EMBO reports Table of Contents for June 2015; Vol. 16, No. 6

June 2015 | Volume 16, Number 6 Submit Table of Contents Opinion Hot off the Press Science & Society Scientific Reports Articles Volume 16, Number 6 Opinion Lost in post‐translation The names we choose to describe or define biological concepts can have a huge impact on the way we think. It is time to reflect on whether certain terms, even those as fundamental as “translation”, are still appropriate for the scientific lexicon. Olivier Putois, François Villa, and Jonathan B Weitzman Published online 16.04.2015 The public in peer review Patients and the wider public are increasingly involved in the assessment of science by funders and journals. The correct timing of such involvement—from study design to publication—is critical to ensure that their views have a real and relevant impact. Michele S Garfinkel Published online 20.04.2015 Hot off the Press Another face of RIPK1 In this issue of EMBO Reports, RIPK1 is shown to inhibit basal autophagy, thereby regulating cellular sensitivity to apoptosis. This is discussed in the context of other RIPK1 functions related to cell death. Douglas R Green Published online 04.05.2015 Science & Society Insect proteins—a new source for animal feed: The use of insect larvae to recycle food waste in high‐quality protein for livestock and aquaculture feeds is held back largely owing to regulatory hurdles Insects could be an environmentally sustainable component of both livestock and human diets, especially as they can be fed on food waste. However, health regulations and Western dietary habits are holding back this promising new approach. Andreas Stamer Published online 05.05.2015 Keeping enzymes kosher: Sacred and secular biotech production Biotech companies increasingly seek certification for compliance with religious and dietary requirements in order to address new consumer markets. Technology plays a crucial role in such inspections alongside centuries old traditions and practices. Johan Fischer Published online 04.05.2015 Simulating the human brain: Scientists have started various major projects to simulate and understand the brain, but many neuroscientists remain sceptical about their scope and aims Several large‐scale projects have begun or are being planned to understand the human brain and find new therapeutic approaches to neurological diseases and disorders. Yet, many neurobiologists are concerned that some of the aims are too ambitious and risk wasting precious research funding. Philip Hunter Published online 08.05.2015 Scientific Reports MPP8 and SIRT1 crosstalk in E‐cadherin gene silencing and epithelial–mesenchymal transition This study shows that two repressive chromatin modifiers, MPP8 and SIRT1, reciprocally promote each other's function through their physical interaction to coordinate epithelial gene silencing and promote EMT. Lidong Sun, Kenji Kokura, Victoria Izumi, John M Koomen, Edward Seto, Jiandong Chen, and Jia Fang Published online 13.04.2015 RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis This study shows that RIP1 identified in a kinome screen for modulators of survival when cells depend on autophagy inhibits basal autophagy through the ERK/TFEB pathway, thereby modulating sensitivity to apoptotic stimuli. Tohru Yonekawa, Graciela Gamez, Jihye Kim, Aik Choon Tan, Jackie Thorburn, Jacob Gump, Andrew Thorburn, and Michael J Morgan Published online 23.04.2015 Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy The GEF DENND3 is shown to have a crucial role in autophagy, under the control of ULK‐mediated phosphoregulation. Phosphorylation upregulates DENND3 GEF activity towards Rab12, facilitating autophagosome trafficking. Jie Xu, Maryam Fotouhi, and Peter S McPherson Published online 29.04.2015 IAP antagonization promotes inflammatory destruction of vascular endothelium Treatment of mice bearing B16 melanomas with an IAP antagonist (Comp A) inhibits tumor growth by disrupting the tumor vasculature. Upon exposure to Comp A tumor cells produce TNF, which together with Comp A induces endothelial cell death. Axel Witt, Jens M Seeger, Oliver Coutelle, Paola Zigrino, Pia Broxtermann, Maria Andree, Kerstin Brinkmann, Christian Jüngst, Astrid C Schauss, Stephan Schüll, Dirk Wohlleber, Percy A Knolle, Martin Krönke, Cornelia Mauch, and Hamid Kashkar Published online 30.03.2015 Articles A sulfur‐based transport pathway in Cu+‐ATPases This study identifies a copper transport pathway dominated by sulfur‐based residues for the Cu+‐ATPase LpCopA from Legionella pneumophila thus providing insights into how metal selectivity and transport is achieved in Cu+‐ATPases. Daniel Mattle, Limei Zhang, Oleg Sitsel, Lotte Thue Pedersen, Maria Rosa Moncelli, Francesco Tadini‐Buoninsegni, Pontus Gourdon, Douglas C Rees, Poul Nissen, and Gabriele Meloni Published online 08.05.2015 Wnt directs the endosomal flux of LDL‐derived cholesterol and lipid droplet homeostasis This study reports that Wnt signaling regulates the production of lipid droplets in a process that strictly depends on endocytosed, LDL‐derived cholesterol and functional endosomes. Cameron C Scott, Stefania Vossio, Fabrizio Vacca, Berend Snijder, Jorge Larios, Olivier Schaad, Nicolas Guex, Dmitry Kuznetsov, Olivier Martin, Marc Chambon, Gerardo Turcatti, Lucas Pelkmans, and Jean Gruenberg Published online 07.04.2015 LKB1 inhibition of NF‐κB in B cells prevents T follicular helper cell differentiation and germinal center formation LKB1‐mediated signaling in B cells is shown to have both cell‐intrinsic and cell‐extrinsic roles in regulating the differentiation of TFH cells and the formation of germinal centers, which occurs in part through enhanced IL‐6 secretion. Nicole C Walsh, Lynnea R Waters, Jessica A Fowler, Mark Lin, Cameron R Cunningham, David G Brooks, Jerold E Rehg, Herbert C Morse III, and Michael A Teitell Published online 26.04.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.