Nature Reviews Immunology Contents May 2015 Volume 15 Number 5 pp 265-329

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TABLE OF CONTENTS
May 2015 Volume 15 Number 5		Advertisement
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RESEARCH HIGHLIGHTS Top Tumour immunology: A triple blow for cancer p265 | doi:10.1038/nri3844 Dual immune checkpoint blockade combined with radiation promotes effective antitumour immunity through distinct mechanisms. PDF Inflammation: Live long and prosper with Siglecs p266 | doi:10.1038/nri3851 Siglec receptors may support longevity in mammals by protecting host cells against damaging free radicals. PDF Cytokines: An antagonistic family member p266 | doi:10.1038/nri3854 Interleukin-17B protects against dextran sodium sulfate-induced colitis by antagonizing the functions of interleukin-25. PDF Immune regulation: Brain–fat axis in adaptive immunity p267 | doi:10.1038/nri3853 Tumour necrosis factor signals in the hypothalamus promote peripheral adaptive immune responses. PDF Cytokines: Where there's smoke, there's fire p268 | doi:10.1038/nri3852 Cigarette smoke exposure enhances lung inflammation in multiple ways. PDF Infection: Virus boosts protection p268 | doi:10.1038/nri3856 Cytomegalovirus infection enhances immunity and improves vaccine responses to influenza virus in humans and provides cross-protection against influenza virus in mice. PDF Regulatory T cells: Young AIREs go on to rule p269 | doi:10.1038/nri3849 Autoimmune regulator (AIRE) promotes the perinatal development of a distinct population of regulatory T cells. PDF Immunology JOBS of the week New Investigators in Immunity and Infection University of Cambridge Postdoctoral Fellow San Diego Biomedical Research Institute Assistant / Associate / Full Professor, Department of Pharmacology University of Virginia Post-Doctoral Fellow University of Chicago Postdoc Fellows in Infection and Immunity, Wuhan Institute of Virology Wuhan Institute of Virology (WIV) More Science jobs from Immunology EVENT 3rd International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism 24.09.15 Chania, Greece More science events from
REVIEWS		Top
Type 2 cytokines: mechanisms and therapeutic strategies Thomas A. Wynn p271 | doi:10.1038/nri3831 The type 2 cytokine response provides important host-protective functions, but dysregulated type 2 immune responses can contribute to the development of disease. In this Review, the author describes the regulatory mechanisms that limit the pathological consequences of persistent type 2 immunity. Abstract | Full Text | PDF
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases David Klatzmann & Abul K. Abbas p283 | doi:10.1038/nri3823 The dominant role of interleukin-2 (IL-2) is in the maintenance of regulatory T cells rather than of effector T cells. This has led to clinical interest in the use of low-dose IL-2 to control autoimmune and inflammatory disorders, with promising initial results. Abstract | Full Text | PDF | Supplementary information
The development and in vivo function of T helper 9 cells Mark H. Kaplan, Matthew M. Hufford & Matthew R. Olson p295 | doi:10.1038/nri3824 This Review summarizes our current understanding of the key factors that regulate the differentiation of T helper 9 (TH9) cells. The authors discuss how TH9 cells can contribute to protective immunity to infection but may also drive immunopathology in diseases such as allergic asthma and inflammatory bowel disease. Abstract | Full Text | PDF
The impact of diet on asthma and allergic diseases Valerie Julia, Laurence Macia & David Dombrowicz p308 | doi:10.1038/nri3830 Accumulating evidence indicates that the food we eat can influence the development of allergic diseases. In this Review, the authors describe the role of both maternal and early childhood food exposure in the prevention of allergy and asthma, and they discuss some of the known dietary components that influence immune homeostasis and the development of allergy. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY Immune biomarkers: the promises and pitfalls of personalized medicine Joanna C. D. Willis & Graham M. Lord p323 | doi:10.1038/nri3820 Immune biomarkers are increasingly being used to inform clinical interventions. In this Science and Society article, the authors discuss the progress that has been made in identifying and applying immune biomarkers in different disease settings. The authors also consider the major challenges facing the field. Abstract | Full Text | PDF
Corrigendum: WNT signalling in the immune system: WNT is spreading its wings Frank J. T. Staal, Tiago C. Luis & Machteld M. Tiemessen p329 | doi:10.1038/nri3847 Full Text | PDF
Erratum: Immune adaptations that maintain homeostasis with the intestinal microbiota Lora V. Hooper & Andrew J. Macpherson p329 | doi:10.1038/nri3848 Full Text | PDF
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