The EMBO Journal Table of Contents for 3 June 2015; Vol. 34, No. 11

3 June 2015 | Volume 34, Number 11 Submit Table of Contents Editorial Have you seen? Reviews Articles Volume 34, Number 11 Editorial Focus on induced pluripotency and cellular reprogramming Thomas Schwarz‐Romond, Evangelos Kiskinis, and Kevin Eggan Published online 27.04.2015 Have you seen? Talk among yourselves: RNA sponges mediate cross talk between functionally related messenger RNAs Recent work shows that bacterial RNAs can act as sponges for sRNAs, thereby altering the regulatory outcome for downstream target mRNAs. Muhammad S Azam and Carin K Vanderpool Published online 27.04.2015 SHP2: a new target for pro‐senescence cancer therapies Pharmacological inhibition of the tyrosine phosphatase SHP2 blocks mouse mammary cancer through the induction of senescence. Manuel Serrano Published online 27.04.2015 A grab to move on: ER–endosome contacts in membrane protrusion formation and neurite outgrowth ER‐localized protrudin and phosphatidylinositol 3‐phosphate and Rab7 GTPase on late endosomes establish contact sites, to transfer kinesin‐1 to the motor adaptor FYCO1, allowing for the movement of late endosomes and thus outgrowth of protrusions and neurites. Michael Krauß and Volker Haucke Published online 09.04.2015 Reviews Focus: Induced Pluripotency & Cellular Reprogramming: Forward engineering neuronal diversity using direct reprogramming Kristin Baldwin & colleagues outline most recent routes to generate a huge spectrum of neuronal subtypes in vitro. Their functionality and resemblance of endogenous tissue raises hopes for cell replacement therapies. Rachel K Tsunemoto, Kevin T Eade, Joel W Blanchard, and Kristin K Baldwin Published online 23.04.2015 Focus: Induced Pluripotency & Cellular Reprogramming: Probing disorders of the nervous system using reprogramming approaches Kiskinis & Ichida highlight recent progress in neurological disease modeling using iPSCs. The reconstitution of the three‐dimensional architecture, including ageing or metabolic parameters will inform the complex nature of neurologic conditions. Justin K Ichida and Evangelos Kiskinis Published online 29.04.2015 Articles Cross talk between ABC transporter mRNAs via a target mRNA‐derived sponge of the GcvB small RNA Decay of the bacterial GcvB sRNA, which keeps it from regulating its mRNA targets, is triggered by a 3′‐UTR‐derived fragment from a target mRNA. This ability of mRNAs to compete for regulatory RNA interaction presents a new mode of RNA cross talk in bacteria. Masatoshi Miyakoshi, Yanjie Chao, and Jörg Vogel Published online 28.01.2015 Shp2 signaling suppresses senescence in PyMT‐induced mammary gland cancer in mice Tyrosine phosphatase Shp2, upregulated in human breast cancer, regulates Src, FAK, and MAPK signaling pathway to suppress senescence and promote tumorigenesis in mouse models. Linxiang Lan, Jane D Holland, Jingjing Qi, Stefanie Grosskopf, Regina Vogel, Balázs Györffy, Annika Wulf‐Goldenberg, and Walter Birchmeier Published online 03.03.2015 Synthetic viability genomic screening defines Sae2 function in DNA repair Identification of Mre11 mutations suppressing the DNA damage sensitivity of Sae2 mutant cells reveals how these resection nucleases cooperate in mitotic yeast cells. Fabio Puddu, Tobias Oelschlaegel, Ilaria Guerini, Nicola J Geisler, Hengyao Niu, Mareike Herzog, Israel Salguero, Bernardo Ochoa‐Montaño, Emmanuelle Viré, Patrick Sung, David J Adams, Thomas M Keane, and Stephen P Jackson Published online 21.04.2015 The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing Transcriptome analysis in mouse 1‐cell embryos reveals widespread transcription of intergenic regions devoid of core‐promoter elements. The resulting RNAs, possibly involved in chromatin remodeling, are poorly processed to prevent aberrant expression. Ken‐ichiro Abe, Ryoma Yamamoto, Vedran Franke, Minjun Cao, Yutaka Suzuki, Masataka G Suzuki, Kristian Vlahovicek, Petr Svoboda, Richard M Schultz, and Fugaku Aoki Published online 20.04.2015 The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing Sugar feeding in flies induces specific gene expression but also triggers a repressive branch via transcription factor Cabut. Induction of Cabut alters accumulation of the metabolic enzyme PEPCK and provides a regulatory link between nutrient sensing and the circadian clock. Osnat Bartok, Mari Teesalu, Reut Ashwall‐Fluss, Varun Pandey, Mor Hanan, Bohdana M Rovenko, Minna Poukkula, Essi Havula, Arieh Moussaieff, Sadanand Vodala, Yaakov Nahmias, Sebastian Kadener, and Ville Hietakangas Published online 27.04.2015 Repression of SRF target genes is critical for Myc‐dependent apoptosis of epithelial cells Oncogenic levels of Myc promote apoptosis by repressing cell adhesion molecules and Akt signaling in epithelial cells, counteracting serum‐response factor activity. Katrin E Wiese, Heidi M Haikala, Björn von Eyss, Elmar Wolf, Cyril Esnault, Andreas Rosenwald, Richard Treisman, Juha Klefström, and Martin Eilers Published online 20.04.2015 Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo This study establishes Rx2 as functional determinant of neuro‐epithelial progenitor fate and uncovers the gene regulatory network that governs Rx2 expression. Robert Reinhardt, Lázaro Centanin, Tinatini Tavhelidse, Daigo Inoue, Beate Wittbrodt, Jean‐Paul Concordet, Juan Ramón Martinez‐Morales, and Joachim Wittbrodt Published online 23.04.2015 Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling Structural and functional analyses of the PERK luminal domain reveal a novel tetrameric arrangement, whose transient formation may be an important step in activation of the unfolded protein response. Marta Carrara, Filippo Prischi, Piotr R Nowak, and Maruf MU Ali Published online 28.04.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.