Nature Reviews Cancer contents May 2015 Volume 15 Number 5 pp255-316

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TABLE OF CONTENTS
May 2015 Volume 15 Number 5		Advertisement
Impact Factor 37.912 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Examining the utility of patient-derived xenograft mouse models Samuel Aparicio, Manuel Hidalgo & Andrew L. Kung	Determine the Metabolic Phenotype of Your Cells Seahorse Bioscience Webinar: The XFp Cell Energy Phenotype Test determines the metabolic phenotype of live cells under both basal and stressed conditions, to reveal their metabolic potential. Presented by David Ferrick, Ph.D., CSO. Register: www.seahorsebio.com
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RESEARCH HIGHLIGHTS Top Metastasis: Spreading the seed p255 | doi:10.1038/nrc3953 Gundem et al. sequenced a series of primary tumours and matched metastases from patients with metastatic prostate cancer; they showed that metastases are often seeded by multiple clones and that there are multiple paths of metastatic spreading. PDF Pancreatic cancer: A matter of timing p256 | doi:10.1038/nrc3948 The BRG1 catalytic subunit of the chromatin remodelling SWI/SNF complex has context-dependent functions during different stages of pancreatic ductal adenocarcinoma development from intraductal papillary mucinous neoplasia, and bromodomain and extraterminal inhibitors might be therapeutically beneficial in this subtype of pancreatic cancer. PDF Therapy: It's raining menin p256 | doi:10.1038/nrc3951 Two papers report on the preclinical efficacy of targeting the menin-MLL interaction in MLL-translocation-associated leukaemias and in prostate cancer. PDF Tumorigenesis: A hairy and nervous start p257 | doi:10.1038/nrc3952 Peterson et al. report that basal cell carcinomas primarily arise from stem cells within hair follicle and touch dome epithelia, and that cutaneous nerves promote tumorigenesis. PDF Immunotherapy: Primed for a response p258 | doi:10.1038/nrc3945 The efficacy of dendritic cell vaccines can be improved in patients with glioblastoma by pre-conditioning the vaccine site with the tetanus/diphtheria toxoid. PDF Immunotherapy: A triple blow for cancer p258 | doi:10.1038/nrc3946 Dual immune checkpoint blockade combined with radiation promotes effective antitumour immunity through distinct mechanisms. PDF IN BRIEF Immunotherapy: Treat your mouse like a 'man | Wildlife cancer: Outbreak of leukaemia in clams | Genetics: Slowing premature ageing | Cell Signalling: Scaffolding proteins under hypoxia PDF Cancer JOBS of the week Tenure, Tenure-track position in Childhood Cancer Research Greehey Children’s Cancer Research Institute Gynecological Cancer Research Position University of Alabama at Birmingham, Department of Pathology Postdoctoral Scholar in Cancer Research Penn State College of Medicine Postdoctoral Position in Cancer Biology at the Perelman School of Medicine University of Pennsylvania Postdoctoral Position at Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center (MSKCC) More Science jobs from Cancer EVENT Metabolism in Cancer and Stromal Cells 08.09.15 Leuven, Belgium More science events from
REVIEWS		Top
Mechanisms of aromatase inhibitor resistance Cynthia X. Ma, Tomas Reinert, Izabela Chmielewska & Matthew J. Ellis p261 | doi:10.1038/nrc3920 This Review discusses the mechanisms underlying resistance to aromatase inhibitor (AI) therapy of patients with oestrogen receptor-positive (ER+) breast cancer, and also assesses the possible therapeutic options for overcoming AI resistance. Abstract | Full Text | PDF
Replication stress and cancer Helene Gaillard, Tatiana Garcia-Muse & Andres Aguilera p276 | doi:10.1038/nrc3916 DNA damage can result in replication stress, which is a source of genome instability and a feature of cancer cells. Revealing the molecular basis of replication stress is crucial to the understanding of tumorigenesis and may provide potential targets for cancer therapy. Abstract | Full Text | PDF | Supplementary information
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor Nancy Ratner & Shyra J. Miller p290 | doi:10.1038/nrc3911 Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome, and somatic NF1 mutations are also common in tumours. The neurofibromin protein (encoded by NF1) is a RAS GTPase-activating protein that activates RAS-MAPK signalling when lost. This Review discusses NF1 disease, neurofibromin signalling pathways and recent developments in NF1 therapeutics. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma Frank B. Furnari, Timothy F. Cloughesy, Webster K. Cavenee & Paul S. Mischel p302 | doi:10.1038/nrc3918 Heterogeneous expression of the epidermal growth factor receptor (EGFR) in glioblastoma poses an important challenge for the effective use of EGFR-targeted therapies. In this Opinion article, Furnari et al. highlight the possible mechanisms underlying EGFR heterogeneity, and the importance in understanding these mechanisms to improve treatment outcome in glioblastoma. Abstract | Full Text | PDF
VIEWPOINT Examining the utility of patient-derived xenograft mouse models Samuel Aparicio, Manuel Hidalgo & Andrew L. Kung p311 | doi:10.1038/nrc3944 In this Viewpoint article, three scientists give their opinions on the generation and uses of patient-derived xenograft (PDX) models and the future of this field. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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