Nature Communications - 3 June 2015

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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Biological invasion and biological control select for different life histories OPEN Ashraf Tayeh, Ruth A. Hufbauer, Arnaud Estoup, Virginie Ravigné, Léa Frachon and Benoit Facon Understanding how biological invaders displace native species is challenging. Here, the authors compare the evolution of life-history strategies in the harlequin ladybird under laboratory conditions and show that invaders reproduce earlier and allocate more resources to reproduction than natives. 02 June 2015 | doi: 10.1038/ncomms8268 Biological Sciences  Ecology  Evolution  Optogenetic control of contractile function in skeletal muscle OPEN Tobias Bruegmann, Tobias van Bremen, Christoph C. Vogt, Thorsten Send, Bernd K. Fleischmann and Philipp Sasse Nerve damage can lead to skeletal muscle paralysis. The authors show that localized photostimulation of skeletal muscle expressing the light-sensitive channel Channelrhodopsin-2 generates contraction in the absence of neural impulses and prove that this strategy can be used for optogenetic opening of explanted murine vocal cords. 02 June 2015 | doi: 10.1038/ncomms8153 Biological Sciences  Medical research  A Mesozoic bird from Gondwana preserving feathers OPEN Ismar de Souza Carvalho, Fernando E. Novas, Federico L. Agnolín, Marcelo P. Isasi, Francisco I. Freitas and José A. Andrade Fossils of Cretaceous birds with feathers are rare and known mostly from China. Here, the authors show an enantiornithine bird from the Lower Cretaceous of Brazil with a fully articulated skeleton and rachis-dominated tail feathers, which has implications for our understanding of feather evolution. 02 June 2015 | doi: 10.1038/ncomms8141 Biological Sciences  Evolution  Palaeontology  Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding OPEN Dolores Pérez-Sala, Clara L. Oeste, Alma E. Martínez, M. Jesús Carrasco, Beatriz Garzón and F. Javier Cañada Vimentin is an intermediate filament protein that is targeted by oxidative modification at its single cysteine residue, C328. Here Pérez-Sala et al. reveal a role for this cysteine in vimentin organization and function, and uncover a protective role for zinc binding in filament stability. 02 June 2015 | doi: 10.1038/ncomms8287 Biological Sciences  Cell biology  Loss of kinesin-14 results in aneuploidy via kinesin-5-dependent microtubule protrusions leading to chromosome cut Viktoriya Syrovatkina and Phong T. Tran Loss of the motor protein kinesin-14 can lead to aneuploidy, but the mechanism is not known. Here the authors show that loss of kinesin-14 in fission yeast leads to long spindle microtubule protrusions that push properly segregated chromosomes into the division site, leading to chromosome cut during cytokinesis. 02 June 2015 | doi: 10.1038/ncomms8322 Biological Sciences  Cell biology  The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation Jeniffer B. Hernandez, Christina Chang, Mathias LeBlanc, David Grimm, John Le Lay, Klaus H. Kaestner, Ye Zheng and Marc Montminy Multiple sclerosis is caused by autoreactive Th17 lymphocytes. Here the authors show that prostaglandin E2 promotes Th17 differentiation by activating transcription of IL-17 by CREB/CRTC2 complex, and that ablation of CRTC2 prevents Th17 differentiation and multiple sclerosis in a mouse model. 02 June 2015 | doi: 10.1038/ncomms8216 Biological Sciences  Immunology  Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint OPEN Gang Zhang, Tiziana Lischetti, Daniel G. Hayward and Jakob Nilsson The spindle assembly checkpoint (SAC) depends on the recruitment of specific protein complexes to the kinetochore. Here Zhang et al. show that Bub1 recruits the RZZ complex and BubR1 to the kinetochore, and loss of the BubR1 binding sequence enhances checkpoint activity suggesting both SAC activating and silencing roles. 02 June 2015 | doi: 10.1038/ncomms8162 Biological Sciences  Cell biology  Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling OPEN Hao Gu, Qidong Li, Shan Huang, Weiguang Lu, Fangyuan Cheng, Ping Gao, Chen Wang, Lin Miao, Yide Mei and Mian Wu The pluripotent state of mouse embryonic stem cells (mESCs) is regulated by extrinsic and intrinsic signals but the underlying mechanisms are not completely understood. Here the authors show that the E3 ligase, March5, contributes to the maintenance of the pluripotent state in mESCs via suppression of ERK activation. 02 June 2015 | doi: 10.1038/ncomms8112 Biological Sciences  Cell biology  Developmental biology  Theory and computation of hot carriers generated by surface plasmon polaritons in noble metals OPEN Marco Bernardi, Jamal Mustafa, Jeffrey B. Neaton and Steven G. Louie Hot carriers generated by surface plasmons in metal structures are garnering interest for their use in optoelectronics or photocatalysis. Bernardi et al. present a quantum mechanical framework to study their properties and find the optimalyconditions for their generation and extraction. 02 June 2015 | doi: 10.1038/ncomms8044 Physical Sciences  Condensed matter  Optical physics  Theoretical physics  Prmt5 is a regulator of muscle stem cell expansion in adult mice OPEN Ting Zhang, Stefan Günther, Mario Looso, Carsten Künne, Marcus Krüger, Johnny Kim, Yonggang Zhou and Thomas Braun Skeletal muscle satellite cells are important for muscle regeneration, but their regulatory mechanisms are largely unknown. Here the authors identify arginine methyltransferase Prmt5 as a key regulator of satellite cell maintenance and function in adult mice, and show that Prmt5 acts mainly but not exclusively on the cell cycle inhibitor p21. 01 June 2015 | doi: 10.1038/ncomms8140 Biological Sciences  Cell biology  Developmental biology  Late glacial initiation of Holocene eastern Mediterranean sapropel formation Rosina Grimm, Ernst Maier-Reimer, Uwe Mikolajewicz, Gerhard Schmiedl, Katharina Müller-Navarra, Fanny Adloff, Katharine M. Grant, Martin Ziegler, Lucas J. Lourens and Kay-Christian Emeis Numerous theories exist regarding the evolution of a deep-water oxygen deficiency in the eastern Mediterranean Sea. Here, the authors test several popular hypotheses with a focus on the S1 event showing that long-term stagnation was necessary, preconditioned by the changes associated with the last deglaciation. 01 June 2015 | doi: 10.1038/ncomms8099 Earth Sciences  Biogeochemistry  Climate science  Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2 Johanna Liebl, Siwei Zhang, Markus Moser, Yan Agalarov, Cansaran Saygili Demir, Bianca Hager, James A. Bibb, Ralf H. Adams, Friedemann Kiefer, Naoyuki Miura, Tatiana V. Petrova, Angelika M. Vollmar and Stefan Zahler The mechanisms regulating lymphatic vessel development and function are still largely unknown. Here, the authors show that the protein kinase Cdk5 is required for lymphatic vessel development by regulating the activity of the transcription factor Foxc2 and its target genes. 01 June 2015 | doi: 10.1038/ncomms8274 Biological Sciences  Cell biology  Developmental biology  Valley polarization assisted spin polarization in two dimensions OPEN V. T. Renard, B. A. Piot, X. Waintal, G. Fleury, D. Cooper, Y. Niida, D. Tregurtha, A. Fujiwara, Y. Hirayama and K. Takashina In the emerging field of valleytronics, the valley degree of freedom of electrons is exploited in addition to charge and spin for novel functionalities. Here, Renard et al. show how valley polarization can facilitate spin-polarization in a silicon-on-insulator quantum well. 01 June 2015 | doi: 10.1038/ncomms8230 Physical Sciences  Applied physics  Condensed matter  Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms Alexej Abyzov, Shantao Li, Daniel Rhee Kim, Marghoob Mohiyuddin, Adrian M. Stütz, Nicholas F. Parrish, Xinmeng Jasmine Mu, Wyatt Clark, Ken Chen, Matthew Hurles, Jan O. Korbel, Hugo Y. K. Lam, Charles Lee and Mark B. Gerstein Structural variation is a major source of complexity in the human genome. Here Abyzov et al. present the identification, classification and analysis of a large database of variants giving an insight into mechanisms generating them. 01 June 2015 | doi: 10.1038/ncomms8256 Biological Sciences  Genetics  Scanning precession electron tomography for three-dimensional nanoscale orientation imaging and crystallographic analysis OPEN Alexander S. Eggeman, Robert Krakow and Paul A. Midgley High-resolution microscopy allows imaging of information on the atomic scale. Here, by combining precession electron diffraction with scanning transmission electron microscopy, the authors demonstrate an efficient, alternative technique to determine the three-dimensional orientation of materials. 01 June 2015 | doi: 10.1038/ncomms8267 Physical Sciences  Materials science  Nanotechnology  Evidence for an anomalous current–phase relation in topological insulator Josephson junctions C. Kurter, A.D.K. Finck, Y. S. Hor and D. J. Van Harlingen A topological insulator-based Josephson junction is expected to host low-energy Andreev-bound states. Here, Kurter et al. study Josephson interferometry and SQUID oscillations in Bi2Se3 junctions to evidence anomalous non-sinusoidal supercurrent contributions as possible signatures of these states. 01 June 2015 | doi: 10.1038/ncomms8130 Physical Sciences  Applied physics  Condensed matter  Coordination and fine motor control depend on Drosophila TRPγ Bradley Akitake, Qiuting Ren, Nina Boiko, Jinfei Ni, Takaaki Sokabe, James D. Stockand, Benjamin A. Eaton and Craig Montell Perception of mechanical tension is important for coordinated locomotion, and in Drosophila, mutations in stretch-sensitive TRPV channels grossly impair locomotor behaviour. Akitake et al. show that the Drosophila TRPC channel TRPγ is, in contrast, specifically required for fine motor control. 01 June 2015 | doi: 10.1038/ncomms8288 Biological Sciences  Neuroscience  Direct observation of TALE protein dynamics reveals a two-state search mechanism OPEN Luke Cuculis, Zhanar Abil, Huimin Zhao and Charles M. Schroeder TALEs are programmable DNA-binding proteins with practical use in genome engineering and synthetic biology. Here the authors use single-molecule fluorescence microscopy to establish that TALE proteins function using two distinct DNA-interaction modes during sequence-specific target search. 01 June 2015 | doi: 10.1038/ncomms8277 Biological Sciences  Biophysics  Molecular biology  A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling OPEN Detlef Vullhorst, Robert M. Mitchell, Carolyn Keating, Swagata Roychowdhury, Irina Karavanova, Jung-Hwa Tao-Cheng and Andres Buonanno The neuregulin receptor ErbB4 is an important modulator of GABAergic interneurons and neural network synchronization but little is known about the endogenous ligands that engage ErbB4 and the downstream targets. Here the authors describe the existence of a cell-autonomous bidirectional pathway that links NMDA receptor activity with NRG signalling in GABAergic interneurons. 01 June 2015 | doi: 10.1038/ncomms8222 Biological Sciences  Neuroscience  Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex OPEN Natalie S. Poulter, Alice Y. Pollitt, Amy Davies, Dessislava Malinova, Gerard B. Nash, Mike J. Hannon, Zoe Pikramenou, Joshua Z. Rappoport, John H. Hartwig, Dylan M. Owen, Adrian J. Thrasher, Stephen P. Watson and Steven G. Thomas During early platelet spreading a novel F-actin structure forms, called the actin nodule. Here Poulter et al. demonstrate that actin nodule formation depends on WASp and the Arp2/3 complex, and using super-resolution microscopy they show that nodules bear a structural resemblance to podosomes. 01 June 2015 | doi: 10.1038/ncomms8254 Biological Sciences  Cell biology  Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein OPEN Dominika T. Gruszka, Fiona Whelan, Oliver E. Farrance, Herman K. H. Fung, Emanuele Paci, Cy M. Jeffries, Dmitri I. Svergun, Clair Baldock, Christoph G. Baumann, David J. Brockwell, Jennifer R. Potts and Jane Clarke Staphylococcal biofilm formation is promoted by the surface protein SasG. Here, the authors characterize the structure and remarkable mechanical strength of the repeat region of SasG, and show how elongation is achieved by obligate folding of the disordered regions within the repeating units. 01 June 2015 | doi: 10.1038/ncomms8271 Biological Sciences  Biophysics  Chemical biology  Chemical reaction mechanisms in solution from brute force computational Arrhenius plots OPEN Masoud Kazemi and Johan Åqvist Obtaining activation entropies and enthalpies of a reaction is important for distinguishing between alternative reaction mechanisms. Here the authors use computational methods to accurately obtain the enthalpic/entropic components of the activation free energy for hydrolytic deamination reactions. 01 June 2015 | doi: 10.1038/ncomms8293 Chemical Sciences  Biochemistry  Organic chemistry  Physical chemistry  Graphitic carbon nitride nanosheet electrode-based high-performance ionic actuator OPEN Guan Wu, Ying Hu, Yang Liu, Jingjing Zhao, Xueli Chen, Vincent Whoehling, Cédric Plesse, Giao T. M. Nguyen, Frédéric Vidal and Wei Chen Electrochemical actuators store electric energy and generate mechanical motion. Here, the authors present an ionic actuator based on a hierarchically porous graphitic carbon nitride electrode, which exhibits high charge storage, fast actuation response, large electromechanical strain and high stability. 01 June 2015 | doi: 10.1038/ncomms8258 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Identification of new susceptibility loci for IgA nephropathy in Han Chinese OPEN Ming Li, Jia-Nee Foo, Jin-Quan Wang, Hui-Qi Low, Xue-Qing Tang, Kai-Yee Toh, Pei-Ran Yin, Chiea-Chuen Khor, Yu-Fen Goh, Ishak D. Irwan, Ri-Cong Xu, Anand K. Andiappan, Jin-Xin Bei, Olaf Rotzschke, Meng-Hua Chen, Ching-Yu Cheng, Liang-Dan Sun, Geng-Ru Jiang, Tien-Yin Wong, Hong-Li Lin et al. IgA nephropathy is a major cause of end-stage renal disease in China, occurring at a high frequency in Asian populations. Here Li and colleagues conduct a four-stage genome-wide association study in a Chinese population, identifying novel loci and variants associated with disease risk. 01 June 2015 | doi: 10.1038/ncomms8270 Biological Sciences  Genetics  Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants OPEN Fiona Allum, Xiaojian Shao, Frédéric Guénard, Marie-Michelle Simon, Stephan Busche, Maxime Caron, John Lambourne, Julie Lessard, Karolina Tandre, Åsa K. Hedman, Tony Kwan, Bing Ge, Lars Rönnblom, Mark I. McCarthy, Panos Deloukas, Todd Richmond, Daniel Burgess, Timothy D. Spector, André Tchernof, Simon Marceau et al. Currently, genome-wide methylation studies are limited to using targeted arrays or enrichment to assess large sample sizes. Here, Allum et al. demonstrate MethylC-Capture Sequencing, a cost-effective method for investigating genetic and epigenetic variation. 29 May 2015 | doi: 10.1038/ncomms8211 Biological Sciences  Genetics  Multisensory training reverses midbrain lesion-induced changes and ameliorates haemianopia Huai Jiang, Barry E. Stein and John G. McHaffie Failure to attend to visual cues is a common consequence of visual cortical injury. Here, the authors demonstrate that auditory–visual cross-modal behavioural training leads to neural plasticity and reinstatement of visuomotor competency in animals rendered unilaterally blind by visual cortical removal. 29 May 2015 | doi: 10.1038/ncomms8263 Biological Sciences  Neuroscience  The dynamics of methylammonium ions in hybrid organic–inorganic perovskite solar cells OPEN Aurelien M. A. Leguy, Jarvist Moore Frost, Andrew P. McMahon, Victoria Garcia Sakai, W. Kochelmann, ChunHung Law, Xiaoe Li, Fabrizia Foglia, Aron Walsh, Brian C. O’Regan, Jenny Nelson, João T. Cabral and Piers R. F. Barnes Hysteresis often exists in the characterization of methylammonium lead halide-based solar cells, but is not well understood. Here, the authors use quasielastic neutron scattering to study the dynamics of dipolar organic cations and shed light on the hysteresis behaviour. 29 May 2015 | doi: 10.1038/ncomms8124 Physical Sciences  Applied physics  Physical chemistry  Self-assembled three-dimensional and compressible interdigitated thin-film supercapacitors and batteries OPEN Gustav Nyström, Andrew Marais, Erdem Karabulut, Lars Wågberg, Yi Cui and Mahiar M. Hamedi It is challenging to construct three-dimensional thin-film energy-storage devices. Here the authors present supercapacitors and batteries based on layer-by-layer self-assembly of interdigitated thin films inside aerogels, demonstrating energy storage as well as compressibility in three-dimensional devices. 29 May 2015 | doi: 10.1038/ncomms8259 Chemical Sciences  Materials science  Nanotechnology  A lead-halide perovskite molecular ferroelectric semiconductor OPEN Wei-Qiang Liao, Yi Zhang, Chun-Li Hu, Jiang-Gao Mao, Heng-Yun Ye, Peng-Fei Li, Songping D. Huang and Ren-Gen Xiong Lead-halide perovskite compounds have seen a considerable interest for their optoelectronic properties. Here, the authors discover a ferroelectric halide perovskite compound as an alternative pathway towards designing semiconductor ferroelectrics. 29 May 2015 | doi: 10.1038/ncomms8338 Physical Sciences  Condensed matter  Materials science  Developmental-stage-dependent transcriptional response to leukaemic oncogene expression OPEN Kakkad Regha, Salam A. Assi, Olga Tsoulaki, Jane Gilmour, Georges Lacaud and Constanze Bonifer Acute myeloid leukaemia often originates from a chromosomal translocation creating a RUNX1/ETO fusion protein. Here Regha et al, generate a mouse stem cell model and demonstrate the fusion protein disrupts transcription in a differentiation-stage-specific manner. 28 May 2015 | doi: 10.1038/ncomms8203 Biological Sciences  Cancer  Genetics  Capping protein integrates multiple MAMP signalling pathways to modulate actin dynamics during plant innate immunity OPEN Jiejie Li, Jessica L. Henty-Ridilla, Benjamin H. Staiger, Brad Day and Christopher J. Staiger Cytoskeletal remodelling is an important component of the innate immune response in plants. Here, Li et al. demonstrate that pathogen-triggered actin remodelling is due to the inhibition of capping protein (CP), and show that CP is required for resistance against plant pathogens. 28 May 2015 | doi: 10.1038/ncomms8206 Biological Sciences  Plant sciences  Abnormal splicing switch of DMD’s penultimate exon compromises muscle fibre maintenance in myotonic dystrophy OPEN Frédérique Rau, Jeanne Lainé, Laetitita Ramanoudjame, Arnaud Ferry, Ludovic Arandel, Olivier Delalande, Arnaud Jollet, Florent Dingli, Kuang-Yung Lee, Cécile Peccate, Stéphanie Lorain, Edor Kabashi, Takis Athanasopoulos, Taeyoung Koo, Damarys Loew, Maurice S. Swanson, Elisabeth Le Rumeur, George Dickson, Valérie Allamand, Joëlle Marie et al. The splicing of the penultimate exon of the dystrophin gene is developmentally regulated. Here the authors show that the dysregulation of this exon’s splicing leads to the expression of an embryonic dystrophin form with a C-terminus distinct from the adult isoform, which leads to muscle wasting in zebrafish and mice. 28 May 2015 | doi: 10.1038/ncomms8205 Biological Sciences  Medical research  Predictive modelling-based design and experiments for synthesis and spinning of bioinspired silk fibres Shangchao Lin, Seunghwa Ryu, Olena Tokareva, Greta Gronau, Matthew M. Jacobsen, Wenwen Huang, Daniel J. Rizzo, David Li, Cristian Staii, Nicola M. Pugno, Joyce Y. Wong, David L. Kaplan and Markus J. Buehler Reproducing many naturally occurring silk fibres—such as spider silk—remains a challenge. Here, the authors develop a predictive modelling approach to understand and design the artificial synthesis and fibre-spinning processes, which are tested in the laboratory to create de novo bioinspired silk fibres. 28 May 2015 | doi: 10.1038/ncomms7892 Physical Sciences  Biophysics  Materials science  Temporal regulation of kin recognition maintains recognition-cue diversity and suppresses cheating OPEN Hsing-I Ho and Gad Shaulsky It is unclear how variation in cues that enable recognition of kin and facilitate cooperation is maintained. Here, the authors show that rare variants of Dictyostelium discoideum are excluded from aggregates when the potential for social cheating is high, but subsequently rejoin the aggregate and produce spores. 28 May 2015 | doi: 10.1038/ncomms8144 Biological Sciences  Evolution  eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference Tingfang Yi, Haribabu Arthanari, Barak Akabayov, Huaidong Song, Evangelos Papadopoulos, Hank H. Qi, Mark Jedrychowski, Thomas Güttler, Cuicui Guo, Rafael E. Luna, Steven P. Gygi, Stephen A. Huang and Gerhard Wagner miRNAs are incorporated into ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs) to exert RNA interference. Here the authors show that translation initiation factor eIF1A interacts with the RISCs component Ago2 to promote miR-451 biogenesis and RNA interference. 28 May 2015 | doi: 10.1038/ncomms8194 Biological Sciences  Biophysics  Molecular biology  Multiparametric AFM reveals turgor-responsive net-like peptidoglycan architecture in live streptococci OPEN Ron Saar Dover, Arkady Bitler, Eyal Shimoni, Patrick Trieu-Cuot and Yechiel Shai The peptidoglycan (PG) layer of the Gram-positive bacteria cell wall resists turgor pressure, but the architecture of this layer is largely unknown. Here the authors use high resolution atomic force microscopy to image the PG layer from live Streptococcus to reveal a net-like arrangement that resists osmotic challenge by stretching and stiffening. 28 May 2015 | doi: 10.1038/ncomms8193 Biological Sciences  Biophysics  Microbiology  Superdense teleportation using hyperentangled photons OPEN Trent M. Graham, Herbert J. Bernstein, Tzu-Chieh Wei, Marius Junge and Paul G Kwiat Implementations of known quantum teleportation techniques suffer from a number of technical limitations, most notably the scaling of the required classical resources. Here, the authors implement a new protocol, superdense teleportation, which requires fewer resources than the conventional approaches. 28 May 2015 | doi: 10.1038/ncomms8185 Physical Sciences  Optical physics  Electronic Raman scattering as an ultra-sensitive probe of strain effects in semiconductors OPEN Brian Fluegel, Aleksej V. Mialitsin, Daniel A. Beaton, John L. Reno and Angelo Mascarenhas Engineering strain in semiconductor structures provides additional control over the optical and electronic properties, which is promising for device applications. Fluegel et al. show that electronic Raman scattering provides a route to sensitively measure the degree of strain in thin semiconductor layers. 28 May 2015 | doi: 10.1038/ncomms8136 Physical Sciences  Applied physics  Condensed matter  A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease OPEN Omar S. Ahmad, John A. Morris, Muhammad Mujammami, Vincenzo Forgetta, Aaron Leong, Rui Li, Maxime Turgeon, Celia M.T. Greenwood, George Thanassoulis, James B. Meigs, Robert Sladek and J. Brent Richards In order to effectively design interventions, it is useful to understand the complex interplay between multiple syndromes. Here, Ahmad et al. use genome-wide association study data and Mendelian randomisation to examine the influence of Type 2 diabetes and fasting glucose levels on coronary heart disease. 28 May 2015 | doi: 10.1038/ncomms8060 Biological Sciences  Genetics  AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation OPEN Albert Herms, Marta Bosch, Babu J.N. Reddy, Nicole L. Schieber, Alba Fajardo, Celia Rupérez, Andrea Fernández-Vidal, Charles Ferguson, Carles Rentero, Francesc Tebar, Carlos Enrich, Robert G. Parton, Steven P. Gross and Albert Pol Lipid droplets (LDs) supply fatty acids to cellular processes and move bidirectionally on microtubules. Here the authors show that nutrient starvation causes dispersal of mitochondria and LD to the periphery of the cell along detyrosinated microtubules and increases LD–mitochondria interactions in an AMPK-dependent manner. 27 May 2015 | doi: 10.1038/ncomms8176 Biological Sciences  Cell biology  Resonance shifts and spill-out effects in self-consistent hydrodynamic nanoplasmonics Giuseppe Toscano, Jakob Straubel, Alexander Kwiatkowski, Carsten Rockstuhl, Ferdinand Evers, Hongxing Xu, N. Asger Mortensen and Martijn Wubs Recent experiments with plasmonic nanostructures have found phenomena that cannot be explained classically, necessitating new theoretical models. Toscano et al. present a self-consistent hydrodynamic theory that describes both the nonlocal response and the electronic spill-out for noble and simple metals. 27 May 2015 | doi: 10.1038/ncomms8132 Physical Sciences  Condensed matter  Optical physics  Theoretical physics  Activating MET kinase rearrangements in melanoma and Spitz tumours Iwei Yeh, Thomas Botton, Eric Talevich, A. Hunter Shain, Alyssa J. Sparatta, Arnaud de la Fouchardiere, Thaddeus W. Mully, Jeffrey P. North, Maria C. Garrido, Alexander Gagnon, Swapna S. Vemula, Timothy H. McCalmont, Philip E. LeBoit and Boris C. Bastian Several oncogenic mutations have been identified in melanoma; however, despite exhaustive sequencing, in a subset of melanomas no oncogenic mutation has been identified. Here, the authors identify new genomic rearrangements causing oncogenic fusions between the kinase domain of MET and several N-terminal partners in Spitzoid tumours. 27 May 2015 | doi: 10.1038/ncomms8174 Biological Sciences  Cancer  Genetics  Medical research    Nature Communications JOBS of the week PhD position University of Fribourg Junior Group Leader CNRS & University of Toulouse Post Doctoral Fellow / Research Associate Emory University Postdoctoral Fellow The BloodCenter of Wisconsin Postdoctoral Scientist in Leukaemia Biology University of Oxford PhD Studentship King's College London Postdoctoral Researcher Maynooth University Research Fellow University of Edinburgh Faculty of Health and Medical Sciences University of Surrey Research Associate Loyola University Chicago More Science jobs from Nature Communications EVENT SMODIA "Statistical Methods for Omics Data Integration and Analysis 2015" 14.09.15 Valencia, Spain More science events from       Latest Corrigendum     Corrigendum: Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids Jan Lipfert, Matthew Wiggin, Jacob W.J. Kerssemakers, Francesco Pedaci and Nynke H. Dekker 27 May 2015 | doi: 10.1038/ncomms8192 Biological Sciences  Biophysics  Molecular biology      Advertisement Nature Immunology Focus on The immunology of HIV Nature Immunology presents a series of specially commissioned articles that discuss the most recent progress in understanding the immune response to HIV and how this new insight can be harnessed for prophylactic vaccines and immunotherapies.  Click here for more information.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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