Lerner Research Institute, Cleveland Clinic Senior Project Manager (m / f) Helmholtz Association Assistant / Associate / Full Professor University of North Texas Health Science Center Research Assistant University of Bristol 2 Post-Doctoral Researcher posts The University of Sheffield Group Leaders Cancer Research UK Beatson Institute in Glasgow Senior Scientist Position Faculty of Medicine of the University of Coimbra (FMUC) More Science jobs from Nature Communications EVENT Nano Israel 2016 02.22.16 Tel Aviv, Israel More science events from       Latest Erratum     Erratum: Low-threshold amplified spontaneous emission and lasing from colloidal nanocrystals of caesium lead halide perovskites OPEN Sergii Yakunin, Loredana Protesescu, Franziska Krieg, Maryna I. Bodnarchuk, Georgian Nedelcu, Markus Humer, Gabriele De Luca, Manfred Fiebig, Wolfgang Heiss and Maksym V. Kovalenko 23 September 2015 | doi: 10.1038/ncomms9515 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology      Advertisement Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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