Nature Cell Biology contents: October 2015 Volume 17 Number 10, pp 1229 - 1370

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Advertisement Cytometry + Microscopy=Images of Every Cell in Flow.  More than 80 image features for every event collected in flow. Thousands of features for morphological analysis of every cell. Integrating Microscopy with ultrasensitive flow cytometry. Amnis Imaging Flow Cytometer: Cutting-edge technology for your groundbreaking research! TABLE OF CONTENTS October 2015 Volume 17, Issue 10 Obituary News and Views Articles Letters Resource Corrigendum Erratum Advertisement Are you ready for the future of cell culture? Our survey seeks to understand how "smart" cell culture technology will shape the future (e.g., imaging cultures anytime from your personal device). Survey responses are confidential. $250 Amazon.com gift card raffle. Click here to start. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease. Part of the Nature Partner Journals series, npj Parkinson's Disease is published in partnership with the Parkinson's Disease Foundation. Open for submissions: http://bit.ly/1uUh8YB   Obituary Top Chris Marshall 1949-2015   p1229 Alison Lloyd and Erik Sahai doi:10.1038/ncb3247 News and Views Top Translating the effects of mTOR on secretory senescence   pp1230 - 1232 Kosuke Tomimatsu and Masashi Narita doi:10.1038/ncb3244 Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization. STIMATE reveals a STIM1 transitional state   pp1232 - 1234 Robert Hooper and Jonathan Soboloff doi:10.1038/ncb3245 Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca2+ entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined. See also: Letter by Jing et al. Articles Top Network plasticity of pluripotency transcription factors in embryonic stem cells   pp1235 - 1246 Adam Filipczyk, Carsten Marr, Simon Hastreiter, Justin Feigelman, Michael Schwarzfischer et al. doi:10.1038/ncb3237 Using single-cell profiling of Nanog and Oct4 protein levels in mouse embryonic stem cells, Schroeder and colleagues show that differences in Nanog levels are not correlated with differences in expression of other pluripotency factors and cell fate. Cell Biology JOBS of the week Postdoctoral Positions in Stem Cell, Developmental, and Cancer Biology Columbia University Medical Center Postdoctoral Fellow – Immunotherapy / T cell biology (#79012) California Institute for Biomedical Research Tenure-Track Faculty Position- Cell Biology Johns Hopkins University PhD student position in Molecular and Cell Biology Nanyang Technological University (NTU) Senior / Principal Scientist - Cell Biology UCB Slough More Science jobs from Cell Biology EVENT Cell Biology and Immunology of Persistent Infection 31.01.16 Banff, Canada More science events from Advertisement More Confidence in Your Western Blotting  Bio-Rad introduces the V3 Western Workflow™, providing increased speed and confidence and improving quantitation compared to your traditional western blotting protocol. Learn how to improve your blotting results here.   Local and tissue-scale forces drive oriented junction growth during tissue extension   pp1247 - 1258 Claudio Collinet, Matteo Rauzi, Pierre-François Lenne and Thomas Lecuit doi:10.1038/ncb3226 Lecuit and colleagues use live imaging and laser ablation approaches to show that germ-band extension of the Drosophila embryo is associated with new junction growth, which is dependent on both tissue-level and local forces. ATM functions at the peroxisome to induce pexophagy in response to ROS   pp1259 - 1269 Jiangwei Zhang, Durga Nand Tripathi, Ji Jing, Angela Alexander, Jinhee Kim et al. doi:10.1038/ncb3230 Zhang et al. report that in response to ROS, ATM regulates peroxisome homeostasis through the phosphorylation of PEX5, which is then ubiquitylated and can be recognized by p62 to specifically activate pexophagy. An interconnected hierarchical model of cell death regulation by the BCL-2 family   pp1270 - 1281 Hui-Chen Chen, Masayuki Kanai, Akane Inoue-Yamauchi, Ho-Chou Tu, Yafen Huang et al. doi:10.1038/ncb3236 Chen et al. produced a quadruple knockout of all the known BH3-only proteins in order to characterize their pro-apoptotic functions. They establish that NOXA is a direct activator of BAX/BAK and not merely a sensitizer as previously suggested. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions   pp1282 - 1293 Rashmi Priya, Guillermo A. Gomez, Srikanth Budnar, Suzie Verma, Hayley L. Cox et al. doi:10.1038/ncb3239 Yap and colleagues report that robustness of RhoA signalling at E-cadherin junctions is achieved through a feedback network that includes myosin II, ROCK1, Rnd3 and p190B RhoGAP. Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans   pp1294 - 1303 J. Amaranath Govindan, Elamparithi Jayamani, Xinrui Zhang, Peter Breen, Jonah Larkins-Ford et al. doi:10.1038/ncb3229 Through RNAi screens in C. elegans, Ruvkun and colleagues identify signalling pathways that induce detoxification genes following disrupted translation, suggesting translational surveillance of toxins and virulence factors. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest   pp1304 - 1316 Elena Doménech, Carolina Maestre, Lorena Esteban-Martínez, David Partida, Rosa Pascual et al. doi:10.1038/ncb3231 Malumbres and colleagues reveal that mitotic arrest is accompanied by reduced mitochondrial mass and oxidative respiration resulting in activation of AMPK and induction of glycolysis to promote cell survival. Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis   pp1317 - 1326 Simone Cardaci, Liang Zheng, Gillian MacKay, Niels J. F. van den Broek, Elaine D. MacKenzie et al. doi:10.1038/ncb3233 SDH inactivation is associated with cancer susceptibility. Cardaci et al. report a metabolic vulnerability in SDH-deficient cells, by showing that they depend on pyruvate carboxylation for the production of aspartate, proliferation and tumour growth. Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation   pp1327 - 1338 Yinghui Li, Qi-Ling Zhou, Wenjie Sun, Prashant Chandrasekharan, Hui Shan Cheng et al. doi:10.1038/ncb3240 The TERT promoter is mutated in many cancers. Li et al. show that non-canonical NF-κB signalling and ETS1/2 transcription factors are jointly needed to activate the C250T mutant TERT promoter, leading to telomerase activity and glioblastoma growth. Advertisement nature.com webcasts Join us for our upcoming webcast with live Q&A: INNOVATIONS IN REGENERATIVE MEDICINE & CURATIVE BIOLOGICS Presented by BioPharma Dealmakers Date: Wednesday, October 14, 2015 Time: 8am PDT, 11am EDT, 4pm BST and 5pm CEST REGISTER FOR FREE  Sponsored by: co.don, Asterias Biotherapeutics, SIWA Regenerative Medicine Corporation, Organovo       Letters Top Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca2+ influx   pp1339 - 1347 Ji Jing, Lian He, Aomin Sun, Ariel Quintana, Yuehe Ding et al. doi:10.1038/ncb3234 Through a proteomic analysis of ER-PM junctions, Zhou and colleagues and Wang and colleagues discover that the transmembrane protein STIMATE is a positive regulator of STIM localization and function, thereby stimulating Ca2+ influx. See also: News and Views by Hooper & Soboloff Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation   pp1348 - 1355 Yanhua Zheng, Xinjian Li, Xu Qian, Yugang Wang, Jong-Ho Lee et al. doi:10.1038/ncb3222 Lu and colleagues report that the O-GlcNAcylated MIF cytokine binds the extracellular domain of EGFR and prevents EGF-induced EGFR activation. Conversely, EGFR activation leads to MMP13-mediated MIF degradation and EGFR-induced tumorigenesis Resource Top Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis   pp1356 - 1369 Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin et al. doi:10.1038/ncb3238 Through proteomics, Harper and colleagues identify proteins interacting with UBXD adaptors for the multifunctional AAA-ATPase VCP and reveal a role for UBXN10 in ciliogenesis. Corrigendum Top Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation   p1370 Maria-Giuseppina Procopio, Csaba Laszlo, Dania Al Labban, Dong Eun Kim, Pino Bordignon et al. doi:10.1038/ncb3242 Erratum Top Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype   p1370 Nicolás Herranz, Suchira Gallage, Massimiliano Mellone, Torsten Wuestefeld, Sabrina Klotz et al. doi:10.1038/ncb3243 Top Advertisement Nature Plants: Call for Papers Nature Plants launched in January and covers all aspects of plants be it their evolution, genetics, development or metabolism, their interactions with the environment, or their societal significance. 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