Nature Reviews Cancer contents February 2015 Volume 15 Number 2 pp65-129

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TABLE OF CONTENTS
February 2015 Volume 15 Number 2
Impact Factor 37.912*	In this issue Comment Research Highlights Progress Reviews Perspectives Also this month Article series: Clinical insights  Featured article: The RUNX family: developmental regulators in cancer Yoshiaki Ito, Suk-Chul Bae & Linda Shyue Huey Chuang
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Article series: Clinical insights Comment: Revisiting tissue specificity of germline cancer predisposing mutations John M. Maris & Alfred G. Knudson p65 | doi:10.1038/nrc3894 Why do inherited germline mutations in common cancer-associated genes cause a restricted pattern of tissue-specific malignancies, but when somatic mutations occur in these genes they exhibit far less tissue restriction? Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Metabolism: Acetate nourishes stressed tumour cells p67 | doi:10.1038/nrc3899 Three papers report on the use of acetate as a nutrient in tumour cells undergoing metabolic stress. PDF Leukaemia: Exploring origins and evolution p68 | doi:10.1038/nrc3897 Genome sequencing of therapy-related acute myeloid leukaemia (t-AML) has revealed that these malignancies do not have more mutations than de novo AML, and that TP53 mutations, which are common in t-AML, are likely to be present before treatment with chemotherapy and expand following treatment. PDF Oncogenes: Nothing but a G thing p68 | doi:10.1038/nrc3898 Yoda et al. have shown that mutations in G protein-[β] (G[β]) subunits occur in haematological malignancies and can transform cells. Mutant G[β] can also confer resistance to different therapeutic kinase inhibitors. PDF Metabolism: The mitochondria thief p70 | doi:10.1038/nrc3901 Tumour cells without mitochondrial DNA acquire mitochondria from host cells to re-establish respiration and tumour-initiating efficacy. PDF Cell migration: Changing shape p70 | doi:10.1038/nrc3902 Madsen et al. have delineated the roles of components of the striatin-interacting phosphatase and kinase (STRIPAK) complex in cancer cell migration and metastasis, which may explain why some of these proteins are overexpressed or mutated in cancer. PDF Therapeutic resistance: Paradox breaking p71 | doi:10.1038/nrc3900 Two studies offer new possibilities to fight BRAF inhibition resistance. PDF IN BRIEF Epigenetics: Epimutation of SDH | Inflammation: Red meat protein in human tissues | Viral tumorigenesis: Similar but different | Inflammation: Immune responses to commensal bacteria PDF Cancer JOBS of the week Postdoctoral Researcher in Cancer Biology University of Pennsylvania Postdoctoral Fellow - MD Anderson Cancer Center MD Anderson Cancer Center Postdoctoral Fellow in Translational Cancer Research Vanderbilt Univeristy Postdoctoral Position in Cancer Immunology Universität Basel Postdoctoral Positions: Cancer Bioengineering and Cancer Biology University of Minnesota More Science jobs from Cancer EVENT Cancer and Metabolism 2015 28.09.15 Cambridge, UK More science events from
Erratum: Feed a cold, starve a tumour Nicola McCarthy p71 | doi:10.1038/nrc3908 Full Text | PDF
PROGRESS		Top
The emerging roles of YAP and TAZ in cancer Toshiro Moroishi, Carsten Gram Hansen & Kun-Liang Guan p73 | doi:10.1038/nrc3876 YAP and TAZ are the major downstream effectors of the Hippo pathway. This Progress article summarizes the latest findings regarding the biological functions of YAP and TAZ, and their role in connecting the Hippo pathway with other relevant pathways in cancer. Abstract | Full Text | PDF
REVIEWS		Top
The RUNX family: developmental regulators in cancer Yoshiaki Ito, Suk-Chul Bae & Linda Shyue Huey Chuang p81 | doi:10.1038/nrc3877 The RUNX transcription factors seem to have dichotomous roles in cancer, sometimes being oncogenic and sometimes acting as tumour suppressors. This Review discusses the many roles of the RUNX family in cancer biology. Abstract | Full Text | PDF | Supplementary information
S100 proteins in cancer Anne R. Bresnick, David J. Weber & Danna B. Zimmer p96 | doi:10.1038/nrc3893 The S100 family of proteins modulates cellular responses by acting both as intracellular Ca2+ sensors and as extracellular factors. Expression of several members of this family is dysregulated in cancer, and each cancer shows a unique S100 protein profile or signature. In this Review, Anne Bresnick and colleagues highlight new findings regarding the role of S100 proteins in cancer diagnosis and treatment. Abstract | Full Text | PDF | Supplementary information
Critical roles of non-histone protein lysine methylation in human tumorigenesis Ryuji Hamamoto, Vassiliki Saloura & Yusuke Nakamura p110 | doi:10.1038/nrc3884 Although dysregulation of histone methylation has been widely studied in cancer, accumulating evidence suggests that cancer-relevant non-histone proteins such as p53, RB1 and signal transducer and activator of transcription 3 (STAT3) are also regulated by lysine methylation. This Review summarizes the possible functions of non-histone protein lysine methylation in cancer. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
SCIENCE AND SOCIETY Philanthropic partnerships and the future of cancer research Yonina R. Murciano-Goroff p125 | doi:10.1038/nrc3862 Complementing government and industry funding, philanthropies have made distinct contributions to altering the trajectory of cancer research. This Science and Society article aims to investigate the changing role of philanthropy in fostering cancer research, with emphasis on the work of non-profit institutions. Abstract | Full Text | PDF
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